Article
Cell Biology
Ana Gomez-Larrauri, Alberto Ouro, Miguel Trueba, Antonio Gomez-Munoz
Summary: C1P is a bioactive sphingolipid that plays key roles in cellular functions and inflammation-associated pathologies. It promotes cell growth and survival through various signaling pathways, and has shown potential as an anti-inflammatory agent in lung inflammation.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Ayako Yamazaki, Ayane Kawashima, Takuya Honda, Takafumi Kohama, Chiaki Murakami, Fumio Sakane, Toshihiko Murayama, Hiroyuki Nakamura
Summary: Ceramide-1-phosphate (C1P) is a sphingolipid that regulates various physiological functions. Although ceramide kinase (CerK) is known to be the main enzyme responsible for C1P production, this study identified diacylglycerol kinase (DGK) zeta as a novel C1P-producing enzyme. The researchers demonstrated that DGK zeta can directly phosphorylate ceramide to produce C1P, and its genetic deletion led to decreased levels of C1P.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Cell Biology
Cintia C. Vaquer, Laila Suhaiman, Martin A. Pavarotti, Rodolfo J. Arias, Anahi B. Pacheco Guinazu, Gerardo A. De Blas, Silvia A. Belmonte
Summary: This study reveals the role of different sphingolipids in the acrosome exocytosis of human spermatozoa. Ceramide increases intracellular calcium and stimulates the acrosome reaction by activating various channels. The addition of ceramide 1-phosphate (C1P) induces exocytosis in intact, capacitated human sperm, requiring extracellular calcium through voltage-operated and store-operated calcium channels. C1P synthesis by ceramide kinase (CERK) is mainly responsible for ceramide-induced exocytosis. The presence of CERK in human sperm and its calcium-stimulated enzymatic activity during the acrosome reaction is reported for the first time. Interestingly, progesterone also requires CERK activity to induce calcium increase and acrosome exocytosis, implicating C1P in the physiological progesterone pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Nutrition & Dietetics
Jakub Okrzeja, Alicja Karwowska, Agnieszka Blachnio-Zabielska
Summary: Abdominal aortic aneurysm (AAA) is an asymptomatic disease primarily caused by inflammation and obesity. Macrophages and disturbed sphingolipid metabolism are closely associated with aneurysm formation.
Article
Biochemistry & Molecular Biology
Mari Kono, Lila E. Hoachlander-Hobby, Saurav Majumder, Ronit Schwartz, Colleen Byrnes, Hongling Zhu, Richard L. Proia
Summary: This study identified genes involved in the uptake and recycling of S1P, an extracellular signaling molecule, and revealed the pathway through which S1P is taken up and recycled in cells. The findings are important for understanding the metabolism of S1P and its role in cellular activities.
JOURNAL OF LIPID RESEARCH
(2022)
Review
Cell Biology
Federica Cirillo, Marco Piccoli, Andrea Ghiroldi, Michelle M. Monasky, Paola Rota, Paolo La Rocca, Adriana Tarantino, Sara D'Imperio, Paola Signorelli, Carlo Pappone, Luigi Anastasia
Summary: Cardiovascular diseases are a major cause of death globally, with an increasing number of patients posing challenges to healthcare systems. Sphingolipids have emerged as important bioactive compounds that play crucial roles in biological processes and have potential therapeutic implications for managing cardiovascular diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Urology & Nephrology
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
Summary: Recent studies have shown that sphingolipids and sphingolipid metabolites play important roles in the pathogenesis and progression of kidney diseases by influencing the intracellular sphingolipid composition of renal cells and the integrity of the glomerular filtration barrier. The sphingolipid metabolite S1P plays a crucial role in renal cells, and aberrant S1P signaling contributes to the pathogenesis and progression of kidney diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Jacek Szamatowicz
Summary: Obesity is a growing global concern, significantly contributing to the development of diseases like type 2 diabetes and cardiovascular disorders. Excessive lipid accumulation in tissues leads to inflammation and metabolic dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yudai Iino, Tatsuro Naganuma, Makoto Arita
Summary: Coordinated lipid metabolism is important for maintaining skin homeostasis. In this study, we analyzed the lipidomic profile of an AD-like dermatitis model to understand the changes in lipid composition during AD pathogenesis. We found that ceramides composed of nonhydroxy fatty acid and dihydrosphingosine were significantly downregulated before AD onset. Additionally, topical application of these ceramides effectively alleviated AD symptoms in mice. Our findings suggest that disruption of epidermal ceramide composition plays a role in AD pathogenesis.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Oncology
Aaron Ciner, Theodore Gourdin, Jeff Davidson, Mylisa Parette, Susan J. Walker, Todd E. Fox, Yixing Jiang
Summary: Ceramide nanopliposomes (CNL), a sphingolipid metabolite, showed promising safety profile and pharmacokinetic parameters in patients with advanced solid tumors. Some signals of efficacy, including prolonged stable disease, were observed. Future studies investigating CNL in combination strategies are planned.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Immunology
Panpan Liu, Guixue Hou, Yehong Kuang, Lei Li, Chao Chen, Bei Yan, Wu Zhu, Jie Li, Mingliang Chen, Juan Su, Liang Lin, Xiang Chen, Cong Peng
Summary: This study investigated the alterations of lipids in psoriatic skin lesions and found enrichments of CerP and ceramides. Consensus clustering of lipid signatures classified psoriasis patients into two subtypes, CC1 and CC2, with CC1 subtype showing more severe symptoms. Further research revealed that C1P, which was dramatically enriched in CC1 subtype, facilitated psoriasis-like inflammatory responses. Inhibiting the production of C1P effectively alleviated the inflammation.
CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fei-Yang Tzou, Thorsten Hornemann, Jui-Yu Yeh, Shu-Yi Huang
Summary: DEGS1 converts dhCer to Cer, and its deficiency leads to the accumulation of dhCer and other dihydrosphingolipid species. DEGS1 plays a critical role in the nervous system and its dysfunction is associated with neurological disorders. Dihydrosphingolipids and their derivatives regulate essential cellular processes, but the understanding of their molecular properties, in vivo functions, and clinical implications related to impaired DEGS1 function is still limited.
PROGRESS IN LIPID RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Paola Di Pietro, Carmine Izzo, Angela Carmelita Abate, Paola Iesu, Maria Rosaria Rusciano, Eleonora Venturini, Valeria Visco, Eduardo Sommella, Michele Ciccarelli, Albino Carrizzo, Carmine Vecchione
Summary: Cardiovascular diseases (CVDs) are the leading cause of death and illness worldwide, accounting for 47% of deaths in Europe. Bioactive sphingolipids, including ceramides and sphingosine-1-phosphate (S1P), have been identified as drivers of CVDs. Monitoring sphingolipid levels could provide insights into the progression and severity of cardiovascular diseases and may be a potential target for therapeutic intervention.
Article
Chemistry, Medicinal
Zhen-Peng Xu, Adnan Mohammed Algradi, Yan Liu, Si-Yi Wang, Yi-Kai Jiang, Wei Guan, Juan Pan, Hai-Xue Kuang, Bing-You Yang
Summary: In this study, 18 bioactive lipids were isolated from the fruits of Solanum xanthocarpum, including 5 new lipids. The separation and structural identification of bioactive lipids were successfully achieved through NMR and MS/MS2. The anti-inflammatory activities of different types of lipids were evaluated, and sphingolipids, oxylipids, and phenylpmpionic acid-fatty acid glyceride polymer exhibited significant anti-inflammatory activities.
Article
Chemistry, Analytical
Luke A. Gallion, Yuli Wang, Angelo Massaro, Ming Yao, Brae Petersen, Quanzheng Zhang, Weigang Huang, Adam J. Carr, Qisheng Zhang, Nancy L. Allbritton
Summary: Capillary electrophoresis with fluorescence detection (CE-F) is a powerful method for measuring enzyme activation in single cells. However, the reporter substrates used in cellular enzymatic assays for CE-F may affect enzyme kinetics. To address this issue, a fix and click method was developed to attach a fluorophore to an enzyme activation reporter prior to analysis by CE-F, allowing for the investigation of sphingolipid signaling in single cells.
ANALYTICAL CHEMISTRY
(2022)
Review
Food Science & Technology
Io-Guane Rivera, Marta Ordonez, Natalia Presa, Ana Gomez-Larrauri, Jorge Simon, Miguel Trueba, Antonio Gomez-Munoz
Article
Pharmacology & Pharmacy
Io-Guane Rivera, Marta Ordonez, Natalia Presa, Patricia Gangoiti, Ana Gomez-Larrauri, Miguel Trueba, Todd Fox, Mark Kester, Antonio Gomez-Munoz
BIOCHEMICAL PHARMACOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Natalia Presa, Ana Gomez-Larrauri, Io-Guane Rivera, Marta Ordonez, Miguel Trueba, Antonio Gomez-Munoz
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Article
Cell Biology
Marta Ordonez, Io-Guane Rivera, Natalia Presa, Antonio Gomez-Munoz
CELLULAR SIGNALLING
(2016)
Article
Biochemistry & Molecular Biology
Antonio Gomez-Munoz, Patricia Gangoiti, Io-Guane Rivera, Natalia Presa, Ana Gomez-Larrauri, Marta Ordonez
CHEMISTRY AND PHYSICS OF LIPIDS
(2016)
Review
Biochemistry & Molecular Biology
Antonio Gomez-Munoz, Natalia Presa, Ana Gomez-Larrauri, Io-Guane Rivera, Miguel Trueba, Marta Ordonez
PROGRESS IN LIPID RESEARCH
(2016)
Article
Cell Biology
Marta Ordonez, Natalia Presa, Miguel Trueba, Antonio Gomez-Munoz
MEDIATORS OF INFLAMMATION
(2017)
Article
Pharmacology & Pharmacy
Alberto Ouro, Lide Arana, Io-Guane Rivera, Marta Ordonez, Ana Gomez-Larrauri, Natalia Presa, Jorge Simon, Miguel Trueba, Patricia Gangoiti, Robert Bittman, Antonio Gomez-Munoz
BIOCHEMICAL PHARMACOLOGY
(2014)
Article
Oncology
Marta Ordonez, Natalia Presa, Asier Dominguez-Herrera, Miguel Trueba, Antonio Gomez-Munoz
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Natalia Presa, Robin D. Clugston, Susanne Lingrell, Samuel E. Kelly, Alfred H. Merrill, Sayantan Jana, Zamaneh Kassiri, Antonio Gomez-Munoz, Dennis E. Vance, Rene L. Jacobs, Jelske N. van der Veen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Review
Biochemistry & Molecular Biology
Jorge Simon, Alberto Ouro, Lolia Ala-Ibanibo, Natalia Presa, Teresa Cardoso Delgado, Maria Luz Martinez-Chantar
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Ana Gomez-Larrauri, Natalia Presa, Asier Dominguez-Herrera, Alberto Ouro, Miguel Trueba, Antonio Gomez-Munoz
Article
Biochemistry & Molecular Biology
Natalia Presa, Asier Dominguez-Herrera, Jelske N. van der Veen, Dennis E. Vance, Antonio Gomez-Munoz
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)