期刊
BIOINFORMATICS
卷 36, 期 12, 页码 3894-3896出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btaa262
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资金
- Inria
- INCEPTION project [PIA/ANR-16-CONV-0005]
Motivation: Genome assembly is increasingly performed on long, uncorrected reads. Assembly quality may be degraded due to unfiltered chimeric reads; also, the storage of all read overlaps can take up to terabytes of disk space. Results: We introduce two tools: yacrd for chimera removal and read scrubbing, and fpa for filtering out spurious overlaps. We show that yacrd results in higher-quality assemblies and is one hundred times faster than the best available alternative.
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