Review
Chemistry, Medicinal
Syaifuzah Sapian, Asma Ali Ibrahim Mze, Fatin Farhana Jubaidi, Nor Anizah Mohd Nor, Izatus Shima Taib, Zariyantey Abd Hamid, Satirah Zainalabidin, Nur Najmi Mohamad Anuar, Haliza Katas, Jalifah Latip, Juriyati Jalil, Nur Faizah Abu Bakar, Siti Balkis Budin
Summary: Cardiovascular diseases (CVDs) are a major global cause of death and disability, with risk factors such as hypertension, hyperglycemia, dyslipidemia, oxidative stress, inflammation, fibrosis, and apoptosis. Conventional pharmacological therapy has side effects, leading to increased interest in alternative treatments from natural products. Roselle has bioactive compounds that have anti-hyperlipidemia, anti-hyperglycemia, anti-hypertension, antioxidative, anti-inflammation, and anti-fibrosis effects, making it a potential therapeutic agent for cardiovascular protection.
Article
Multidisciplinary Sciences
Abdoudramane Sanou, Kiessoun Konate, Roger Dakuyo, Kabore Kabore, Hemayoro Sama, Mamoudou Hama Dicko
Summary: This study investigated the physicochemical, phytochemical, and antioxidant properties of two varieties of Hibiscus sabdariffa. The red phenotype showed the best nutritional and therapeutic potential, making it an interesting candidate for the pharmaceutical and food industries.
Review
Immunology
Francis U. Umeoguaju, Benson C. Ephraim-Emmanuel, Joy O. Uba, Grace E. Bekibele, Nwondah Chigozie, Orish Ebere Orisakwe
Summary: Hibiscus sabdariffa calyx water decoction extract can significantly lower the levels of inflammatory immune mediators, showing potential in treating disorders involving hyperactive immune system or chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Textiles
Fatemeh Shahmoradi Ghaheh, Meghdad Kamali Moghaddam, Majid Tehrani
Summary: This study investigates the feasibility of dyeing viscose rayon fabric using an anthocyanin solution extracted from H. sabdariffa L. calyces. Natural mordants, including walnut hull and alginate, were found to improve color strength and color fastness. The after-mordanting method resulted in the highest wash and light fastness. Overall, walnut husk mordant increased color strength and decreased lightness compared to other natural mordants in all three mordanting methods.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Biochemistry & Molecular Biology
Folake Idowu-Adebayo, Mary J. Toohey, Vincenzo Fogliano, Anita R. Linnemann
Summary: Adding turmeric to zobo drink can enhance the content of vitamins, polyphenols, and minerals, improving the antioxidant and nutritional quality of the drink. Consuming turmeric-fortified zobo can contribute significantly to the daily recommended intake of iron and zinc.
Article
Chemistry, Applied
Hector A. Romero Hernandez, Tomy J. Gutierrez, Juscelino Tovar, Luis A. Bello-Perez
Summary: Native and OSA-esterified corn starches were used to manufacture starch-polyphenol V-type complexes using aqueous extract of Roselle as a source of polyphenols. The complexes were formed through hydrogen bond and hydrophobic interactions between the starch and polyphenols. The presence of Roselle extract increased the retrogradation tendency of starch, allowing the production of starchy materials with high resistant starch content and low digestion rate.
FOOD HYDROCOLLOIDS
(2023)
Review
Food Science & Technology
Ana Maria Garcia-Munoz, Ana I. Garcia-Guillen, Desiree Victoria-Montesinos, Maria Salud Abellan-Ruiz, Begona Alburquerque-Gonzalez, Fernando Canovas
Summary: Metabolic syndrome is linked to increased risks of cardiovascular disease and type 2 diabetes, further exacerbated by a sedentary lifestyle and situations like the COVID-19 pandemic. Recent studies suggest that consumption of polyphenol-rich fruits and vegetables has a protective effect in reducing cardiovascular risk. Hibiscus sabdariffa (HS) in combination with other plant extracts has been gaining attention for its potential in treating metabolic syndrome. A systematic review and meta-analysis of randomized clinical trials were conducted to examine the effects of HS with other plant extracts on metabolic syndrome prevention, revealing improvements in anthropometric parameters, blood pressure, and lipid profile.
Article
Biochemistry & Molecular Biology
Duanyang Wang, Maki Nagata, Masako Matsumoto, Yhiya Amen, Dongmei Wang, Kuniyoshi Shimizu
Summary: This study evaluated the bioactivities of different parts of Hibiscus sabdariffa L. and found that hibiscus acid has the potential to promote extracellular matrix synthesis, exhibit anti-inflammatory activity, and counter oxidative stress.
Article
Cardiac & Cardiovascular Systems
Ramon Aranda-Domene, Esteban Orenes-Pinero, Jose Maria Arribas-Leal, Sergio Canovas-Lopez, Jesus Hernandez-Cascales
Summary: This study investigated the inotropic and chronotropic effects of glucagon in failing and nonfailing human hearts, as well as the presence of glucagon receptors. The results showed that glucagon did not exert any effects on human heart samples and no glucagon receptors were detected.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jie Gao, Guanyin Yuan, Zhan Xu, Luyao Lan, Wenkuan Xin
Summary: Bile acids, endogenous steroids derived from cholesterol metabolism, may be involved in cardiopathy of cholestatic liver diseases. Chenodeoxycholic acid and deoxycholic acid are associated with colon cancer, gallstones, and gastrointestinal disorders, while their effects on the heart are less understood. Experimental findings suggest that these bile acids exhibit positive inotropic effects and negative chronotropic effects on rat hearts.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biology
Hamada F. A. Ahmed, Sameh Elnaggar, Gomaa A. Abdel-Wahed, Ragab S. Taha, Awais Ahmad, Wadei A. Al-Selwey, Hoda M. H. Ahmed, Naeem Khan, Mahmoud F. Seleiman
Summary: Fungal root rot and wilt diseases are major challenges for roselle production, but the excessive use of chemical fungicides can have environmental risks. This study investigated the induction of systemic resistance (ISR) in roselle using biotic and abiotic inducers. The results showed that these inducers effectively inhibited the growth of pathogenic fungi and reduced disease development. ISR is a promising approach to suppress root rot and wilt diseases in roselle and promote crop growth without environmental risks.
Article
Plant Sciences
Marwah Al-Anbaki, Anne-Laure Cavin, Renata Campos Nogueira, Jaafar Taslimi, Hayder Ali, Mohammed Najem, Mustafa Shukur Mahmood, Ibrahim Abdullah Khaleel, Abdulqader Saad Mohammed, Hasan Ramadhan Hasan, Laurence Marcourt, Fabien Felix, Nicolas Vinh Tri Low-Ders, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Marie Watissee, Bertrand Graz
Summary: The study evaluated the feasibility of using Hibiscus sabdariffa decoction to control hypertension in displaced persons in Iraq. Results showed a significant reduction in blood pressure for participants in the intervention group compared to the control group, indicating the potential effectiveness of hibiscus decoction in managing hypertension.
Article
Pharmacology & Pharmacy
He-qiang Zhang, Jia-le Lin, Lei Pan, Liang Mao, Jing-long Pang, Qian Yuan, Gui-yang Li, Gang-si Yi, Yang-bin Lin, Bao-long Feng, Yun-da Li, Yan Wang, Ling-jun Jie, Yan-hui Zhang
Summary: This study found that enzastaurin prolongs QT interval in cancer patients and investigated its mechanism of action. The results showed that enzastaurin inhibits the conduction of rapid delayed rectifier potassium current (IKr) by binding to the human Ether-`a-go-go-Related gene (hERG) channel in both open and closed states. Additionally, enzastaurin moderately inhibits the slow delayed rectifier potassium current (IKs) and impairs cardiac function.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ixchell Y. Sedillo-Torres, alvaro O. Hernandez-Rangel, Yolanda Gomez-y-Gomez, Daniel Cortes-Avalos, Blanca Estela Garcia-Perez, Juan C. Villalobos-Rocha, Cesar H. Hernandez-Rodriguez, Luis Gerardo Zepeda-Vallejo, Paulina Estrada-de los Santos, Maria Elena Vargas-Diaz, Jose Antonio Ibarra
Summary: An organic extract of Hibiscus sabdariffa L. containing hibiscus acid was found to inhibit motility and reduce the secretion of virulence factors in Salmonella enterica serovars Typhi and Typhimurium. The compound was not toxic to eukaryotic cells and could reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial studies suggested that the mode of action of hibiscus acid might involve the disruption of membrane proton balance.
Article
Chemistry, Applied
Caroline Maria Calliari, Marianne Ayumi Shirai, Alessandro Alberto Casazza, Margherita Pettinato, Patrizia Perego
Summary: This work aimed to optimize the obtention of microcapsules of Hibiscus sabdariffa L. tea by spray-drying, using inulin as a carrier agent. The effects of inlet temperature, feed flow rate, and inulin concentration were evaluated. It was possible to obtain pale-rose, slightly sweet instant powders with good total polyphenol content and anthocyanins encapsulation efficiency, indicating physico-chemical and microbiological stability of the microcapsules. The optimum conditions were found to be 5 g L-1 of inulin, inlet temperature of 170°C, and feed flow rate of 83 mL min(-1).
NATURAL PRODUCT RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anand Ramalingam, Norsyahida Mohd. Fauzi, Siti Balkis Budin, Rebecca Ritchie, Satirah Zainalabidin
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Anand Ramalingam, Norsyahida Mohd Fauzi, Siti Balkis Budin, Satirah Zainalabidin
Summary: This study found that prolonged nicotine administration increases myocardial susceptibility to I/R injury in rats, which is associated with increased mitochondrial permeability transition driven by ROS.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fatin Farhana Jubaidi, Satirah Zainalabidin, Vanitha Mariappan, Siti Balkis Budin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Fatin Farhana Jubaidi, Satirah Zainalabidin, Izatus Shima Taib, Zariyantey Abd Hamid, Siti Balkis Budin
Summary: Diabetic cardiomyopathy, a major mortality risk factor among diabetic patients worldwide, is characterized by cardiac structural and functional alterations induced by hyperglycemia-initiated oxidative stress. Flavonoids, the most abundant phytochemicals in plants, have been extensively studied for their therapeutic potential in protecting the heart against diabetes-induced cardiomyopathy through their anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Fatin Farhana Jubaidi, Satirah Zainalabidin, Lai Ying, Nur Liyana Mohammed Yusof, Siti Balkis Budin
Summary: The study demonstrated that H. sabdariffa Linn. polyphenol-rich extract significantly improved vascular function and reduced oxidative stress in diabetic rats, leading to decreased blood pressure, enhanced vasorelaxation, and alleviated oxidative damage.
Article
Multidisciplinary Sciences
Anand Ramalingam, Siti Balkis Budin, Norsyahida Mohd Fauzi, Rebecca H. Ritchie, Satirah Zainalabidin
Summary: This study demonstrates that targeting mitochondrial ROS with mitoTEMPO or resveratrol partially attenuates nicotine-induced cardiac remodeling and dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Nur Afizah Yusoff, Izatus Shima Taib, Siti Balkis Budin, Mahaneem Mohamed
Summary: The study found that paternal exposure to FNT reduced sperm quality and caused DNA fragmentation in F0 male Sprague Dawley rats, altering the histology and morphometry of the selected organs in the F1 progeny.
Article
Biology
Nor Hidayah Mustafa, Juriyati Jalil, Mohammed S. M. Saleh, Satirah Zainalabidin, Ahmad Yusof Asmadi, Yusof Kamisah
Summary: Cardiac hypertrophy is an early hallmark of heart failure, and therapeutic strategies targeting the MAPK/NFAT signaling pathway may help prevent cardiac dysfunction. The study investigated the effects of various fractions of Parkia speciosa Hassk ethanol extract on angiotensin II-induced cardiomyocyte hypertrophy. The ethyl acetate (EA) fraction demonstrated the most potent antihypertrophic effect and attenuated the activation of the MAPK/calcineurin-NFAT signaling pathway.
Review
Biochemistry & Molecular Biology
Muhamad Adib Abdul Ghani, Azizah Ugusman, Jalifah Latip, Satirah Zainalabidin
Summary: One out of every three deaths worldwide is attributed to cardiovascular diseases (CVDs), resulting in an estimated 17.9 million deaths annually. This number is expected to rise to over 24 million by 2030. Common CVDs include coronary heart disease, myocardial infarction, stroke, and hypertension. Studies have shown that inflammation and apoptosis contribute to CVD development by damaging tissues in the cardiovascular system. Terpenophenolic compounds, found in plants such as Humulus and Cannabis, have been shown to exhibit protective properties against inflammation and apoptosis in the cardiovascular system. This review discusses the molecular actions of specific terpenophenolic compounds and their potential as nutraceutical drugs to reduce the burden of cardiovascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nur Liyana Mohammed Yusof, Tengku Nurul Tasnim Tengku Affendi, Fatin Farhana Jubaidi, Satirah Zainal Abidin, Siti Balkis Budin
Article
Biology
Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Syarifah Aisyah Syed Abd Halim, Nahdia Afiifah Abdul Jalil, Nor Haliza Mohamad Najib, Seong Lin Teoh, Siti Balkis Budin
Article
Multidisciplinary Sciences
Nur Afizah Yusoff, Mahaneem Mohamed, Siti Balkis Budin, Izatus Shima Taib
Article
Biology
Lislivia-Yiang-Nee Si, Anand Ramalingam, Shafreena Shaukat Ali, Amnani Aminuddin, Pei-Yuen Ng, Jalifah Latip, Yusof Kamisah, Siti Balkis Budin, Satirah Zainalabidin
Review
Cardiac & Cardiovascular Systems
Shafreena Shaukat Ali, Wan Amir Nizam Wan Ahmad, Siti Balkis Budin, Satirah Zainalabidin
REVIEWS IN CARDIOVASCULAR MEDICINE
(2020)