Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice

Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy

(2019) Thijs J. Beldman et al.   ACS Nano

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies—Statement From ATVB CouncilHighlights

(2018) Peggy Robinet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis

(2018) Paola Perrotta et al.   VASCULAR PHARMACOLOGY

Vasa Vasorum Angiogenesis: Key Player in the Initiation and Progression of Atherosclerosis and Potential Target for the Treatment of Cardiovascular Disease

(2018) Daniel G. Sedding et al.   Frontiers in Immunology

Autophagy in Cardiovascular Aging

(2018) Mahmoud Abdellatif et al.   CIRCULATION RESEARCH

The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses

(2018) Ruyuan Zhang et al.   INFLAMMATION

Animal models of atherosclerosis

(2017) Besa Emini Veseli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

(2017) Anne-Clemence Vion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenesis in the atherosclerotic plaque

(2017) Caroline Camaré et al.   Redox Biology

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

(2017) Trudy McGarry et al.   Scientific Reports

Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities

(2016) Andreas Pircher et al.   ATHEROSCLEROSIS

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization

(2016) Margreet R. de Vries et al.   CURRENT OPINION IN LIPIDOLOGY

Intraplaque neovascularization as a novel therapeutic target in advanced atherosclerosis

(2016) Bieke Van der Veken et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cholesterol-independent effects of atorvastatin prevent cardiovascular morbidity and mortality in a mouse model of atherosclerotic plaque rupture

(2016) Lynn Roth et al.   VASCULAR PHARMACOLOGY

Effects of Cancer Therapy Targeting Vascular Endothelial Growth Factor Receptor on Central Blood Pressure and Cardiovascular System

(2015) Antonella Moreo et al.   AMERICAN JOURNAL OF HYPERTENSION

HIF-1  and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages

(2015) A. Tawakol et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chronic intermittent mental stress promotes atherosclerotic plaque vulnerability, myocardial infarction and sudden death in mice

(2015) Lynn Roth et al.   ATHEROSCLEROSIS

Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation

(2015) Lisardo Boscá et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Contribution of Angiogenesis to the Process of Metastasis

(2015) Diane R. Bielenberg et al.   CANCER JOURNAL

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

(2015) Scott Boyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Markers to Delineate Murine M1 and M2 Macrophages

(2015) Kyle A. Jablonski et al.   PLoS One

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions

(2014) Naveen S. Vasudev et al.   ANGIOGENESIS

Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death

(2014) Carole Van der Donckt et al.   EUROPEAN HEART JOURNAL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure

(2012) Zhehao Dai et al.   Journal of Cardiology

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

(2012) Sucheta Telang et al.   Journal of Translational Medicine

Intraplaque haemorrhages as the trigger of plaque vulnerability

(2011) J.-B. Michel et al.   EUROPEAN HEART JOURNAL

Impaired Fibrillin-1 Function Promotes Features of Plaque Instability in Apolipoprotein E–Deficient Mice

(2009) Jozef L. Van Herck et al.   CIRCULATION

Thin-Walled Microvessels in Human Coronary Atherosclerotic Plaques Show Incomplete Endothelial Junctions

(2009) Judith C. Sluimer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS