Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Applied
Qunqun Du, Qiang Liu
Summary: A novel ROS-responsive transdermal nanocarrier was designed to efficiently enhance transdermal delivery and anti-pigmentation, releasing the whitening agent Glabridin in a controlled manner to reverse UV-induced damage.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Biophysics
Kaijun Gou, Wei Xin, Jinying Lv, Zihao Ma, Juqin Yang, Lin Zhao, Ying Cheng, Xuchun Chen, Rui Zeng, Heran Li
Summary: The study aimed to develop a nano-drug delivery system that can respond to stimuli intelligently in the tumor microenvironment (TME). A pH-responsive chitosan-modified chiral mesoporous silica nanoparticles (CS-CMSN) was successfully prepared and studied for its physicochemical properties, drug release performance, potential anti-tumor effect, and biological safety. The results showed that CS-CMSN had good encapsulation ability for doxorubicin (DOX) and controllable pH-responsive drug release properties. In vitro cell experiments demonstrated that DOX@CS-CMSN was highly taken up by 4T1 cells, enhanced toxicity to 4T1 tumor cells, and promoted cell apoptosis. CS-CMSN also exhibited good biosafety in vitro and in vivo. Overall, the delivery of DOX by CS-CMSN nanocarriers holds promise for tumor-targeted therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Yuqi Chen, Xuelian Wang, Zhuhang Lu, Cong Chang, Yueli Zhang, Bo Lu
Summary: Surface modification of HMSNs with unique advantages has been successfully achieved for drug delivery and effective cancer treatment. Functionalized nanoparticles were developed for targeted and dual-responsive release of loaded DOX·HCL and ICG. The addition of CS and HDA further enhanced the targeted drug delivery system, which exhibited excellent drug loading capacity and pH/enzyme-responsive drug release properties, effectively inhibiting cancer cells viability.
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2023)
Article
Biophysics
Menghui Wan, Shuoshuo Lv, Tao Hong, Yanbao Zhao, Lichao Peng, Lei Sun
Summary: In this study, a multiple stimuli-responsive IMI@HCuS@mSiO2 @-ss-C8CD delivery system was constructed for pesticide delivery. The system utilized modified carboxymethyl 8-cyclodextrin as sealing materials, hollow copper sulfide nanoparticles with amino-functionalized mesoporous silica shell as carriers, and imidacloprid as the model drug. The system exhibited excellent foliage adhesion and multiple stimuli-responsive release properties. It also showed high photothermal conversion effect and improved photostability of the model drug.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Wen Bao, Haibo Ma, Nan Wang, Zhanhang He
Summary: A pH-responsive mesoporous silica targeted drug delivery system was designed and synthesized in this study, showing significant drug release stability and targeted therapy on cancer cells. Results demonstrated that the system had a higher drug release rate under acidic conditions and could effectively target and treat cancer cells through in vitro experiments using CLSM and MTT assays.
MATERIALS TECHNOLOGY
(2021)
Article
Engineering, Environmental
Yingjian Ma, Yinmin Wang, Rui Zhao, Zhijie Wang, Shuang Li, Meng Yu, Sen Pang, Xinyu Guo, Yong Xu, Xuemin Wu
Summary: Using advanced functional materials and technologies to construct new, efficient, and controlled-release pesticide formulations can effectively improve the target utilization of pesticides and reduce their impact on nontarget organisms and the surrounding environment. The study presents a strategy for preparing pH-responsive nanodrug delivery systems that can release pesticides rapidly in acidic environments. The results show that the nanodrug delivery system has longer-lasting fungicidal activity and lower impact on non-target organisms and the environment. Moreover, it can provide trace elements required by plants to promote crop growth without disturbing normal growth.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Amir E. Kaziem, Liupeng Yang, Yigang Lin, Yuting Tan, Zixia Song, Hanhong Xu, Zhixiang Zhang
Summary: Interactive release formulations, such as the ABM-loaded HMS-CMS nanoparticles, can enhance the insecticidal activity and photostability of abamectin, resulting in improved effectiveness against pests like Spodoptera littoralis.
ACS APPLIED NANO MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Haidi Guan, Zhongwei Xu, Qinghua Liu, Qianshan Tan, Yihui Chen, Shuaishuai Chen, Jingfeng Wu, Fengchao Wang, Jixi Zhang, Lihua Sun, Weidong Xiao
Summary: Repurposing clinically approved drugs to construct novel nanomedicines is an attractive therapeutic approach, especially in the treatment of inflammatory bowel disease (IBD). This study developed a pH-responsive nanomedicine based on mesoporous polydopamine nanoparticles (MPDA NPs) for the selective enrichment of anti-inflammatory drugs and reactive oxygen species (ROS) scavenging at the site of inflammation. The nanomedicine (PAA@MPDA-SAP NPs) showed efficient drug loading of sulfasalazine (SAP) and demonstrated excellent biocompatibility and anti-inflammatory repair ability in in vitro and in vivo experiments. Overall, this work provides a theoretical basis for the development of nanomedicines for IBD therapy.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Bing Cong, Pengli Li, Hongling Li, Chenglin Hong, Xiuwen Qiao
Summary: In this study, a sandwich-type immunosensor for the sensitive detection of AFP was developed, and an off-on strategy was applied to amplify the signal. The sensor demonstrated high sensitivity and a low detection limit.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Kokila Thirupathi, Madhappan Santhamoorthy, Sivaprakasam Radhakrishnan, Selvakumari Ulagesan, Taek-Jeong Nam, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: A mesoporous silica-based drug delivery system was synthesized by conjugating a PNIPAm-PAAm copolymer onto the mesoporous silica surface. The copolymer acts as a gatekeeper that responds to temperature and pH changes, allowing controlled drug delivery. The system exhibited good biocompatibility and was readily taken up by MDA-MB-231 cells, making it suitable for drug delivery applications where sustained drug release at higher temperatures is required.
Article
Biophysics
Shu Wu, Jinjing Shi, Xia Chen, Lu Bai, Qiuhua Wu, Guolin Zhang
Summary: Novel multi-responsive drug delivery vehicles (CDs/PNVCL@HMSNs) were prepared by grafting amino-terminated poly (N-vinyl caprolactam) (PNVCL-NH2) and amino-rich carbon dots (CDs) on the surface of aldehyde-functionalized HMSNs (HMSNs-CHO) via Schiff base reaction. The drug release behaviors of CDs/PNVCL@HMSNs-DOX showed temperature and pH responsiveness due to the poly (N-vinyl caprolactam) (PNVCL) and Schiff base bond. The multi-responsive CDs/PNVCL@HMSNs are intriguing drug carriers, which combine drug delivery and NO release in one.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Environmental
Yunhao Gao, Yu Liu, Xueyin Qin, Ziping Guo, Donglin Li, Chenggang Li, Hu Wan, Fuxing Zhu, Jianhong Li, Zhuo Zhang, Shun He
Summary: The study presented controlled-release formulations with pH/cellulase dual stimuli responsiveness for efficient fungicidal activity against Magnaporthe oryzae and reduced genotoxicity of pyraclostrobin. These formulations are promising for sustainable crop disease protection.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Qian Liu, Zhenrong Tan, Dafeng Zheng, Xueqing Qiu
Summary: A magnetic delivery system for targeted drug was developed using aminated lignosulfonate (ALS) and carboxymethyl chitosan (CMCS) to fabricate nano Fe3O4 with pH responsiveness. The system successfully loaded doxorubicin hydrochloride (DOX) and demonstrated controlled release of the drug. The particle size ranged from 79.9-169.9 nm under optimized conditions and exhibited excellent pH responsiveness. The drug-loaded particles showed significant growth inhibition on cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Lu Zhang, Hai-Mei Li, Ji-Lei Chen, Wen-Yan She, Yi Zhao, Yang Liu, Feng-Lei Jiang, Yi Liu, Peng Jiang
Summary: Two organic molecules based on merocyanine have been synthesized in this study, which can self-assemble to form nanoparticles in water. These molecules have potential applications in areas such as fluorescent anticounterfeit printing ink, pH detection, and near-infrared imaging. They exhibit excellent antiphotobleaching ability, mitochondrial targeting ability, and in vivo and in vitro near-infrared imaging capabilities, showing superior chemotherapy capabilities and biocompatibility in a tumor-bearing mouse model.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Analytical
Lu Zhang, Feng-Lei Jiang, Qing-Lian Guo, Yi Liu, Peng Jiang
Summary: Tumor targeting therapy and photodynamic therapy are effective anti-cancer therapies. The design and synthesis of multifunctional organic phototheranostic agents play an increasingly positive role in cancer diagnosis and treatment.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Lu Zhang, Feng-Lei Jiang, Yi Liu, Peng Jiang
Summary: In recent years, there has been increasing attention on the development and application of integrated probes for theranostics. This study successfully obtained two aggregation-induced emission luminogens (AIEgens) that possess excellent in vivo and in vitro long-term near-infrared imaging and photodynamic therapy capabilities, as well as subcellular organelle targeting ability, by linking different functional groups. The presence or absence of thiophene in the AIEgens leads to different structure-oriented characteristics.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Xin Ding, Tianyu Wang, Shiwei Bai, Yunfeng Wan, Shuai Zhu, Tao Li, Na Peng, Tao Qiu, Yi Liu
Summary: This article describes a method for preparing bowl-shaped gold@polydopamine yolk-shell nanoparticles with simultaneous multimodal therapeutic and imaging capabilities, which can be used in biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Haimei Li, Yiman Huang, Yi Liu, Peng Jiang
Summary: Glucose oxidase (GOD) has wide applications in biosensing and cancer treatment due to its unique biocatalytic properties. The interaction between GOD and a cancer therapeutic agent has not been well-studied.
Article
Multidisciplinary Sciences
Mingyue Yang, Peisong Wang, Tao Liu, Xiaojuan Zou, Ying Xia, Chenxu Li, Xiaosong Wang
Summary: The purpose of this study was to identify genes and pathways involved in the pathogenesis of systemic lupus erythematosus (SLE). High throughput sequencing revealed a large number of differential genes, including CDC6, which was highly expressed in SLE patients and correlated with disease severity. Inhibiting the expression of CDC6 suppressed cell proliferation in SLE patients. These findings suggest that the cell cycle pathway and abnormal expression of CDC6 may be implicated in the hyperproliferation and pathogenesis of SLE.
SCIENTIFIC REPORTS
(2023)
Review
Materials Science, Biomaterials
Jilei Chen, Wenrong Fu, Feng-Lei Jiang, Yi Liu, Peng Jiang
Summary: This article provides a detailed introduction to the synthesis methods of MXenes and the analysis of their advantages and disadvantages. It comprehensively reviews the latest developments of MXenes in the field of biology, including biosensing, antibacterial activity, reactive oxygen species (ROS) and free radical scavenging, tissue repair, and antitumor therapy. The challenges and future development trends of MXenes in biological applications are also discussed.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Mingyue Yang, Jinkai Xin, Heyun Fu, Liuyan Yang, Shourong Zheng
Summary: In this study, a novel amino-functionalized hierarchical porous carbon material was successfully fabricated for efficient electrochemical detection of heavy metal ions in water. The sensor exhibited low detection limits for individual and simultaneous detection of heavy metal ions, surpassing most reported sensors. It also displayed excellent anti-interference ability, repeatability, and stability for HMI detection in actual water samples.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Yang Liu, Yi Zhao, Haimei Li, Xiaoyang Zhang, Zichen Wang, Wenyan She, Fenglei Jiang, Yi Liu, Peng Jiang
Summary: In this study, a dual-targeted, multifunctional nanoplatform (FAA@CM) was successfully synthesized for trimodal imaging-guided photothermal/chemodynamic synergistic therapy. The nanoplatform achieved highly precise tumor-specific delivery through dual-targeting capability derived from 4T1 cell membrane cloaking and magnetic targeting. It exhibited trimodal imaging capabilities and enabled complete elimination of 4T1 tumors in mice.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Inorganic & Nuclear
Shu-Lan Li, Xu Chu, Hong-Li Dong, Hua-Ying Hou, Yi Liu
Summary: Chemodynamic therapy (CDT) has emerged as a promising strategy for suppressing malignant tumors in recent years. Nanoplatform-based CDT, which is highly effective, non-invasive, and independent of external energy input, shows great potential. However, its efficacy is still suboptimal, limiting its practical use in the clinic.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Energy & Fuels
Ruiling Li, Chengyuan Liu, Li Li, Junjie Xu, Jinjin Ma, Jiaqi Ni, Jing Yan, Jun Han, Yang Pan, Yi Liu, Lilin Lu
Summary: Regulating the chemical state of Co sites by preferred exposure of CeO2 facets enables the development of high-performance Co-based catalysts for ethanol steam reforming reaction. The as-prepared Co/CeO2-(M) catalyst, with Co sites in lower oxidation state, exhibits higher C-C bond cleavage capability and more excellent catalytic performance than Co/CeO2-(U), achieving a hydrogen selectivity as high as 97% at ethanol conversion of 100%. This work provides an effective strategy to enhance the catalytic performances of Co-based catalysts for ethanol steam reforming reaction and expands the understanding about ethanol steam reforming reaction mechanism.
Article
Psychology, Multidisciplinary
Ming-yue Yang, Zhao-ying Wang, Jie-mei Liu, Jian Lu, Tao Chen, Rui-ting Zhang
Summary: Accumulated evidence supports the association between early life adversity (ELA) and depressive symptoms, but previous studies have only focused on one dimension of ELA without considering other dimensions. This study explores the relationships between depressive symptoms and different types of ELAs using network analysis.
CURRENT PSYCHOLOGY
(2023)
Article
Polymer Science
Ruixue Niu, Zhening Zheng, Xuedong Lv, Benqiao He, Sheng Chen, Jiaying Zhang, Yanhong Ji, Yi Liu, Liuchun Zheng
Summary: The introduction of pentaerythritol as a branching agent in the synthesis of poly(butylene dodecanedioate) (PBD) can improve the melt strength and blow-molding properties of the polymer. The introduction of a small amount of pentaerythritol generates branching and crosslinking structures, leading to improved impact strength and tensile modulus. The PER-branched PBDs also exhibited enhanced crystallization ability and shear-thickening behavior.
Review
Polymer Science
Zhijun Wang, Lili Fu, Dongliang Liu, Dongxu Tang, Kun Liu, Lu Rao, Jinyu Yang, Yi Liu, Yuesheng Li, Huangqin Chen, Xiaojie Yang
Summary: This paper summarizes the typical complex materials of photocatalysts, photosensitizers, and hydrogels, as well as their antibacterial activities and the basic mechanisms of photothermal and photodynamic effects. In addition, the application of hydrogel-based photoresponsive materials in microbial inactivation is discussed, including the challenges faced in their application. The advantages of photosensitive antibacterial complex hydrogels are highlighted, and their application and research progress in various fields are introduced in detail.
Article
Chemistry, Physical
Xing-Yu Liu, Shuai-Chen Du, Feng-Lei Jiang, Peng Jiang, Yi Liu
Summary: The fibrillation process of human insulin (HI) is closely related to the therapy for type II diabetes (T2D). L-Lysine carriers with a size of around 5 nm were synthesized to adjust and control the fibrillation process. ThT fluorescence analysis and transmission electron microscopy (TEM) characterization revealed the kinetics and regulation of HI fibrillation. Isothermal titration calorimetry (ITC) explored the thermodynamic regulatory mechanism of the carriers at all stages of HI fibrillation. Surprisingly, the concentration of carriers plays a role in promoting or inhibiting fiber growth. The combination between carriers and HI during the lag time is a key factor influencing the fibrillation process.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
