Article
Multidisciplinary Sciences
Juan Macias, Paz Gonzalez-Moreno, Esther Sanchez-Garcia, Ramon Morillo-Verdugo, Jose J. Perez-Venegas, Ana Pinilla, Ma Mar Macho, Ma Victoria Martinez, Alejandro Gonzalez-Serna, Anais Corma, Luis M. Real, Juan A. Pineda
Summary: A retrospective study comparing COVID-19 incidence in Spanish patients with autoimmune rheumatic diseases treated with and without hydroxychloroquine showed that there was no significant difference in the incidence and severity of COVID-19 between the two groups.
Review
Rheumatology
Rebecca Grainger, Pedro M. Machado, Philip C. Robinson
Summary: This review discusses the risk of infection, outcomes, and risk factors for poor outcomes in patients with rheumatic disease in the context of COVID-19. It also explores data from other immune-mediated diseases, limitations of current research efforts, translation of knowledge into practice guidance, and future research agenda.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2021)
Article
Oncology
Noha Sharafeldin, Benjamin Bates, Qianqian Song, Vithal Madhira, Yao Yan, Sharlene Dong, Eileen Lee, Nathaniel Kuhrt, Yu Raymond Shao, Feifan Liu, Timothy Bergquist, Justin Guinney, Jing Su, Umit Topaloglu
Summary: The largest multicenter cohort of cancer patients with COVID-19 to date was constructed by the U.S. N3C collaboration. It was found that COVID-19 positivity significantly increased the risk of all-cause mortality in cancer patients. Factors such as age, gender, region, comorbidities, and specific cancer types were associated with increased mortality risk in cancer patients with COVID-19.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Immunology
Fadi Kharouf, Tali Eviatar, Maya Braun, Elisheva Pokroy-Shapira, Michal Brodavka, Yair Zloof, Nancy Agmon-Levin, Kochava Toledano, Shirly Oren, Merav Lidar, Devy Zisman, Yonit Tavor, Mirit Amit-Vazina, Firas Sabbah, Gabriel S. Breuer, Amir Dagan, Rima Beshara-Garzuzi, Doron Markovits, Muna Elias, Joy Feld, Oshrat Tayer-Shifman, Tal Gazitt, Tatiana Reitblatt, Limor Rubin, Amir Haddad, Sami Giryes, Daphna Paran, Hagit Peleg, Yair Molad, Ori Elkayam, Dror Mevorach, Alexandra Balbir-Gurman, Yolanda Braun-Moscovici
Summary: This study aimed to characterize the course of COVID-19 in autoimmune inflammatory rheumatic disease (AIIRD) patients in Israel, considering the outcomes of different outbreaks, the effect of vaccination campaigns, and AIIRD activity post-recovery. The results showed that COVID-19 is more severe and has increased mortality in active AIIRD patients. Vaccination with 3 doses of the mRNA vaccine protected against severe COVID-19 during the outbreak.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jessica Seessle, Tim Waterboer, Theresa Hippchen, Julia Simon, Marietta Kirchner, Adeline Lim, Barbara Mueller, Uta Merle
Summary: Long COVID, defined as persistent symptoms after SARS-CoV-2 infection, can last for at least 1 year and significantly impact life quality. Neurocognitive symptoms, possibly related to autoimmunity indicated by elevated ANA titers, are more common in females and can persist even when SARS-CoV-2 antibody levels are not significantly different from patients without symptoms.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Celeena Jefferson, Eric Watson, Julia M. Certa, Kirsha S. Gordon, Lesley S. Park, Gypsyamber D'Souza, Lorie Benning, Alison G. Abraham, Deana Agil, Sonia Napravnik, Michael J. Silverberg, Wendy A. Leyden, Jacek Skarbinski, Carolyn Williams, Keri N. Althoff, Michael A. Horberg
Summary: This study explores racial/ethnic and sex disparities during the COVID-19 pandemic, even in healthcare settings with reduced barriers to accessing care. Black patients and men are more likely to experience hospitalization and death related to COVID-19.
Article
Medicine, General & Internal
Daniel Antwi-Amoabeng, Bryce D. Beutler, Gurpreet Chahal, Sumaiya Mahboob, Nageshwara Gullapalli, Rudy Tedja, Farah Madhani-Lovely, Chris Rowan
Summary: This study compared the proportion of patients admitted for COVID-19-related symptoms and those admitted for other reasons who were incidentally found to be positive for SARS-CoV-2, revealing changes in patient classification at different stages of the pandemic.
Article
Clinical Neurology
Guilhem Sole, Stephane Mathis, Diane Friedman, Emmanuelle Salort-Campana, Celine Tard, Francoise Bouhour, Armelle Magot, Djillali Annane, Bernard Clair, Gwendal Le Masson, Antoine Soulages, Fanny Duval, Louis Carla, Marie-Helene Violleau, Tiphaine Saulnier, Sandrine Segovia-Kueny, Lea Kern, Jean-Christophe Antoine, Guillemette Beaudonnet, Frederique Audic, Laurent Kremer, Jean-Baptiste Chanson, Aleksandra Nadaj-Pakleza, Tanya Stojkovic, Pascal Cintas, Marco Spinazzi, Alexandra Foubert-Samier, Shahram Attarian
Summary: This registry-based cohort study revealed that COVID-19 had limited impact on most patients with myasthenia gravis, and immunosuppressive medications and corticosteroids used for MG management were not risk factors for poor outcomes. However, the risk for severe COVID-19 was higher in patients with high MGFA classes (>=IV) prior to COVID-19 onset.
Article
Multidisciplinary Sciences
Tun-Linn Thein, Li Wei Ang, Barnaby Edward Young, Mark I-Cheng Chen, Yee-Sin Leo, David Chien Boon Lye
Summary: The study identified shortness of breath as the strongest predictor for distinguishing between COVID-19 and influenza, followed by diarrhea. Higher lymphocyte count was predictive of COVID-19 compared to influenza and dengue. Cough and higher platelet count were associated with increased odds of COVID-19 compared to dengue, while symptoms like headache, joint pain, skin rash, and vomiting/nausea indicated dengue.
SCIENTIFIC REPORTS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Lakshman Perera Samaranayake, Chaminda Jayampath Seneviratne, Kausar Sadia Fakhruddin
Summary: The successful development of a vaccine against COVID-19 within a short period of time is a testament to human ingenuity, with vaccination being crucial for dental professionals as it may become a mandatory requirement in dental practice.
Article
Obstetrics & Gynecology
Michael Richley, Rashmi R. Rao, Yalda Afshar, Jenny Mei, Thalia Mok, Tara Vijayan, Stacey Weinstein, Christine U. Pham, Jason Madamba, Christina S. Shin, Deborah Suda, Christina S. Han
Summary: This study presents a retrospective case series of pregnant patients who received monoclonal antibody treatment for COVID-19, and the results suggest that pregnant patients who received treatment generally had favorable outcomes.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, Research & Experimental
Li Huang, Che Zhang, Xihui Zhou, Zhou Zhao, Weiping Wang, Weidong Leng, Xiao Su, Qizhou Lian
Summary: This study analyzed the characteristics and outcomes of patients with or without convalescent plasma (CP) transfusion for coronavirus disease-2019. The results showed that while CP transfusion was clinically safe, it did not provide significant clinical benefits for critically ill patients with more comorbidities at the late stage of disease during a 28-day observation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Rheumatology
Alice Fike, Julia Hartman, Christopher Redmond, Sandra G. Williams, Yanira Ruiz-Perdomo, Jun Chu, Sarfaraz Hasni, Michael M. Ward, James D. Katz, Pravitt Gourh
Summary: Latino patients with rheumatic diseases have a higher rate of COVID-19 compared with the general Latino population. Obesity is a risk factor for COVID-19, and COVID-19 is a risk factor for rheumatic disease flare. Latino patients with risk factors should be closely followed up, especially post-COVID-19 in anticipation of disease flare.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Virology
Lutfiye Karcioglu Batur, Nezih Hekim
Summary: This study identified a significant correlation between polymorphisms in the IL-10 gene at rs1800896, IL-17A gene at rs2275913, and IL-17F gene at rs763780, and the prevalence and mortality rates of COVID-19 among populations of 23 countries.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Dechuan Kong, Yuanping Wang, Lu Lu, Huanyu Wu, Chuchu Ye, Abram L. Wagner, Jixing Yang, Yaxu Zheng, Xiaohuan Gong, Yiyi Zhu, Bihong Jin, Wenjia Xiao, Shenghua Mao, Chenyan Jiang, Sheng Lin, Ruobing Han, Xiao Yu, Peng Cui, Qiwen Fang, Yihan Lu, Hao Pan
Summary: International travel can lead to the spread of COVID-19, as shown in this study of Chinese tour groups in Europe. The disease mainly spread through familial and propagative transmission within the tour groups, impacting individuals in shared flights, shopping venues, and return flights to China.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Rheumatology
Naomi J. Patel, Kristin M. D'Silva, Matthew D. Li, Tiffany Y. T. Hsu, Michael DiIorio, Xiaoqing Fu, Claire Cook, Lauren Prisco, Lily Martin, Kathleen M. M. Vanni, Alessandra Zaccardelli, Yuqing Zhang, Jayashree Kalpathy-Cramer, Jeffrey A. Sparks, Zachary S. Wallace
Summary: COVID-19 patients with rheumatic disease have more severe lung involvement. Higher pulmonary x-ray (PXS) scores are associated with mechanical ventilation and death.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Medha Barbhaiya, Jaime E. Hart, Susan Malspeis, Sara K. Tedeschi, Trang VoPham, Jeffrey A. Sparks, Elizabeth W. Karlson, Francine Laden, Karen H. Costenbader
Summary: This study aimed to investigate the association between UV radiation exposure and the risk of developing SLE. The results showed that there was no significant association between UV exposure and SLE risk, but higher UV exposure was associated with increased risk of malar rash.
ARTHRITIS CARE & RESEARCH
(2023)
Letter
Rheumatology
Michael Putman, Jilaine Bolek Berquist, Eric M. Ruderman, Jeffrey A. Sparks
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Sinead Maguire, Samar Al-Emadi, Paula Alba, Mathia Cecilia Aguiar, Talal Al Lawati, Gelsomina Alle, Bonnie Bermas, Suleman Bhana, Anic Branimir, Inita Bulina, Megan Clowse, Karina Cogo, Iris Colunga, Claire Cook, Karen J. Cortez, Kathryn Dao, Milena Gianfrancesco, Monique Gore-Massey, Laure Gossec, Rebecca Grainger, Jonathon Hausman, Tiffany Y. T. Hsu, Kimme Hyrich, Carolina Isnardi, Yumeko Kawano, Rachael Kilding, Daria A. Kusevich, Saskia Lawson-Tovey, Jean Liew, Eoghan McCarthy, Anna Montgumery, Sebastian Moyano, Noreen Nasir, Ivan Padjen, Charalampos Papagoras, Naomi J. Patel, Mariana Pera, Cecilia Pisoni, Guillermo Pons-Estel, Antonio L. Quiambao, Rosana Quintana, Eric Ruderman, Sebastian Sattui, Veronica Savio, Savino Sciascia, Marieta Sencarova, Rosa Serrano Morales, Faizah Siddique, Emily Sirotich, Jeffrey Sparks, Anja Strangfeld, Paul Sufka, Helen Tanner, Yohana Tissera, Zachary Wallace, Marina L. Werner, Leanna Wise, Angus B. Worthing, JoAnn Zell, Julija Zepa, Pedro M. Machado, Jinoos Yazdany, Philip Robinson, Richard Conway
Summary: This study describes obstetric outcomes based on COVID-19 vaccination status in pregnant women with rheumatic and musculoskeletal diseases (RMDs). The results show that unvaccinated pregnant women have a higher rate of preterm births, and the need for COVID-19 pharmacological treatment is rare regardless of vaccination status.
Article
Rheumatology
Naomi J. Patel, Xiaosong Wang, Xiaoqing Fu, Yumeko Kawano, Claire Cook, Kathleen M. M. Vanni, Grace Qian, Emily Banasiak, Emily Kowalski, Yuqing Zhang, Jeffrey A. Sparks, Zachary S. Wallace
Summary: Rheumatic disease patients on multiple immunomodulators are at a higher risk of breakthrough infection, while recipients of mRNA-1273 vaccine have a lower risk compared to BNT162b2 recipients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Manuel F. Ugarte-Gil, Graciela S. Alarcon, Andrea M. Seet, Zara Izadi, Anna D. Montgomery, Ali Duarte-Garcia, Emily L. Gilbert, Maria O. Valenzuela-Almada, Leanna Wise, Jeffrey A. Sparks, Tiffany Y. -T. Hsu, Kristin M. D'Silva, Naomi J. Patel, Emily Sirotich, Jean W. Liew, Jonathan S. Hausmann, Paul Sufka, Rebecca Grainger, Suleman Bhana, Zachary Wallace, Lindsay Jacobsohn, Anja Strangfeld, Elsa F. Mateus, Kimme L. Hyrich, Laure Gossec, Loreto Carmona, Saskia Lawson-Tovey, Lianne Kearsley-Fleet, Martin Schaefer, Pedro M. Machado, Philip C. Robinson, Milena Gianfrancesco, Jinoos Yazdany
Summary: A study on individuals with SLE in the US found that Black and Hispanic patients had higher odds of experiencing more severe COVID-19 outcomes compared to White patients, which may be attributed to socioeconomic and health disparities.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Claire E. Cook, Naomi J. Patel, Xiaoqing Fu, Xiaosong Wang, Yumeko Kawano, Kathleen M. M. Vanni, Grace Qian, Emily Banasiak, Emily Kowalski, Hyon K. Choi, Yuqing Zhang, Jeffrey A. Sparks, Zachary S. Wallace
Summary: This study compared the effectiveness of mRNA vaccines (BNT162b2 vs mRNA-1273) against COVID-19 infection among patients with SARDs on immunomodulatory medications. The results showed that the risk of breakthrough infection was similar after receiving either BNT162b2 or mRNA-1273 in patients with SARDs. Therefore, patients with SARDs initiating the vaccine series should be encouraged to receive whichever mRNA vaccine is available.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Hemin Lee, Jeffrey A. Sparks, Su Been Lee, Kazuki Yoshida, Joan E. Landon, Seoyoung C. Kim
Summary: This study aims to determine the accuracy of ICD-10 diagnosis codes for rheumatoid arthritis (RA) serostatus using a US claims database (Optum Clinformatics Data Mart) and compare the results to a previous study. The results showed that the PPVs for seropositive and seronegative RA in the Optum database were lower than those in MarketScan, but improved when more restricted definitions of M05 and M06 were used.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Rheumatology
Jing Cui, Susan Malspeis, May Y. Choi, Bing Lu, Jeffrey A. Sparks, Kazuki Yoshida, Karen H. Costenbader
Summary: This study developed a risk prediction model for systemic lupus erythematosus (SLE) based on known genetic, lifestyle, environmental, and family history risk factors. The model accurately classified future SLE risk in a cohort of female nurses, incorporating genetic data and easily assessable risk factors.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Anne R. Bass, Eliza Chakravarty, Elie A. Akl, Clifton O. Bingham, Leonard Calabrese, Laura C. Cappelli, Sindhu R. Johnson, Lisa F. Imundo, Kevin L. Winthrop, Reuben J. Arasaratnam, Lindsey R. Baden, Roberta Berard, S. Louis Bridges Jr, Jonathan T. L. Cheah, Jeffrey R. Curtis, Polly J. Ferguson, Ida Hakkarinen, Karen B. Onel, Grayson Schultz, Vidya Sivaraman, Benjamin J. Smith, Jeffrey A. Sparks, Tiphanie P. Vogel, Eleanor Anderson Williams, Cassandra Calabrese, Joanne S. Cunha, Joann Fontanarosa, Miriah C. Gillispie-Taylor, Elena Gkrouzman, Priyanka Iyer, Kimberly S. Lakin, Alexandra Legge, Mindy S. S. Lo, Megan M. Lockwood, Rebecca E. Sadun, Namrata Singh, Nancy Sullivan, Herman Tam, Marat Turgunbaev, Amy S. Turner, James Reston
Summary: This guideline provides evidence-based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs). It includes expanded indications for some vaccines in patients with RMDs and addresses the safe use of live attenuated vaccines in patients taking immunosuppressive medications.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Anne R. Bass, Noha Abdel-Wahab, Pankti D. Reid, Jeffrey A. Sparks, Cassandra Calabrese, Deanna P. Jannat-Khah, Nilasha Ghosh, Divya Rajesh, Carlos Andres Aude, Lydia Gedmintas, Lindsey MacFarlane, Senada Arabelovic, Adewunmi Falohun, Komal Mushtaq, Farah Al Haj, Adi Diab, Ami A. Shah, Clifton O. Bingham, Karmela Kim Chan, Laura C. Cappelli
Summary: This study compares the safety and effectiveness of biologic and conventional DMARDs for ICI-IA. The results show that biologic DMARDs can achieve faster arthritis control than MTX, but may be associated with a shorter time to cancer progression.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Cesar A. Virgen, Jeffrey A. Sparks, Anju Nohria, Meabh J. O'Hare, Amrita Goyal, Jordan T. Said, Marianne Tawa, Nicole R. LeBoeuf, Thomas S. Kupper, David C. Fisher, Cecilia Larocca
Summary: This study identified muscular immune-related adverse events associated with mogamulizumab in T-cell lymphoma patients. Among 42 patients, 5 cases of mogamulizumab-associated myositis and/or myocarditis were found, with 2 cases also affected by myasthenia gravis. The incidence of these muscular adverse events may be higher than previously reported and can occur late in the treatment.
Letter
Oncology
Pankti Reid, Jeffrey A. Sparks, Anne R. Bass
Article
Rheumatology
Xiaofeng Jiang, Jeffrey Sparks, Zachary Wallace, Xinjia Deng, Hui Li, Na Lu, Dongxing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Jie Wei, Yuqing Zhang
Summary: This study compares the risk of SARS-CoV-2 infection and severe sequelae in patients with systemic lupus erythematosus (SLE) and the general population, based on their COVID-19 vaccination status. It was found that unvaccinated patients with SLE had a higher risk of SARS-CoV-2 infection and severe sequelae compared to the general population. However, no significant differences were observed between vaccinated patients with SLE and the vaccinated general population during the 9-month follow-up.
Review
Rheumatology
Rathnam Venkat, Zachary S. S. Wallace, Jeffrey A. A. Sparks
Summary: This review examines the impact of disease-modifying antirheumatic drugs (DMARDs) on COVID-19 severity and vaccine immunogenicity, and discusses the COVID-19 outcomes in rheumatoid arthritis (RA) patients. The findings suggest that rituximab is associated with severe COVID-19 and impaired vaccine immunogenicity, while JAK inhibitors and glucocorticoids have a modest association with these effects. TNF inhibitors may have a protective effect against severe COVID-19 and do not seem to affect vaccine immunogenicity. Holding methotrexate doses around COVID-19 vaccination improves immunogenicity but may increase the risk of RA flare.
CURRENT RHEUMATOLOGY REPORTS
(2023)