期刊
CARBOHYDRATE POLYMERS
卷 235, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.115935
关键词
gamma-cyclodextrin metal-organic framework; Activation; Honokiol; Supercritical carbon dioxide; Bioavailability
资金
- National Natural Science Foundation of China [81573619]
A facile method for the activation of gamma-cyclodextrin metal-organic framework (CD-MOF) without channel blockage and framework collapse was first developed using supercritical carbon dioxide (scCO(2)), which enabled higher surface area and larger pore volume. The scCO(2)-assisted impregnation method was also applied to introduce the insoluble drug, honokiol (HNK), into the pores of CD-MOF with higher cargo loading compared to the conventional liquid phase incorporation in ethanol. Notably, the resulting HNK-loaded CD-MOF (HNK@CD-MOF) had improved apparent solubility and enhanced dissolution rate. The intestinal cellular uptake and transport experiments demonstrated that CD-MOF could enhance cellular uptake and increase drug transport across the intestinal epithelial cells compared to the cyclodextrin inclusion complex. Moreover, the in vivo pharmacokinetic studies further confirmed that CD-MOF could significantly improve the oral absorption and bioavailability of HNK. Overall, the scCO(2) activation and scCO(2)-assisted impregnation approaches were demonstrated as promising strategies to maximize the potential capability of CD-MOF.
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