Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Weibin He, Hongxia Li, Yijie Lai, Yunhao Wu, Yiwen Wu, Adolfo Ramirez-Zamora, Wei Yi, Chencheng Zhang
Summary: STN-DBS is an effective treatment for advanced PD and isolated dystonia, improving major motor symptoms; however, it can lead to weight gain postoperatively. In patients with isolated dystonia, postoperative weight gain is more common in females, and is influenced by preoperative weight and sex, but not by the efficacy of STN-DBS on motor symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Suzhen Lin, Lingbing Wang, Yimei Shu, Shunyu Guo, Tao Wang, Hongxia Li, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: Bilateral STN-DBS plus unilateral PVP may be an effective rescue procedure for patients with isolated dystonia who experienced suboptimal movement improvement following GPi-DBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Letter
Clinical Neurology
Yunhao Wu, Yixin Pan, Peng Huang, Tao Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Hongxia Li, Yiwen Wu
Summary: Lingual dystonia is a rare disease that severely affects daily activities. Previous studies have shown the efficacy of GPi-DBS on patients with refractory lingual symptoms, but high-level evidence is lacking. Our retrospective study on six lingual dystonia patients treated with subthalamic DBS demonstrates its immediate and long-lasting efficacy.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Danilo Genovese, Francesco Bove, Leonardo Rigon, Tommaso Tufo, Alessandro Izzo, Paolo Calabresi, Anna Rita Bentivoglio, Carla Piano
Summary: This study assessed the clinical safety and efficacy of frameless bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients at 5 years after surgery. The results demonstrate that this technique is safe and well-tolerated, with sustained motor efficacy at 5 years post-surgery.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Hye Ran Park, Hyung-Jun Im, Jeongbin Park, Byung Woo Yoon, Yong Hoon Lim, Eun Jin Song, Kyung Ran Kim, Jae Meen Lee, Kawngwoo Park, Kwang Hyon Park, Hyun Joo Park, Jung-Hwan Shin, Kyung Ah Woo, Jee Young Lee, Suyeon Park, Han-Joon Kim, Beomseok Jeon, Sun Ha Paek
Summary: This study investigated the survival rate and long-term outcome of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). The study found that the Unified Parkinson's Disease Rating Scale (UPDRS) score significantly improved until 5 years after surgery, but showed a tendency to increase again after 10 years. Additionally, patients with both electrodes located within the STN had a higher survival rate and maintained ambulation.
Article
Clinical Neurology
Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Carla Budriesi, Valentina Fioravanti, Giulia Di Rauso, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Noemi Guagnano, Elisa Bardi, Maria Giulia Corni, Jessica Rossi, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Giuseppe Vannozzi, Elena Bergamini, Giacomo Pavesi, Sara Meoni, Valerie Fraix, Alessandro Fraternali, Annibale Versari, Mirco Lusuardi, Giuseppe Biagini, Andrea Merlo, Elena Moro, Franco Valzania
Summary: This study assessed the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on gait in advanced Parkinson's Disease (PD) patients. The results showed that in the long-term after surgery, STN-DBS can contribute to gait and postural control improvement when used together with dopamine replacement therapy.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Maria Antonietta Volonte, Giacomo Clarizio, Sebastiano Galantucci, Pietro Giuseppe Scamarcia, Rosalinda Cardamone, Lina Raffaella Barzaghi, Monica Falautano, Pietro Mortini, Giancarlo Comi, Massimo Filippi
Summary: This study evaluated the long-term effectiveness of STN-DBS treatment on advanced PD patients over a span of 14 years. Results showed significant improvement in tremor, rigidity, and daily dopaminergic dose, but no lasting effect on axial symptoms and cognitive functions. STN-DBS remains an effective therapy for advanced PD patients, extending the period of acceptable quality of life despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Aske Nicolai Hock, Steen Rusborg Jensen, Katrine Wordenskjold Svaerke, Jannick Brennum, Bo Jespersen, Ove Bergdal, Merete Karlsborg, Lena Elisabeth Hjermind, Annemette Lokkegaard
Summary: This long-term follow-up study observed 14 patients with cervical or generalized dystonia who received stimulation in GPi, STN or both targets. The results showed that both GPi-DBS and STN-DBS had long-term effects and were equally safe and effective for up to 15 years in dystonia treatment.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Geriatrics & Gerontology
Mingming Zhao, Hui Chen, Xin Yan, Jianguang Li, Chao Lu, Bin Cui, Wenjun Huo, Shouming Cao, Hui Guo, Shuang Liu, Chunjuan Yang, Ying Liu, Feng Yin
Summary: This study aimed to define an optimal location using the medial subthalamic nucleus border as an anatomical reference and to explore the influence of the location of active contacts on outcomes and programming strategies in patients with primary dystonia. The findings showed that stimulation contacts located behind or adjacent to the medial STN border were most likely to produce ideal therapeutic effects.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Qing-Pei Hao, Wen-Tao Zheng, Zi-Hao Zhang, Ye-Zu Liu, Hu Ding, Jia Ouyang, Zhi Liu, Guang-Yong Wu, Ru-En Liu
Summary: This study found that bilateral subthalamic nucleus deep brain stimulation is a safe and effective alternative treatment for primary Meige syndrome, leading to improvements in motor function and quality of life. However, it did not yield significant amelioration in cognitive, mental, sleep status and other neuropsychological functions after 3 years of neurostimulation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Yuhan Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study aimed to evaluate optimal stimulation parameters for treating dystonia with STN-DBS. Results showed that the optimal parameters vary among patients, with improvement rate being linearly dependent on stimulation parameters. Adverse effects include dyskinesia and depression.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Carla Fernandez-Garcia, Mariana H. G. Monje, Victor Gomez-Mayordomo, Guglielmo Foffani, Rafael Herranz, Maria Jose Catalan, Mercedes Gonzalez-Hidalgo, Jorge Matias-Guiu, Fernando Alonso-Frech
Summary: This study evaluated the effectiveness of directional subthalamic stimulation in Parkinson's disease based on intraoperatively recorded beta oscillations. The results showed a strong correlation between clinical efficacy and beta activity, and selecting the contacts with the highest beta peaks improved the therapeutic window. Long-term follow-up showed similar improvements in both groups, validating the efficacy of directional stimulation guided by intraoperative beta oscillations.
Article
Clinical Neurology
Anna Castrioto, Bettina Debu, Emilie Cousin, Pierre Pelissier, Eugenie Lhommee, Amelie Bichon, Emmanuelle Schmitt, Andrea Kistner, Sara Meoni, Eric Seigneuret, Stephan Chabardes, Paul Krack, Elena Moro, Valerie Fraix
Summary: This study reports on the long-term nonmotor and motor outcomes in a large cohort of people with advanced Parkinson disease treated for over 10 years with subthalamic nucleus stimulation. The results show that subthalamic stimulation has long-term improvement effects on independence and quality of life.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil
Summary: Stimulation of the zona incerta can reduce heat pain perception, but does not affect warmth perception or pressure pain. These findings provide a mechanistic explanation for sensory changes observed in Parkinsonian patients undergoing subthalamic deep brain stimulation and identify the zona incerta as a potential target for neuromodulation of pain.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Chencheng Zhang, Kaiwen Zhu, Zhengyu Lin, Peng Huang, Yixin Pan, Bomin Sun, Dianyou Li
Summary: The study found that during the COVID-19 pandemic, the number of DBS telemedicine service requests and patients examined increased. The main reason for requests was poor symptom control, with most patients experiencing satisfactory adjustments in DBS tele-programming parameters, and no significant adverse events or treatment interruptions due to connection failures or other issues.
Review
Clinical Neurology
Yuhan Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study aimed to evaluate optimal stimulation parameters for treating dystonia with STN-DBS. Results showed that the optimal parameters vary among patients, with improvement rate being linearly dependent on stimulation parameters. Adverse effects include dyskinesia and depression.
JOURNAL OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Luis Manssuer, Ding Qiong, Yijie Zhao, Rocky Yang, ChenCheng Zhang, Shikun Zhan, Bomin Sun, Valerie Voon
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Psychiatry
Saurabh Sonkusare, Qiong Ding, Yingying Zhang, Linbin Wang, Hengfen Gong, Alekhya Mandali, Luis Manssuer, Yi-Jie Zhao, Yixin Pan, Chencheng Zhang, Dianyou Li, Bomin Sun, Valerie Voon
Summary: This study examines direct neuronal activity of habenula in treatment resistant depressed patients undergoing DBS surgery and finds findings convergent with depression models of aberrant excitatory glutamatergic output of the habenula driving inhibition of monoaminergic systems.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Chencheng Zhang, Yingying Zhang, Huichun Luo, Xinmeng Xu, Ti-fei Yuan, Dianyou Li, Yi-yun Cai, Hengfen Gong, Dai-hui Peng, Yi-ru Fang, Valerie Voon, Bomin Sun
Summary: This study investigated the safety and clinical effectiveness of HB-DBS treatment for patients with TRD or BD, and found that it can alleviate depressive and anxiety symptoms. However, the dropout rate was high and the variability in clinical response existed.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Hongyang Li, Daoqing Su, Yijie Lai, Xinmeng Xu, Chencheng Zhang, Bomin Sun, Dianyou Li, Yixin Pan
Summary: The study reported five cases of charging difficulties with rechargeable implanted pulse generators (r-IPGs) postoperatively, which were resolved by reoperation. Various predisposing factors leading to this rare complication were identified and successfully addressed, with no recurrence of charging problems in the cases to date.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Wen-Yi Liu, Tao-Hsin Tung, Chencheng Zhang, Leiyu Shi
Summary: This review summarizes recent empirical evidence on the prevention and management of falls and fear of falling in patients with Parkinson's disease. By analyzing the causes of falls and constructing a fall prevention model, it provides effective strategies for the prevention and management of falls and fear of falling in clinical practice for Parkinson's disease patients.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Weibin He, Chenhui Li, Hongjuan Dong, Lingmin Shao, Bo Yin, Dianyou Li, Liguo Ye, Ping Hu, Chencheng Zhang, Wei Yi
Summary: Globus pallidus internus deep brain stimulation (GPi-DBS) is an effective and safe treatment option for chorea-acanthocytosis (ChAc) patients, especially for those with oromandibular dystonia. However, there are no reliable predictors of efficacy at the moment.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Engineering, Electrical & Electronic
Rui Guo, Jie Sun, Chencheng Zhang, Xiaohua Qian
Summary: This paper proposes a vision-based method for automated assessment of Parkinson's disease motor symptoms. By using a self-supervised metric learning scheme and a graph convolutional network, it improves the spatial-temporal representations of human skeleton sequences extracted from videos. The method achieves effective aggregation of skeletal joint features and maximizes the potential consistency between joint and bone information streams. Experimental results demonstrate the superiority of this method over existing sensor-based methods, making it a reliable tool for real-time PD diagnosis or remote continuous monitoring.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Rui Guo, Jie Sun, Chencheng Zhang, Xiaohua Qian
Summary: This study proposes a novel method for the assessment of bradykinesia in Parkinson's disease. The method utilizes a contrastive graph convolutional network to extract fine-grained motion features from videos. The experimental results demonstrate the reliability and high accuracy of this method, highlighting its importance for automated and objective assessment.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saurabh Sonkusare, Ding Qiong, Yijie Zhao, Wei Liu, Ruoqi Yang, Alekhya Mandali, Luis Manssuer, Chencheng Zhang, Chunyan Cao, Bomin Sun, Shikun Zhan, Valerie Voon
Summary: Using intracranial electroencephalography, this study investigated the amygdala, orbitofrontal cortex (OFC), and medial prefrontal cortex (mPFC) and found that they play important roles in the emotion circuit. The three regions showed different emotion-induced responses and interactions. The results demonstrated greater broadband gamma activity in the negative condition, increased beta activity in the amygdala and OFC, and decreased beta activity in mPFC during the emotional picture viewing task. Furthermore, model-based computational analyses revealed unidirectional connectivity from mPFC to the amygdala and bidirectional communication between OFC-amygdala and OFC-mPFC.
MOLECULAR PSYCHIATRY
(2023)
Letter
Clinical Neurology
Zhitong Zeng, Zhengyu Lin, Peng Huang, Halimureti Paerhati, Chencheng Zhang, Dianyou Li
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Hailun Cui, Yingying Zhang, Yijie Zhao, Ying Zhao, Qiong Ding, Ruiqin Chen, Luis Manssuer, Chencheng Zhang, Wenjuan Liu, Dianyou Li, Bomin Sun, Valerie Voon
Summary: Ablative procedures like anterior capsulotomy can effectively treat refractory OCD. A study found that white matter tracts in the ventral internal capsule connecting the rostral cingulate, ventrolateral prefrontal cortex, and thalamus are the optimal target for clinical efficacy in OCD deep brain stimulation. Using fMRI and neuropsychological tests, the study investigated the prefrontal regions and cognitive processes involved in capsulotomy effects. Results showed improved OCD symptoms and quality of life in post-capsulotomy patients, with changes in brain activity and connectivity in regions associated with OCD. These findings contribute to the optimization of neuromodulation approaches for OCD.
MOLECULAR PSYCHIATRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Xinlu Tang, Rui Guo, Chencheng Zhang, Xiahai Zhuang, Xiaohua Qian
Summary: This study proposes a causality-driven graph-convolutional-network framework based on quantitative susceptibility mapping (QSM) for the automated classification of postural abnormalities in Parkinson's disease (PD) patients. The method achieves promising performance in the diagnosis of PD posture abnormalities through stability constraints and intra-class homogeneity constraints.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Computer Science, Information Systems
Rui Guo, Xiangxin Shao, Chencheng Zhang, Xiaohua Qian
Summary: Automated assessment of gait motor disorder in Parkinson's disease patients is urgently needed in clinical practice. This study proposes a novel graph convolutional network model for video assessment of PD gait motor disorder. The model can simultaneously model spatial information and temporal variations, and extract discriminative features through a multi-scale attention mechanism. Experimental results on a clinical video dataset demonstrate the good performance of the proposed model, outperforming existing assessment methods.
IEEE TRANSACTIONS ON MULTIMEDIA
(2022)