Article
Cell Biology
Julia K. Panzer, Alejandro Tamayo, Alejandro Caicedo
Summary: This study identifies a defect in autocrine signaling in pancreatic alpha cells of individuals with type 1 diabetes, which leads to inadequate glucagon response and susceptibility to hypoglycemia. Reactivating residual AMPA/kainate receptor function with positive allosteric modulators can restore normal glucagon secretion and prevent hypoglycemia, providing a potential therapeutic approach for managing diabetes.
Article
Pharmacology & Pharmacy
Mohamed S. Abdel-Bakky, Abdulmajeed Alqasoumi, Waleed M. Altowayan, Elham Amin, Mostafa A. Darwish
Summary: This study discovered the critical role of ADAM10 and CXCL16 in the development of T1D, and the protective effect of resveratrol (RES) in preventing the deleterious effects caused by STZ. ADAM10 and CXCL16 may serve as potential therapeutic targets for T1D.
Review
Biochemistry & Molecular Biology
Lorella Marselli, Emanuele Bosi, Carmela De Luca, Silvia Del Guerra, Marta Tesi, Mara Suleiman, Piero Marchetti
Summary: Research has shown that ARG2 plays a role in regulating beta cell function by controlling the synthesis of polyamines, which may be relevant to the pathophysiology of type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Erwin Ilegems, Galyna Bryzgalova, Jorge Correia, Burcak Yesildag, Edurne Berra, Jorge L. Ruas, Teresa S. Pereira, Per-Olof Berggren
Summary: This study found the presence of HIF-1 alpha in pancreatic cells during the progression of type 2 diabetes, and demonstrated that treatment with the HIF-1 alpha inhibitor PX-478 can improve beta cell function, prevent diabetes progression, and increase insulin secretion. The results showed that PX-478 treatment has an improving effect on mouse and human islets.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Food Science & Technology
Simeng Bao, Hongzhi Zheng, Chengjie Chen, Yuhang Zhang, Lina Bao, Bei Yang, Yongyong Hou, Yanyan Chen, Qiang Zhang, Jingbo Pi, Jingqi Fu
Summary: The deficiency of Nfe2l1 in pancreatic beta cells significantly reduced STZ-induced damage and dysfunction, improving glucose tolerance and insulin secretion. This protective effect is partly due to the metabolic switch induced by Nfe2l1 deficiency to enhance glycolysis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Michitada Hirano, Yusei So, Shin Tsunekawa, Mio Kabata, Sho Ohta, Hiroshi Sagara, Nao Sankoda, Jumpei Taguchi, Yosuke Yamada, Tomoyo Ukai, Makoto Kato, Jiro Nakamura, Manabu Ozawa, Takuya Yamamoto, Yasuhiro Yamada
Summary: Hirano et al. demonstrate that expression of Mycl can increase proliferation and expand the functional beta-cell population in adult pancreatic islets, improving glucose control. Their findings suggest that transient expression of Mycl can normalize hyperglycemia in diabetic mice and stimulate the division of human adult cadaveric islet cells. This study provides insights into a potential regenerative strategy for beta cells.
Article
Biology
Richard Bertram, Isabella Marinelli, Patrick A. Fletcher, Leslie S. Satin, Arthur S. Sherman
Summary: This article describes the history and development of the study on electrical bursting oscillations in pancreatic β-cells, and celebrates the 40th anniversary of the publication of the Chay-Keizer model.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Plant Sciences
Prawej Ansari, Peter R. Flatt, Patrick Harriott, J. M. A. Hannan, Yasser H. A. Abdel-Wahab
Summary: The study demonstrated the antidiabetic effects of Acacia arabica bark extract, showing potential as a treatment for diabetes. The isolated phytoconstituents, including quercetin and kaempferol, improved glucose tolerance and insulin secretion, indicating the benefits of using them as antidiabetic agents.
Review
Endocrinology & Metabolism
Guzel Burganova, Claire Bridges, Peter Thorn, Limor Landsman
Summary: Insulin-producing beta-cells are the majority in pancreatic islets and their dysfunction is a key factor in the loss of glucose regulation in type 2 diabetes. The close interaction between beta-cells and the intra-islet microvasculature, which includes endothelial cells and pericytes, plays a crucial role in regulating beta-cell functions. The vascular cells directly regulate beta-cell activity through the secretion of growth factors and other molecules, promoting insulin gene expression, insulin secretion, and beta-cell proliferation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Estefania Quesada-Masachs, Samuel Zilberman, Sakthi Rajendran, Tiffany Chu, Sara McArdle, William B. Kiosses, Jae-Hyun M. Lee, Burcak Yesildag, Mehdi A. Benkahla, Agnieszka Pawlowska, Madeleine Graef, Susanne Pfeiffer, Zbigniew Mikulski, Matthias von Herrath
Summary: This study characterized and quantified the expression of HLA class II in human pancreatic tissue, showing that HLA-II can be expressed by pancreatic beta cells from patients with type 1 diabetes. It also demonstrated that this upregulation can be induced in vitro in healthy isolated human islets or reaggregated human islets by treatment with proinflammatory cytokines. The findings support a role for HLA-II in type 1 diabetes pathogenesis as potential targets for autoreactive CD4(+) lymphocytes.
Article
Multidisciplinary Sciences
Hwee Hui Lau, Nicole A. J. Krentz, Fernando Abaitua, Marta Perez-Alcantara, Jun-Wei Chan, Jila Ajeian, Soumita Ghosh, Yunkyeong Lee, Jing Yang, Swaraj Thaman, Benoite Champon, Han Sun, Alokkumar Jha, Shawn Hoon, Nguan Soon Tan, Daphne Su-Lyn Gardner, Shih Ling Kao, E. Shyong Tai, Anna L. Gloyn, Adrian Kee Keong Teo
Summary: The coding variant of the PAX4 gene is associated with an altered risk of type 2 diabetes in East Asian populations. This study found that individuals carrying the specific allele of PAX4 exhibited decreased pancreatic beta cell function, and a newly identified allele was found in some diabetes patient pedigrees. Knockdown of the PAX4 gene resulted in impaired insulin secretion and altered hormone gene expression in a human beta cell model. In vitro differentiation experiments also showed that cells carrying specific risk alleles exhibited increased polyhormonal endocrine cell formation and decreased insulin content.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Ahmed K. Elsayed, Nehad M. Alajez, Essam M. Abdelalim
Summary: Our study reveals the association between FOXA2 loss and altered lncRNA expression profile, providing novel insights into the regulatory role of lncRNA and mRNA networks in pancreatic islet development.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Paulina Karen Mendoza Sanchez, Mona Khazaei, Eva Gatineau, Shirin Geravandi, Blaz Lupse, Huan Liu, Ralf Dringen, Anne Wojtusciszyn, Patrick Gilon, Kathrin Maedler, Amin Ardestani
Summary: LDHA, a key metabolic enzyme preferentially catalyzing the conversion of pyruvate to lactate, is mainly localized in human α-cells and upregulated in diabetic conditions. Inhibition of LDHA enhances insulin secretion in isolated human islets, but does not significantly correct deregulated insulin or glucagon secretion under diabetic conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Huihui Hong, Jia Xu, Haotian He, Xue Wang, Lingling Yang, Ping Deng, Lu Yang, Miduo Tan, Jingjing Zhang, Yudong Xu, Tong Tong, Xiqin Lin, Huifeng Pi, Yuanqiang Lu, Zhou Zhou
Summary: Cd exposure induces metabolic toxicity in pancreatic beta-cells, disrupting glucose and lipid homeostasis, and may be associated with the development of diabetes mellitus.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Jenna Ko, Vivian A. Fonseca, Hongju Wu
Summary: Pax4 is a transcription factor essential for the development and function of pancreatic beta cells. It plays a crucial role in cell fate determination and proliferation in the pancreas. Mutations in Pax4 are associated with diabetes pathogenesis, and targeting Pax4 may hold promise for diabetes treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Madelyn C. Huang, Christelle Douillet, Ellen N. Dover, Chongben Zhang, Rowan Beck, Alunad Tejan-Sie, Sergey A. Krupenko, Miroslav Styblo
ENVIRONMENTAL HEALTH PERSPECTIVES
(2018)
Article
Engineering, Environmental
Rowan Beck, Paige Bommarito, Christelle Douillet, Matt Kanke, Luz M. Del Razo, Gonzalo Garcia-Vargas, Rebecca C. Fry, Praveen Sethupathy, Miroslav Styblo
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Environmental Sciences
Paige A. Bommarito, Rowan Beck, Christelle Douillet, Luz M. Del Razo, Gonzalo-G Garcia-Vargas, Olga L. Valenzuela, Luz C. Sanchez-Pena, Mirek Styblo, Rebecca C. Fry
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2019)
Article
Toxicology
Rowan Beck, Mohit Chandi, Matt Kanke, Miroslav Styblo, Praveen Sethupathy
ARCHIVES OF TOXICOLOGY
(2019)
Article
Toxicology
Jenna E. Todero, Kieran Koch-Laskowski, Qing Shi, Matt Kanke, Yu-Han Hung, Rowan Beck, Miroslav Styblo, Praveen Sethupathy
Summary: Arsenic, a pervasive environmental toxin, can cause type 2 diabetes through chronic exposure. This study reveals that arsenic treatment impairs insulin secretion in pancreatic beta cells and alters the microRNA profile. Multi-omic analysis shows that arsenic affects pathways related to insulin secretion and diabetes, and different forms of arsenic have distinct effects on cell cycle and beta cell maintenance factors. miR-29a is identified as a potential master regulator of these genes.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Endocrinology & Metabolism
Rowan Beck, Miroslav Styblo, Praveen Sethupathy
CURRENT DIABETES REPORTS
(2017)
Article
Toxicology
E. N. Dover, R. Beck, M. C. Huang, C. Douillet, Z. Wang, E. L. Klett, Miroslav Styblo
ARCHIVES OF TOXICOLOGY
(2018)