4.7 Article

yacrd and fpa: upstream tools for long-read genome assembly

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BIOINFORMATICS
卷 36, 期 12, 页码 3894-3896

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OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btaa262

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  1. Inria
  2. INCEPTION project [PIA/ANR-16-CONV-0005]

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Motivation: Genome assembly is increasingly performed on long, uncorrected reads. Assembly quality may be degraded due to unfiltered chimeric reads; also, the storage of all read overlaps can take up to terabytes of disk space. Results: We introduce two tools: yacrd for chimera removal and read scrubbing, and fpa for filtering out spurious overlaps. We show that yacrd results in higher-quality assemblies and is one hundred times faster than the best available alternative.

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