期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1873, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2020.188340
关键词
Exosomes; Tumor-derived exosomes; Communication; Tumor microenvironment; Metastasis; Tumor-stroma
资金
- Pershing Square Sohn Cancer Research Alliance Prize
- Simons Foundation
- Deutsche Forschungsgemeinschaft [DA 2249/1-1, KU 3264/1-1]
Tumor-derived exosomes are nano-sized vesicles acting as mull-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic acids (microRNAs and DNA fragments), lipids, proteins, and even pharmacological compounds from a donor cell to recipient cells. The transfer of cargo to recipient cells enables tumor-derived exosomes to influence diverse cellular functions like proliferation, cell survival, and migration in recipient cells, highlighting tumor-derived exosomes as important players in communication within the tumor microenvironment and at distant sites. In this review, we discuss the mechanisms associated with exosome biogenesis and cargo sorting. In addition, we highlight the communication of tumor-derived exosomes in the tumor microenvironment during different phases of tumor development, focusing on angiogenesis, immune escape mechanisms, drug resistance, and metastasis.
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