Review
Cell Biology
Cheng-Liang Kuo, Ananth Ponneri Babuharisankar, Ying-Chen Lin, Hui-Wen Lien, Yu Kang Lo, Han-Yu Chou, Vidhya Tangeda, Li-Chun Cheng, An Ning Cheng, Alan Yueh-Luen Lee
Summary: Oxidative stress is characterized by an excessive level of reactive oxygen species (ROS) generated from vigorous metabolism and oxygen consumption. The precise balance of oxidative stress between mitochondria and other organelles is crucial for cell survival. ROS produced from mitochondria play a major role in tumorigenesis, affecting various aspects such as proliferation, migration/invasion, angiogenesis, inflammation, and immunoescape. The dynamic balance of oxidative stress not only orchestrates complex cell signaling events in cancer cells but also influences the tumor microenvironment (TME), particularly immune cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Veronica Romano, Immacolata Belviso, Alessandro Venuta, Maria Rosaria Ruocco, Stefania Masone, Federica Aliotta, Giuseppe Fiume, Stefania Montagnani, Angelica Avagliano, Alessandro Arcucci
Summary: Cutaneous melanoma tissue is a network of cancer cells and tumor microenvironment characterized by high structural and cellular plasticity. The interactions between TME components and cancer cells lead to dramatic alterations in ECM remodelling, stromal cell phenotypes, and therapeutic responses. Melanoma-associated fibroblasts (MAFs) and normal fibroblasts within TME play crucial roles in influencing melanoma growth and outcomes through their cellular interactions and secretory profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiyi Wei, Xi Zhang, Shuai Wang, Yichun Wang, Chengjian Ji, Liangyu Yao, Ninghong Song
Summary: Metabolic reprogramming and the role of glutamine in clear cell renal cell carcinoma (ccRCC) were investigated in this study. The study analyzed gene expression profiles and clinical data to identify differential expression genes related to glutamine metabolism and the prognostic value of glutamine in ccRCC. The findings suggest that glutamine metabolism is associated with prognosis, immune infiltration, immune checkpoints, and oncogenic pathways in ccRCC, indicating its potential as a target for novel immunotherapies.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Danwen Wang, Zhao Deng, Mengxin Lu, Kai Deng, Zhiqiang Li, Fenfang Zhou
Summary: This study identified 12 differentially expressed oxidative stress-related genes (DEOSGs) and their regulatory networks in clear cell renal cell carcinoma (ccRCC). The high expression of MELK and PYCR1 in ccRCC was verified, and their knockdown inhibited ccRCC cell proliferation by inducing apoptosis and cell cycle arrest. These findings suggest that MELK and PYCR1 could be potential biomarkers and targets for predicting the prognosis and progression of ccRCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jianqiang Chen, Xiangxiang Jin, Zhe Shen, Yanan Mei, Jufan Zhu, Xiaodan Zhang, Guang Liang, Xiaohui Zheng
Summary: The combination treatment of TMPyP4 and H2O2 sensitizes cancer cells to cell death, while having no effect on normal cells. This combination activates high levels of ROS and mitochondrial membrane potential, leading to DNA damage and apoptosis in cancer cells. Furthermore, the treatment upregulates pro-apoptotic proteins and downregulates anti-apoptotic proteins in cancer cells, showcasing the potential of H2O2 to enhance the anticancer activity of TMPyP4.
Article
Engineering, Biomedical
Jun Zhang, Jie Yang, Tiantian Zuo, Siyu Ma, Nadira Xokrat, Zongwei Hu, Zhihua Wang, Rui Xu, Yawen Wei, Qi Shen
Summary: A novel kind of nanoparticles modified with beta-cyclodextrin grafted heparin successfully inhibited breast cancer metastasis through a hybrid mechanism of intracellular ROS activation and extracellular modulation of tumor microenvironment. This approach combined the activation of ferroptosis pathway with the inhibition of TGF-beta signaling, leading to a satisfactory anti-tumor metastasis effect in in vivo experiments.
Article
Nanoscience & Nanotechnology
Bo Han, Tao Wang, Zhigang Xue, Tao Wen, Ling Lu, Jie Meng, Jian Liu, Sizhu Wu, Jianchun Yu, Haiyan Xu
Summary: In conclusion, due to its ability to scavenge reactive oxygen species, elemene nanoemulsion effectively inhibited the metastasis of breast cancer cells to the lung and liver, prolonging the survival of TNBC mice. Mechanistic studies showed that the nanoemulsion reduced the stabilization of HIF-1 alpha, decreased angiogenesis, and lowered levels of NLRP3 inflammasomes and IL-1 beta production.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jianquan Wang, Lingyun Hao, Xinhua Li, Sen Liu
Summary: Insufficient oxygen supply and hypoxia during tumor treatment can affect the therapeutic effect. However, the use of W18O49@EP nanoparticles can release reactive oxygen species during combined radiotherapy and photodynamic therapy, enhancing the treatment outcome.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Na Tao, Huihuang Li, Liu Deng, Senfeng Zhao, Jiang Ouyang, Mei Wen, Wansong Chen, Ke Zeng, Chuanwan Wei, You-Nian Liu
Summary: The study presents a multifunctional platform based on Au nanoparticles and carbon dots modified hollow black TiO2 nanosphere for reversing immunosuppression and alleviating hypoxia in the tumor microenvironment. This platform effectively kills tumor cells by eliciting immune infiltration, alleviating hypoxia, and improving sonodynamic therapy efficiency.
Article
Oncology
Rilan Bai, Jiuwei Cui
Summary: Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their metabolic pathways via mitochondria, which play crucial roles in the survival, immune evasion, tumor progression, and treatment resistance of the hypoxic tumor microenvironment. Targeting the mitochondria-related pathway with anticancer drugs can enhance the immune recognition of cancer cells, tumor antigen presentation ability, and anti-tumor function of immune cells. This review focuses on the effects of mitochondrial morphology and function on immune cells, the impact of mitochondrial changes on tumor immune escape and immune cell function, and the research progress and challenges of novel anti-tumor immunotherapy strategies targeting mitochondria.
Article
Engineering, Biomedical
Shuting Lu, Wei Feng, Caihong Dong, Xinran Song, Xiang Gao, Jinhe Guo, Yu Chen, Zhongqian Hu
Summary: A hybrid sonosensitizer, M@C, integrating cyanobacteria and ultrasmall oxygen-deficient bimetallic oxide nanosonosensitizers, is designed to overcome hypoxia-induced tumor resistance and enhance sonodynamic therapy (SDT) efficiency. The sustained oxygen production by cyanobacteria under light illumination promotes nanosonosensitizers to generate more ROS against cancer cells, ultimately improving SDT effectiveness. This work demonstrates the potential of rationally engineered biohybrid microorganism-based sonosensitizers for enhancing SDT in the treatment of hypoxic tumors.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jung Bae Seong, Bokyung Kim, Soyoon Kim, Mi Hye Kim, Young-Ho Park, Youngjeon Lee, Hong Jun Lee, Chang-Won Hong, Dong-Seok Lee
Summary: This study revealed that deficiency of the antioxidant enzyme peroxiredoxin 5 (Prx5) in macrophages induced M2 macrophage polarization, promoting lung cancer progression. However, suppression of ROS generation by N-acetyl cysteine (NAC) inhibited the M2-like polarization of Prx5-deficient macrophages, leading to inhibition of lung cancer cell proliferation and migration, and suppression of tumor growth. These findings suggest that blocking the M2 polarization of macrophages may promote lung cancer regression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Dan He, Zhijie Ma, Ke Xue, Haiyan Li
Summary: JM2 inhibits breast tumor growth by inducing apoptosis and inhibiting proliferation, stimulating mitochondrial aggregation and regulating cell cycle. The JM2 grafted hyaluronic acid hydrogel effectively suppresses malignant proliferation of tumor cells and reduces breast tumor recurrence.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Saif Sattar Alaqbi, Lynsey Burke, Inna Guterman, Caleb Green, Kevin West, Raquel Palacios-Gallego, Hong Cai, Constantinos Alexandrou, Ni Ni Moe Myint, Emma Parrott, Lynne M. Howells, Jennifer A. Higgins, Donald J. L. Jones, Rajinder Singh, Robert G. Britton, Cristina Tufarelli, Anne Thomas, Alessandro Rufini
Summary: Research on the metabolism of non-essential amino acid proline in cancer has gained attention. The expression levels of proline biosynthesis enzymes are significantly increased during colorectal tumorigenesis. The expression of mitochondrial PYCR enzymes is crucial for cancer cells' survival and proliferation.
Review
Oncology
Roger Carles-Fontana, Nigel Heaton, Elena Palma, Shirin Khorsandi
Summary: Mitochondria are important organelles involved in cellular processes and are altered in pathological states, including cancer. Cancer cells adapt different strategies to generate sufficient energy for their high proliferation rates, often mediated by extracellular signals such as extracellular vesicles (EVs). This review discusses EV-mediated mitochondrial reprogramming mechanisms that support cancer survival and progression, as well as the potential of using EVs as delivery vectors for targeting mitochondria in cancer therapy.
Article
Medical Laboratory Technology
Chi-Chen Fan, Chung-Hsing Chen, Chi Chou, Ting-Yu Kao, An Ning Cheng, Alan Yueh-Luen Lee, Cheng-Liang Kuo
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Multidisciplinary Sciences
Yu-Lin Chen, Yi-Chen Yen, Chuan-Wei Jang, Ssu-Han Wang, Hsin-Ting Huang, Chung-Hsing Chen, Jenn-Ren Hsiao, Jang-Yang Chang, Ya-Wen Chen
Summary: EPHA10 is implicated in tumor growth and metastasis of oral squamous cell carcinoma, with its ligand EFNA4 inducing cell migration and up-regulation of SNAIL, NANOG, and OCT4. Inhibition of ERK and knockdown of NANOG abolish these effects, suggesting a potential therapeutic target for OSCC.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
An Ning Cheng, Li-Chun Cheng, Cheng-Liang Kuo, Yu Kang Lo, Han-Yu Chou, Chung-Hsing Chen, Yi-Hao Wang, Tsung-Hsien Chuang, Shih-Jung Cheng, Alan Yueh-Luen Lee
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Semon Wu, I-Chieh Tseng, Wen-Cheng Huang, Cheng-Wen Su, Yu-Heng Lai, Che Lin, Alan Yueh-Luen Lee, Chan-Yen Kuo, Li-Yu Su, Ming-Cheng Lee, Te-Cheng Hsu, Chun-Hsien Yu
Article
Environmental Sciences
Batel Blechter, Jason Y. Y. Wong, Chao Agnes Hsiung, H. Dean Hosgood, Zhihua Yin, Xiao-Ou Shu, Han Zhang, Jianxin Shi, Lei Song, Minsun Song, Wei Zheng, Zhaoming Wang, Neil Caporaso, Laurie Burdette, Meredith Yeager, Sonja I. Berndt, Maria Teresa Landi, Chien-Jen Chen, Gee-Chen Chang, Chin-Fu Hsiao, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Li-Hsin Chien, Chung-Hsing Chen, Tsung-Ying Yang, Chih-Liang Wang, Jen-Yu Hung, Chien-Chung Lin, Reury-Perng Perng, Chih-Yi Chen, Kun-Chieh Chen, Yao-Jen Li, Chong-Jen Yu, Yi-Song Chen, Ying-Hsiang Chen, Fang-Yu Tsai, Wei Jie Seow, Bryan A. Bassig, Wei Hu, Bu-Tian Ji, Wei Wu, Peng Guan, Qincheng He, Yu-Tang Gao, Qiuyin Cai, Wong-Ho Chow, Yong-Bing Xiang, Dongxin Lin, Chen Wu, Yi-Long Wu, Min-Ho Shin, Yun-Chul Hong, Keitaro Matsuo, Kexin Chen, Maria Pik Wong, Daru Lu, Li Jin, Jiu-Cun Wang, Adeline Seow, Tangchun Wu, Hongbing Shen, Joseph F. Fraumeni, Pan-Chyr Yang, I-Shou Chang, Baosen Zhou, Stephen J. Chanock, Nathaniel Rothman, Nilanjan Chatterjee, Qing Lan
Summary: The study identified interactions between genetic susceptibility and coal use in Asian women, showing weaker genetic susceptibility to lung adenocarcinoma among never-smoking women who use coal. This suggests potential differences in lung cancer pathogenesis based on exposure to coal combustion products, with novel findings of sub-multiplicative gene-environment interactions in the cancer literature.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cell Biology
Vidhya Tangeda, Yu Kang Lo, Ananth Ponneri Babuharisankar, Han-Yu Chou, Cheng-Liang Kuo, Yung-Hsi Kao, Alan Yueh-Luen Lee, Jang-Yang Chang
Summary: Mitochondrial Lon plays a crucial role in cisplatin-induced mtDNA damage and oxidative stress by modulating calcium levels, resulting in increased resistance of cancer cells to cisplatin treatment.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Cheng-Liang Kuo, Han-Yu Chou, Hui-Wen Lien, Chia-An Yeh, Jing-Rong Wang, Chung-Hsing Chen, Chi-Chen Fan, Chih-Ping Hsu, Ting-Yu Kao, Tai-Ming Ko, Alan Yueh-Luen Lee
Summary: Fc-VEGF fusion antibody drug normalizes intratumor vasculature to reprogram the immunosuppressive tumor microenvironment, enhancing cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Li-Hsin Chien, Tzu-Yu Chen, Chung-Hsing Chen, Kuan-Yu Chen, Chin-Fu Hsiao, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Ming-Shyan Huang, Yuh-Min Chen, Chih-Yi Chen, Sheng-Kai Liang, Chung-Yu Chen, Chih-Liang Wang, Hsiao-Han Hung, Hsin-Fang Jiang, Jia-Wei Hu, Nathaniel Rothman, Qing Lan, Tsang-Wu Liu, Chien-Jen Chen, Pan-Chyr Yang, I-Shou Chang, Chao A. Hsiung
Summary: This study proposes methods for adapting risk models for populations without prospective cohorts, using the example of adapting a lung cancer risk model in Taiwan. The adapted models show high performance in calibration and clinical usefulness.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Po-Liang Cheng, Tzu-Hung Hsiao, Chung-Hsing Chen, Miao-Neng Hung, Pei-Pei Jhan, Li-Wen Lee, Ting-Shuan Wu, Jia-Rung Tsai, Chieh-Lin Jerry Teng
Summary: This study aimed to identify potential mechanisms of chemoresistance of the 7 + 3 induction in acute myeloid leukemia (AML) cells using a single-cell RNA sequencing (scRNA-seq) approach. The results showed that chemoresistant AML cells had premature accumulation during early hematopoiesis and expressed more leukemic stem cell markers than chemosensitive cells. In addition, patients with higher expression of chemoresistant genetic markers had worse overall survival.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Cell Biology
Ananth Ponneri Babuharisankar, Cheng-Liang Kuo, Han-Yu Chou, Vidhya Tangeda, Chi-Chen Fan, Chung-Hsing Chen, Yung-Hsi Kao, Alan Yueh-Luen Lee
Summary: During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER-mitochondria contact sites (EMC). This study explores the mechanism of how mitochondrial sensors trigger and stabilize the FUNDC1-ULK1 complex by chaperone Lon in the EMC for cell survival and cancer progression. It is found that Lon induces mitophagy through binding with mitochondrial Na+/Ca2+ exchanger (NCLX) to promote FUNDC1-ULK1-mediated mitophagy at the EMC site.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Cheng-Liang Kuo, Ananth Ponneri Babuharisankar, Ying-Chen Lin, Hui-Wen Lien, Yu Kang Lo, Han-Yu Chou, Vidhya Tangeda, Li-Chun Cheng, An Ning Cheng, Alan Yueh-Luen Lee
Summary: Oxidative stress is characterized by an excessive level of reactive oxygen species (ROS) generated from vigorous metabolism and oxygen consumption. The precise balance of oxidative stress between mitochondria and other organelles is crucial for cell survival. ROS produced from mitochondria play a major role in tumorigenesis, affecting various aspects such as proliferation, migration/invasion, angiogenesis, inflammation, and immunoescape. The dynamic balance of oxidative stress not only orchestrates complex cell signaling events in cancer cells but also influences the tumor microenvironment (TME), particularly immune cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.