Article
Chemistry, Physical
Ola A. El-Gammal, Farid Sh Mohamed, Ghada N. Rezk, Ashraf A. El-Bindary
Summary: Metal complexes of Co(II), Ni(II) and Cu(II) with a new Schiff base have been synthesized and characterized. The study suggests potential therapeutic applications against cancer and COVID-19. Additionally, antioxidant and antibacterial activities of these complexes have been evaluated.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Hanan B. Howsaui, Abeer A. Sharfalddin, Magda H. Abdellattif, Amal S. Basaleh, Mostafa A. Hussien
Summary: Novel anti-cancer transition metal complexes were successfully synthesized and characterized using Schiff base derived from 2-aminopyrazine and salicylaldehyde. The complexes exhibited different structures and properties under different metal ions, showing promising anti-cancer activity. The Cu(II) complex showed practical results with HOP-62 cell lines, while the Zn(II) and Co(II) complexes demonstrated non-toxicity at doses up to 370 mg/kg based on LD50 values.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Physical
Khlood S. Abou-Melha, Gamil A. Al-Hazmi, Ismail Althagafi, Arwa Alharbi, Fathy Shaaban, Nashwa M. El-Metwaly, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: The structures, conductivity, coordination geometries and DNA binding activities of hydrazone chelating ligand and its cobalt, copper and nickel complexes prepared by diazotization, coupling and metallization process were investigated. The complexes bind to DNA in grooves and partially incorporate into DNA base stacks, showing potential antioxidant and antibacterial activities.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Spectroscopy
Bingjun Shen, Huiru Yang, Jiaqi Chen, Xiaoyun Liu, Mingyue Zhou
Summary: This study investigated the interaction mechanism between Juglone and DNA through various experimental techniques, revealing that Juglone can quench the fluorescence of DNA, affect the absorption spectrum, enhance resonance scattering peak, and increase the melting point of DNA. The results provide insights into the binding characteristics and thermodynamic properties of Juglone with DNA.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Physical
Ameneh Heidari, Hassan Mansouri-Torshizi, Maryam Saeidifar, Effat Dehghanian, Khatereh Abdi, Hojar Samareh Delarami
Summary: In this study, three metal complexes with picolinic acid coordinated to palladium were synthesized and analyzed using DFT calculations. The complex with zero charge showed better cytotoxic and DNA interaction affinity, indicating its potential for further development as a therapeutic agent.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Adesola Abimbola Adeleke, Md Shahidul Islam, Olakunle Sanni, Chunderika Mocktar, Sizwe J. Zamisa, Bernard Omondi
Summary: The study synthesized five ligands and their silver(I) complexes, which were characterized spectroscopically. Some of the silver complexes showed better antibacterial and antioxidant activities compared to standard drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Somaye Cheraghi, Pelin Senel, Burcu Dogan Topal, Soykan Agar, Mahsa Majidian, Mine Yurtsever, Esen Bellur Atici, Aysegul Golcu, Sibel A. Ozkan
Summary: In this study, the interaction mechanism between Eltrombopag and DNA was investigated using voltammetry, spectroscopic techniques, and viscosity measurements. A DNA-based biosensor and nano-biosensor were developed to detect the binding of DNA and Eltrombopag. Experimental results showed that Eltrombopag strongly interacts with dsDNA, as evidenced by the reduction of dGuo and dAdo oxidation signals in the presence of the drug. UV absorption, fluorescence emission spectroscopy, and viscosity measurements were used to further characterize the binding mode of the drug. Molecular docking and molecular dynamics simulations revealed that Eltrombopag binds to DNA through intercalation.
Article
Chemistry, Multidisciplinary
Nasima Arshad, Naeem Abbas, Fouzia Perveen, Bushra Mirza, Aeshah M. Almuhaini, Saad Alkahtani
Summary: In this study, computational molecular docking and spectroscopic techniques were used to investigate the DNA binding interactions of NPA ligand and its metal complexes. The metal complexes exhibited stronger binding affinity and significant antibacterial and tumor inhibitory activities compared to the ligand.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Nimya Ann Mathews, M. R. Prathapachandra Kurup
Summary: This study synthesized new ternary complexes derived from multisubstituted thiosemicarbazone ligands and characterized their properties using various spectroscopic and analytical methods. The complexes showed strong interactions with DNA, cleaving DNA without external agents, and exhibited potential cytotoxicity against human breast cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Samar E. Abd-ElRazek, Sabreen M. El-Gamasy
Summary: Complexes of transition metal ions (Co(II), Ni(II), Cu(II), and Zn(II)) with Benzoyl Acetohyrazone ligand were synthesized and characterized. The complexes showed good antimicrobial activity, with (5, 10, 14) exhibiting the highest activity against Aspergillus niger and complex (2) showing interesting activity against Escherichia coli. Gel electrophoresis experiments demonstrated the cleavage effect of the ligand and its complexes on viral B-DNA.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Salman Khursheed, Mohammad Rafiq Wani, G. G. H. A. Shadab, Sartaj Tabassum, Farukh Arjmand
Summary: Two fluorine/bromine-substituted chromone (bpy) copper (II) complexes were prepared and characterized, showing strong DNA binding and efficient DNA cleavage abilities. Anticancer screening against various cancer cell lines revealed selective cytotoxic responses, with complex 2 exhibiting higher potency. Cellular uptake studies and oxidative stress assays were also conducted to validate the induced cell death phenomenon.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Taraneh Kajinehbaf, Naader Alizadeh
Summary: Vanadyl sulfate is widely used in the medical field due to its physiological benefits. A fluorescent sensor using citrate doped polypyrrole was developed for dual detection of VO2+ and Fe3+ ions, showing time-dependent responses and linear detection ranges for both ions. The probe provides a promising strategy for rapid screening of VO2+ and Fe3+ in biological fluids.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Noha Nabil, Omima M. Adly, Magdy Shebl, Ali Taha, Fatma Samy
Summary: A series of novel octahedral chromone complexes were successfully synthesized. The structures of the complexes were confirmed by various characterization techniques. The synthesized complexes exhibited antimicrobial activity, which correlated well with the molecular docking results.
Article
Spectroscopy
Elaheh Movahedi, Hafez Razmazma, Alireza Rezvani, Alireza Nowroozi, Ali Ebrahimi, Vaclav Eigner, Michal Dusek, Farukh Arjmand
Summary: A new mixed-ligand Cu(II) complex was synthesized and characterized by various experimental (FTIR spectroscopy, CHN analysis, and X-ray crystallography) and theoretical (UV-Vis absorption spectroscopy, molecular docking simulation, and QM/MM) methods. The complex demonstrated intercalation with DNA base pairs and exhibited cytotoxicity against human breast adenocarcinoma cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
S. Ponkarpagam, K. N. Vennila, Kuppanagounder P. Elango
Summary: The interaction between the oral contraceptive drug Ormeloxifene (ORM) and calf thymus DNA (CT-DNA) was studied using various spectral techniques, and it was found that ORM binds to CT-DNA in the minor groove, mainly driven by H-bonding and van der Waals forces.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Organic
Ismail Althagafi, Ehab Abdel-Latif
Summary: A series of new 6,8-dichloro-imidazo[1,2-a]pyridine derivatives incorporating pyridine, thiazole, and pyrazole ring systems were synthesized and evaluated for their antibacterial potency. The results indicated that the imidazopyridine-thiazole hybrids exhibited remarkable antibacterial activities.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Engineering, Chemical
Ahmed Fawzy, Refat El-Sayed, Areej Al Bahir, Moataz Morad, Ismail Althagafi, Khalid Althagafy
Summary: This study investigated the use of pyrazolopyrimidine derivative-based nonionic surfactants as inhibitors for carbon steel corrosion in acidic media. The surfactants exhibited high inhibition efficiencies, attributed to their strong adsorption on the steel surface and formation of a protective film. The findings suggested potential biological activities and useful surface properties of the designed surfactants, making them versatile for various industrial applications.
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Gamil A. A. S. AlHazmi, Khlood G. AbouMelha, Mohamed A. El-Desouky, Ashraf El-Bindary
Summary: Zirconium metal organic framework (Zr-MOF) was synthesized by hydrothermal method, and various spectroscopic methods were used for sample characterization. The adsorption of doxorubicin (DOX) onto Zr-MOF was studied. The effects of DOX concentration, contact time, solution pH, and temperature were investigated. The surface properties of Zr-MOF were determined by scanning electron microscopy (SEM). The adsorption efficiency of Zr-MOF for DOX was found to be higher at pH 6. The equilibrium isotherms and kinetic data were described using different adsorption models. The docking interactions between DOX and lung cancer and liver cancer receptors were evaluated.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Mohamed A. El-Bindary, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: Metal-organic framework (MOF) hybrid materials, specifically Zr-MOF with encapsulated doxorubicin (DOX@Zr-MOF), have shown promising results in pH-responsive drug release and enhanced cytotoxicity against cancer cells. This simple one-pot approach could potentially serve as a multifunctional drug delivery vehicle for various applications, including cancer treatment. Further studies are needed to explore the potential of DOX@Zr-MOF in targeting specific cancer types and antimicrobial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
M. G. El-Desouky, A. A. El-Bindary, M. A. M. El-Afify, N. Hassan
Summary: The global community is currently facing the COVID-19 pandemic, caused by the SARS-CoV-2 virus. Scientists are researching potential drug candidates by screening ligands and drugs for structure-based design and docking to the main viral protease. Additionally, complexes of Cu(II), Ni(II), Zn(II), and Mn(II) with a specific ligand were synthesized and characterized.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ghaferah H. Al-Hazmi, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: Zinc oxide nanoparticles were produced at various calcination temperatures, with high surface area and small particle radius. The Williamson-Hall technique and size-strain approach were used to measure crystallite size and strain in ZnO nanoparticles. The experimental results, based on SEM and XRD, showed good agreement in crystal size of ZnO NPs prepared at different calcination temperatures.
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
(2022)
Article
Environmental Sciences
Gamil A. A. Al-Hazmi, Adel A. El-Zahhar, Mohamed G. El-Desouky, Mohamed A. El-Bindary, Ashraf A. El-Bindary
Summary: Inadequate pharmaceutical wastewater treatment leads to the contamination of aquatic environment with anticancer contaminants, posing risks to aquatic life and humans. This research evaluates the effectiveness of a Fe3O4@ZIF-8 nanocomposite as an adsorbent for removing the chemotherapeutic drug doxorubicin from water. The results show that the proposed treatment method achieves successful elimination of doxorubicin, and the adsorption process is thermodynamically favorable and endothermic.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Chemistry, Physical
Tariq A. Altalhi, Mohamed M. Ibrahim, Gaber A. M. Mersal, M. H. H. Mahmoud, Tushar Kumeria, Mohamed G. El-Desouky, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: In this study, mango seeds activated carbon (MSAC) nanoparticles were prepared with high biocompatibility for potential use as drug carriers. The experimental results showed that the nanocomposite significantly enhanced the adsorption performance of the anti-cancer drug DOX, indicating its potential in drug delivery applications.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Mahmoud E. E. Awad, Amr M. M. Farrag, Ashraf A. A. El-Bindary, Mohamed A. A. El-Bindary, Hala A. A. Kiwaan
Summary: In this study, a simple technique for the production of TiO2-QDs-Kao photocatalyst was reported. The photocatalyst exhibited excellent degradation efficiency for RhB dye under visible light. The mechanism of photocatalytic degradation was based on the transport of electrons and holes. Additionally, the photocatalyst showed high stability and reusability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Walied A. A. Mohamed, Waleed M. Saad, Farid Sh. Mohamed, Ashraf A. El-Bindary
Summary: Three types of titanium dioxide quantum dots (TQDs) samples were synthesized at low calcination temperatures using a modified precipitation method. The samples were characterized and evaluated for their photocatalytic activity and application in real industrial effluent treatment.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Multidisciplinary Sciences
Ghada N. Rezk, Ola A. El -Gammal, Salhah H. Alrefaee, Ismail Althagafi, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: A hydrazone ligand was successfully created by combining hydrazide with 2-Acetylpyridine. Copper (II) hydrazone complexes were synthesized using various copper (II) salts and studied using analytical techniques. The complexes exhibited tridentate behavior and octahedral geometries. Their properties were analyzed through computational calculations and experimental assays, revealing potential antimicrobial and antioxidant effects.
Article
Engineering, Chemical
Ghaferah H. Al-Hazmi, Moamen S. Refat, Mohamed G. El-Desouky, Farouk K. M. Wali, Ashraf A. El-Bindary
Summary: Nickel oxide nanoparticles were synthesized and used for the adsorption of acid yellow 99 (AY99). The experimental results showed that NiO had a good adsorption effect on AY99, which could meet the requirements of practical applications.
DESALINATION AND WATER TREATMENT
(2022)
Review
Engineering, Chemical
M. G. El-Desouky, M. A. G. Khalil, M. A. M. El-Afify, A. A. El-Bindary, M. A. El-Bindary
Summary: This article discusses the serious pollution problem of organic dyes in wastewater, compares several dye removal processes, and focuses on the latest developments in porous materials for organic dye adsorption. The article also explores the importance of dye wastewater treatment and various characteristics and treatment methods for dyes.
DESALINATION AND WATER TREATMENT
(2022)
Article
Engineering, Chemical
Ghaferah H. Al-Hazmi, Moamen S. Refat, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: In this study, environmentally safe zinc oxide nanoparticles were synthesized through calcination of zeolitic imidazolate framework 7. The capability of these nanoparticles to remove Congo red from wastewater samples was tested, and the results showed good adsorption performance. The nanoparticles demonstrated high adsorption capacity and remained effective even after multiple reuse cycles.
DESALINATION AND WATER TREATMENT
(2022)
Article
Engineering, Chemical
Gamil A. A. Al-Hazmi, Mohamed A. El-Bindary, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: In this study, a new adsorbent was prepared by loading date seed activated carbon on zeolitic imidazolate framework-8. The adsorbent showed high sorption capacity for Gentian violet and could be efficiently recycled for multiple cycles. This material has the potential to be a promising adsorbent for Gentian violet removal from industrial wastewater.
DESALINATION AND WATER TREATMENT
(2022)