Article
Neurosciences
Milan Pantovic, Lidio Lima de Albuquerque, Sierra Mastrantonio, Austin S. Pomerantz, Erik W. Wilkins, Zachary A. Riley, Mark A. Guadagnoli, Brach Poston
Summary: Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm, but its effect on complex motor tasks involving whole-body coordination is unclear. This study found that tDCS applied over multiple days can improve motor learning in a complex overhand throwing task.
Article
Biotechnology & Applied Microbiology
Milan Pantovic, Daniel E. Lidstone, Lidio Lima de Albuquerque, Erik W. Wilkins, Irwin A. Munoz, Daniel G. Aynlender, Desiree Morris, Janet S. Dufek, Brach Poston
Summary: This study found that multi-day c-tDCS does not improve motor learning in a complex overhand throwing task or increase primary motor cortex (M1) excitability.
BIOENGINEERING-BASEL
(2023)
Article
Neurosciences
Dominic M. D. Tran, Nicolas A. McNair, Justin A. Harris, Evan J. Livesey
Summary: Research shows that the brain's response to stimuli from one's own actions and predictable stimuli can both be attenuated, indicating that predictive coding may be governed by domain-general mechanisms. This has important methodological implications for designing TMS experiments that control for the predictability of TMS pulses.
Review
Clinical Neurology
Anjali Sivaramakrishnan, Sandeep K. Subramanian
Summary: This systematic review examined the effects of aerobic exercise on neuroplasticity measures and behavioral measures in stroke patients. The review found that moderate to vigorous intensity aerobic exercise may induce changes in neuroplasticity parameters in stroke patients, although the results varied and the methodological quality of the studies was moderate. There is a need for a consensus on an exercise priming paradigm and for larger controlled studies of higher quality.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Daniele Belvisi, Andrea Fabbrini, Maria Ilenia De Bartolo, Matteo Costanzo, Nicoletta Manzo, Giovanni Fabbrini, Giovanni Defazio, Antonella Conte, Alfredo Berardelli
Summary: The study aimed to identify the pathophysiological substrate of Parkinson's disease subtypes using neurophysiological techniques. Two clinical clusters were identified, with one having milder symptoms and the other having a combination of severe motor and nonmotor manifestations. Differences in motor system dysfunction were observed between the subtypes, while sensory function and sensorimotor integration mechanisms did not differ.
MOVEMENT DISORDERS
(2021)
Article
Multidisciplinary Sciences
Jin Seung Choung, Sohom Bhattacharjee, Jeong Pyo Son, Jong Moon Kim, Dong Sik Cho, Choon Sik Cho, MinYoung Kim
Summary: Repetitive transcranial magnetic stimulation (rTMS) is being explored as a new treatment technique for brain lesions, but the effects in animals cannot directly represent the effects in humans due to differences in size and mechanistic characteristics. This study aimed to develop a mouse rTMS device to simulate clinical application. The magnetic field intensity generated by the mouse coil was lower than that by the human coil, and the predicted simulation values matched the measured intensity in vivo. Further research using miniaturized rTMS devices for mice should be conducted to make the findings more relevant to humans.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Rehabilitation
Kerstin L. C. Erfmann, Phoebe R. Macrae, Richard D. Jones, Esther Guiu Hernandez, Maggie-Lee Huckabee
Summary: This study evaluated the effects of cerebellar tDCS on motor learning for swallowing and found that cerebellar tDCS inhibited temporal aspects of motor skill learning in swallowing.
DISABILITY AND REHABILITATION
(2022)
Article
Behavioral Sciences
Arran T. T. Reader, Sara Coppi, Victoria S. S. Trifonova, H. Henrik Ehrsson
Summary: In this study, the researchers attempted to replicate the reduction in MEP amplitude associated with the rubber hand illusion (RHI) and identify the components of the illusion that might explain these changes. Despite participants reporting the presence of the illusion and shifts in perceived real hand position towards the fake limb, no reduction in MEP amplitude was observed.
BRAIN AND BEHAVIOR
(2023)
Article
Anesthesiology
Robert Suchting, Antonio L. Teixeira, Brian Ahn, Gabriela D. Colpo, Juyoung Park, Hyochol Ahn
Summary: This study suggests that transcranial direct current stimulation (tDCS) could potentially reduce pain by decreasing brain-derived neurotrophic factor (BDNF) levels, and have effects on related neural circuits.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Chemistry, Analytical
Semen Kurkin, Susanna Gordleeva, Andrey Savosenkov, Nikita Grigorev, Nikita Smirnov, Vadim V. Grubov, Anna Udoratina, Vladimir Maksimenko, Victor Kazantsev, Alexander E. Hramov
Summary: This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on brain activity and the latency of motor imagery (MI) response by stimulating the left dorsolateral prefrontal cortex (DLPFC) and measuring the functional connectivity with the right precuneus (PrecuneusR). Results show that stimulation of the left DLPFC increases theta-band power in PrecuneusR and speeds up MI responses in 50% of participants.
Article
Hospitality, Leisure, Sport & Tourism
Yitong Lin, Yanling Pi, Yanqiu Wang, Xue Xia, Fanghui Qiu, Na Cao, Zhen Wang, Yu Liu, Jian Zhang, Xiaoying Tan
Summary: This study provides empirical evidence for the importance of the left DLPFC in the working memory manipulation during motor skill learning.
PSYCHOLOGY OF SPORT AND EXERCISE
(2022)
Article
Clinical Neurology
Mengmeng Fu, Hua Wei, Xianghong Meng, Hai Chen, Baoxiang Shang, Fuyong Chen, Zhaoyang Huang, Ying Sun, Yuping Wang
Summary: This study aimed to assess the efficacy and safety of low-frequency rTMS targeting the bilateral parietal cortex in patients with TS. The results showed that bilateral rTMS significantly improved motor tics, phonic tics, and premonitory urges in TS patients, with improvements lasting for at least 1 month.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lidio Lima de Albuquerque, Milan Pantovic, Mitchell Clingo, Katherine Fischer, Sharon Jalene, Merrill Landers, Zoltan Mari, Brach Poston
Summary: Parkinson's disease is a neurodegenerative disorder that impairs motor function. Transcranial direct current stimulation (c-tDCS) has been shown to improve motor skills. However, this study found that a single session of c-tDCS did not enhance motor skill acquisition or transfer in patients with Parkinson's disease.
Article
Otorhinolaryngology
Aysenur Genc, Sabri Cemil Isler, Cengizhan Keskin, Ali Emre Oge, Zeliha Matur
Article
Clinical Neurology
Tuncay Gunduz, Murat Kurtuncu, Zeliha Matur, Erdem Tuzun, Utku Limon, Burak Tanyildiz, Belgin Izgi, Nergis Erdogan, Ali Emre Oge, Hakan Gurvit, Basar Bilgic, Gulsen Akman-Demir
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Genetics & Heredity
Garen Haryanyan, Ozkan Ozdemir, Kemal Tutkavul, Aysin Dervent, Semih Ayta, Cigdem Ozkara, Baris Salman, Emrah Yucesan, Yesim Kesim, Seda Susgun, Ugur Ozbek, Betul Baykan, Sibel A. Ugur Iseri, Nerses Bebek
Summary: Lafora disease is a severe form of progressive myoclonus epilepsy that is inherited in an autosomal recessive manner. It is associated with pathogenic variations in the EPM2A or NHLRC1 genes. The disease typically begins with seizures in adolescence and progresses to dementia, status epilepticus, and death within 10 years. Late-onset and slow progressing forms have also been reported, with some cases showing homozygosity for specific gene variants.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Behavioral Sciences
Kardelen Eryurek, Cigdem Ulasoglu-Yildiz, Zeliha Matur, A. Emre Oge, Hakan Gurvit, Tamer Demiralp
Summary: Research on motor sequence learning reveals distinct stages where early learning is characterized by spatial learning dominance and late learning shows automatic performance improvement. Activation changes in sensorimotor and association areas are identified using functional magnetic resonance imaging (fMRI). The default mode and dorsal attention networks play a critical role in regulating attention demands during various stages of motor sequence learning.
Article
Dentistry, Oral Surgery & Medicine
Aysenur Genc, Sabri Cemil Isler, Cengizhan Keskin, Ali EmreOge, Zeliha Matur
Summary: This study found that patients with skeletal deformities have shorter duration of masseter inhibitory reflex, which may be an adaptive response to trigeminal reflex mechanism. Following bilateral sagittal split osteotomy, some patients showed abnormal blink reflex and masseter inhibitory reflex, but these abnormalities did not correlate with clinical sensory deficits.
JOURNAL OF OROFACIAL ORTHOPEDICS-FORTSCHRITTE DER KIEFERORTHOPADIE
(2023)
Article
Clinical Neurology
Melek Ozarslan, Zeliha Matur, Erdem Tuzun, Ali Emre Oge
Summary: Cutaneous allodynia is a common symptom in migraine, especially in chronic migraine. This study aimed to investigate the effects of cutaneous allodynia and onabotulinumtoxinA (BoNT-A) injection on thermal thresholds measured by quantitative sensory testing (QST). The study also evaluated the effects of BoNT-A on headache, cutaneous allodynia, and other accompanying symptoms of migraine.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Sevcan Mercan, Nihan Hande Akcakaya, Baris Salman, Zuhal Yapici, Ugur Ozbek, Sibel Aylin Ugur Iseri
Summary: This study aimed to dissect the clinical and genetic features in five distinct IDM cases, and identified biallelic loss of function variants in WDR62 and AP4M1 genes in three families, as well as de novo missense variants in SOX11 and TRIO genes in two families. Underline the importance of using multiple inheritance models in NGS data analysis.
Article
Urology & Nephrology
Ezgi Tuna Erdogan, Kerem Ozel, Zeliha Matur, Orkhan Alizada, Huseyin Canaz, Ibrahim Alatas
Summary: This study aimed to determine the correlation between tibial somatosensory evoked potentials (SEP) and urodynamics in children with spina bifida (SB). The results showed a strong correlation between high SEP scores and detrusor sphincter dyssynergia.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Aysenur Genc, Sabri Cemil Isler, Ali Emre Oge, Zeliha Matur
Summary: This report investigated the effect of using alloplastic implants as an adjunct to orthognathic surgery on the jaw reflex. The study found that the use of porous polyethylene implants may decrease masticatory reflex activity.
ANNALS OF DENTAL SPECIALTY
(2022)
Meeting Abstract
Clinical Neurology
Ayse Ozdag Acarli, Arman Cakar, Ayse Candayan, Hacer Durmus, Serdar Ceylaner, Zeliha Matur, Ali Oge, Yesim Parman
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Gokhan Canaz, Huseyin Canaz, Ezgi T. Erdogan, Ibrahim Alatas, Erhan Emel, Zeliha Matur
JOURNAL OF PEDIATRIC NEUROSCIENCES
(2020)
Article
Clinical Neurology
Aysenur Onalan, Zeliha Matur, Munevver Pehlivan, Gulsen Akman
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2020)
Article
Neurosciences
Mecbure Nalbantoglu, Ozlem Gungor Tuncer, M. Eren Acik, Zeliha Matur, Burcu Altunrende, Ebru Ozgonenel, Levent Ozgonenel
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2020)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.