Article
Immunology
Tejpal Gill, Patrick Stauffer, Mark Asquith, Ted Laderas, Tammy M. Martin, Sean Davin, Matthew Schleisman, Claire Ramirez, Kimberly Ogle, Ingrid Lindquist, Justine Nguyen, Stephen R. Planck, Carley Shaut, Sarah Diamond, James T. Rosenbaum, Lisa Karstens
Summary: This study investigated the altered immunoglobulin A (IgA) response in the gut and oral microbial communities of patients with axial spondyloarthritis (axSpA). The results showed that axSpA patients had distinct populations of immunoreactive microbes in their fecal and salivary microbiomes. Predictive metagenomic analysis revealed perturbation of metabolites and metabolic pathways in axSpA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ana Triguero-Martinez, Emilia Roy-Vallejo, Eva Gloria Tomero, Nuria Montes, Hortensia de la Fuente, Ana Maria Ortiz, Santos Castaneda, Amalia Lamana, Isidoro Gonzalez-Alvaro
Summary: Gal1 serum levels are lower in SpA patients compared to RA patients and similar to HD patients. Gal1 could serve as a diagnostic biomarker for distinguishing RA and SpA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ngoc Tuan Nguyen, Wei-Hsin Sun, Tzu-Hsuan Chen, Po-Chun Tsai, Chih-Chen Chen, Shir-Ly Huang
Summary: This study compares intestinal samples from rheumatoid arthritis (RA) mice and healthy mice, finding that RA mice have lower microbial diversity indices and a higher ratio of Firmicutes to Bacteroidetes in cecal mucus, which could serve as an indicator of RA. The study also shows that TDAG8 deficiency reduces the abundance of proinflammation-related bacteria, relieving the severity and pain of RA. Blocking TDAG8 function partially restores the microbiome composition in RA. These findings provide insights into the interaction between specific bacteria and gut mucus in the RA model and suggest TDAG8 modulation as a potential microbiota-based therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Valeria Caputo, Martina Libera, Sofia Sisti, Benedetta Giuliani, Roberta A. Diotti, Elena Criscuolo
Summary: Human Immunodeficiency Virus (HIV) remains a major global health issue, and the mucosal innate immune response and microbiota play crucial roles in HIV infection. The mucosae act as a physical barrier that can be compromised by the virus, leading to innate immune response, and the mucosal microbiota can influence the development of opportunistic infections. However, a proper characterization of mucosal innate immune response and microbiota is still lacking, and further studies are needed to understand their potential in vaccine development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Modupe O. Coker, Cristiana Cairo, Alfredo Garzino-Demo
Summary: HIV-infected individuals on ART are at a higher risk for oral pathologies due to changes in oral microbial communities, which may lead to increased susceptibility to inflammation. Further research is needed to understand how interventions targeting inflammation and microbial diversity can mitigate these comorbidities.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zoya Qaiyum, Melissa Lim, Robert D. Inman
Summary: The genetic and clinical similarities between spondyloarthritis (SpA) and inflammatory bowel disease (IBD) have led to a focus on the gut-joint axis of inflammation, resulting in three key hypotheses attempting to unravel this complex relationship. These hypotheses explore the interactions between the immune system, microbiome, and joint inflammation in SpA, providing insights for potential novel therapeutic targets and implications for predicting the likelihood of IBD development in SpA patients or the presence of coincident SpA-IBD.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Nutrition & Dietetics
Frank Piva, Philippe Gervois, Youness Karrout, Famara Sane, Marie-Benedicte Romond
Summary: This study investigates the protective potential of Bifidobacterium longum cell wall lipoproteins (Lpps) in rheumatoid arthritis (RA) and finds that they can modulate the gut microbiota and alleviate arthritis symptoms. The dosage of Lpps is critical for preventing arthritis progression and appropriately modulating the microbiome. The results also suggest that Lpps may trigger the immune system.
Editorial Material
Rheumatology
Juergen Braun, Dietmar Krause, Uta Kiltz
Summary: This editorial discusses the impact evaluation of a nurse-led program for patient self-assessment and self-management in axial spondyloarthritis, presented in a prospective, multicenter, randomized, controlled trial (COMEDSPA) conducted by Anna Molto et al.
Article
Fisheries
Syed Monzur Morshed, Tsung-Han Lee
Summary: The environment has a significant impact on fish as it affects the microbiome and mucosal immunity, which are crucial for their overall health. However, there is a lack of research on the interaction between the microbiome and mucosal immunity under different environmental conditions. This review summarizes the existing literature on the effects of environmental changes, such as temperature, salinity, dissolved oxygen, pH, and photoperiod, on the fish microbiome and mucosal immunity. Understanding the mucosal immunity-microbiome interaction can also enhance aquaculture practices during environmental stress.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Microbiology
Yuchen Liu, Lianhong Li, Huaxiang Yan, Zhonghua Ning, Zhong Wang
Summary: The study demonstrated that supplementing L. salivarius SNK-6 can improve feed intake and disease resistance in laying hens, but may lead to changes in production performance. This immunomodulatory function is possibly achieved by regulating the cecal microbial composition.
Article
Medicine, General & Internal
Juan L. Prados-Ojeda, Rogelio Luque-Luque, Rafael M. Gordillo-Urbano, Ipek Guler, Clementina Lopez-Medina, Eduardo Collantes-Estevez, Alejandro Escudero-Contreras
Summary: The study found a higher prevalence of subclinical psychotic symptoms in patients with RA and SpA compared to the general population, indicating a potential association between inflammation and depression/subclinical psychotic symptoms. Despite similar mental dimension scores in the SF-12 Health Survey, patients showed greater distress due to the presence of symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Yunju Jeong, JooYeon Jhun, Seon-Yeong Lee, Hyun Sik Na, JeongWon Choi, Keun-Hyung Cho, Seung Yoon Lee, A. Ram Lee, Sang-Jun Park, Hyun Ju You, Ji-Won Kim, Myeong Soo Park, Bin Kwon, Mi-La Cho, Geun Eog Ji, Sung-Hwan Park
Summary: The study found significant differences in gut microbiota composition in patients with different RF levels, and B. longum RAPO may alleviate RA by inhibiting the production of IL-17, reducing inflammation, bone damage, and cartilage damage. Further investigation is needed to evaluate the safety and efficacy of B. longum RAPO in patients with RA and other autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Haifeng Lu, Yujun Yao, Jiezuan Yang, Hua Zhang, Lanjuan Li
Summary: Researchers believe that changes in the intestinal microbiome and miRNA profile may impact the progression of undifferentiated arthritis and play a significant role in the development of rheumatoid arthritis. However, the causal relationship between the two has not been fully elucidated.
RHEUMATOLOGY INTERNATIONAL
(2021)
Review
Nutrition & Dietetics
Manuela Cassotta, Tamara Y. Forbes-Hernandez, Danila Cianciosi, Maria Elexpuru Zabaleta, Sandra Sumalla Cano, Irma Dominguez, Beatriz Bullon, Lucia Regolo, Jose Miguel Alvarez-Suarez, Francesca Giampieri, Maurizio Battino
Summary: Modern high-throughput 'omics' science tools are being applied to nutritional sciences and rheumatoid arthritis research to understand the interactions between nutrients and the genome, transcriptome, proteome, metabolome, and microbiota, as well as their impact on health and disease. The role of nutritional factors and the gut microbiome in RA risk and progression is increasingly being recognized, and the opportunities and challenges of utilizing novel 'omics' technologies in exploring new avenues in RA and nutritional research are being discussed.
Article
Medicine, Research & Experimental
Jiaqian Wang, Yuan Xue, Liang Zhou
Summary: By using bioinformatics analysis, this study explored the differences in immune mechanisms and diagnostic markers between SpA and RA. The results showed that differentially expressed genes (DEGs) were mainly enriched in cell chemotaxis, lymphocyte activation, primary immunodeficiency and other immune responses. The differences in immune cells between SpA, RA and normal controls were mainly concentrated in B and T lymphocytes, macrophages and dendritic cells. C19orf12 + S1PR3 was found to be most associated with these immune cells and can be used as a diagnostic marker for this type of immune diseases. Additionally, MZB1 + XIST was closely related to T cells, NK cells and dendritic cells, and may serve as a marker to distinguish between the two diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)