Article
Medicine, General & Internal
Manon C. W. Spaander, Ann G. Zauber, Sapna Syngal, Martin J. Blaser, Joseph J. Sung, Y. Nancy You, Ernst J. Kuipers
Summary: In the past decades, the incidence of early-onset colorectal cancer (CRC) or young-onset CRC (YO-CRC) has increased globally in both men and women. About 20% of YO-CRC patients have a hereditary cancer syndrome, while most cases have no genetic predisposition. Lifestyle changes such as antibiotic use, low physical activity, and obesity since the 1950s have been suggested as important factors in YO-CRC development by affecting the gut microbiome. Long-term prospective studies with childhood lifestyle data are needed to better understand the underlying mechanisms and relationships between environmental factors and YO-CRC.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Multidisciplinary Sciences
Yongzhi Yang, Lutao Du, Debing Shi, Cheng Kong, Jianqiang Liu, Guang Liu, Xinxiang Li, Yanlei Ma
Summary: The incidence of young-onset sporadic colorectal cancer (yCRC) is increasing. Gut microbial diversity is increased in yCRC patients, and fecal microbial markers could be utilized for detection.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Ameer Farooq, Carl J. Brown, Eric C. Sayre, Manoj J. Raval, Jonathan M. Loree, Ria Garg, Mary A. De Vera
Summary: The study found that young colorectal cancer patients did not have higher healthcare utilization than individuals without the disease in the years leading up to their diagnosis, except for the year before diagnosis, indicating a potential window for earlier diagnosis.
Review
Pediatrics
Thomas H. Dierikx, Anton H. L. C. van Kaam, Tim G. J. de Meij, Ralph de Vries, Wes Onland, Douwe H. Visser
Summary: A systematic review and meta-analysis showed that umbilical cord blood culture has higher sensitivity and comparable specificity compared to peripheral blood culture for neonatal early-onset sepsis diagnosis. The quality of evidence was considered low due to imperfect diagnostic methods for neonatal early-onset sepsis. Umbilical cord blood culture may be considered as a diagnostic tool for early-onset sepsis, potentially avoiding iatrogenic anemia caused by peripheral blood culture.
PEDIATRIC RESEARCH
(2022)
Article
Surgery
Maria Daca-Alvarez, Marc Marti, Antonino Spinelli, Noel F. F. C. de Miranda, Claire Palles, Alfredo Vivas, Andrew Lachtford, Kevin Monahan, Marek Szczepkowski, Wieslaw Tarnowski, Silviu-Tiberiu Makkai-Popa, Rosario Vidal, Irene Lopez, Elena Hurtado, Fernando Jimenez, Marta Jimenez-Toscano, Edurne Alvaro, Gonzalo Sanz, Araceli Ballestero, Sirio Melone, Lorena Brandariz, Isabel Prieto, Damian Garcia-Olmo, Teresa Ocana, Rebeca Moreira, Lorena Moreno, Sabela Carballal, Leticia Moreira, Maria Pellise, Rogelio Gonzalez-Sarmiento, Andreana N. Holowatyj, Jose Perea, Francesc Balaguer
Summary: This study aimed to explore the impact of family history on preventing early-onset colorectal cancer, finding that the proportion of preventable cases varied based on different guidelines. Early colonoscopy could significantly decrease the incidence of familial early-onset colorectal cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Editorial Material
Oncology
Robin Mendelsohn, Randze Lerie Palmaira, Melissa Lumish, Joseph Bacani, Asha Krishnan, Jill Weiss, Rosemary Semler, Anne Casson, Ashley Arkema, Jeanne Carter, Christian Nelson, John Mulhall, Julio Garcia-Aguilar, Zsofia Stadler, Hadley Maya, Andrea Cercek
Summary: This article discusses the establishment of the Center for Young Onset Colorectal Cancer at the Memorial Sloan Kettering Cancer Center in response to the increase in young colorectal cancer cases and the complex care needs of young cancer patients. Lessons learned during the first 2 years, including program development and specific services provided, are also outlined.
Review
Oncology
Joy Zhou Done, Sandy H. Fang
Summary: Despite the overall decline in colorectal cancer incidence since the early 1990s, the incidence in patients under 50 years old has almost doubled. A systematic review on young-onset colorectal cancer highlighted an increasing incidence and emphasized the importance of considering colorectal cancer in the differential diagnosis of gastrointestinal symptoms in young adults.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
C. Fernandez-Rozadilla, M. Alvarez-Barona, I Quintana, A. Lopez-Novo, J. Amigo, J. M. Cameselle-Teijeiro, E. Roman, D. Gonzalez, X. Llor, L. Bujanda, X. Bessa, R. Jover, F. Balaguer, A. Castells, S. Castellvi-Bel, G. Capella, A. Carracedo, L. Valle, Clara Ruiz-Ponte
Summary: The study aimed to identify novel genetic variants associated with early-onset CRC by sequencing patients and searching for rare, high-impact variants in selected genes. Although a recurring truncating variant was found, no promising CRC predisposing genes were identified. The study suggested that CRC onset may be oligogenic and potential risk alleles tend to appear more frequently in younger cases. Larger and robust studies are needed to unravel the genetics behind early-onset CRC development.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
David Paul Lovell
Summary: This article discusses issues related to the design and interpretation of biomarker studies, provides various guidelines, and lists points to consider when evaluating studies.
Article
Public, Environmental & Occupational Health
Irit Ben-Aharon, Ran Rotem, Cheli Melzer-Cohen, Gilad Twig, Andrea Cercek, Elizabeth Half, Tal Goshen-Lago, Gabriel Chodik, David Kelsen
Summary: A case-control study found that the use of specific medications may be associated with early-onset colorectal cancer (EOCRC), while the relationship with other factors (such as obesity and diabetes) has not been definitively proven. This finding contributes to further research to validate and determine the specific mechanisms by which these pharmaceutical agents induce EOCRC.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Gastroenterology & Hepatology
Joshua Demb, Lin Liu, Caitlin C. Murphy, Chyke A. Doubeni, Maria Elena Martinez, Samir Gupta
Summary: The incidence of young-onset colorectal cancer (YCRC) is increasing, and there may be an association between iron-deficiency anaemia (IDA), haematochezia, and YCRC in US Veterans aged 18-49. By comparing individuals with IDA or haematochezia to those without, the cumulative incidence and risk of YCRC can be assessed.
Article
Health Care Sciences & Services
Yoon Suk Jung, Huiyeon Song, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Summary: Large-scale studies on the association between family history and colorectal cancer (CRC) risk in Asians are lacking. We conducted a study in the Korean population and found that individuals with a family history of CRC, especially in younger age groups, had a higher risk of developing CRC compared to those without a family history.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Amparo Roca, Raquel Muelas, Manuel Alejandro, Gema Romero, Jose Ramon Diaz
Summary: The aim of this study was to determine the effect of intramammary infection (IMI) onset on ewe milk's electrical conductivity (EC) and evaluate the detection capability of different algorithms based on daily glandular milk EC measurement. An experiment was conducted with 26 Manchega sheep in Spain. The study monitored milk variables (production, EC) daily for 2 weeks before infection and an additional 4 weeks after infection. The best algorithm for IMI detection achieved a sensitivity of 50% and specificity of 100% by detecting deviations greater than 3s of the conductivity ratio between collateral glands compared to a 10-day moving average.
Article
Biochemistry & Molecular Biology
Gui-Ming Li, Guo-Zhong Xiao, Peng-Fei Qin, Xing-Yang Wan, Yuan-Ji Fu, Yi-Hui Zheng, Min-Yi Luo, Dong-Lin Ren, Shi-Ping Liu, Hua-Xian Chen, Hong-Cheng Lin
Summary: There are significant differences in the tumor microenvironment (TME) between young-onset colorectal cancer (yCRC) and old-onset colorectal cancer (oCRC). The TME of yCRC is more immunosuppressive, with malignant cells playing a crucial role.
Article
Cell Biology
William Lee, Zishan Wang, Miriam Saffern, Tomi Jun, Kuan-lin Huang
Summary: Young adult tumors exhibit unique genomic characteristics with more driver mutations and copy-number alterations compared to later-onset tumors, despite lower overall mutation burden. Analysis of tumor immune microenvironments reveals elevated TGF-b response and decreased IFN-g response in young adult tumors, compared to later-onset tumors.
Article
Oncology
Kristina M. Jordahl, Anna Shcherbina, Andre E. Kim, Yu-Ru Su, Yi Lin, Jun Wang, Conghui Qu, Demetrius Albanes, Volker Arndt, James W. Baurley, Sonja I. Berndt, Stephanie A. Bien, D. Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Daniel D. Buchanan, Arif Budiarto, Peter T. Campbell, Robert Carreras-Torres, Graham Casey, Tjeng Wawan Cenggoro, Andrew Chan, David Conti, Christopher H. Dampier, Matthew A. Devall, Virginia Diez-Obrero, Niki Dimou, David A. Drew, Jane C. Figueiredo, Steven Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Heather Hampel, Sophia Harlid, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Mark A. Jenkins, Amit Joshi, Temitope Keku, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, Victor Moreno, John L. Morrison, Neil Murphy, Hongmei Nan, Rami Nassir, Polly A. Newcomb, Mireia Obon-Santacana, Shuji Ogino, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D. P. Pharoah, Elizabeth A. Platz, John Potter, Ross L. Prentice, Gad Rennert, Edward Ruiz-Narvaez, Lori C. Sakoda, Peter C. Scacheri, Stephanie L. Schmit, Robert E. Schoer, Martha L. Slattery, Mariana C. Stern, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Yu Tian, Konstantinos K. Tsilidis, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Natalia Zemlianskaia, Jenny Chang-Claude, W. James Gauderman, Li Hsu, Anshul Kundaje, Ulrike Peters
Summary: This study reveals that the association between colorectal cancer and the 10q24.2/COX15 gene region is strongest in nondrinkers. The rs1318920 variant is identified as the putative causal regulatory variant for this region, suggesting a possible multifaceted functional effect.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Editorial Material
Gastroenterology & Hepatology
Samir Gupta, Aaron P. Thrift
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Samir Gupta, Ashley Earles, Ranier Bustamante, Olga V. Patterson, Andrew J. Gawron, Tonya R. Kaltenbach, Hanin Yassin, Mark Lamm, Shailja C. Shah, Sameer Dev Saini, Deborah A. Fisher, Maria Elena Martinez, Karen Messer, Joshua Demb, Lin Liu
Summary: In this study, the colonoscopist's adenoma detection rate (ADR) was found to be independently associated with the risk of moderate-to-high complexity adenomas. Compared to the highest quintile (ADR >47.0%), the risk of moderate-to-high complexity adenomas increased by 1.48- to 1.66-fold in the lowest 3 quintiles (ADR <19.7%-39.3%).
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mehul Trivedi, Suha Godil, Joshua Demb, Ashley Earles, Ranier Bustamante, Olga Patterson, Andrew J. Gawron, Tonya Kaltenbach, Sumana Mahata, Lin Liu, Samir Gupta
Summary: This study aimed to investigate the clinical characteristics and long-term outcomes associated with traditional serrated adenomas (TSAs). The results showed that TSA patients have an increased risk for colorectal cancer (CRC) and a risk of developing other high-risk neoplasia during follow-up surveillance colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Eric E. Low, Rena Yadlapati, Lin Liu, Ranier Bustamante, Samir Gupta
Summary: The study team established a large cohort of individuals with achalasia within the Veterans Health Administration (VHA), allowing for further investigation of risk factors and outcomes of this esophageal motility disorder.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Huichuan Yu, Xiaolin Wang, Liangliang Bai, Guannan Tang, Kelly T. Carter, Ji Cui, Pinzhu Huang, Li Liang, Yanqing Ding, Muyan Cai, Meijin Huang, Huanliang Liu, Guangwen Cao, Steven Gallinger, Rish K. Pai, Daniel D. Buchanan, Aung Ko Win, Polly A. Newcomb, Jianping Wang, William M. Grady, Yanxin Luo
Summary: This study demonstrated the prognostic significance of DNA methylation in early-stage colorectal cancer patients, with MePEC identifying an epigenetic subtype at high risk of recurrence and improving the prognostic accuracy of current clinical variables.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Medicine, Research & Experimental
Minhee L. Sung, Adam Viera, Denise Esserman, Guangyu Tong, Daniel Davidson, Sherry Aiudi, Genie L. Bailey, Ashley L. Buchanan, Marianne Buchelli, Mark Jenkins, Betsey John, Jennifer Kolakowski, Albana Lame, Sean M. Murphy, Elizabeth Porter, Laura Simone, Manuel Paris, Carla J. Rash, E. Jennifer Edelman
Summary: This study introduces a new research called CoMPASS, which aims to promote HIV risk reduction among persons who inject drugs (PWID). It is a hybrid type 1 effectiveness-implementation trial that utilizes rewards and ongoing support to encourage PWID to use HIV preexposure prophylaxis (PrEP). Trained PrEP navigators deliver interventions, including PrEP and other relevant treatments. The primary outcome is sustained PrEP adherence at 24 weeks. The results of this study will provide insights into the feasibility and impact of implementing CoMPASS in community-based organizations.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Sonja Berndt, Daniel D. Buchanan, Amanda J. Cross, Brenda Diergaarde, Steven J. Gallinger, Marc J. Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, Mark A. Jenkins, Yi Lin, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Mireia Obon-Santacana, Rish K. Pai, Lori C. Sakoda, Robert E. Schoen, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Syed H. Zaidi, John D. Potter, Jeffrey A. Meyerhardt, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Ulrike Peters, Amanda Phipps, Shuji Ogino
Summary: This study analyzed 13,101 colorectal cancer cases and found a significant association between tumor location and molecular features. The detailed colonic location and tumor molecular features play an important role in the prognostication and precision medicine of colon cancer.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Yas Casey, Joshua Demb, Ngozi Enwerem, Lin Liu, Christian Jackson, Ashley Earles, Ranier Bustamante, Sumana Mahata, Shailja Shah, Samir Gupta
Summary: Young-onset advanced adenoma diagnosis is associated with an 8-fold increased risk of incident colorectal cancer compared with normal colonoscopy. However, the cumulative incidence and mortality of colorectal cancer at 10 years among individuals with either young onset non-advanced or advanced adenoma diagnosis were both relatively low.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Eric E. Low, Qingyuan Song, Rena Yadlapati, Evan S. Dellon, Seema Aceves, Lin Liu, Samir Gupta, Yash A. Choksi, Shailja C. Shah
Summary: Researchers developed and validated two highly accurate coding algorithms for EoE, establishing a nationwide VHA cohort for adults with EoE for future studies.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fay Kastrinos, Sonia S. Kupfer, Samir Gupta
Summary: Current colorectal cancer (CRC) screening recommendations are based on age, but precision screening using additional factors could improve outcomes and resource utilization. Prediction models can identify high-risk groups for more intensive screening and low-risk groups for less invasive screening. Developing reliable and accurate prediction models and studying their feasibility and cost-effectiveness are critical for future implementation of precision CRC screening.
Review
Genetics & Heredity
Fiona Jane Bruinsma, James G. Dowty, Aung Ko Win, Laura C. Goddard, Prachi Agrawal, Domenico Attina', Nabil Bissada, Monica De Luise, Daniel B. Eisen, Mitsuko Furuya, Giuseppe Gasparre, Maurizio Genuardi, Anne-Marie Gerdes, Thomas Van Overeem Hansen, Arjan C. Houweling, Paul Christiaan Johannesma, Andre Lencastre, Derek Lim, Noralane M. Lindor, Valentina Luzzi, Maeve Lynch, Antonella Maffe, Fred H. Menko, Guido Michels, Jose S. Pulido, Ryu H. Jay, Elke C. Sattler, Ortrud K. Steinlein, Sara Tomassetti, Kathy Tucker, Daniela Turchetti, Irma van de Beek, Lore van Riel, Maurice van Steensel, Thierry Zenone, Maurizo Zompatori, Jennifer Walsh, Davide Bondavalli, Eamonn R. Maher, Ingrid M. Winship
Summary: BHD syndrome is a rare genetic syndrome caused by FLCN gene variants, which can increase the risk of various manifestations including fibrofolliculomas, pulmonary cysts, pneumothorax, and renal cell carcinoma. This study provides updated penetrance estimates based on a large dataset, which are crucial for the genetic counseling and clinical management of BHD syndrome.
JOURNAL OF MEDICAL GENETICS
(2023)
Correction
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Diez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Bohm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Article
Oncology
John Lai, Chi Kuen Wong, Daniel F. Schmidt, Miroslaw K. Kapuscinski, Karen Alpen, Robert J. Macinnis, Daniel D. Buchanan, Aung K. Win, Jane C. Figueiredo, Andrew T. Chan, Tabitha A. Harrison, Michael Hoffmeister, Emily White, Loic Le Marchand, Rish K. Pai, Ulrike Peters, John L. Hopper, Mark A. Jenkins, Enes Makalic
Summary: The DEPTH analysis method can be used to identify candidate susceptibility regions for colorectal cancer, and it has identified regions that conventional analyses cannot detect in larger datasets. DEPTH identified many new candidate susceptibility regions in the CCFR and GECCO studies, and it found four reproducible regions.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Jennifer G. McIntosh, Jon Emery, Anna Wood, Patty Chondros, Tina Campbell, Edweana Wenkart, Ian Dixon, Julie Toner, Javiera Martinez Gutierrez, Linda Govan, Gemma Buckle, Mark Jenkins
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)