期刊
APPLIED SURFACE SCIENCE
卷 508, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2019.145240
关键词
Magnesium alloy; Silica nanoparticles; Layer-by-layer assembly; Corrosion resistance; Tunable release; Antibacterial performance
类别
资金
- National Natural Science Foundation of China [51571134]
- Shandong University of Science and Technology Research Fund [2014TDJH104]
- Natural Science Foundation of Shandong Province [ZR2017BEM002, ZR2019BEM012]
- Science and Technology Innovation Fund of SDUST [SDKDYC190301]
Complications related to corrosion and infection of magnesium (Mg) implants are encountered by physical barrier and local drug delivery system. In this work, the multilayer films composed of ciprofloxacin (CIP) and SiO2 nanoparticles were fabricated on Mg alloys by the spin-spray layer-by-layer assembly method. The resultant films were characterized via FT-IR, XPS, SEM and EDS techniques. The corrosion behaviors of the multilayer films were investigated via electrochemical tests and hydrogen evolution experiment. The obtained films showed corrosion resistance, self-healing ability, antibacterial efficacy and a prolonged release profile. The results also suggested that the loading dosage and the release rate of CIP could be controlled by the assembly parameters. Moreover, the in vitro release kinetics of CIP from the multilayer films could be fitted with the pseudo-second-order model.
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