☆ 4.7 Article

Enhancement of Loading Efficiency by Coloading of Doxorubicin and Quercetin in Thermoresponsive Polymeric Micelles

BIOMACROMOLECULES (2020)

期刊

BIOMACROMOLECULES

卷 21, 期 4, 页码 1427-1436

出版社

AMER CHEMICAL SOC

DOI: 10.1021/acs.biomac.9b01742

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Biochemistry & Molecular Biology Chemistry, Organic Polymer Science

资金

National Science Foundation [CHE-1609880]
Welch Foundation [AT1740]
Eugene McDermott Foundation

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摘要

Chemotherapy faces challenges, including poor aqueous solubility of the drugs, and cardiotoxicity. Micellar drug delivery systems (DDS) are used to encapsulate anticancer drugs for better therapeutic effects, however, with poor loading content. Herein, we synthesized a micellar DDS using gamma-benzyloxy substituted poly(epsilon-caprolactone) as the hydrophobic block and coloaded anticancer doxorubicin (Dox) and antioxidant quercetin (Que). gamma-Substituted oligo(ethylene) glycol (OEG) poly(epsilon-caprolactone)s were used as hydrophilic blocks to make the polymers thermoresponsive. Variation of the OEG chain allowed the tunability of the lower critical solution temperature. Moreover, drug loading and release were studied. Thermodynamic stability, size, and morphology were determined by fluorescence measurements, dynamic light scattering, and transmission electron microscopy. Combination loading demonstrated improved loading of Dox and Que. Biological studies were performed using HepG2 human liver cancer and H9c2 rat heart cells. The use of biodegradable, biocompatible, and thermoresponsive polymers along with the coloading approach is a good strategy in developing DDSs.

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Mokdad, Sara Momtazmanesh, Lorenzo Monasta, Md Moniruzzaman, Ute Mons, Fateme Montazeri, AmirAli Moodi Ghalibaf, Yousef Moradi, Maryam Moradi, Mostafa Moradi Sarabi, Negar Morovatdar, Shane Douglas Morrison, Jakub Morze, Elias Mossialos, Ebrahim Mostafavi, Ulrich Otto Mueller, Francesk Mulita, Admir Mulita, Efren Murillo-Zamora, Kamarul Imran Musa, Julius C. Mwita, Shankar Prasad Nagaraju, Mohsen Naghavi, Firzan Nainu, Tapas Sadasivan Nair, Hastyar Hama Rashid Najmuldeen, Vinay Nangia, Shumaila Nargus, Abdallah Y. Naser, Hasan Nassereldine, Zuhair S. Natto, Javaid Nauman, Biswa Prakash Nayak, Rawlance Ndejjo, Hadush Negash, Ruxandra Irina Negoi, Hau Thi Hien Nguyen, Dang H. Nguyen, Phat Tuan Nguyen, Van Thanh Nguyen, Hien Quang Nguyen, Robina Khan Niazi, Yeshambel T. Nigatu, Dina Nur Anggraini Ningrum, Muhammad A. Nizam, Lawrence Achilles Nnyanzi, Mamoona Noreen, Jean Jacques Noubiap, Ogochukwu Janet Nzoputam, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Nkechi Martina Odogwu, Oluwakemi Ololade Odukoya, Vivek Anand Ojha, Hassan Okati-Aliabad, Akinkunmi Paul Okekunle, Osaretin Christabel Okonji, Patrick Godwin Okwute, Isaac Iyinoluwa Olufadewa, Obinna E. Onwujekwe, Michal Ordak, Alberto Ortiz, Uchechukwu Levi Osuagwu, Abderrahim Oulhaj, Mayowa O. Owolabi, Alicia Padron-Monedero, Jagadish Rao Padubidri, Raffaele Palladino, Demosthenes Panagiotakos, Songhomitra Panda-Jonas, Ashok Pandey, Anamika Pandey, Seithikurippu R. Pandi-Perumal, Anca Mihaela Pantea Stoian, Shahina Pardhan, Tarang Parekh, Utsav Parekh, Maja Pasovic, Jay Patel, Jenil R. Patel, Uttam Paudel, Veincent Christian Filipino Pepito, Marcos Pereira, Norberto Perico, Simone Perna, Ionela-Roxana Petcu, Fanny Emily Petermann-Rocha, Vivek Podder, Maarten J. Postma, Ghazaleh Pourali, Naeimeh Pourtaheri, Elton Junio Sady Prates, Mirza Muhammad Fahd Qadir, Ibrahim Qattea, Pourya Raee, Ibrar Rafique, Mehran Rahimi, Mahban Rahimifard, Vafa Rahimi-Movaghar, Md Obaidur Rahman, Muhammad Aziz Rahman, Mohammad Hifz Ur Rahman, Mosiur Rahman, Md Mosfequr Rahman, Mohamed Rahmani, Shayan Rahmani, Vahid Rahmanian, Setyaningrum Rahmawaty, Niloufar Rahnavard, Bibek Rajbhandari, Pradhum Ram, Sheena Ramazanu, Juwel Rana, Nemanja Rancic, Muhammad Modassar Ali Nawaz Ranjha, Chythra R. Rao, Deepthi Rapaka, Drona Prakash Rasali, Sina Rashedi, Vahid Rashedi, Ahmed Mustafa Rashid, Mohammad-Mahdi Rashidi, Zubair Ahmed Ratan, Salman Rawaf, Lal Rawal, Elrashdy Moustafa Mohamed Redwan, Giuseppe Remuzzi, Kannan R. R. Rengasamy, Andre M. N. Renzaho, Luis Felipe Reyes, Nima Rezaei, Nazila Rezaei, Mohsen Rezaeian, Hossein Rezazadeh, Seyed Mohammad Riahi, Yohanes Andy Rias, Muhammad Riaz, Daniela Ribeiro, Monica Rodrigues, Jefferson Antonio Buendia Rodriguez, Leonardo Roever, Peter Rohloff, Gholamreza Roshandel, Abazar Roustazadeh, Godfrey M. Rwegerera, Aly M. A. Saad, Maha Mohamed Saber-Ayad, Siamak Sabour, Leila Sabzmakan, Basema Saddik, Erfan Sadeghi, Umar Saeed, Sahar Saeedi Moghaddam, Sare Safi, Sher Zaman Safi, Amene Saghazadeh, Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Amirhossein Sahebkar, Soumya Swaroop Sahoo, Harihar Sahoo, K. M. Saif-Ur-Rahman, Mirza Rizwan Sajid, Sarvenaz Salahi, Saina Salahi, Mohamed A. Saleh, Mohammad Amin Salehi, Joshua A. Salomon, Juan Sanabria, Rama Krishna Sanjeev, Francesco Sanmarchi, Milena M. Santric-Milicevic, Made Ary Sarasmita, Saman Sargazi, Brijesh Sathian, Thirunavukkarasu Sathish, Monika Sawhney, Markus P. Schlaich, Maria Ines Schmidt, Art Schuermans, Abdul-Aziz Seidu, Nachimuthu Senthil Kumar, Sadaf G. Sepanlou, Yashendra Sethi, Allen Seylani, Maryam Shabany, Tahereh Shafaghat, Melika Shafeghat, Mahan Shafie, Nilay S. Shah, Samiah Shahid, Masood Ali Shaikh, Mohd Shanawaz, Mohammed Shannawaz, Sadaf Sharfaei, Bereket Beyene Shashamo, Rahman Shiri, Aminu Shittu, K. M. Shivakumar, Siddharudha Shivalli, Parnian Shobeiri, Fereshteh Shokri, Kerem Shuval, Migbar Mekonnen Sibhat, Luis Manuel Lopes Rodrigues Silva, Colin R. Simpson, Jasvinder A. Singh, Paramdeep Singh, Surjit Singh, Md Shahjahan Siraj, Anna Aleksandrovna Skryabina, Abdullah Al Mamun Sohag, Hamidreza Soleimani, Solikhah Solikhah, Mohammad Sadegh Soltani-Zangbar, Ranjani Somayaji, Reed J. D. Sorensen, Antonina V. Starodubova, Sujata Sujata, Muhammad Suleman, Jing Sun, Johan Sundstrom, Rafael Tabares-Seisdedos, Seyyed Mohammad Tabatabaei, Seyed-Amir Tabatabaeizadeh, Mohammad Tabish, Majid Taheri, Ensiyeh Taheri, Elahe Taki, Jacques J. L. Lukenze Tamuzi, Ker-Kan Tan, Nathan Y. Tat, Birhan Tsegaw Taye, Worku Animaw Temesgen, Mohamad-Hani Temsah, Riki Tesler, Pugazhenthan Thangaraju, Kavumpurathu Raman Thankappan, Rajshree Thapa, Samar Tharwat, Nihal Thomas, Jansje Henny Vera Ticoalu, Amir Tiyuri, Marcello Tonelli, Marcos Roberto Tovani-Palone, Domenico Trico, Indang Trihandini, Jaya Prasad Tripathy, Samuel Joseph Tromans, Guesh Mebrahtom Tsegay, Abdul Rohim Tualeka, Derara Girma Tufa, Stefanos Tyrovolas, Sana Ullah, Era Upadhyay, Seyed Mohammad Vahabi, Asokan Govindaraj Vaithinathan, Rohollah Valizadeh, Kim Robin van Daalen, Priya Vart, Shoban Babu Varthya, Tommi Juhani Vasankari, Siavash Vaziri, Madhur Verma Verma, Georgios-Ioannis Verras, Danh Cao Vo, Birhanu Wagaye, Yasir Waheed, Ziyue Wang, Yanqing Wang, Cong Wang, Fang Wang, Gizachew Tadesse Wassie, Melissa Y. Wei Wei, Abrha Hailay Weldemariam, Ronny Westerman, Nuwan Darshana Wickramasinghe, Yifan Wu, Ratna D. W. I. Wulandari, Juan Xia, Hong Xiao, Suowen Xu, Xiaoyue Xu, Dereje Y. Yada, Lin Yang, Hiroshi Yatsuya, Metin Yesiltepe, Siyan Yi, Hunachew Kibret Yohannis, Naohiro Yonemoto, Yuyi You, Sojib Bin Zaman, Nelson Zamora, Iman Zare, Kourosh Zarea, Armin Zarrintan, Mikhail Sergeevich Zastrozhin, Naod Gebrekrstos Zeru, Zhi-Jiang Zhang, Chenwen Zhong, Jingjing Zhou, Magdalena Zielinska, Yossef Teshome Zikarg, Sanjay Zodpey, Mohammad Zoladl, Zhiyong Zou, Alimuddin Zumla, Yves Miel H. Zuniga, Dianna J. Magliano, Christopher J. L. Murray, Simon I. Hay, Theo Vos

Summary: Diabetes is a major global cause of death and disability, with the total prevalence expected to continue to rise globally by 2050. Type 2 diabetes accounts for the majority of diabetes cases, largely due to obesity caused by multiple factors.

LANCET (2023)

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Review Biotechnology & Applied Microbiology

Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles

Fateme Davarani Asl, Marziyeh Mousazadeh, Shirinsadat Taji, Abbas Bahmani, Patricia Khashayar, Mostafa Azimzadeh, Ebrahim Mostafavi

Summary: AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs.

NANOMEDICINE (2023)

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Article Chemistry, Analytical

Nanobiotechnological approaches in anticoagulant therapy: The role of bioengineered silver and gold nanomaterials

Hamed Barabadi, Hesam Noqani, Fatemeh Ashouri, Abhinav Prasad, Kamyar Jounaki, Kiana Mobaraki, Yugal Kishore Mohanta, Ebrahim Mostafavi

Summary: Nanotechnology has shown remarkable applications in medicine and industry due to its unique properties at the nanoscale. One notable medical use of nanomaterials is their anticoagulant activity, which can prevent blood coagulation and reduce the risk of serious conditions such as strokes and heart attacks. Further research is needed to confirm the safety and efficacy of nanoparticles and to explore their potential as alternatives to conventional anticoagulants. Green synthesis of metal nanoparticles, especially silver and gold nanoparticles, using biological methods is highly recommended. Challenges and alternative approaches for the use of these nanoparticles as anticoagulants have also been discussed.

TALANTA (2023)

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Article Nanoscience & Nanotechnology

Chalcogenopheno[3,2-b]pyrrole-Containing Donor-Acceptor-Donor Organic Semiconducting Small Molecules for Organic Field-Effect Transistors

Ziyuan Ma, Chinthaka M. Udamulle Gedara, Hanghang Wang, Michael C. Biewer, Mihaela C. Stefan

Summary: This study systematically investigated the differences between chalcogenopheno[3,2-b]pyrroles and thieno[3,2-b]thiophene. The chalcogenopheno[3,2-b]pyrrole-containing molecules showed lower band gaps, polymorphism, and better charge transport properties compared to thieno[3,2-b]thiophene-containing molecules.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Review Biochemistry & Molecular Biology

Heavy metals in contact dermatitis: A review

Sajad Chamani, Leila Mobasheri, Zeinab Rostami, Iman Zare, Ali Naghizadeh, Ebrahim Mostafavi

Summary: Contact dermatitis is an inflammatory skin reaction caused by direct contact with chemical substances and can be irritant or allergic. It presents with symptoms like rash, itching, redness, swelling, and lesions. Heavy metals like chromium, copper, and lead can cause allergic and systemic contact dermatitis. Patch testing and evaluation of cytokine production are used to detect contact dermatitis.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2023)

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Review Pharmacology & Pharmacy

Medulloblastoma targeted therapy: From signaling pathways heterogeneity and current treatment dilemma to the recent advances in development of therapeutic strategies

Qiyue Wang, Xiaofei Xin, Qihao Dai, Mengjuan Sun, Jinhua Chen, Ebrahim Mostafavi, Yan Shen, Xueming Li

Summary: Medulloblastoma, a common pediatric brain tumor, can be divided into four subtypes. However, issues such as non-selective drug cytotoxicity, low drug accumulation in the brain, and tumor microenvironment pose obstacles to treatment effectiveness. This review summarizes the recent advances in modern therapeutic strategies for medulloblastoma.

PHARMACOLOGY & THERAPEUTICS (2023)

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Review Medicine, Research & Experimental

Systemic allergic contact dermatitis to palladium, platinum, and titanium: mechanisms, clinical manifestations, prevalence, and therapeutic approaches

Ali Sadrolvaezin, Arezou Pezhman, Iman Zare, Shima Zahed Nasab, Sajad Chamani, Ali Naghizadeh, Ebrahim Mostafavi

Summary: Contact dermatitis is an inflammatory skin disease caused by chemicals or metal ions. Heavy metals such as palladium, platinum, and titanium can cause allergic reactions and skin inflammation. Occupational metal contact dermatitis is the most common type of work-related skin disorders.

MEDCOMM (2023)

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Review Materials Science, Multidisciplinary

Silicon Compound Nanomaterials: Exploring Emission Mechanisms and Photobiological Applications

Ateet Dutt, Rafael Antonio Salinas, Shirlley E. Martinez-Tolibia, Juan Ramon Ramos-Serrano, Manmohan Jain, Leon Hamui, Carlos David Ramos, Ebrahim Mostafavi, Yogendra Kumar Mishra, Yasuhiro Matsumoto, Guillermo Santana, Vijay Kumar Thakur, Ajeet Kumar Kaushik

Summary: Research has shown that embedding silicon-based compound nanomaterials in matrices such as oxide, nitride, and carbide can improve their optical performance and industrial acceptability. However, exploring the emission mechanisms of these materials has remained a challenge for the past few decades. This review discusses the morphological and optoelectronic properties of Si-based compound nanomaterials and their correlation with quantum confinement effects and different surface states to find precise emission mechanisms.

ADVANCED PHOTONICS RESEARCH (2023)

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Article Polymer Science

A binary neodymium catalyst for the polymerization of lactones

Ruvanthi N. Kularatne, Somayeh Taslimy, Abhi Bhadran, John Michael O. Cue, Chandima Bulumulla, Erika L. Calubaquib, Ruwan Gunawardhana, Michael C. Biewer, Mihaela C. Stefan

Summary: Polylactones are widely used in biomedical applications and drug delivery due to their biocompatibility and biodegradability. In this study, we demonstrate the ability to polymerize ε-caprolactone and γ-functionalized ε-caprolactone monomers using the NdCl3 & BULL;3TEP/TIBA catalytic system. This system shows low sensitivity to substituents in the monomers and is able to polymerize ε-caprolactone monomers with ester linkages at the γ-position.

POLYMER CHEMISTRY (2023)

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Review Chemistry, Multidisciplinary

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Iman Zare, Reza Taheri-Ledari, Farhad Esmailzadeh, Mohammad Mehdi Salehi, Adibeh Mohammadi, Ali Maleki, Ebrahim Mostafavi

Summary: DNA hydrogels are efficient drug delivery systems that have attracted significant attention in recent years. They can be functionalized to target drug delivery and modify the therapeutic cargoes' half-life. The programmability of these 3D scaffolds allows for fundamental effects, especially in treating cancer diseases.

NANOSCALE (2023)

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