Article
Cell & Tissue Engineering
Li Pi, Li Yang, Bai-Rong Fang, Xian-Xi Meng, Li Qian
Summary: This study investigates the effects of MALAT1 from human adipose-derived stem cell (ADSC) exosomes on skin wound healing. The results showed that ADSC exosomes promoted the proliferation and migration of human skin fibroblasts (HSFs) and increased MALAT1 expression. MALAT1 silencing inhibited HSF viability and migration, promoted apoptosis, and suppressed angiogenesis by upregulating miR-378a. Overexpression of miR-378a inhibited HSF migration and proliferation by downregulating FGF2 expression. Exosomal MALAT1 accelerated skin wound healing by mediating the miR-378a/FGF2 axis.
REGENERATIVE MEDICINE
(2022)
Article
Plant Sciences
Yuhui Mi, Lei Zhong, Saijian Lu, Po Hu, Yang Pan, Xuelin Ma, Binghui Yan, Zhenhuan Wei, Guangming Yang
Summary: The study aimed to evaluate the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and to reveal the mechanisms involved, including the Wnt/beta-catenin pathway and TERT.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Dermatology
Sehee Choi, Minguen Yoon, Kang-Yell Choi
Summary: Current research focuses on accelerating cutaneous wound healing and preventing scar formation through regenerative therapies using growth factors and stem cells. However, the clinical use of these therapeutic approaches is limited due to high costs and technical requirements, highlighting the importance of understanding the molecular mechanisms involved in signaling pathways and neogenic synthesis for the development of novel regenerative wound-healing agents.
ADVANCES IN WOUND CARE
(2022)
Article
Medicine, Research & Experimental
Jing Dan, Ting Tan, Man Wu, Jin Gong, Qingguo Yang, Linling Wang, Ping Wang
Summary: Corneal epithelial abnormality in diabetic keratopathy is associated with delayed wound healing. The Wnt/beta-catenin signaling pathway plays a role in the development and stratification of corneal epithelial cells. This study showed downregulation of Wnt/beta-catenin signaling pathway factors in diabetic corneas. Topical treatment with lithium chloride increased the wound healing rate in diabetic mice, accompanied by upregulation of Wnt7a, beta-catenin, cyclin D1, and p-Gsk3b levels, as well as beta-catenin nuclear translocation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Cell & Tissue Engineering
Long Ouyang, Daojing Qiu, Xin Fu, Aiping Wu, Pengyuan Yang, Zhigang Yang, Qian Wang, Li Yan, Ran Xiao
Summary: In this study, researchers found that delayed wound healing in diabetes is caused by excessive recruitment and retention of pro-inflammatory cells and factors. They identified a gene called Hpgds that is down-regulated in diabetic wounds, and found that overexpression of Hpgds accelerates wound healing by reducing inflammation and promoting M2 macrophage polarization.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Fei Gao, Jilai Yin, Yongcun Wang, Hao Li, Daping Wang
Summary: miR-182 overexpression is positively correlated with distant metastasis in cervical cancer patients. It promotes the growth of cervical cancer cells and affects the progression of cervical cancer through the Wnt/β-catenin axis and its downstream genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Jianghui Ying, Qiang Wang, Lu Lu, Jiaqi Liu, Rong Guo, Hao Hu, Hua Jiang, Fazhi Qi
Summary: Kindlin-2 is a key regulator in the wound healing process, affecting cell migration, tube formation, and adhesion, as well as interacting with the Wnt/beta-catenin signaling pathway. Interfering with Kindlin-2 expression delays wound healing and reduces neovascularization, highlighting its importance in tissue repair and suggesting potential therapeutic targets for abnormal wound healing.
Article
Biochemistry & Molecular Biology
Shi-lei Liu, Chen Cai, Zi-yi Yang, Zi-you Wu, Xiang-song Wu, Xue-feng Wang, Ping Dong, Wei Gong
Summary: DGCR5 is highly expressed in pancreatic cancer tissues and associated with poor prognosis, its depletion can inhibit cell proliferation, migration, and invasion, while xenograft assay validated its role in promoting tumor growth. Mechanistically, DGCR5 acts as a ceRNA regulating TOP2A via miR-3163 and inhibiting the Wnt/β-catenin pathway, and downregulation enhances cell sensitivity to gemcitabine. Additionally, PAX5 can bind to DGCR5 promoter region and increase transcription, suggesting its potential as a diagnostic biomarker and therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Minfeng Wu, Jianhua Huang, Jingjuan Shi, Lei Shi, Qingyu Zeng, Hongwei Wang
Summary: Ruyi Jinhuang Powder (RJP) has significant therapeutic effects on diabetic ulcers as it promotes fibroblast proliferation and migration through activating Wnt/beta-catenin signaling pathway. In addition, RJP reduces inflammation and improves wound healing.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Yun-Nan Lin, Keng-Fan Liu, Chun-Ting Wang, Savitha Ramachandran, Ching-Jen Wang, Yur-Ren Kuo
Summary: This study demonstrated that both ESWT and BIO treatment significantly promoted diabetic wound healing and were associated with the GSK-3 beta-mediated Wnt/beta-catenin signaling pathway.
Article
Multidisciplinary Sciences
Weiping Xia, Xiang Chen, Zewu Zhu, Hequn Chen, Bingsheng Li, Kangning Wang, Li Huang, Zhi Liu, Zhi Chen
Summary: The study found that lncRNA MALAT1 promotes the process of renal interstitial fibrosis through the miR-124-3p/ITGB1 signaling pathway, suggesting its potential as a therapeutic target for RIF.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Eunhwan Kim, Yumi Hwang, Heejene Kim, Geon-Uk Kim, Yeong Chan Ryu, Minguen Yoon, Kang-Yell Choi
Summary: In this study, the researchers found that the activation of the Wnt/beta-catenin signaling pathway increases PKM2 expression and pyruvate kinase (PK) activity during wound healing in mice. They also discovered that the allosteric activator of PKM2, TEPP-46, enhances keratinocyte migration and wound healing. Furthermore, the combination of TEPP-46 and a Wnt/beta-catenin signaling activator, KY19382, significantly accelerates wound healing and induces angiogenesis in the wound beds.
Article
Biochemistry & Molecular Biology
Zheng Zhang, Weiwei Jiang, Miao Hu, Rui Gao, Xuhui Zhou
Summary: Dysfunction in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is regulated by miR-486-3p/CTNNBIP1 axis, where miR-486-3p promotes osteogenesis through activating the Wnt/beta-catenin signaling pathway, while overexpression of CTNNBIP1 inhibits osteogenic differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Minguen Yoon, Eunhwan Kim, Seol Hwa Seo, Geon-Uk Kim, Kang-Yell Choi
Summary: The Wnt/beta-catenin signaling pathway plays important roles in wound healing, and a study tested the effect of a small molecule called KY19382 on cutaneous wound healing by activating this pathway. KY19382 significantly enhanced cell migration and increased levels of key proteins involved in wound healing without causing significant cytotoxicity. In a murine wound healing model, KY19382 accelerated re-epithelialization, collagen deposition, and stem cell activation. Overall, KY19382 may have the potential to be used as a new wound healing agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yan Lu, Meng Tian, Jiongbo Liu, Kuanhong Wang
Summary: The study identified LINC00511 as a lncRNA associated with TMZ resistance in GBM, upregulated in resistant cells and correlated with poor prognosis in patients. LINC00511 was found to regulate Wnt/beta-catenin signaling, impacting TMZ sensitivity in GBM cells. These findings suggest LINC00511 as a potential therapeutic target and biomarker for GBM patients.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)