Article
Chemistry, Applied
Max Roemer, Ian Luck, Nicholas Proschogo
Summary: This paper investigates the synthesis of aryl amines from halobenzenes via copper mediated reactions using sodium azide under mild conditions. The reaction proceeds stepwise through the formation of aryl azides, which are then reduced to amines. The methodology allows for the synthesis of amines from different positions of halobenzenes with electron withdrawing groups. The use of modified stirring bars as heterogeneous catalysts is also demonstrated.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Alex Gibney, Raphael E. F. de Paiva, Vandana Singh, Robert Fox, Damien Thompson, Joseph Hennessy, Creina Slator, Christine J. McKenzie, Pegah Johansson, Vickie McKee, Fredrik Westerlund, Andrew Kellett
Summary: In this study, a Cu-catalysed azide-alkyne cycloaddition reaction produced a 1,2,3-triazole linker that was used to create Cu-binding artificial metallo-nucleases (AMNs). A bioactive C-3-symmetric ligand called TC-Thio was developed using biologically inert reaction partners. The ligand formed Cu-II and Cu-I complexes through Cu coordination, and showed potent DNA binding and cleaving abilities. Mechanistic studies revealed that DNA recognition occurred at the minor groove, leading to oxidative damage through a pathway dependent on superoxide and peroxide. Single molecule imaging demonstrated that the complex caused DNA damage recognized by base excision repair enzymes, comparable to the clinical drug temozolomide.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Ruijia Huang, Ying Xu, Jihui Du, Qiong Guan, Xiaoqing Cai, Feng Li, Jidong Wang, Wenwen Chen
Summary: Copper is an essential element in the human body and its excessive presence is associated with various diseases. A chemical sensor based on the Cu-catalyzed click reaction and fluorescence-enhanced substrate has been developed for selective detection of Cu2+. This sensor can detect Cu2+ as low as 3.87 nM within 10 minutes and has potential applications in disease diagnosis and antibiotic susceptibility testing.
Article
Multidisciplinary Sciences
Yawen You, Qingqing Deng, Yibo Wang, Yanjuan Sang, Guangming Li, Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: This study reports on a DNA-based biocompatible, highly efficient, and precisely targeted copper nanocatalyst, which exhibits excellent catalytic activity and achieves efficient prodrug activation and antitumor effects in cancer cells.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zhuangzhuang Wang, Xuehao Zhou, Shaofeng Gong, Jianwei Xie
Summary: Cu(im)(2)-derived Cu@N-C composites were used as efficient heterogeneous catalysts for the first time in the one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles. The catalyst exhibited easy reusability, broad substrate scope, and high reaction yields, confirming its heterogeneous nature.
Article
Chemistry, Multidisciplinary
Chunwei Dong, Ren-Wu Huang, Arunachalam Sagadevan, Peng Yuan, Luis Gutierrez-Arzaluz, Atanu Ghosh, Saidkhodzha Nematulloev, Badriah Alamer, Omar F. Mohammed, Irshad Hussain, Magnus Rueping, Osman M. Bakr
Summary: In this study, a synthesis method for obtaining an atomically precise nanoparticle with a surface-defective analogue is reported. The loss of a single surface atom drastically alters the reactivity of the nanoparticle, showing promising activity for click chemistry, especially photoinduced azide-alkyne cycloaddition. This study not only uncovers the effect of single-surface atom modification on nanoparticle properties but also demonstrates the potential of single-atom surface modification as a means for designing nanoparticle catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Leona L. Rodrigues, Aaron S. Micallef, Michael C. Pfrunder, Vinh X. Truong, John C. McMurtrie, Tim R. Dargaville, Anja S. Goldmann, Florian Feist, Christopher Barner-Kowollik
Summary: A highly efficient ligation system based on visible light-induced rearrangement was introduced, generating a thiophenol for rapid thiol-Michael additions without the need for additives. The self-catalyzed ligation through pyridine mediated deprotonation of the photochemically generated thiophenol was described, leading to additive-free thiol-Michael reactions. The study explored various reaction conditions, solvents, and substrates, showcasing excellent end group fidelity in polymer modification.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Youxin Fu, Hugo Helbert, Nadja A. Simeth, Stefano Crespi, Gerbren B. Spoelstra, Jan Maarten van Dijl, Marleen van Oosten, Luiza Reali Nazario, Dion van der Born, Gert Luurtsema, Wiktor Szymanski, Philip H. Elsinga, Ben L. Feringa
Summary: The study developed an ultrafast photoclick method based on photocycloaddition reaction for the synthesis of short-lived F-18-PET tracers. The reaction can be completed in 60 seconds using a flow photo-microreactor, demonstrating practicality by preparing clinically relevant tracers for prostate cancer and bacterial infection imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Anurag Noonikara-Poyil, Alvaro Munoz-Castro, H. V. Rasika Dias
Summary: This study describes the isolation and full characterization of a thermally stable, copper(I) acetylene complex using a highly fluorinated bis(pyrazolyl)borate ligand support, as well as the details of a related copper(I) complex. Raman data show significant red-shifts in C equivalent to C stretch of different alkynes bound to copper(I), with computational analysis indicating that the interaction is primarily of the electrostatic character. The study also highlights the catalytic activity of a mononuclear copper complex in [3 + 2] cycloadditions and compares its effectiveness with a trinuclear copper catalyst.
Article
Chemistry, Multidisciplinary
Sagar M. Mane, Chaitany Jayprakash Raorane, Jae Cheol Shin
Summary: A mesoporous silica adsorbent was prepared using a sol-gel co-condensation method, showing high selectivity for adsorption of copper ions with fast adsorption rate and efficient recyclable stability.
Article
Chemistry, Organic
Hiroto Kimura, Kohsuke Aikawa, Takuya Hashimoto
Summary: CuAAC and SuFEx reactions are two important methods for connecting molecules in click chemistry. This study presents a copper-catalyzed aminoazidation reaction using NFC, which attaches both an azide and a fluorosulfonyl group to an alkene in one step. The derivatization of the product through consecutive CuAAC and SuFEx reactions allows rapid diversification of molecular structure.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Yingfeng Wang, Maoli Yin, Zhipeng Ma, Yang Wang, Wei Li, Huang Hu, Xin Hong
Summary: In this study, N-halamines were introduced into mesoporous silica to enhance its surface area retention rate and water treatment properties. The modified mesoporous silica showed effective antibacterial properties against E. coli and S. aureus, and exhibited good adsorption abilities for organic dyes. These findings suggest that the modified mesoporous silica has great potential for applications in wastewater purification.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Chenchen Ge, Jiaofu Li, Dou Wang, Kongpeng Lv, Quan Liu, Yan Shen, Xiaoqing Zhuang, Wankun Luo, Zongze Wu, Yuhua Zhang, Lulin Shi, Liping Liu, Shiyun Bao, Han Zhang
Summary: This novel sensing platform utilizes the excellent fluorescence quenching ability of graphdiyne (GDY) and the high specificity of click chemistry to enable sensitive detection of copper(ii) ions (Cu2+) in living cells and body fluids.
Article
Materials Science, Multidisciplinary
Daquan Zhang, Jiamin Lu, Cheng Shi, Kai Zhang, Jin Li, Lixin Gao
Summary: This study demonstrates that constructing covalent layer-by-layer assembly films on copper surfaces can significantly enhance corrosion resistance, with an optimum of three assembly layers achieving a protection efficiency of 96.9%. The mechanism of protection is attributed to the formation of covalent triazole films catalyzed by cuprous oxide, as discussed through surface analysis and molecular dynamics simulations.
Review
Chemistry, Multidisciplinary
Kun Lan, Qiulong Wei, Dongyuan Zhao
Summary: This Review discusses the synthesis of novel mesoporous TiO2 materials, with a focus on the monomicelle assembly strategy for controlling the formation of mesostructured TiO2. Typical applications of mesoporous TiO2 in batteries and photocatalysis are highlighted, and the outlook for the synthesis of mesoporous TiO2 with tailored architectures through self-assembly is discussed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Physical
Saravanan Nagappan, Malarkodi Duraivel, Shamim Ahmed Hira, Kandasamy Prabakar, Chang-Sik Ha, Sang Hoon Joo, Ki Min Nam, Kang Hyun Park
Summary: This review highlights the significance of heteroatom doped core-shell nanostructures (HCSNs) as superior electrocatalysts for the oxygen reduction reaction (ORR), emphasizing how various heteroatom dopants contribute to enhanced ORR performance. Nitrogen doping in different forms of CSNs creates high surface area and reactive active sites for improved ORR efficiency, making them promising for practical applications in ORR electrodes. Additionally, the combination of multiple heteroatom dopants in CSNs shows potential for synthesizing highly efficient ORR electrodes.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Nanoscience & Nanotechnology
Mohammad Yusuf, Shamim Ahmed Hira, Kang Hyun Park
Summary: This study reports a novel hierarchical porous hybrid structure material Cu9S5-MnWO4 that can be used in photocatalytic reactions. Designing heterogeneous catalysts based on this structure can be applied in the fabrication and modification of various photocatalysts.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Energy & Fuels
Saravanan Nagappan, Malarkodi Duraivel, Vijayakumar Elayappan, Nallal Muthuchamy, Balaji Mohan, Amarajothi Dhakshinamoorthy, Kandasamy Prabakar, Jae-Myung Lee, Kang Hyun Park
Summary: Recently, metal-organic frameworks (MOFs)-based cathode materials have gained significant attention for their high surface area, controlled architecture, porosity, and tunability. By altering the synthesis techniques, the performance of MOF-based cathodes can be improved for specific battery applications. The review article provides a comprehensive overview of the uniqueness and history of MOF-based cathodes, their advantages and disadvantages, various synthesis approaches, and their use in different battery applications.
Article
Electrochemistry
Karkuzhali Rajendran, Muthuchamy Nallal, Muthusankar Ganesan, Manoj Shanmugasundaram, Shamim Ahmed Hira, Gopu Gopalakrishnan, Sethupathi Murugan, Gedanken Aharon, Kang Hyun Park
Summary: In this study, a three-dimensional hybrid nanocomposite (3D-CeVO4/MWNT HNC) was developed, which exhibited excellent properties for energy storage and sensors. It is considered to be the best material to overcome the future energy demand and economic crisis.
ELECTROCHIMICA ACTA
(2023)
Article
Electrochemistry
June Sung Lim, Jinjong Kim, Kug-Seung Lee, Young Jin Sa, Sang Hoon Joo
Summary: This study investigates the impacts of catalyst loading and metal center on the 2e(-) ORR activity and selectivity of M-N/C catalysts. It is found that meso-Co-N/C and meso-Ni-N/C catalysts exhibit the best 2e(-) ORR performance under acidic and alkaline electrolytes, respectively, at low catalyst loadings. However, the H2O2 production activity of meso-Co-N/C catalyst dramatically declines at high catalyst loadings, while the activity of meso-Ni-N/C catalyst is nearly insensitive to the catalyst loading.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Saravanan Nagappan, Malarkodi Duraivel, SeongHoon Han, Mohammad Yusuf, Manjiri Mahadadalkar, KyeongMun Park, Amarajothi Dhakshinamoorthy, Kandasamy Prabakar, Sungkyun Park, Chang-Sik Ha, Jae-Myung Lee, Kang Hyun Park
Summary: Graphene, a two-dimensional material with a large surface area, is widely used in various fields. Recently, there has been increased focus on developing metal-free graphenes doped with heteroatoms as efficient electrocatalysts for oxygen reduction reactions (ORRs). Our study found that graphene prepared from graphene oxide (GO) by pyrolysis under a nitrogen atmosphere at 900 degrees C showed better ORR activity compared to pristine GO. Various pyrolysis conditions were tested, and the results suggest that the ORR electrocatalytic activity of graphene is influenced by these conditions. The prepared graphenes, particularly G100-1B and G100-2B, displayed promising ORR activity for fuel cell and metal-air battery applications.
Article
Chemistry, Multidisciplinary
S. Nagappan, M. Duraivel, N. Muthuchamy, S. H. Han, B. Mohan, S. Park, K. Prabakar, J-M. Lee, K. H. Park
Summary: Recently, there has been a lot of interest in the development of biodegradable polymer-derived and heteroatom-doped carbon-Fe3O4 electrocatalysts due to their easy manufacturing, biocompatibility, environmental friendliness, and ability to induce porosity. A highly stable and hierarchical N-doped carbon-Fe3O4 electrocatalyst was created through pyrolysis of a chitosan gel membrane with 2 (w/v)% ferric chloride hexahydrate at different temperatures. The addition of Fe to the chitosan significantly improved the electrocatalytic activity for the oxygen reduction reaction (ORR), presenting a new opportunity for further applications.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Public, Environmental & Occupational Health
Ananda Babu Sairam, Anandhavelu Sanmugam, Ashwini Pushparaj, Gaayathri Mahesh Kumar, Nithila Sundarapandian, Sulakshuna Balaji, Muthuchamy Nallal, Kang Hyun Park
Summary: The demand for drug delivery systems (DDSs) has increased due to the ambiguity of certain diseases and the potential toxicity of many medicines. Nanomedicine, specifically the use of nanocarriers and medication formulations, has become a unique concept for enhanced drug bioaccessibility, long-term drug administration, and dose reduction. Among various nanomedicine techniques, polymeric nanoparticles (poly-NPs) have shown great potential in improving drug pharmacokinetics. However, the safety and toxicity of poly-NPs in long-term studies using high doses remain poorly understood. This article discusses the toxicity of nanoparticles (NPs) used in DDSs, including polylactide-co-glycolide, polylactic acid, polycaprolactone, and poly(alkyl cyanoacrylates).
ACS CHEMICAL HEALTH & SAFETY
(2023)
Article
Engineering, Environmental
Myohwa Ko, June Sung Lim, Ji-Wook Jang, Sang Hoon Joo
Summary: Hydrogen peroxide (H2O2) is a valuable chemical used widely, but its current production methods are energy-intensive and environmentally unfriendly. The photoelectrochemical two-electron O2 reduction reaction (2e- ORR) and 2e- water oxidation reaction (2e- WOR) have emerged as promising alternatives to produce H2O2 in a bias-free, cost-effective, and environmentally benign manner. This Perspective reviews the photoelectrochemical routes to H2O2 production and its in situ application for valuable chemical synthesis, discussing design principles, benchmarking solar-to-chemical conversion efficiencies, and presenting future perspectives on this field.
ACS ES&T ENGINEERING
(2023)
Article
Environmental Sciences
Manjiri A. Mahadadalkar, NaHyun Park, Mohammad Yusuf, Saravanan Nagappan, Muthuchamy Nallal, Kang Hyun Park
Summary: Water pollution caused by industrial wastewater is a critical environmental problem. Synthetic dyes used in various industries have complex composition, high toxicity, and low biodegradability, causing negative impacts on ecosystems. To address this issue, TiO2 fibers photocatalyst doped with Fe was synthesized using sol-gel and electrospinning techniques for the degradation of dyes. The fabricated fibers showed excellent photocatalytic degradation activity, with 99% degradation of rhodamine B in 120 minutes. The fibers also demonstrated good photocatalytic activity even after 5 cycles of reuse.
Article
Chemistry, Inorganic & Nuclear
Balaji Mohan, Kyung Hee Oh, Kyeongmun Park, Mohammad Yusuf, Ji Chan Park, Kang Hyun Park, Buhyun Youn
Summary: In this study, hollow cubic Cu(x)O nanoparticles (approx. 23 nm) incorporated with CNF (HC-Cu(x)O/CNF) were fabricated by the controlled thermal oxidation of solid cubic Cu2O nanoparticles (approx. 21 nm) supported on carbon nanofibers (SC-Cu2O/CNF) under airflow. These hollow Cu(x)O nanocubes with increased surface areas exhibited excellent catalytic activity for unsymmetrical chalcogenide synthesis under ligand-free conditions. The synthesis process involved the transformation of solid Cu(2)O cubes/CNF to hollow Cu(x)O cubes/CNF through thermal oxidation, utilizing the Kirkendall effect.
INORGANIC CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Ho Young Kim, Minki Jun, Sang Hoon Joo, Kwangyeol Lee
Summary: Intermetallic nanoarchitectures have shown great potential as efficient electrocatalysts for energy conversion reactions. By generating well-defined nanoarchitectures, the performance of intermetallic catalysts can be significantly enhanced. These nanoarchitectures possess high intrinsic activity due to their unique structural factors, such as controlled facets, surface defects, and nanoscale confinement effects. Notable examples of intermetallic nanoarchitectures include facet-controlled intermetallic nanocrystals and multidimensional nanomaterials.
ACS NANOSCIENCE AU
(2023)
Article
Chemistry, Multidisciplinary
Sulakshana Shenoy, Chitiphon Chuaicham, Keiko Sasaki, Sungkyun Park, Muthuchamy Nallal, Kang Hyun Park, Karthikeyan Sekar
Summary: A novel one-pot synthesis method was proposed for designing bimetallic oxide-nitride electrocatalysts with tunable morphologies. The method showed remarkable catalytic efficacy and stability without the need for a distinct nitridation process.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jae Hyung Kim, Sinmyung Yoon, Du San Baek, Jihun Kim, Jinjong Kim, Kwangjin An, Sang Hoon Joo
Summary: The thermal stability of Os-based catalysts can be dramatically improved by downsizing Os nanoparticles into atomically dispersed species. This study highlights the unique catalytic behavior of atomically dispersed catalysts, which is distinct from that of nanoparticle-based catalysts.
