期刊
CARBOHYDRATE POLYMERS
卷 245, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116457
关键词
Dextran; fucoidan; MRI; human platelets; crosslinking; submicronic particles
资金
- French National Research Agency [ANR-10-INSB-04]
- INSERM
- Universite de Paris
- Universite Sorbonne Paris Nord
- UMS34 FRIM
- [ANR-16-CE18-0031NANOPACT]
Early detection of thrombotic events remains a big medical challenge. Dextran-based submicronic particles bearing Gd(DOTA) groups and functionalized with fucoidan have been produced via a simple and green water -in-oil emulsification/co-crosslinking process. Their capacity to bind to human activated platelets was evidenced in vitro as well as their cytocompatibility with human endothelial cells. The presence of Gd(DOTA) moieties was confirmed by elemental analysis and total reflection X-ray fluorescence (TRXF) spectrometry. Detailed char-acterization of particles was performed in terms of size distribution, morphology, and relaxation rates. In par-ticular, longitudinal and transversal proton relaxivities were respectively 1.7 and 5.0 times higher than those of DOTAREM. This study highlights their potential as an MRI diagnostic platform for atherothrombosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据