期刊
CARBOHYDRATE POLYMERS
卷 236, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116045
关键词
Mussel inspired; Hydrogel; Carboxymethyl konjac glucomannan; Dopamine; Catechol
资金
- National Natural Science Foundation of China [31772045]
- program on Fujian Agriculture and Forestry University of doctoral students going abroad [324-112110089]
- scientific research foundation graduate school of Fujian Agriculture and Forestry University [324-1122yb064]
A novel EGCG-loaded DCKGM-CCKGM-Fe(3+)hydrogel was prepared by Dopamine-carboxymethyl konjac glucomannan (DCKGM) and an L-Cysteine-carboxymethyl konjac glucomannan (CCKGM) with Fe3+ as a cross-linking agent. Due to the dynamic property of Fe3+-phenolic hydroxyl coordination bond and intermolecular hydrogen bonding, the resultant hydrogel featured injectable, adhesive, temperature and pH-sensitive properties. The mechanisms were characterized using Rheological analysis, Fourier transform infrared spectroscopy, X-ray diffraction patterns, and scanning electron microscopy. Furthermore, the weak alkaline condition (pH 7.4) can trigger the release of EGCG, there was a cumulative release of 54.71 % of the loaded EGCG within 12 h in PBS at pH 1.2. When the pH of PBS was increased to 7.4, the cumulative release of EGCG increased to 68.54 %. Consequently, the EGCG-loaded DCKGM-CCKGM-Fe3+ hydrogel (Fe(3+)Hydrogel) is a good candidate for the carrier for drug delivery. This paper provided a novel way for the preparation of hydrogel.
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