LJ-529, a partial peroxisome proliferator-activated receptor gamma (PPARγ) agonist and adenosine A3 receptor agonist, ameliorates elastase-induced pulmonary emphysema in mice

Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm

(2019) Huimin Yan et al.   Scientific Reports

CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production

(2019) A. S. M. Rafiul Haque et al.   Scientific Reports

Pharmacological Therapy of COPD: Reasons for Optimism

(2018) Bartolome R. Celli   CHEST

Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD

(2018) Kei Yamasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

(2018) Paulina Krzyszczyk et al.   Frontiers in Physiology

Basophils trigger emphysema development in a murine model of COPD through IL-4–mediated generation of MMP-12–producing macrophages

(2018) Sho Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A murine model of elastase- and cigarette smoke-induced emphysema

(2017) Rubia Rodrigues et al.   Jornal Brasileiro de Pneumologia

Polypharmacology of N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential

(2017) Jinha Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production

(2017) Yuko Horio et al.   PLoS One

Roflumilast: a review of its use in the treatment of COPD

(2016) Jadwiga Wedzicha et al.   International Journal of Chronic Obstructive Pulmonary Disease

Airway epithelial cell PPARγ modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice

(2015) Siva Kumar Solleti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway

(2015) Tianhua Ren et al.   Scientific Reports

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(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Agonistic induction of PPARγ reverses cigarette smoke–induced emphysema

(2014) Ming Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

(2014) Zhihong Yang et al.   Frontiers in Immunology

Adenosine A3 Receptor Activation Attenuates Lung Ischemia-Reperfusion Injury

(2013) Daniel P. Mulloy et al.   ANNALS OF THORACIC SURGERY

The effect of peroxisome proliferator-activated receptor-  ligands on in vitro and in vivo models of COPD

(2013) S. Lea et al.   EUROPEAN RESPIRATORY JOURNAL

Regulation of Inflammation by Adenosine

(2013) György Haskó et al.   Frontiers in Immunology

Regulation of Macrophage Function by Adenosine

(2012) György Haskó et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Emerging anti-inflammatory strategies for COPD

(2012) Mario Cazzola et al.   EUROPEAN RESPIRATORY JOURNAL

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Elastase-induced pulmonary emphysema: insights from experimental models

(2011) Mariana A. Antunes et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components

(2010) Harry Martin   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ inhibits NF-κB-dependent transcriptional activation in skeletal muscle

(2009) A. H. V. Remels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Noninvasive and Invasive Pulmonary Function in Mouse Models of Obstructive and Restrictive Respiratory Diseases

(2009) Jeroen A. J. Vanoirbeek et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanisms of emphysema in  1-antitrypsin deficiency: molecular and cellular insights

(2009) B. Gooptu et al.   EUROPEAN RESPIRATORY JOURNAL

PPARγ regulates retinoic acid-mediated DC induction of Tregs

(2009) William J. Housley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adenosine signaling and the regulation of chronic lung disease

(2009) Yang Zhou et al.   PHARMACOLOGY & THERAPEUTICS

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(2008) Joanne L. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A3Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis

(2008) Eva Morschl et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Structure−Activity Relationships of Truncatedd- andl-4′-Thioadenosine Derivatives as Species-Independent A3Adenosine Receptor Antagonists(1)

(2008) Lak Shin Jeong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

(2007) Ramya Kapadia   Frontiers in Bioscience-Landmark