Graphene oxide as a carbo-catalyst for the synthesis of tri-substituted 1,3,5-triazines using biguanides and alcohols

This work reports a simple, metal free and cost-effective protocol for the preparation of tri substituted 1,3,5-triazine using graphene oxide as a carbo-catalyst. Substituted triazine can be synthesized in good to excellent yields under mild reaction conditions. Furthermore, the use of graphene oxide as a catalyst results in a product free from metal traces. Recyclability study shows that it can be recycled up to six cycles without significant loss in catalytic activity. To show the scalability of the developed methodology, gram scale synthesis was also carried out.