Article
Surgery
Rosalinda Filippo, Maria Conticchio, Francesca Ratti, Riccardo Inchingolo, Maximiliano Gelli, Ferdinando Massimiliano Anelli, Alexis Laurent, Giulio Cesare Vitali, Paolo Magistri, Giacomo Assirati, Emanuele Felli, Taiga Wakabayashi, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Nicola de'Angelis, Delgado Francisco Javier Briceno, Antonio Gaetano Rampoldi, Rene Adam, Daniel Cherqui, Luca Aldrighetti, Riccardo Memeo
Summary: This study compared the outcomes of liver resection (LR) and radiofrequency ablation (RFA) in octogenarian patients with hepatocellular carcinoma (HCC). The results showed that LR had a higher rate of complications, longer operative time, and hospital stays, but had better long-term outcomes in terms of survival rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Yinglin Long, Zhou Yang, Qingjing Zeng, Zhongqi Liu, Erjiao Xu, Xuqi He, Lianxiong Yuan, Binsheng Fu, Kai Li
Summary: This study found that thermal ablation is a safe and effective alternative to liver transplantation for hepatocellular carcinoma patients with clinically significant portal hypertension (CSPH). The ablation group had higher rates of intrahepatic recurrence compared to the transplantation group, but overall survival rates were comparable. Major complications were significantly lower in the ablation group compared to the transplantation group.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zhang-You Guo, Yuan Hong, Bing Tu, Yao Cheng, Xiao-Mei Wang
Summary: Liver resection is feasible for hepatocellular carcinoma (HCC) patients with significant portal hypertension (SPH), despite being a relative contraindication.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Koichiro Haruki, Kenei Furukawa, Yuki Fujiwara, Tomohiko Taniai, Ryoga Hamura, Yoshihiro Shirai, Jungo Yasuda, Hironori Shiozaki, Shinji Onda, Takeshi Gocho, Hiroaki Shiba, Teruyuki Usuba, Yukio Nakabayashi, Shuichi Fujioka, Tomoyoshi Okamoto, Toru Ikegami
Summary: The study evaluates the significance of anatomical resection (AR) on therapeutic outcomes of patients with small hepatocellular carcinoma (HCC) using propensity score-matched (PSM) analysis. Results show that AR may improve disease-free survival in HCC patients with tumors of <= 5 cm diameter, with significantly lower liver remnant recurrence in the AR group.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Shi-Ye Yang, Jin-Kai Feng, Mao-Lin Yan, Lei Guo, Yun-Fei Duan, Jia-Zhou Ye, Zong-Han Liu, Yan-Jun Xiang, Li Xu, Jie Xue, Jie Shi, Wan Yee Lau, Shu-Qun Cheng, Wei-Xing Guo
Summary: This study aimed to compare the perioperative results and long-term oncological outcomes of HCC patients with T2DM treated with LLR versus OLR. The LLR group had less blood loss, shorter hospitalization, and fewer postoperative complications compared to the OLR group. LLR showed significantly better overall survival and recurrence-free survival for HCC patients with T2DM regardless of the course of T2DM.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Shilei Bai, Lei Hu, Jianwei Liu, Minmin Sun, Yanfu Sun, Feng Xue
Summary: This study investigated the potential effect of postoperative adjuvant therapy with lenvatinib on the long-term prognosis of hepatitis B virus-related hepatocellular carcinoma with microvascular invasion (MVI). The results showed that patients who received postoperative lenvatinib had improved recurrence rates and survival rates compared to those who did not receive the treatment. Nomograms were also used to accurately predict long-term survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Dan-Jun Song, Kai Zhu, Jin-Peng Tan, Jia-Bin Cai, Min-Zhi Lv, Jie Hu, Zhen-Bin Ding, Guo-Ming Shi, Ning Ren, Xiao-Wu Huang, Ying-Hong Shi, Shuang-Jian Qiu, Qing-Hai Ye, Hui-Chuan Sun, Qiang Gao, Jian Zhou, Jia Fan, Xiao-Ying Wang
Summary: LLR can result in less liver function damage, better attenuation of inflammatory response, faster recovery, and parallel oncologic outcomes compared to OLR.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Xiu-Ping Zhang, Shuai Xu, Zhao-Yi Lin, Qing-Lun Gao, Kang Wang, Zi-Li Chen, Mao-Lin Yan, Fan Zhang, Yu-Fu Tang, Zhi-Ming Zhao, Cheng-Gang Li, Wan Yee Lau, Shu-Qun Cheng, Ming-Gen Hu, Rong Liu
Summary: This study aimed to evaluate the impact of anatomical resection (AR) versus nonanatomical resection (NAR) combined with resection margin (RM) on long-term prognosis in HCC patients with MVI. The results showed that AR combined with wide RM can significantly improve overall and recurrence-free survival rates for these patients.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Jun Fu, Qinjunjie Chen, Yuyan Yu, Wuyi You, Zongren Ding, Yuzhen Gao, Haitao Li, Yongyi Zeng
Summary: Clinically significant portal hypertension (CSPH) is a significant risk factor for post-hepatectomy liver failure (PHLF) and overall survival (OS) in patients with intrahepatic cholangiocarcinoma (ICC) and cirrhosis. Proper patient selection before surgery can help avoid PHLF and improve the prognosis of ICC patients.
Article
Surgery
Yichuan Yuan, Wei He, Zhiwen Yang, Jiliang Qiu, Zhenkun Huang, Yunxing Shi, Zhu Lin, Yun Zheng, Minshan Chen, Wan Yee Lau, Binkui Li, Yunfei Yuan
Summary: This study compared the efficacy of combining systemic therapy with transarterial-based therapy versus transarterial chemoembolization (TACE) alone in hepatocellular carcinoma (HCC) patients with portal vein tumour thrombus (PVTT). The combination therapy group had higher overall survival rates, longer progression-free survival, and more cases of tumor downstaging and pathological complete response after salvage liver resection. The adverse event rates were similar between the two groups. Therefore, combining therapy is a safe and promising treatment option for HCC patients with PVTT.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Surgery
Kazuteru Monden, Hiroshi Sadamori, Masayoshi Hioki, Satoshi Ohno, Norihisa Takakura
Summary: This study compares the safety and feasibility of laparoscopic liver resection (LLR) versus open liver resection (OLR) for the treatment of hepatocellular carcinoma (HCC) in older patients. The results show that LLR is safe and feasible for selected older patients with HCC, with less blood loss and shorter postoperative hospital stay.
Article
Oncology
Jing-Jing Yu, Ya-Ni Li, Chang Shu, Hui-Yuan Yang, Zhao Huang, Ran Tao, Yue-Yue Chen, Xiao-Ping Chen, Wei Xiao
Summary: A retrospective analysis found that HCC patients with portal vein tumor thrombosis (PVTT) had significantly higher preoperative circulating tumor cell (CTC) counts compared to those without PVTT. Patients with CTC counts ≥ 2 had significantly lower overall survival and disease-free survival rates. Therefore, preoperative CTC counts have the potential to be a valuable clinical tool in predicting the prognosis of HCC patients with PVTT.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Junhao Zheng, Xu Feng, Yuelong Liang, Jingwei Cai, Zhaoqi Shi, Mubarak Ali Kirih, Liye Tao, Xiao Liang
Summary: The study shows that laparoscopic liver resection is safe and feasible for HCC patients with clinically significant portal hypertension, expanding the indications for hepatectomy. Patients with portal hypertension may have a longer postoperative hospital stay, but there were no significant differences in operation time, blood loss volume, transfusion rates, etc. between the portal hypertension and non-portal hypertension groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Plant Sciences
Shaoju Luo, Hao Hu
Summary: The effectiveness of huaier granules in prolonging overall survival and reducing recurrence risk after curative resection of HCC has been demonstrated. Specifically, for solitary HCC with a diameter <= 30 mm, huaier granules can improve overall survival, while for solitary HCC with a diameter >30 mm, huaier granules can improve both overall survival and recurrence-free survival.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Surgery
Kang-Jun Zhang, Lei Liang, Yong-Kang Diao, Ya-Ming Xie, Dong-Dong Wang, Fei-Qi Xu, Tai-Wei Ye, Wen-Feng Lu, Jian Cheng, Guo-Liang Shen, Wei-Feng Yao, Yi Lu, Zun-Qiang Xiao, Jun-Gang Zhang, Cheng-Wu Zhang, Dong-Sheng Huang, Jun-Wei Liu
Summary: There were no significant differences in perioperative complications or long-term prognosis between laparoscopic and open liver resection for large HCC.
Article
Surgery
Yusuke Kawakami, Tomohiko Adachi, Shinichiro Ono, Naoki Kuroshima, Hajime Imamura, Toshiyuki Adachi, Takanori Hirayama, Amane Kitasato, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi
Summary: The objective of this study was to identify the most effective individual drug in a triple-drug therapy for preventing postoperative pancreatic fistula (POPF) using a rat model. The researchers compared the effects of a somatostatin analog, gabexate mesilate, and imipenem/cilastatin on POPF in rats and evaluated levels of serum amylase and lipase, ascitic amylase and lipase, intraperitoneal adhesion, and pancreatic inflammation. The results showed that the somatostatin analog was the most effective drug against POPF, as it significantly reduced levels of ascitic amylase and lipase and inflammation in the pancreas.
INTERNATIONAL SURGERY
(2023)
Meeting Abstract
Oncology
Kazuma Kobayashi, Takuro Fujita, Yusuke Inoue, Satomi Okada, Toshiyuki Adachi, Sayaka Kuba, Michi Morita, Taiichiro Kosaka, Takayuki Tanaka, Shinichiro Kobayashi, Yasuhiro Maruya, Akihiko Soyama, Tomohiko Adachi, Minoru Fukuda, Takuya Honda, Shinichiro Ito, Masaaki Hidaka, Kengo Kanetaka, Susumu Eguchi
ANNALS OF ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Masaaki Hidaka, Susumu Eguchi, Kiyoshi Hasegawa, Tsuyoshi Shimamura, Etsuro Hatano, Hideki Ohdan, Taizo Hibi, Yasushi Hasegawa, Junichi Kaneko, Ryoichi Goto, Hiroto Egawa, Hidetoshi Eguchi, Kunihisa Tsukada, Hiroshi Yotsuyanagi, Akihiko Soyama, Takanobu Hara, Mitsuhisa Takatsuki
Summary: This study aimed to evaluate the outcomes of liver transplantation (LT) for patients co-infected with HCV/HIV and found that sustained viral response (SVR) for HCV had the highest impact on patient survival. Achieving SVR for HCV before or after LT is crucial for better transplantation outcomes in these patients.
HEPATOLOGY RESEARCH
(2023)
Article
Surgery
Shohei Narita, Satoshi Miuma, Sadayuki Okudaira, Yoshito Koga, Masanori Fukushima, Ryu Sasaki, Masafumi Haraguchi, Akihiko Soyama, Masaaki Hidaka, Hisamitsu Miyaaki, Mitsuru Futakuchi, Kazuhiro Nagai, Tatsuki Ichikawa, Susumu Eguchi, Kazuhiko Nakao
Summary: This study retrospectively evaluated the usefulness of late protocol liver biopsy (PLB) after adult liver transplantation. The results showed that PLB is valuable for detecting subclinical rejection and allowing for appropriate immunosuppressive dose adjustment.
CLINICAL TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Takahiro Ikeda, Tomohiko Adachi, Takayuki Tanaka, Daisuke Miyamoto, Hajime Imamura, Hajime Matsushima, Kazuo Yamamoto, Masaaki Hidaka, Kengo Kanetaka, Susumu Eguchi
Summary: This study demonstrates that sympathetic nerve stimulation not only directly promotes the growth of pancreatic cancer but also exacerbates it by creating an immunosuppressive environment in the blood and tumor tissue.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Transplantation
Takanobu Hara, Akihiko Soyama, Hideki Ishimaru, Hajime Matsushima, Hajime Imamura, Shuto Miyamura, Takashi Hamada, Kunihito Matsuguma, Masayuki Fukumoto, Takayuki Tanaka, Tomohiko Adachi, Masaaki Hidaka, Susumu Eguchi
Summary: Portal vein thrombosis following liver transplantation can be treated with endovascular techniques. Trans-splenic access is an interesting option as it avoids liver graft damage, but it is not possible after splenectomy. We report a successful case of percutaneous intervention with direct puncture of the retropancreatic splenic vein for portal vein thrombosis following living donor liver transplantation with simultaneous splenectomy. Our technique proved effective with no recurrence of thrombosis for 2 years.
TRANSPLANTATION DIRECT
(2023)
Article
Medicine, General & Internal
Masanori Fukushima, Hisamitsu Miyaaki, Ryu Sasaki, Masafumi Haraguchi, Satoshi Miuma, Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Susumu Eguchi, Kazuhiko Nakao
Summary: This study investigated the natural course of cryptogenic cirrhosis after liver transplantation and the etiology of cryptogenic cirrhosis. It was found that patients with cryptogenic cirrhosis had a high prevalence of liver steatosis and steatohepatitis, with younger patients having a higher risk of non-alcoholic steatohepatitis.
Article
Pediatrics
Taiichiro Kosaka, Akihiko Soyama, Takuro Fujita, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Tomohiko Adachi, Masaaki Hidaka, Susumu Eguchi
Summary: This study reports the first case of a pediatric patient undergoing a hybrid procedure for living donor liver transplantation. The surgery was successful and the patient achieved a rapid recovery, with normal liver function and restored secondary sexual characteristics.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Peilin Li, Yusuke Inoue, Daisuke Miyamoto, Toshiyuki Adachi, Satomi Okada, Tomohiko Adachi, Akihiko Soyama, Masaaki Hidaka, Kengo Kanetaka, Shinichiro Ito, Daichi Sadatomi, Sachiko Mogami, Naoki Fujitsuka, Weili Gu, Susumu Eguchi
Summary: This study found that Daikenchuto has potential therapeutic effects on chemotherapy-induced acute small intestinal mucositis in a rat model. The results showed that Daikenchuto can protect against mucosal damage by reducing inflammation, stimulating cell proliferation, and stabilizing the mucosal barrier.
Article
Immunology
Syuhei Yoshimoto, Akihiko Soyama, Masayuki Fukumoto, Takanobu Hara, Masaaki Hidaka, Shinji Torai, Hiroo Kasamatsu, Jun Ishikawa, Masayuki Ohara, Eiji Kobayashi, Susumu Eguchi
Summary: This study explored the feasibility of using livers from uncontrolled donors after circulatory death (u-DCD) through transplantation. A pig model simulating u-DCD was used, and liver function was evaluated after 24 hours of perfusion. The results showed that u-DCD livers can be successfully transplanted using ex vivo machine perfusion.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Oncology
Masatoshi Kudo, Tomoko Aoki, Kazuomi Ueshima, Kaoru Tsuchiya, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Yasunori Minami, Hiroshi Ida, Naoshi Nishida, Chikara Ogawa, Tetsu Tomonari, Noriaki Nakamura, Hidekatsu Kuroda, Atsushi Takebe, Yoshifumi Takeyama, Masaaki Hidaka, Susumu Eguchi, Stephen L. Chan, Masayuki Kurosaki, Namiki Izumi
Summary: The concept of curative conversion by combining systemic therapy and locoregional therapy in intermediate-stage HCC has not been reported before. This study aimed to show the value of curative conversion in immunotherapy-treated HCC. The results showed that 35% of patients achieved CR through resection, ablation, or super selective TACE.
Article
Gastroenterology & Hepatology
Hajime Matsushima, Akihiko Soyama, Takanobu Hara, Yasuhiro Maruya, Takuro Fujita, Hajime Imamura, Tomohiko Adachi, Masaaki Hidaka, Susumu Eguchi
Summary: This study retrospectively analyzed 280 cases of adult living donor liver transplantation (LDLT) and found that a graft-to-recipient weight ratio (GRWR) of less than 0.6% was associated with an increased risk of small-for-size syndrome (SFSS). Although overall graft survival rates were similar, appropriate donor and recipient selection is crucial for successful LDLT with very small grafts.
LIVER TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Ken Kurisaki, Akihiko Soyama, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Takayuki Tanaka, Tomohiko Adachi, Shinichiro Ito, Kengo Kanetaka, Masaaki Hidaka, Shinji Okano, Susumu Eguchi
Summary: We present a case of pathologic complete response in a patient with advanced hepatocellular carcinoma (HCC) complicated with portal venous tumor thrombus, treated with atezolizumab and bevacizumab, followed by radical resection. The patient showed significant tumor shrinkage and decrease in tumor marker levels after systemic therapy. Radical resection was performed and a complete response was observed in the pathological examination. This case highlights the potential efficacy of atezolizumab plus bevacizumab as a treatment option for advanced HCC.
Article
Surgery
Shinichiro Kobayashi, Kengo Kanetaka, Akira Yoneda, Naoyuki Yamaguchi, Kazuma Kobayashi, Yasuhiro Nagata, Yasuhiro Maruya, Shun Yamaguchi, Masaaki Hidaka, Susumu Eguchi
Summary: This study aimed to evaluate the safety and efficacy of endoscopic examinations of the anastomotic region in the acute period after esophagectomy. It found that the endoscopic mucosal ischemic index can effectively predict the occurrence of anastomotic complications after surgery.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Medicine, Research & Experimental
Kosho Yamanouchi, Sayaka Kuba, Megumi Matsumoto, Hiroshi Yano, Michi Morita, Chika Sakimura, Ryota Otsubo, Masaaki Hidaka, Takeshi Nagayasu, Susumu Eguchi
Summary: This study investigated the effectiveness of compression therapy using sleeves and stockings in preventing peripheral neuropathy induced by docetaxel. The results showed that this compression therapy did not demonstrate efficacy in preventing peripheral neuropathy caused by docetaxel.
ACTA MEDICA OKAYAMA
(2022)
