Molecular polygamy: The promiscuity of l-phenylalanyl-tRNA-synthetase triggers misincorporation ofmeta- andortho-tyrosine in monoclonal antibodies expressed by Chinese hamster ovary cells

Reduced Amino Acid Specificity of Mammalian Tyrosyl-tRNA Synthetase Is Associated with Elevated Mistranslation of Tyr Codons

(2014) Medha Raina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

(2014) Tammy J Bullwinkle et al.   eLife

Aggregation and Chemical Modification of Monoclonal Antibodies under Upstream Processing Conditions

(2013) Stefan Dengl et al.   PHARMACEUTICAL RESEARCH

Glutathione and modulation of cell apoptosis

(2012) Magdalena L. Circu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies

(2012) Lauren Feeney et al.   BIOTECHNOLOGY AND BIOENGINEERING

Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures

(2012) Katharina Diepold et al.   PLoS One

Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach

(2012) Anne Zeck et al.   PLoS One

Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNAPhe with 3,4-Dihydroxy-L-Phenylalanine

(2011) Nina Moor et al.   CHEMISTRY & BIOLOGY

Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS

(2011) Miriam Hensel et al.   PLoS One

Control of misincorporation of serine for asparagine during antibody production using CHO cells

(2010) Anurag Khetan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Structure of Human Cytosolic Phenylalanyl-tRNA Synthetase: Evidence for Kingdom-Specific Design of the Active Sites and tRNA Binding Patterns

(2010) Igal Finarov et al.   STRUCTURE

Discovery and Investigation of Misincorporation of Serine at Asparagine Positions in Recombinant Proteins Expressed in Chinese Hamster Ovary Cells

(2009) Dingyi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine

(2009) L. Klipcan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of specific oxidized amino acids on protein turnover in J774 cells

(2008) Rachael A. Dunlop et al.   BIOCHEMICAL JOURNAL

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY