Article
Biochemistry & Molecular Biology
Evgeniya S. Grigoryeva, Luibov A. Tashireva, Olga E. Savelieva, Marina V. Zavyalova, Nataliya O. Popova, Gleb A. Kuznetsov, Elena S. Andryuhova, Vladimir M. Perelmuter
Summary: In this study, we investigated the expression of integrins beta 3, beta 4, and alpha V beta 5 on exosomes and tumor cells, and their association with distant metastasis in breast cancer patients. We found that exosomal integrin beta 4 was associated with lung metastasis, while integrin beta 3 was not evaluable due to its rarity in brain metastasis. Exosomal integrin alpha V beta 5 showed no association with liver metastasis. Furthermore, integrin beta 4 in the primary tumor was associated with liver metastasis, and beta 4+ tumor cells in liver metastasis patients showed increased expression of E-cadherin+ and CD44+CD24- cells compared to patients with lung or no distant metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xin Zhou, Junhong Li, Ludvig J. Backman, Patrik Danielson
Summary: This study investigated the effects of IL-1 beta and TGF beta 1 on corneal stromal cell differentiation. IL-1 beta treatment reduced the keratocyte phenotype, while TGF beta 1 treatment induced differentiation towards myofibroblasts. The crosstalk between IL-1 beta and TGF beta 1 was mediated by the NF-kappa B signaling pathway, with IL-1 beta inhibiting TGF beta 1-induced keratocyte-myofibroblast differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Michele Minopoli, Sabrina Sarno, Lucia Cannella, Salvatore Tafuto, Gosue Scognamiglio, Michele Gallo, Flavio Fazioli, Rosa Azzaro, Gaetano Apice, Biagio De Angelis, Elena Tamborini, Cecilia Garofalo, Ymera Pignochino, Laura Mercatali, Toni Ibrahim, Rita Falcioni, Beatrice Valenti, Roberta Maestro, Katia Scotlandi, Annarosaria De Chiara, Maria Vincenza Carriero
Summary: Myxoid liposarcoma (MLPS) is the second most common subtype of liposarcoma and tends to metastasize to soft tissues. The study demonstrates that high-grade MLPS tissues are characterized by a lack of T lymphocytes and an abundance of M2-like macrophages, while low-grade MLPS tissues are mainly infiltrated by T lymphocytes. This interaction between MLPS cells and macrophages may contribute to the invasive capability of MLPS cells.
Article
Neurosciences
Isidora Paredes, Jose Ricardo Vieira, Bhavin Shah, Carla F. Ramunno, Julia Dyckow, Heike Adler, Melanie Richter, Geza Schermann, Evangelia Giannakouri, Lucas Schirmer, Hellmut G. Augustin, Carmen Ruiz de Almodovar
Summary: Bidirectional crosstalk between neural and vascular compartments plays a critical role in oligodendrocyte precursor cell specification, with neural progenitor cells expressing angiopoietin-1 and endothelial cells producing transforming growth factor beta 1 in response. This collaboration demonstrates the complex relationship between NPCs and the vasculature in regulating oligodendrogenesis.
NATURE NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Dominique S. Rubenich, Natalia Omizzollo, Miroslaw J. Szczepanski, Torsten E. Reichert, Theresa L. Whiteside, Nils Ludwig, Elizandra Braganhol
Summary: Neutrophils play a crucial role in tumor progression and communicate with tumor cells through small extracellular vesicles. These vesicles modulate inflammatory responses in the tumor microenvironment. Understanding the signaling balance between tumor-derived and neutrophil-derived vesicles may lead to novel approaches for controlling tumor progression in the future.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Ming Liu, Na Wu, Keman Xu, Fatma Saaoud, Eleni Vasilopoulos, Ying Shao, Ruijing Zhang, Jirong Wang, Haitao Shen, William Y. Yang, Yifan Lu, Yu Sun, Charles Drummer, Lu Liu, Li Li, Wenhui Hu, Jun Yu, Domenico Pratico, Jianxin Sun, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Summary: This study revealed significant differences in the expression of organelle crosstalk regulators in various diseases and tumors, particularly highlighting their roles in inflammatory diseases and cancers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Peizhe Lin, Yijing Yan, Ze Zhang, Qiutong Dong, Jia Yi, Qingbo Li, Ao Zhang, Xianbin Kong
Summary: Colorectal cancer (CRC) is highly prevalent and has a significant impact on human health globally. Current treatments are not effective in improving survival rate and quality of life, necessitating the development of new strategies. Adoptive cell therapy, specifically focusing on gamma delta T cells, has shown potential in triggering cytotoxicity, cytokine secretion, immune cell recruitment, and inhibiting CRC progress. However, there is a risk of inflammation and immune inhibition associated with gamma delta T cell therapy. This review highlights the dual function of gamma delta T cells and their relationship with intestinal flora, providing a conceptual framework for their application in CRC therapies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shiyu Ji, Wenbo Wu, Qi Jiang
Summary: This review provides an overview of the crucial functions of endothelial cells in angiogenesis, metastasis, and drug resistance in prostate cancer, as well as their prospective therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jingping Zhou, Shaolong Zhang, Changying Guo
Summary: The tumor microenvironment is shaped by various cell types that interact with tumor cells to influence tumor development. Macrophages and NK cells play a crucial role in regulating the immune response within the TME through cytokine signaling and cell-to-cell interactions, affecting the efficacy of immune responses against cancer cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Pil Soo Sung
Summary: Tumor-associated macrophages (TAMs) play a crucial role in hepatocellular carcinoma (HCC) progression and treatment resistance by interacting with various cell populations in the tumor microenvironment.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Neurosciences
Xu Guo, Rui Sui, Haozhe Piao
Summary: This review summarizes the role of exosomes released by glioma cells in the tumor microenvironment, including mediating intercellular communication, inducing macrophage polarization, and inhibiting immune cell activity. Exosomes play a crucial regulatory role in the development and immune evasion of glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
Fang-yan Gao, Xin-tong Li, Kun Xu, Run-tian Wang, Xiao-xiang Guan
Summary: The dysregulation of the MYC oncogenic family is commonly observed in various tumors and is associated with poor prognosis. The members of the MYC family are transcription factors responsible for regulating gene expression. Among them, c-MYC is closely related to tumor progression and specifically associated with breast cancer prevalence.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Zheng Peng, Meng Hao, Haibo Tong, Hongmei Yang, Bin Huang, Zhigang Zhang, Kathy Qian Luo
Summary: This study investigates the heterotypic intercellular interactions between liver cancer cells and fibroblasts and identifies fibronectin and integrin-??5??1 as key regulatory molecules in promoting liver cancer cell growth. The study also finds that the upregulation of fibronectin, integrin-??5, and integrin-??1 is associated with microvascular invasion in HCC tumors.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shahang Luo, Guanghui Yang, Peng Ye, Nengqi Cao, Xiaoxia Chi, Wen-Hao Yang, Xiuwen Yan
Summary: This review comprehensively summarizes the mechanisms of interaction between cancer stem cells (CSCs) and tumor-associated macrophages (TAMs), and discusses potential therapeutic strategies. It is of great significance for understanding tumor progression and developing new treatment strategies.
Article
Neurosciences
Andrew J. Lopuch, Brian D. Swinehart, Eden L. Widener, Z. Logan Holley, Katherine M. Bland, Christopher J. Handwerk, Cooper A. Brett, Hollyn N. Cook, Anna R. Kalinowski, Hilda Rodriguez, M. Irene Song, George S. Vidal
Summary: This study found that Itgb3 plays a specific role in shaping forebrain circuitry that is relevant to repetitive self-grooming and social behaviors. However, it is still unknown whether forebrain Itgb3 is required for a preference for social novelty and whether cHET mice are haploinsufficient in terms of repetitive self-grooming and social behaviors.
Article
Oncology
Emma Newport, Ana Rita Pedrosa, Delphine Lees, Matthew Dukinfield, Edward Carter, Jesus Gomez-Escudero, Pedro Casado, Vinothini Rajeeve, Louise E. Reynolds, Pedro R. Cutillas, Stephen W. Duffy, Beatriz De Luxan Delgado, Kairbaan Hodivala-Dilke
Summary: The study identified the impact of EC FAK kinase activity on tumor cell sensitivity to DNA-damaging therapies, suggesting a modulation of tumor growth and chemotherapy response.
JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, General & Internal
Peter W. Horby, Guilherme Pessoa-Amorim, Natalie Staplin, Jonathan R. Emberson, Mark Campbell, Enti Spata, Leon Peto, Nigel J. Brunskill, Simon Tiberi, Victor Chew, Thomas Brown, Hasan Tahir, Beate Ebert, David Chadwick, Tony Whitehouse, Rahuldeb Sarkar, Clive Graham, J. Kenneth Baillie, Buddha Basnyat, Maya H. Buch, Lucy C. Chappell, Jeremy Day, Saul N. Faust, Raph L. Hamers, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with COVID-19, aspirin was not associated with reductions in 28-day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.
Article
Oncology
Marius Tham, Hans-Juergen Stark, Anna Jauch, Catherine Harwood, Elizabeth Pavez Lorie, Petra Boukamp
Summary: The BRAF inhibitor vemurafenib can activate the MEK-ERK signaling pathway in both keratinocytes and fibroblasts, leading to cutaneous adverse events. The effects of vemurafenib on skin keratinocytes depend on their genetic background and can result in tumor progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxan-Delgado, Oscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J. G. Drake, Jesus Gomez-Escudero, Frances M. Richards, Celine Weller, Christof Dormann, Ya-Ming Meng, Peter B. Vermeulen, Dieter Saur, Victoria Sanz-Moreno, Ping-Pui Wong, Cyrill Geraud, Pedro R. Cutillas, Kairbaan Hodivala-Dilke
Summary: This study reveals that endothelial cell focal adhesion kinase (FAK) plays a role in regulating pancreatic ductal adenocarcinoma (PDAC) metastasis and impacting the outcome of gemcitabine treatment. The findings suggest the potential clinical utility of combinatorial endothelial cell FAK targeting with gemcitabine in controlling metastasis in PDAC patients.
Review
Cell Biology
Vittoria Graziani, Irene Rodriguez-Hernandez, Oscar Maiques, Victoria Sanz-Moreno
Summary: This review focuses on the role of amoeboid behavior in cancer cell invasion and metastasis, as well as the molecular biomarkers and physicochemical triggers associated with it. The authors suggest that targeting these characteristics could lead to therapeutic opportunities for cancer treatment.
TRENDS IN CELL BIOLOGY
(2022)
Article
Oncology
C. Barcelo, P. Siso, I. de la Rosa, C. Megino-Luque, R. Navaridas, O. Maiques, I. Urdanibia, N. Eritja, X. Soria, M. Potrony, N. Calbet-Llopart, S. Puig, X. Matias-Guiu, R. M. Marti, A. Macia
Summary: Secreted M-CSF induces a BRAFi-resistant phenotype and signifies a worse prognosis in metastatic BRAF(V600E) melanoma patients. These findings identify secreted M-CSF as a promising therapeutic target for treating BRAFi-resistant melanomas.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Yaiza Jung-Garcia, Oscar Maiques, Joanne Monger, Irene Rodriguez-Hernandez, Bruce Fanshawe, Marie-Charlotte Domart, Matthew J. Renshaw, Rosa M. Marti, Xavier Matias-Guiu, Lucy M. Collinson, Victoria Sanz-Moreno, Jeremy G. Carlton
Summary: Metastasis involves cancer cells spreading from the primary tumor to other sites. Researchers discovered increased expression of the protein LAP1 in metastatic melanoma cells, primary melanoma tumors, and metastases. They found that a shorter isoform of LAP1, LAP1C, supports constrained cell migration and invasion by allowing a weaker coupling between the nuclear envelope and the nuclear lamina. This suggests that LAP1 contributes to melanoma aggressiveness.
NATURE CELL BIOLOGY
(2023)
Review
Cell Biology
Samantha George, Joshua Alexander James Martin, Vittoria Graziani, Victoria Sanz-Moreno
Summary: Cell migration plays a crucial role in immune responses and cancer metastasis. Amoeboid migrating cells use myosin II-powered blebs to move and change their shape and direction. Both immune cells and metastatic cancer cells utilize amoeboid migration, but with different purposes and processes. Exploring the similarities and differences between amoeboid immune and cancer cells can enhance our understanding of metastasis and provide insights for targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Eva Crosas-Molist, Vittoria Graziani, Oscar Maiques, Pahini Pandya, Joanne Monger, Remi Samain, Samantha L. George, Saba Malik, Jerrine Salise, Valle Morales, Adrien Le Guennec, R. Andrew Atkinson, Rosa M. Marti, Xavier Matias-Guiu, Guillaume Charras, Maria R. Conte, Alberto Elosegui-Artola, Mark Holt, Victoria Sanz-Moreno
Summary: Cell migration is controlled by AMP-activated protein kinase (AMPK) acting as an adhesion sensing molecular hub. High AMPK activity in low adhering migratory cells induces mitochondrial fission and amoeboid migration. Reducing adhesion or activating AMPK promotes efficient rounded-amoeboid migration. This study reveals how mitochondrial dynamics and AMPK contribute to cell migration.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Raymond Kiu, Alexander G. Shaw, Kathleen Sim, Antia Acuna-Gonzalez, Christopher A. Price, Harley Bedwell, Sally A. Dreger, Wesley J. Fowler, Emma Cornwell, Derek Pickard, Gusztav Belteki, Jennifer Malsom, Sarah Phillips, Gregory R. Young, Zoe Schofield, Cristina Alcon-Giner, Janet E. Berrington, Christopher J. Stewart, Gordon Dougan, Paul Clarke, Gillian Douce, Stephen D. Robinson, J. Simon Kroll, Lindsay J. Hall
Summary: Genomic and phenotypic analyses of 272 infant-associated Clostridium perfringens isolates suggest that pfoA is an important toxin gene in C. perfringens linked with preterm infant intestinal diseases. The gene encoding toxin perfringolysin O, pfoA, was largely deficient in a human-derived hypovirulent lineage, as well as certain colonization factors, in contrast to typical pfoA-encoding virulent lineages. These findings suggest both the importance of pfoA(+)C. perfringens as a gut pathogen in preterm infants and areas for further investigation, including potential intervention and therapeutic strategies.
NATURE MICROBIOLOGY
(2023)
Article
Microbiology
Nancy M. Y. Teng, Raymond Kiu, Rhiannon Evans, David J. Baker, Christian Zenner, Stephen D. Robinson, Lindsay J. Hall
Summary: Two novel bacterial isolates were obtained from faecal samples of patients attending the Breast Care clinic at the Norwich and Norfolk University Hospital. Strain LH1062T was predicted to be a potential novel genus most closely related to Coprobacillus, whilst LH1063T was predicted to be a novel species belonging to Coprobacter. The strains were characterized using various methods, including genetic analysis and phenotypic testing.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Remi Samain, Oscar Maiques, Joanne Monger, Hoyin Lam, Juliana Candido, Samantha George, Nicola Ferrari, Leonie Kohihammer, Sophia Lunetto, Adrian Varela, Jose L. Orgaz, Felip Vilardell, Jorge Juan Olsina, Xavier Matias-Guiu, Debashis Sarker, Adrian Biddle, Frances R. Balkwill, Jim Eyles, Robert W. Wilkinson, Hemant M. Kocher, Fernando Calvo, Claire M. Wells, Victoria Sanz-Moreno
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to its high metastasis tendency and immunosuppressive microenvironment. The ROCK-Myosin II activity in PDAC cells supports an amoeboid invasive and immunosuppressive program, leading to in vivo metastasis. CD73, an immune checkpoint, is highly expressed in amoeboid PDAC cells and contributes to their invasive, metastatic, and immunomodulatory traits.
Review
Oncology
Jaume Barcelo, Remi Samain, Victoria Sanz-Moreno
Summary: ROCK belongs to the AGC family of Ser/Thr protein kinases and is involved in various cellular processes. It plays a crucial role in regulating cytoskeletal dynamics through actomyosin contractility, which is important for cell migration, proliferation, and survival in many cancer types. Targeting ROCK and its downstream effectors holds potential for cancer treatment, and local use of ROCK inhibitors may reduce side effects. Therefore, different therapeutic strategies and the latest generation of ROCK inhibitors are proposed for clinical use.