Review
Medicine, General & Internal
Yachen Shi, Qingyun Wang, Ruize Song, Yan Kong, Zhijun Zhang
Summary: Non-coding RNAs, such as microRNAs, circular RNAs, and long non-coding RNAs, play important roles in regulating normal biological processes and may be implicated in the pathogenesis of human diseases like depression. Clinical studies have shown that abnormal expression of ncRNAs in depressed patients compared to healthy individuals, with potential for ncRNAs to serve as biomarkers for diagnosis and treatment. Despite uncertainties regarding their precise roles, ncRNAs demonstrate promising clinical value in the management of depression.
Article
Biochemistry & Molecular Biology
Brendin Flinn, Christopher Adams, Nepal Chowdhury, Todd Gress, Nalini Santanam
Summary: Epicardial fat plays a key role in cardiovascular diseases, and the non-coding RNA and transcriptomic alterations of epicardial fat in coronary artery disease have been found to be unique. Analysis of microRNA and long non-coding RNA revealed sex-dependent mi/lncRNA changes in epicardial fat of patients with coronary artery disease. These changes are associated with inflammation, adipogenesis, cardiomyocyte apoptosis, atherosclerosis, and myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Guangxian Wu, Xinzhe Du, Zexuan Li, Yanhong Du, Jinzhi Lv, Xinrong Li, Yong Xu, Sha Liu
Summary: This review summarizes the involvement of long non-coding RNAs in the pathogenesis of schizophrenia and discusses their potential as biomarkers and therapeutic targets.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Cell Biology
Elisabetta Lauretti, Konrad Dabrowski, Domenico Pratico
Summary: Non-protein-coding RNAs have been found to play significant roles in neurodegenerative disorders such as Alzheimer's disease, affecting gene expression, amyloid-beta production, and other key mechanisms underlying disease pathology.
AGEING RESEARCH REVIEWS
(2021)
Review
Medicine, Research & Experimental
Ying Liu, Wei Ding, Jianxun Wang, Xiang Ao, Junqiang Xue
Summary: Cardiovascular disease (CVD) is a major global health threat, and cardiomyocyte death is considered the underlying cause of various CVDs. Ferroptosis, a form of iron-dependent cell death, plays a crucial role in CVD progression, yet its mechanisms are not fully understood. Recent studies have shown that non-coding RNAs (ncRNAs), especially microRNAs, long non-coding RNAs, and circular RNAs, are involved in the regulation of ferroptosis and can influence CVD progression. Furthermore, some ncRNAs show potential as diagnostic biomarkers and therapeutic targets in CVD treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medical Laboratory Technology
Arezoo Solati, Sina Thvimi, Seyyed Hossein Khatami, Zahra Shabaninejad, Yalda Malekzadegan, Mehdi Alizadeh, Pegah Mousavi, Mortaza Taheri-Anganeh, Damoun Razmjoue, Sedigheh Bahmyari, Hojat Ghasemnejad-Berenji, Asma Vafadar, Elahe Soltani Fard, Hassan Ghasemi, Ahmad Movahedpour
Summary: Gynecologic cancer refers to tumors affecting the reproductive tissues and organs of women. Recent studies have shown that non-coding RNAs play a crucial role in modulating cellular functions within gynecological cancer, and they may serve as biomarkers and therapeutic agents.
CLINICA CHIMICA ACTA
(2023)
Article
Pathology
Fatemeh Dashti, Seyed Mohammad Ali Mirazimi, Golnesa Kazemioula, Mohammad Mohammadi, Marjan Hosseini, Zahra Razaghi Bahabadi, Maryam Sadat Mirazimi, Mohammad Hassan Jafari Najaf Abadi, Ali Shahini, Maryam Afshari, Hamed Mirzaei
Summary: Malignant melanoma is a rare but deadly skin malignancy that can invade other organs and metastasize. Surgery is a common treatment choice for melanoma patients. Non-coding RNAs, particularly long non-coding RNAs (lncRNAs), have been extensively studied in melanoma and may serve as potential markers for diagnosis, prognosis, and treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Ania Canseco-Rodriguez, Valeria Masola, Vincenza Aliperti, Maria Meseguer-Beltran, Aldo Donizetti, Ana Maria Sanchez-Perez
Summary: Neuroinflammation plays a major role in the onset of Alzheimer's Disease (AD), and it exerts its toxic effect through regulation of non-coding RNAs such as miRNAs. Although the association between miRNAs and inflammation in AD has been studied, the role of long non-coding RNAs (lncRNAs) in neurodegenerative diseases is less explored. Recent studies have shown that specific lncRNAs in plasma-isolated extracellular vesicles (EVs) may serve as reliable biomarkers for AD, which holds promise for improving risk prediction and patient stratification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yang Yang, GuangXuan Hu, GenMeng Wan, MengHuan Li, Bo Chang, XueJie Yi
Summary: Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases that affect skeletal muscle quality and function. Early diagnosis and treatment are crucial to prevent irreversible muscle damage. Non-coding RNAs (ncRNAs) play important roles in regulating IIMs, including inflammatory transfer, muscle regeneration, differentiation, and antibody levels. Detection of ncRNAs in blood and hair holds great potential for diagnosing, preventing, and treating IIMs in conjunction with other methods. However, the specific roles and mechanisms of ncRNAs in regulating IIMs and their subtypes are still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
George Sentis, Catherine Loukogiannaki, Nikos Malissovas, Dionysis Nikolopoulos, Theodora Manolakou, Sofia Flouda, Maria Grigoriou, Aggelos Banos, Dimitrios T. T. Boumpas, Anastasia Filia
Summary: By analyzing transcriptomic data of whole blood samples, differentially expressed long non-coding RNAs (lncRNAs) associated with quiescent disease and flares in lupus nephritis (LN) were identified. Four disease-activity-associated lncRNAs were validated and could potentially serve as blood-based biomarkers and liquid biopsy for LN.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yingli Guo, Yajuan Xie, Yao Luo
Summary: This review summarizes the latest research on the functions of long non-coding RNAs (lncRNAs) in the tumor immune microenvironment. These lncRNAs play important roles in tumorigenesis and development by regulating various biological processes. Additionally, the review discusses the current understanding of strategies for targeting lncRNAs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao
Summary: Bladder cancer is characterized by dysregulated lncRNAs, which play key roles in tumorigenesis, progression, and prognosis. These lncRNAs can serve as potential diagnostic and prognostic biomarkers for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Song Meng, Ponnie Robertlee Dolo, Pei Guo, Jian Hong, Chao Li, Xiaocheng Zhu, Dinghua Zhou
Summary: This study investigated the expression of long non-coding RNA LINC01279 in gastric cancer and its relationship with clinicopathological features and prognosis. The results showed that LINC01279 was highly expressed in gastric cancer tissues and serum, and was associated with tumor invasion and prognosis.
ASIAN JOURNAL OF SURGERY
(2022)
Review
Oncology
Maryam Farzaneh, Sajad Najafi, Mohadeseh Sheykhi-Sabzehpoush, Fereshteh Nezhad Dehbashi, Omid Anbiyaee, Ava Nasrolahi, Shirin Azizidoost
Summary: Leukemia is a group of heterogeneous hematological cancers with increasing prevalence worldwide, and its etiology remains unclear. Leukemia stem cells (LSCs) play a crucial role in maintaining the growth of the leukemic clone and are resistant to chemotherapy and radiotherapy. Recent studies have shown altered expression profiles of long non-coding RNAs (lncRNAs) in LSCs, influencing the survival, proliferation, and differentiation of LSCs. LncRNAs serve as prognostic markers and potential novel treatment options for leukemia.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Genetics & Heredity
Xiang Ao, Wei Ding, Xiaoge Li, Qingling Xu, Xinhui Chen, Xuehao Zhou, Jianxun Wang, Ying Liu
Summary: Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and mitochondrial dysfunction is considered a major contributor to CVD pathogenesis. Non-coding RNAs (ncRNAs) have been shown to regulate mitochondrial functions and play crucial roles in CVD progression. Some ncRNAs also have potential as biomarkers and therapeutic targets for CVD treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Neurosciences
Hojun Lee, Kijeong Kim, Boa Kim, Junchul Shin, Sudarsan Rajan, Jingwei Wu, Xiongwen Chen, Michael D. Brown, Sukho Lee, Joon-Young Park
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Correction
Medicine, Research & Experimental
Dezhong Yang, Wenbin Fu, Liangpeng Li, Xuewei Xia, Qiao Liao, Rongchuan Yue, Hongmei Chen, Xiongwen Chen, Songzhu An, Chunyu Zeng, Wei Eric Wang
Article
Cardiac & Cardiovascular Systems
Ying Zhang, Wei Eric Wang, Xiaoying Zhang, Ying Li, Biyi Chen, Chong Liu, Xiaojie Ai, Xiaoxiao Zhang, Ying Tian, Chen Zhang, Mingxin Tang, Christopher Szeto, Xiang Hua, Mingxin Xie, Chunyu Zeng, Yingjie Wu, Lin Zhou, Weizhong Zhu, Daohai Yu, Steven R. Houser, Xiongwen Chen
CIRCULATION RESEARCH
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Xiongwen Chen, Xiaoying Zhang, Scott Gross, Steven R. Houser, Jonathan Soboloff
CIRCULATION RESEARCH
(2019)
Article
Nutrition & Dietetics
Jining Yang, Xiaoying Zhang, Long Yi, Ling Yang, Wei Eric Wang, Chunyu Zeng, Mantian Mi, Xiongwen Chen
NUTRITION & METABOLISM
(2019)
Article
Cardiac & Cardiovascular Systems
Polina Gross, Jaslyn Johnson, Carlos M. Romero, Deborah M. Eaton, Claire Poulet, Jose Sanchez-Alonso, Carla Lucarelli, Jean Ross, Andrew A. Gibb, Joanne F. Garbincius, Jonathan Lambert, Erdem Varol, Yijun Yang, Markus Wallner, Eric A. Feldsott, Hajime Kubo, Remus M. Berretta, Daohai Yu, Victor Rizzo, John Elrod, Abdelkarim Sabri, Julia Gorelik, Xiongwen Chen, Steven R. Houser
Summary: The joining region in JPH2 interacts with LTCC-alpha 1C subunit, causing LTCCs to distribute to dyads and colocalize with RyRs, facilitating dyad assembly and maintaining normal CICR in cardiomyocytes. Disruption of this interaction leads to T-tubule remodeling, impaired excitation-contraction coupling, and altered myocyte bioenergetics.
CIRCULATION RESEARCH
(2021)
Review
Physiology
Chong Liu, Ping Ke, Jingjing Zhang, Xiaoying Zhang, Xiongwen Chen
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Lixiao Zhen, Qian Zhao, Jinhui Lu, Shengqiong Deng, Zhen Xu, Lin Zhang, Yuzhen Zhang, Huimin Fan, Xiongwen Chen, Zhongmin Liu, Yuying Gu, Zuoren Yu
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Pharmacology & Pharmacy
Jing Wang, Tianshu Liu, Xiongwen Chen, Qiaofeng Jin, Yihan Chen, Li Zhang, Zhengyang Han, Dandan Chen, Yuman Li, Qing Lv, Mingxing Xie
Summary: Th17 cells play a significant role in the pathogenesis of myocarditis, and Bazedoxifene can affect STAT3 signaling to effectively inhibit the progression of cardiac inflammation. Therefore, Bazedoxifene may be a promising therapeutic strategy for the treatment of experimental autoimmune myocarditis.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Ya Liu, Xiongwen Chen, Hai-Gang Zhang
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yijia Li, Xiongwen Chen, Yue Qi, Yichen Qu, Akshay Kumar, Songbo Dong, Yan Yang, Qiong Zhao
Summary: This study evaluated the impact of gender on Sievers types, valvulopathy, aortopathy, and outcomes of aortic valve replacement (AVR) in Chinese patients with bicuspid aortic valve (BAV). The results showed that male patients had more severe valvulopathy and aortopathy, as well as a higher risk of left ventricular dysfunction after AVR. Importantly, male patients developed these conditions at a younger age.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2022)
Article
Cardiac & Cardiovascular Systems
Yijia Li, Jaslyn P. Johnson, Yijun Yang, Daohai Yu, Hajime Kubo, Remus M. Berretta, Tao Wang, Xiaoying Zhang, Michael Foster, Jun Yu, Douglas G. Tilley, Steven R. Houser, Xiongwen Chen
Summary: Maternal hypothyroidism can negatively impact the cardiac disease responses of offspring by reducing early postnatal cardiomyocyte proliferation and resulting in a smaller number of larger cardiac myocytes. These changes are associated with more severe cardiac disease responses following injury.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin Zhang, Yijia Li, Xiaoying Zhang, Valentino Piacentino, David M. Harris, Remus Berretta, Kenneth B. Margulies, Steven R. Houser, Xiongwen Chen
Article
Cell Biology
Tongtong Cao, Daniela Liccardo, Ryan LaCanna, Xiaoying Zhang, Rong Luz, Brian N. Finck, Tani Leigh, Xiongwen Chen, Konstantinos Drosatos, Ying Tian
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
Yinxia Xu, Junping Zhang, Xiaoying Zhang, Ping Guo, Helen Chew, Matthew Chrzanowski, Jenni Firrman, Nianli Sang, Xiongwen Chen, Yong Diao, Weidong Xiao