Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

(2016) A.M. Bertholet et al.   NEUROBIOLOGY OF DISEASE

Sumoylation of LYS590 of NCX3 f-Loop by SUMO1 Participates in Brain Neuroprotection Induced by Ischemic Preconditioning

(2016) Ornella Cuomo et al.   STROKE

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

(2015) Hanne Hoitzing et al.   BIOESSAYS

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

(2015) Antonio Zorzano et al.   Frontiers in Aging Neuroscience

Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection

(2014) M J Sisalli et al.   CELL DEATH AND DIFFERENTIATION

Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development

(2014) Takaya Ishihara et al.   MOLECULAR AND CELLULAR BIOLOGY

NCX3 regulates mitochondrial Ca 2+ handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death

(2013) Antonella Scorziello et al.   JOURNAL OF CELL SCIENCE

Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2

(2013) Piya Ghose et al.   PLoS Genetics

Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response

(2012) Timothy E. Shutt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

(2011) Hyungsoo Kim et al.   MOLECULAR CELL

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1

(2011) Ronald A. Merrill et al.   PLOS BIOLOGY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anoxia-Induced NF-kB-Dependent Upregulation of NCX1 Contributes to Ca 2+ Refilling Into Endoplasmic Reticulum in Cortical Neurons

(2009) Rossana Sirabella et al.   STROKE

Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia

(2008) Annalisa Carlucci et al.   EMBO JOURNAL

Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

(2008) Mike Strauss et al.   EMBO JOURNAL

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome

(2008) Annalisa Carlucci et al.   TRENDS IN CELL BIOLOGY