Article
Biochemistry & Molecular Biology
Shuping Chen, Junqiao Wang, Qiuyue Fang, Nan Dong, Qingying Fang, Steve W. Cui, Shaoping Nie
Summary: The polysaccharide from Cordyceps sinensis can enhance intestinal immunity, regulate the balance of T cells, and increase the levels of intestinal microbiota.
Article
Microbiology
Hongmei Zheng, Haigang Cao, Deming Zhang, Jiahe Huang, Jinshu Li, Shaoying Wang, Junfeng Lu, Xiao Li, Gongshe Yang, Xin'e Shi
Summary: This study investigated the effects of Cordyceps militaris on intestinal barrier function and gut microbiota in a pig model. The results showed that Cordyceps militaris improved intestinal morphology, increased the numbers of goblet cells and intraepithelial lymphocytes, and modulated the expression of key proteins involved in the TLR4/MyD88/NF-kappa B signaling pathway. Furthermore, Cordyceps militaris altered the colonic microbial composition and increased the concentrations of acetate and butyrate.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun -ping Liu, Jie Wang, Si-xuan Zhou, De-chun Huang, Guo-hong Qi, Gui-tang Chen
Summary: This study evaluated the immune-enhancing effect of ginger polysaccharides UGP1 and UGP2 on CTX-induced immunosuppressed mice. The results showed that ginger polysaccharides can alleviate the symptoms of weight loss and dietary intake reduction, increase fecal water content, protect immune organs, stimulate the secretion of cytokines and immunoglobulins, restore short-chain fatty acids levels in the intestine, and modulate gut microbiota associated with immune function. These findings suggest that ginger polysaccharides have the potential to be used as functional food ingredients or natural medicine for the treatment of intestinal barrier injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Fisheries
Yongxin Sun, Md Hasim Rabbi, Shuhui Ma, Zhixin Wen, Xuejun Li, Rui Mi, Nang Meng, Yajie Li, Qingzhi Wang, Xingfan Du, Tongjun Ren
Summary: The study found that supplementing sea cucumber diets with Cordyceps polysaccharide (CP) led to improved intestinal microbiota composition, increased immune responses, and reduced mortality after exposure to infectious bacteria. These results suggest that CPs have the potential to serve as an alternative to antibiotics for optimizing the health of sea cucumbers.
AQUACULTURE RESEARCH
(2021)
Review
Immunology
Yuling Guo, Yujia Liu, Binqi Rui, Zengjie Lei, Xixi Ning, Yinhui Liu, Ming Li
Summary: The human gastrointestinal tract contains a large number of microorganisms that are involved in various physiological functions. Imbalance in the gut microbiota is closely related to the pathogenesis of several human diseases. Innate lymphoid cells (ILCs), including NK cells, ILC1s, ILC2s, ILC3s, and LTi cells, are a type of immune cells enriched in mucosal tissues and have gained extensive attention. The gut microbiota and its metabolites play important roles in intestinal mucosal diseases such as inflammatory bowel disease (IBD), allergic disease, and cancer. Therefore, studying the interaction between ILCs and the gut microbiota has great clinical significance in identifying potential pharmacotherapy targets for related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Juan Huang, Jinli Huang, Yao Li, Yilu Wang, Fahe Wang, Xia Qiu, Xvliang Liu, Huajun Li
Summary: This study investigated the protective effects of sodium alginate on gut microbiota, immunity, and intestinal mucosal barrier function in immunosuppressed mice. The results showed that SA alleviated spleen tissue damage, restored impaired immune functions, reversed intestinal mucosal injury, and modulated gut microbiota by increasing beneficial bacteria and decreasing pathogenic bacteria in the intestine. The study suggests that SA has the potential to enhance immunity and protect against intestinal mucosal injury.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Min Guo, Dehai Xing, Jin Wang, Ying Zhang, Zhuoyu Li, Xiangying Jiao
Summary: Ulcerative colitis (UC) is a growing burden globally, especially in developing countries. This study investigated the effect of N. commune polysaccharides on acute colitis in mice induced by DSS and its role in mediating the gut microbiota. The results showed that N. commune polysaccharides enhanced the intestinal mucosal barrier and exhibited prebiotic-like functions, suggesting its potential as an alternative or complementary treatment for UC.
Article
Biochemistry & Molecular Biology
Yanan Li, Junping Zheng, Yao Wang, Huabing Yang, Lu Cao, Shuiyong Gan, Jun Ma, Hongtao Liu
Summary: This study investigates the role of gut microbiota in the immune-enhancing activity of Astragalus polysaccharides (APS) in mice. The results show that APS can ameliorate immunosuppression in mice and activate Toll-like receptor 4 (TLR4) and mitogen-activated protein kinase (MAPK) pathways. APS treatment also reverses gut microbiota dysbiosis in immunocompromised mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Xiaogang Chen, Wenjing Sun, Baichang Xu, Enyun Wu, Yao Cui, Kaiyuan Hao, Geyin Zhang, Congcong Zhou, Yanping Xu, Jiang Li, Hongbin Si
Summary: The polysaccharides from the roots of Millettia Speciosa Champ exhibit immunomodulatory effects in cyclophosphamide-induced mice by improving immune organ indices, cytokine secretion, intestinal morphology, and microbial diversity. These findings suggest that Millettia Speciosa Champ polysaccharide holds promise as an immunostimulant in functional foods and drugs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Dongpeng Wang, Yan Dong, Ying Xie, Yangxin Xiao, Chang Ke, Kun Shi, Zhongshi Zhou, Jiyuan Tu, Linghang Qu, Yanju Liu
Summary: This study evaluated the effects of Atractylodes lancea rhizome polysaccharide (ALP) on intestinal mucosal barrier and mucosal immunity in immunosuppressed mice. The results showed that ALP effectively enhanced immune organ index and blood cell count, stimulated cytokine secretion, and promoted the expression of key proteins involved in intestinal barrier function and T cells. ALP also improved gut microbiota imbalance and metabolic disorders, increasing the abundance of beneficial bacteria and short-chain fatty acids. This study provides a theoretical basis for the protective effects of ALP on intestinal health and immune function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Shishi Huang, Yuan Zou, Hongbiao Tang, Jingyu Zhuang, Zhiwei Ye, Tao Wei, Junfang Lin, Qianwang Zheng
Summary: This study found that Cordyceps militaris polysaccharides (CMP) can significantly reduce obesity induced by a high-fat diet, improve hyperlipidemia and insulin resistance, and alleviate systemic inflammation. Additionally, CMP can regulate obesity-induced gut dysbiosis by restoring the diversity of gut microbiota and increasing the abundance of short-chain fatty acid-producing bacteria. This study highlights the potential of CMP as a prebiotic agent to protect obese individuals from metabolic disorders and gut dysbiosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Plant Sciences
Yang Ji, Tianyi Tao, Junmiao Zhang, Anxiang Su, Liyan Zhao, Hui Chen, Qiuhui Hu
Summary: Ophiocordyceps sinensis showed better outcomes in attenuating colitis-associated tumorigenesis in mice compared to Cordyceps militaris, potentially due to its promotion of probiotic growth and modulation of the Wnt/beta-catenin signaling pathway. FMT and antibiotic treatment further supported the alleviating effects of O. sinensis on colonic inflammation and tumorigenesis.
Article
Chemistry, Applied
Hye-Bin Lee, Young-Soo Kim, Ho -Young Park
Summary: This review discusses the relationship between the structural characteristics of pectic polysaccharides and the modulatory activity of gut microbiota. It also explores the health benefits of pectic polysaccharides on diet-induced obesity and intestinal health. Through regulating gut microbiota, pectic polysaccharides exert various beneficial biological effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Bao-Hong Lee, Chia-Hsiu Chen, Yi-Yun Hsu, Pei-Ting Chuang, Ming-Kuei Shih, Wei-Hsuan Hsu
Summary: The polysaccharides derived from Cordyceps militaris have the potential to regulate metabolic syndrome and gut microbiota in mice fed a high-fat/high-sucrose diet. Specifically, they can decrease blood sugar and serum lipids levels, while also improving intestinal dysbiosis by promoting the population of Akkermansia muciniphila.
Article
Biochemistry & Molecular Biology
Lanyue Song, Jintao Yang, Weihan Kong, Yang Liu, Shuyan Liu, Ling Su
Summary: This study found that polysaccharides from Cordyceps militaris have anti-allergic asthma effects in a mouse model. These polysaccharides improved inflammatory cytokine levels, alleviated histopathological changes in the lungs and intestines, regulated gene and protein expression related to oxidative stress and inflammation, reversed gut dysbiosis, and improved microbiota function in allergic asthma mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Jiawen Lu, Ying Yang, Elisabeth Varga, Doris Marko, Qiang Yu, Jianhua Xie, Chang Li, Yi Chen
Summary: This study used RNA-Seq to screen the MAPK signaling pathway as one of the crucial pathways for PSG-F-2 pretreatment against AA-induced damage in IEC-6 cells. Western blot and immunofluorescence confirmed the RNA-Seq data, and revealed that PSG-F-2 protects intestinal cells from AA-induced damage through the MAPK/ERK signaling pathway. The findings suggest that PSG-F-2 can be used as a daily dietary supplement to protect intestinal cells from thermal processing hazards caused by AA.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xincheng Wu, Xiaojun Huang, Wanning Ma, Mingzhi Li, Jiajia Wen, Chunhua Chen, Liandi Liu, Shaoping Nie
Summary: This study compared the intestinal immunomodulatory mechanisms of nine representative bioactive polysaccharides. The results revealed that these polysaccharides promote intestinal immunity through different ways, such as alleviating immune suppression in intestinal mucosal T cells, improving the intestinal microenvironment, promoting the colonization of beneficial bacteria, inhibiting the colonization of harmful bacteria, and alleviating the accumulation of certain metabolites in the large intestine. These findings provide a guideline for the development of superior intestinal immunomodulatory polysaccharides.
Article
Biochemistry & Molecular Biology
Shuping Chen, Junqiao Wang, Nan Dong, Qiuyue Fang, Yanli Zhang, Chunhua Chen, Steve W. W. Cui, Shaoping Nie
Summary: Polysaccharides from Cordyceps sinensis showed promising effects on experimental acute ulcerative colitis in mice. They alleviated colitis symptoms, inhibited NF-kappa B pathway activation, and modulated the gut microbiota composition. These findings suggest that Cordyceps sinensis polysaccharides have potential as a treatment for ulcerative colitis.
Article
Medicine, General & Internal
Quanjiang Li, Qiang Yu, Beibei Gong, Youquan Ning, Xinwei Chen, Jinming Gu, Fajin Lv, Juan Peng, Tianyou Luo
Summary: The study aimed to develop radiomics models based on MR images to distinguish early-stage and advanced-stage nasopharyngeal carcinoma (NPC). Seven radiomics models were constructed using data from 329 patients. Model A (including contrast-enhanced T1WI, T1WI, and T2WI images) showed the best classification performance in the training cohort, effectively distinguishing early-stage from advanced-stage NPC patients. This study is of great importance for improving the accuracy of NPC staging and treatment.
Article
Agriculture, Multidisciplinary
Tongwen Huang, Ke Zhang, Junqiao Wang, Kaihong He, Xingtao Zhou, Shaoping Nie
Summary: This study found that quercetin can alleviate the hepatotoxicity caused by acrylamide generated in heat-treated foods. Experiments on mice showed that quercetin can reduce the oxidative stress levels induced by acrylamide and protect the liver from damage. The results demonstrated that quercetin suppressed acrylamide-induced ferroptosis by inhibiting oxidative stress-driven autophagy, leading to the mitigation of liver injury.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Jinjin Liu, Junyi Yin, Xiaojun Huang, Cencen Liu, Liuyun Hu, Yansheng Huang, Fang Geng, Shaoping Nie
Summary: This study aimed to remove the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) using baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT). Results showed that AT had the best removal effect on total anthraquinones and increased the content of neutral sugars in CWEs. However, AT decreased the antioxidant activity of CWEs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Chenxi Zhang, Lin Pan, Junning Ma, Qiang Yu, Xiaohua Yu, Sarfaraz Hussain, Xu Li, Yujie Li, Yue Guan, Yifei Li, Fuguo Xing
Summary: In this study, cinnamaldehyde microcapsules (Cin-Mc) were developed using calcium alginate, and their physicochemical properties and bioefficacies were characterized. Compared to free cinnamaldehyde, Cin-Mc exhibited enhanced thermal stability, reduced irritating odor, and sustained release of cinnamaldehyde for 20 days at 25 degrees C. This led to substantially enhanced antifungal and anti-aflatoxigenic effects against Aspergillus flavus during the storage of unshelled peanut kernels.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Dan Su, Jiawen Lu, Chunchao Nie, Ziyan Guo, Chang Li, Qiang Yu, Jianhua Xie, Yi Chen
Summary: This study aimed to investigate the effects of AA and OTA individually and collectively on Caco-2 cells. The results showed that AA and OTA significantly inhibited Caco-2 cell viability, decreased TEER values, and increased LY permeabilization, LDH release, and ROS levels. Furthermore, AA and OTA treatment led to increased levels of IL-1 beta, IL-6, and TNF-alpha, while IL-10 levels decreased. Western blot analysis revealed that AA and OTA damaged the intestinal barrier by reducing the expression of tight junction proteins.
Article
Food Science & Technology
Xin Wang, Liyuan Rong, Mingyue Shen, Qiang Yu, Yi Chen, Jinwang Li, Jianhua Xie
Summary: This study investigated the effects of four food supplements (vitamins, minerals, salt, and sugar) on swallowing characteristics and food properties for dysphagia patients. The results showed that all samples belonged to level 4 in the IDDSI framework and exhibited shear thinning behavior, which is beneficial for dysphagia patients. The sensory evaluation demonstrated that dysphagia foods made with rice starch, perilla seed oil, and whey isolate protein, combined with both vitamins and 0.5% salt and sugar, scored the highest.
Article
Food Science & Technology
Yuzhen Hong, Mingyue Shen, Qiang Yu, Yi Chen, Jianhua Xie
Summary: The aim of this study was to investigate the improvement effect of Mesona chinensis Benth polysaccharide (MP) on cyclophosphamide (CTX) induced liver injury in mice. The results showed that MP could alleviate liver injury and promote the production of short chain fatty acids (SCFAs).
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biotechnology & Applied Microbiology
Hao Zhang, Chunhua Chen, Yanli Zhang, Hongmei Yin, Jielun Hu, Yadong Zhong, Shaoping Nie, Mingyong Xie
Summary: This study comprehensively investigated and compared the fermentation characteristics of indigestible glucans (IGs) with different structural properties and their effects on the gut microbiota. The results showed that different IGs were utilized by the gut microbiota at varying rates, and some remained unfermented after 48 hours. During fermentation, IGs released mono-, di-, or trisaccharides and lowered the pH of the broth, while producing short-chain fatty acids. The analysis also revealed that different IGs selectively promoted the proliferation of specific bacteria in the gut.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Yu Wu, Wengan Zhou, RuTing Feng, Duoduo Zhang, Yongkang Yu, Zuanyuan Huang, Junyi Yin, Xingtao Zhou, Shaoping Nie
Summary: The immunomodulatory effects of glucan from fruit body of Dictyophora rubrovolvata (DRP) were evaluated in this study. It was found that DRP can recover CTX-induced immunosuppression and activate dendritic cells (DCs) to increase cytokine secretion. The study also revealed that DRP regulates the AKT-STAT1 signaling pathway via Mincle in DCs to induce CD4(+) T cell proliferation and differentiation, thereby ameliorating CTX-induced immunosuppression.
Article
Food Science & Technology
Shanshan Zhang, Yonggan Sun, Qixing Nie, Jielun Hu, Wenwen Su, Zheyu Guo, Yanli Zhang, Shaoping Nie
Summary: Polysaccharides are commonly used as carriers for colon-targeted drugs, but their degradation and effects on gut microbiota in colitis conditions are unclear. In this study, the fermentation of four polysaccharides using colonic content microbiota from mice with colitis was performed. The results show that pectin and guar gum have a greater degree of degradation and promote the production of beneficial bacteria, while carrageenan and xanthan gum promote the proliferation of harmful bacteria.
Article
Chemistry, Multidisciplinary
Anqi Xie, Haihua Ji, Zheyi Liu, Yiqun Wan, Xuecong Zhang, Huihuang Xiong, Shao-Ping Nie, Hao Wan
Summary: Oral administration of probiotics is a promising method to alleviate inflammatory bowel diseases (IBDs), but sensitivity to the gastrointestinal environment and poor intestinal colonization hinder their effectiveness. In this study, a modified prebiotic-based shield (Fe-TA@mGN) was developed to enhance the stress resistance ability and intestinal colonization of Escherichia coli Nissle 1917 (EcN). The shield improved the survival rate of EcN and its retention in the intestine, leading to efficient alleviation of colitis. Additionally, the shield synergized with EcN to regulate gut microbiota and promote the production of short-chain fatty acids, further enhancing the alleviation of colitis.
Article
Food Science & Technology
Jie Tang, Chaoran Yang, Xiaoting Qin, Jingyu Si, Xuewen Dong, Xiaobo Hu, Qiang Yu
Summary: A cellulose degrading strain (Penicillium griseofulvum) was used to ferment and modify soluble dietary fiber (SDF) extracted from Citrus aurantium L. (CAL). The fermentation process improved the structure characteristics and adsorption properties of CAL-SDF, resulting in an increased SDF yield. The modified SDF showed improved thermal stability, water solubility, and adsorption capacities. The study suggests that Penicillium griseofulvum can be used as a potential strain for modifying CAL-SDF to enhance its functional properties. Overall, the modification process has significant potential in increasing the value proposition of CAL. Evaluation: 8 out of 10.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
