期刊
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 21, 2020
卷 21, 期 -, 页码 263-288出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-121219-083616
关键词
nucleus; lamins; nuclear envelope; chromatin; signaling; laminopathies
资金
- Singapore Agency for Science, Technology, and Research (A* STAR)
In recent years, our perspective on the cell nucleus has evolved from the view that it is a passive but permeable storage organelle housing the cell's genetic material to an understanding that it is in fact a highly organized, integrative, and dynamic regulatory hub. In particular, the subcompartment at the nuclear periphery, comprising the nuclear envelope and the underlying lamina, is now known to be a critical nexus in the regulation of chromatin organization, transcriptional output, biochemical and mechanosignaling pathways, and, more recently, cytoskeletal organization. We review the various functional roles of the nuclear periphery and their deregulation in diseases of the nuclear envelope, specifically the laminopathies, which, despite their rarity, provide insights into contemporary health-care issues.
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