Article
Virology
Jiaofeng Huang, Yinlian Wu, Mingfang Wang, Su Lin
Summary: This study aimed to evaluate the association between serum 25-hydroxyvitamin D levels and herpes simplex virus (HSV) infection. The results showed a negative correlation between vitamin D levels and HSV-1 and HSV-2 infection, suggesting that vitamin D deficiency is an independent risk factor for HSV infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Pharmacology & Pharmacy
Hanna H. Schalkwijk, Robert Snoeck, Graciela Andrei
Summary: Herpes simplex viruses (HSV) can cause significant morbidity and mortality in both immunocompetent and immunocompromised individuals, and the nucleoside analogue acyclovir has greatly improved the management of HSV infections. However, acyclovir resistant strains have been reported, especially in immunocompromised patients. This review discusses the prevalence of acyclovir resistance in HSV infections and alternative antiviral treatments.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Ophthalmology
Ian McCormick, Charlotte James, Nicky J. Welton, Philippe Mayaud, Katherine M. E. Turner, Sami L. Gottlieb, Allen Foster, Katharine J. Looker
Summary: According to research data, an estimated 1.7 million people had HSV keratitis in 2016, with the majority being epithelial keratitis. The global burden of HSV ocular disease may have been underestimated, with limited data on other HSV eye conditions, especially outside the USA and Europe.
OPHTHALMIC EPIDEMIOLOGY
(2022)
Review
Immunology
Iara M. M. Backes, David A. A. Leib, Margaret E. E. Ackerman
Summary: The fetal/neonatal period is a critical stage for interventions and also a vulnerable period for viral infections. Maternal transfer of antibodies can reduce the risk of neonatal herpes simplex virus (nHSV) infections. Exploring the combination of antibody-based interventions and antiviral therapy is important for reducing infant mortality and long-term morbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Abigail L. Whitford, Corinne A. Clinton, E. B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Summary: The cellular protein DLK plays an essential role in the reactivation of herpes simplex virus, and the mechanisms of gene expression during reactivation are distinct from replication.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
Masoud Dadashi, Bahareh Hajikhani, Mona Ghazi, Shahrooz Yazdani, Mehdi Goudarzi, Mohammad Javad Nasiri, Shervin Shokouhi, Parviz Owlia, Somayeh Yaslianifard
Summary: This study analyzed the prevalence of C. pneumoniae, H. pylori, CMV, and HSV in CAD patients, revealing a significant increase in prevalence in serological studies compared to molecular studies for C. pneumoniae and H. pylori. The prevalence of CMV and HSV remained consistent across both types of studies.
MICROBIAL PATHOGENESIS
(2021)
Review
Microbiology
Hongyan Guo, Heather S. Koehler, Richard D. Dix, Edward S. Mocarski
Summary: HSV1 is a common human pathogen that can cause oral and ocular diseases. Host immune mechanisms and cell death pathways play important roles in controlling HSV1 infection, while the virus has evolved strategies to evade host cell death.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Dor Rafael, Enosh Tomer, Oren Kobiler
Summary: Latent infection is a characteristic feature of herpesviruses, where the number of latent viral genomes reactivating per cell is limited and typically only one genome reactivates in each cell.
MICROBIOLOGY SPECTRUM
(2022)
Article
Critical Care Medicine
Tanguy Chaumette, Raphael Cinotti, Alice Molle, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cedric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Regis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, Antoine Roquilly
Summary: Brain injury induces immunosuppression, increasing the risk of viral reactivations and impairing neurological recovery. This study found that lung replication of herpesviridae is associated with poor recovery after brain injury, and a specific monocyte signature can predict the neurological outcome at 6 months.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Clemens Scherer, Enzo Luesebrink, Leonhard Binzenhofer, Thomas J. Stocker, Danny Kupka, Hieu Phan Chung, Era Stambollxhiu, Ahmed Alemic, Antonia Kellnar, Simon Deseive, Konstantin Stark, Tobias Petzold, Christian Hagl, Joerg Hausleiter, Steffen Massberg, Martin Orban
Summary: The reactivation of herpes simplex virus in patients with cardiogenic shock is associated with increased levels of C-reactive protein and fraction of inspired oxygen. HSV reactivation was detected in 24.3% of patients with cardiogenic shock.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Virology
Bangxing Hong, Upasana Sahu, Matthew P. Mullarkey, Balveen Kaur
Summary: Oncolytic herpes simplex virus (oHSV) shows promise as a treatment for solid tumors, but there are still barriers that limit its efficacy. This review focuses on the essential viral genes that allow for virus replication and spread, with the aim of enhancing oHSV infection and replication among tumor cells.
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Farah M. Shurrab, Duaa W. Al-Sadeq, Fatima Humaira Amanullah, Enas S. Al-Absi, Hamda Qotba, Hadi M. Yassine, Laith J. Abu-Raddad, Gheyath K. Nasrallah
Summary: There is a low risk of serological cross-reactivity between DENV and SARS-CoV-2 when using advanced detection assays.
Letter
Medicine, General & Internal
Laith J. Abu-Raddad, Hiam Chemaitelly, Roberto Bertollini
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Medicine, General & Internal
Laith J. Abu-Raddad, Hiam Chemaitelly, Roberto Bertollini
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Susanne F. Awad, Julia A. Critchley, Laith J. Abu-Raddad
Summary: This study investigated and forecasted the impact of diabetes mellitus (DM) on tuberculosis (TB) epidemiology in Indonesia. The findings suggest that DM will play an increasingly significant role in the incidence and mortality of TB over the next three decades. Sensitivity and uncertainty analyses confirmed the predictions, and joint management and programs are proposed to reduce TB incidence and mortality.
Article
Multidisciplinary Sciences
Laith J. Abu-Raddad, Hiam Chemaitelly, Houssein H. Ayoub, Patrick Tang, Peter Coyle, Mohammad R. Hasan, Hadi M. Yassine, Fatiha M. Benslimane, Hebah A. Al-Khatib, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F. Abdul-Rahim, Gheyath K. Nasrallah, Mohamed Ghaith Al-Kuwari, Adeel A. Butt, Hamad Eid Al-Romaihi, Abdullatif Al-Khal, Mohametabd H. Al-Thani, Roberto Bertollini
Summary: The viral loads of SARS-CoV-2 breakthrough infections and reinfections are generally lower than primary infections in unvaccinated individuals, indicating potentially lower infectiousness. COVID-19 vaccines not only protect against acquisition of infection but also appear to protect against transmission.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Farah M. Shurrab, Duaa W. Al-Sadeq, Haissam Abou-Saleh, Nader Al-Dewik, Amira E. Elsharafi, Fatima M. Hamaydeh, Bushra Y. Abo Halawa, Tala M. Jamaleddin, Huda M. Abdul Hameed, Parveen B. Nizamuddin, Fathima Humaira Amanullah, Hanin I. Daas, Laith J. Abu-Raddad, Gheyath K. Nasrallah
Summary: The level of neutralizing antibodies (NAbs) differs between individuals who have not received the mRNA COVID-19 vaccine and those who have been previously infected. The mRNA-1273 vaccine generates a higher NAbs response compared to the BNT162b2 vaccine, and previously infected individuals generate the highest level of NAbs response.
Article
Infectious Diseases
Monia Makhoul, Farah Abou-Hijleh, Shaheen Seedat, Ghina R. Mumtaz, Hiam Chemaitelly, Houssein Ayoub, Laith J. Abu-Raddad
Summary: This study analyzes the biases in PCR and serological testing data for tracking epidemic dynamics of SARS-CoV-2. The results show that prolonged PCR positivity leads to biased epidemiological measurements, while the time delay in detecting antibodies underestimates the true prevalence of infection.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Farah M. Shurrab, Nadin Younes, Duaa W. Al-Sadeq, Na Liu, Hamda Qotba, Laith J. Abu-Raddad, Gheyath K. Nasrallah
Summary: The performance of the fluorescence LFIA Finecare (TM) 2019-nCoV S-RBD test was evaluated and found to have high sensitivity and specificity, with consistent results compared to reference assays. This test can be used for quantitative measurement of SARS-CoV-2 antibodies and serves as an alternative method to assess antibody response after infection or vaccination in small or non-laboratory settings.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Lorenzo Subissi, Anne von Gottberg, Lipi Thukral, Nathalie Worp, Bas B. Oude Munnink, Surabhi Rathore, Laith J. Abu-Raddad, Ximena Aguilera, Erik Alm, Brett N. Archer, Homa Attar Cohen, Amal Barakat, Wendy S. Barclay, Jinal N. Bhiman, Leon Caly, Meera Chand, Mark Chen, Ann Cullinane, Tulio de Oliveira, Christian Drosten, Julian Druce, Paul Effler, Ihab El Masry, Adama Faye, Simani Gaseitsiwe, Elodie Ghedin, Rebecca Grant, Bart L. Haagmans, Belinda L. Herring, Shilpa S. Iyer, Zyleen Kassamali, Manish Kakkar, Rebecca J. Kondor, Juliana A. Leite, Yee-Sin Leo, Gabriel M. Leung, Marco Marklewitz, Sikhulile Moyo, Jairo Mendez-Rico, Nada M. Melhem, Vincent Munster, Karen Nahapetyan, Djin-Ye Oh, Boris Pavlin, Thomas P. Peacock, Malik Peiris, Zhibin Peng, Leo L. M. Poon, Andrew Rambaut, Jilian Sacks, Yinzhong Shen, Marilda M. Siqueira, Sofonias K. Tessema, Erik M. Volz, Volker Thiel, Sylvie van der Werf, Sylvie Briand, Mark D. Perkins, Maria D. Van Kerkhove, Marion P. G. Koopmans, Anurag Agrawal
Article
Medicine, General & Internal
L. J. Abu-Raddad, H. Chemaitelly, H. H. Ayoub, S. AlMukdad, H. M. Yassine, H. A. Al-Khatib, M. K. Smatti, P. Tang, M. R. Hasan, P. Coyle, Z. Al-Kanaani, E. Al-Kuwari, A. Jeremijenko, A. H. Kaleeckal, A. N. Latif, R. M. Shaik, H. F. Abdul-Rahim, G. K. Nasrallah, M. G. Al-Kuwari, A. A. Butt, H. E. Al-Romaihi, M. H. Al-Thani, A. Al-Khal, R. Bertollini
Summary: A study in Qatar showed that booster vaccination significantly reduced the incidence of infection with the omicron variant, providing strong protection against Covid-19-related hospitalization and death. Booster effectiveness was observed for both mRNA vaccines, BNT162b2 and mRNA-1273, with lower infection rates and reduced severity of cases among those who received the booster dose.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jeffrey Lazarus, Diana Romero, Christopher J. Kopka, Salim Abdool Karim, Laith J. Abu-Raddad, Gisele Almeida, Ricardo Baptista-Leite, Joshua A. Barocas, Mauricio L. Barreto, Yaneer Bar-Yam, Quique Bassat, Carolina Batista, Morgan Bazilian, Shu-Ti Chiou, Carlos del Rio, Gregory J. Dore, George F. Gao, Lawrence O. Gostin, Margaret Hellard, Jose L. Jimenez, Gagandeep Kang, Nancy Lee, Mojca Maticic, Martin McKee, Sabin Nsanzimana, Miquel Oliu-Barton, Bary Pradelski, Oksana Pyzik, Kenneth Rabin, Sunil Raina, Sabina Faiz Rashid, Magdalena Rathe, Rocio Saenz, Sudhvir Singh, Malene Trock-Hempler, Sonia Villapol, Peiling Yap, Agnes Binagwaho, Adeeba Kamarulzaman, Ayman El-Mohandes
Summary: Despite scientific and medical advances, political, socioeconomic, and behavioral factors continue to undermine the response to the COVID-19 pandemic. A Delphi study involving a diverse panel of experts from 112 countries and territories developed a set of recommendations across various domains to address this global threat to public health.
Article
Medicine, General & Internal
Sachin Silva, Houssein H. Ayoub, Christine Johnston, Rifat Atun, Laith J. Abu-Raddad
Summary: This study estimated the economic and quality-of-life losses due to genital herpes in low- and middle-income countries (LMICs) and the potential contribution of herpes simplex virus type 2 (HSV-2) infections to HIV transmission. The findings showed that the economic losses caused by genital herpes can be substantial, and the quality-of-life losses outweigh the spending on treatment and productivity reduction. If HSV-2 has indeed contributed to the spread of HIV, then a significant proportion of the costs associated with HIV treatment and wage losses can be attributed to HSV-2. Therefore, developing a vaccine against HSV-2 should be a global priority.
Review
Virology
Manale Harfouche, Asalah Alareeki, Aisha M. M. Osman, Ahmed S. Alaama, Joumana G. Hermez, Laith J. Abu-Raddad
Summary: This study characterized the epidemiology of herpes simplex virus type 2 (HSV-2) infection in the Middle East and North Africa (MENA) region. The prevalence of HSV-2 infection in MENA was found to be lower compared to other world regions, but the infection rate may be increasing. Despite conservative sexual norms, 1 in 20 adults in MENA is chronically infected. These findings highlight the need for expanded surveillance and monitoring of HSV-2 infection in MENA.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Health Care Sciences & Services
Asalah Alareeki, Aisha M. M. Osman, Mohannad N. Khandakji, Katharine J. Looker, Manale Harfouche, Laith J. Abu-Raddad
Summary: This study investigated the HSV-2 seroprevalence in Europe among at-risk populations and its detection rates in genital ulcer disease and genital herpes. The findings showed a high HSV-2 infection rate in Europe and emphasized the importance of investing in HSV-2 vaccine development and sexual and reproductive health services.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Review
Public, Environmental & Occupational Health
Sawsan AlMukdad, Manale Harfouche, Uzma S. Farooqui, Lana Aldos, Laith J. Abu-Raddad
Summary: This study aimed to characterize the epidemiology of herpes simplex virus type 1 (HSV-1) in Australia and New Zealand. The findings revealed a high seroprevalence of HSV-1 among adults in Australia and an increasing proportion of genital acquisition among young individuals.
EPIDEMIOLOGY AND INFECTION
(2023)
