期刊
CELL
卷 181, 期 3, 页码 520-535出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.04.010
关键词
-
资金
- National Science Foundation [MCB-1914542]
- NIH [MH11481707, AR073846, DC016960]
The ability of cells to organize into multicellular structures in precise patterns requires that they recognize'' one another with high specificity. We discuss recent progress in understanding the molecular basis of cell-cell recognition, including unique phenomena associated with neuronal interactions. We describe structures of select adhesion receptor complexes and their assembly into larger intercellular junction structures and discuss emerging principles that relate cell-cell organization to the binding specificities and energetics of adhesion receptors. Armed with these insights, advances in protein design and gene editing should pave the way for breakthroughs toward understanding the molecular basis of cell patterning in vivo.
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