期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1866, 期 5, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2020.165675
关键词
Zinc; Pancreas; Diabetes; Amylin; Insulin; Oligomer
资金
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro [PP-SUS-FAPERJ E-26/110.282/2014, APQ1/FAPERJ E-26/111.485/2014, JCNE/FAPERJ E-26/201.520/2014-BOLSA, CNE/FAPERJ E26/201.320/2014-BOLSA, CNE/FAPERJ E-26/202.998/2017-BOLSA, PAPD/FAPERJ E-26/202.080/2015-BOLSA, APQ1/FAPERJ 26/111.715/2013]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [PQ2/305872/2016-8, PQ2/311582/2017-6]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES/Ciencias sem Fronteiras/Pesquisador Visitante Especial) [88881.062218/2014-0]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
- Programa Nacional de Apoio ao Desenvolvimento da Metrologia, Qualidade e Tecnologia (PRONAMETRO) from the Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO)
Zinc is a key component of several proteins, interacting with the pancreatic hormones insulin and amylin. The role of zinc in insulin oligomerization and crystallinity is well established, although the effects of dietary zinc restriction on both energetic metabolism and beta-pancreatic hormonemia and morphology remain unexplored. Here we report the effects of dietary zinc restriction on the endocrine pancreas and metabolic phenotype of mice. Nontransgenic male Swiss mice were fed a low-zinc or control diet for 4 weeks after weanling. Growth, glycemia, insulinemia and amylinemia were lower and pancreatic islets were smaller in the intervention group despite the preserved insulin crystallinity in secretory granules. We found strong immunostaining for insulin, amylin and oligomers in apoptotic pancreatic islet. High production of beta-pancreatic hormones in zinc-restricted animals counteracted the reduced islet size caused by apoptosis. These data suggest that zinc deficiency is sufficient to promote islet beta-cell hormonal disruption and degeneration.
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