Article
Medicine, General & Internal
Chenggong Zhu, Wenqing Zhang, Xiuying Wang, Lanzhou Jiao, Liyan Chen, Jiyong Jiang
Summary: The study showed that high preoperative serum SCC-Ag levels are closely related to the clinicopathological features and lymph node metastasis in cervical squamous cell carcinoma patients. SCC-Ag levels greater than or equal to 2.75 ng/mL serve as an independent factor for predicting lymph node metastasis before surgery in early stage cervical cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingguo Zhao, Wenming Li, Jiulou Zhang, Shui Tian, Yang Zhou, Xiaoquan Xu, Hao Hu, Dapeng Lei, Feiyun Wu
Summary: This study aimed to investigate the role of CT radiomics in preoperative prediction of lymph node metastasis (LNM) in laryngeal squamous cell carcinoma (LSCC). A radiomics model incorporating radiomic signature and independent clinical factors was established and showed better discrimination and clinical usefulness compared to clinical model and traditional CT report. The CT-based radiomics nomogram can improve preoperative identification of nodal status and assist in clinical decision-making in LSCC.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yong-Heng Luo, Xi-Long Mei, Qin-Ru Liu, Bo Jiang, Sheng Zhang, Ke Zhang, Xia Wu, Yong-Mei Luo, Ya-Jun Li
Summary: DECT parameters can be used to identify metastatic cervical lymph nodes in patients with oral squamous cell carcinoma and are related to pathological features. Some DECT parameters are correlated with pathological changes in lymph nodes and can aid in the detection of metastatic cervical lymph nodes in OSCC.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Philipp Thoenissen, Anja Heselich, Stefanie Deeg, Sarah Al-Maawi, Anna Tanneberger, Robert Sader, Shahram Ghanaati
Summary: This study aims to identify lymph node involvement in OSCC performed in a bilateral systematic approach based on presurgical MRI and CT. The results showed positive lymph node involvement in levels 1 and 2, while no involvement was seen in level 5. Therefore, without any clinical or imaging suspicion, expanding to 5-level MRND should be avoided.
FRONTIERS IN ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Simeng Yang, Jing Zhao, Hongqin Zhao, Yan Hu, Haiyan Zhu
Summary: A nomogram was developed and validated to predict pelvic lymph node metastasis in patients with cervical squamous cell carcinoma. The nomogram was based on clinical data and showed good calibration and discrimination, making it a useful tool for physicians to develop optimal treatment strategies.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Qiuyuan Huang, Suyu Li, Xiaoying Chen, Xiaohong Liu, Guangrun Zhou, Liyuan Huang, Xiaoyan Li, Kaiwu Lin, Xiangqin Zheng
Summary: The aim of this study was to construct a preoperative model predicting lymph node metastasis (LNM) in IB1-IIA2 stage cervical squamous cell cancer (CSCC) based on hematological indexes. The model demonstrated good discrimination and calibration, and can assist physicians in assessing the risk of LNM in preoperative patients.
Article
Oncology
Wen-Fei Wei, Xiao-Jing Chen, Luo-Jiao Liang, Lan Yu, Xiang-Guang Wu, Chen-Fei Zhou, Zi-Ci Wang, Liang-Sheng Fan, Zheng Hu, Li Liang, Wei Wang
Summary: This study identified a specific subset of periostin(+) CAFs that promote lymph node metastasis in CSCC mainly by impairing the lymphatic endothelial barriers, providing a basis for potential stromal fibroblast-targeted interventions to block CAF-dependent metastasis.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Songtao Zhang, Runfang Zhang, Chao Wang, Wenbo Gong, Miaomiao Xue, Lina Liu, Yuanyuan Zhang
Summary: In previously untreated oral SCC patients, Level VI metastasis is rare but associated with poor prognosis, presenting with adverse pathologic features, metastatic foci size ranging from 2.6 to 4.5 cm, high recurrence and mortality rates.
Article
Oncology
Yusuke Sato, Satoru Motoyama, Yuki Wada, Akiyuki Wakita, Yuta Kawakita, Yushi Nagaki, Kaori Terata, Kazuhiro Imai, Akira Anbai, Manabu Hashimoto, Yoshihiro Minamiya
Summary: NACRT followed by esophagectomy with three-field lymph node dissection is feasible and offers the potential for long-term survival of clinical Stage III patients and even clinical Stage IVB patients with supraclavicular LN metastasis as the only distant metastatic factor. At least in patients with upper and middle thoracic ESCC, treating supraclavicular LNs as regional LNs seems to be appropriate.
Article
Oncology
Xiaofeng Duan, Xiaobin Shang, Jie Yue, Zhao Ma, Chuangui Chen, Peng Tang, Hongjing Jiang, Zhentao Yu
Summary: A nomogram was developed to predict lymph node metastasis for patients with early-stage esophageal squamous cell carcinoma, which was validated by an independent cohort. The study confirms the accuracy of the nomogram in predicting the risk of lymph node metastasis for these patients.
Article
Oncology
Ann-Kristin Struckmeier, Ebrahim Yekta, Abbas Agaimy, Markus Kopp, Mayte Buchbender, Tobias Moest, Rainer Lutz, Marco Kesting
Summary: This study evaluated the diagnostic accuracy of contrast-enhanced CT in detecting lymph node metastases in patients with oral squamous cell carcinoma (OSCC). The results showed that accentuated lymph nodes had higher sensitivity, while melted lymph nodes had higher specificity. Additionally, CT had higher diagnostic accuracy for detecting lymph node metastases in level IIa and IIb compared to level III. Patients with accentuated lymph nodes were more likely to have small, well-differentiated tumors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Qi Wang, Huiru Zou, Yue Wang, Jianwei Shang, Li Yang, Jun Shen
Summary: The study investigated the role of MUC1 in CCR7-CCL21 axis-induced metastasis of tongue squamous cell carcinoma (TSCC). Results showed that CCR7 and MUC1 may serve as potential biomarkers for TSCC treatment, as they are correlated with metastasis and survival rates in TSCC patients. CCL21 up-regulated MUC1 expression in TSCC cells, showing a positive correlation with migration and invasion capacities.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Oncology
Seong Yong Park, Junghee Lee, Yeong Jeong Jeon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim
Summary: The presence of supraclavicular lymph node metastasis did not significantly impact the overall survival of esophageal squamous cell carcinoma patients who underwent 3-field lymph node dissection, regardless of clinical suspicion or pathologic confirmation.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hayato Tomita, Tsuneo Yamashiro, Joichi Heianna, Toshiyuki Nakasone, Yusuke Kimura, Hidefumi Mimura, Sadayuki Murayama
Summary: The study demonstrates that machine learning-based analysis with CT texture analysis can accurately differentiate between benign and metastatic cervical lymph nodes in OSCC patients.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Jian Huang, Zhiyuan Wu, Junwu Xu
Summary: This study investigated the effects of a novel biofilm composite nano-drug delivery system on lymph node metastasis from oral squamous cell carcinoma, showing significant inhibition of proliferation activity in oral squamous cancer cells and control of cancer cell metastasis to cervical lymph nodes.
FRONTIERS IN ONCOLOGY
(2022)
