Enantioselective Synthesis of N–C Axially Chiral Compounds by Cu‐Catalyzed Atroposelective Aryl Amination

Enantioselective Atropisomeric Anilides Synthesis via Cu-Catalyzed Intramolecular Adjacent C–N Coupling

(2019) Xiaozhong Fan et al.   ACS Catalysis

Enantioselective Synthesis of Atropisomers Featuring Pentatomic Heteroaromatics by Pd-Catalyzed C–H Alkynylation

(2019) Shuo Zhang et al.   ACS Catalysis

Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation

(2019) Honghe Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Synthesis of N-C Axially Chiral Sulfonamides through Chiral Palladium-catalyzed N-Allylation

(2019) Yuki Kikuchi et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of Axially Chiral Biaryls via Cu-Catalyzed Acyloxylation of Cyclic Diaryliodonium Salts

(2019) Kai Zhu et al.   ACS Catalysis

The Buchwald-Hartwig Amination after 25 Years

(2019) Ruth Dorel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of N–C Axial Chirality through Atroposelective C–H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis

(2019) Jitan Zhang et al.   ORGANIC LETTERS

The 25th Anniversary of the Buchwald–Hartwig Amination: Development, Applications, and Outlook

(2019) Paola A. Forero-Cortés et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination

(2019) He-Yuan Bai et al.   Nature Communications

Construction of Axially Chiral Compounds via Asymmetric Organocatalysis

(2018) Yong-Bin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Regiospecific N-Arylation of Aliphatic Amines under Mild and Metal-Free Conditions

(2018) Nibadita Purkait et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts

(2018) Hua Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent encounters with atropisomerism in drug discovery

(2018) Peter W. Glunz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Atropisomerism in medicinal chemistry: challenges and opportunities

(2018) Sean T Toenjes et al.   Future Medicinal Chemistry

Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor

(2018) Jayaraman Chandrasekhar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Buchwald-Hartwig reaction: An overview

(2018) Majid M. Heravi et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes

(2018) Bin Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

(2018) Gregory Beutner et al.   ORGANIC LETTERS

Synthesis of Axially Chiral C–N Scaffolds via Asymmetric Coupling with Enantiopure Sulfinyl Iodanes

(2018) James Rae et al.   ACS Catalysis

Highly Efficient Syntheses of C−N Axially Chiral 1-(ortho -hydroxyaryl)uracil using a Chiral Auxiliary and a Chiral Base

(2018) Futoshi Hasegawa et al.   Asian Journal of Organic Chemistry

Enhanced Reactivity by Torsional Strain of Cyclic Diaryliodonium in Cu-Catalyzed Enantioselective Ring-Opening Reaction

(2018) Kun Zhao et al.   Chem

Atroposelective Catalytic Asymmetric Allylic Alkylation Reaction for Axially Chiral Anilides with Achiral Morita–Baylis–Hillman Carbonates

(2018) Shou-Lei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu-Catalyzed Enantioselective Atropisomer Synthesis via Thiolative Ring Opening of Five-Membered Cyclic Diaryliodoniums

(2018) Mengqing Hou et al.   ORGANIC LETTERS

EPR Evidence for the Origin of Nonlinear Effects in an Enantioselective Cu(II)-Catalyzed Spiroannulation

(2018) Brittany M. Armstrong et al.   ACS Catalysis

Enantioselective Copper-Catalyzed Arylation-Driven Semipinacol Rearrangement of Tertiary Allylic Alcohols with Diaryliodonium Salts

(2017) Daniel H. Lukamto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic synthesis of axially chiral atropisomers

(2017) P. Renzi   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery and Assessment of Atropisomers of (±)-Lesinurad

(2017) Jianfei Wang et al.   ACS Medicinal Chemistry Letters

Cyclic Hypervalent Iodine Reagents for Atom-Transfer Reactions: Beyond Trifluoromethylation

(2016) Yifan Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Synthetic Applications of Hypervalent Iodine Compounds

(2016) Akira Yoshimura et al.   CHEMICAL REVIEWS

Synthesis of axially chiral biaryl compounds by asymmetric catalytic reactions with transition metals

(2016) Pauline Loxq et al.   COORDINATION CHEMISTRY REVIEWS

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

(2016) Scott H. Watterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chiral N-1-adamantyl-N-trans-cinnamylaniline type ligands: synthesis and application to palladium-catalyzed asymmetric allylic alkylation of indoles

(2016) Takashi Mino et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic Enantioselective Synthesis of N–C Axially Chiral Mebroqualone and Its Derivatives through Reductive Asymmetric Desymmetrization

(2016) Motohiro Hirai et al.   ORGANIC LETTERS

Diaryliodonium Salts in Organic Syntheses: A Useful Compound Class for Novel Arylation Strategies

(2016) Zoltán Novák et al.   SYNLETT

Transition-Metal-Mediated Direct C–H Amination of Hydrocarbons with Amine Reactants: The Most Desirable but Challenging C–N Bond-Formation Approach

(2016) Hyunwoo Kim et al.   ACS Catalysis

The synthesis of optically active N–C axially chiral tetrahydroquinoline and its response to an acid-accelerated molecular rotor

(2015) Yuya Suzuki et al.   CHEMICAL COMMUNICATIONS

Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations

(2015) Elango Kumarasamy et al.   CHEMICAL REVIEWS

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

(2015) J. Wencel-Delord et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of a C-N Axially ChiralN-Arylisatin through Asymmetric IntramolecularN-Arylation

(2015) Atsuo Nakazaki et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives

(2015) Tomoaki Hirata et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts

(2015) Elise Cahard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination

(2015) Matthew E. Diener et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A twist of nature – the significance of atropisomers in biological systems

(2015) Jamie E. Smyth et al.   NATURAL PRODUCT REPORTS

Chiral N -( tert -butyl)- N -methylaniline type ligands: synthesis and application to palladium-catalyzed asymmetric allylic alkylation

(2015) Takashi Mino et al.   TETRAHEDRON

Copper-Catalyzed para-Selective C–H Amination of Electron-Rich Arenes

(2015) Beatrise Berzina et al.   ACS Catalysis

Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products

(2014) Kentaro Okano et al.   CHEMICAL COMMUNICATIONS

Copper-Catalyzed Intermolecular C–H Amination of (Hetero)arenes via Transient Unsymmetrical λ3-Iodanes

(2014) Igors Sokolovs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Atropisomeric Compounds with an N‒C Chiral Axis

(2014) Isao Takahashi et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

C–N bond forming cross-coupling reactions: an overview

(2013) Jitender Bariwal et al.   CHEMICAL SOCIETY REVIEWS

Discovery of Selective Small Molecule Type III Phosphatidylinositol 4-Kinase Alpha (PI4KIIIα) Inhibitors as Anti Hepatitis C (HCV) Agents

(2013) Anna L. Leivers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atropisomeric 4-Phenyl-4H-1,2,4-triazoles as Selective Glycine Transporter 1 Inhibitors

(2013) Takashi Sugane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Copper-Catalyzed Construction of Aryl Pyrroloindolines via an Arylation–Cyclization Cascade

(2012) Shaolin Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proton Grease: An Acid Accelerated Molecular Rotor

(2012) Brent E. Dial et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Significant Asymmetric Amplification in Enantioselective Cu/DiPPAM-catalyzed 1,6- and 1,4-Conjugate Additions of Diethylzinc to (Di)enones

(2012) Magaly Magrez et al.   ORGANIC LETTERS

Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase

(2011) Shaun R. Selness et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Atropisomerism at C-N Bonds of Acyclic Amines: Synthesis and Application to Palladium-Catalyzed Asymmetric Allylic Alkylations

(2011) Takashi Mino et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Assessing Atropisomer Axial Chirality in Drug Discovery and Development

(2011) Steven R. LaPlante et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Asymmetric Synthesis of Axially Chiral o-Iodoanilides by Phase-Transfer Catalyzed Alkylations

(2011) Seiji Shirakawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

The mechanism of the modified Ullmann reaction

(2010) Elena Sperotto et al.   DALTON TRANSACTIONS

Guest-Accelerated Molecular Rotor

(2010) Brent E. Dial et al.   ORGANIC LETTERS

Nonlinear Effects in Asymmetric Catalysis

(2009) Tummanapalli Satyanarayana et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diaryliodonium Salts: A Journey from Obscurity to Fame

(2009) Eleanor���A. Merritt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Metolachlor Herbicide: An Exercise in Today's Stereochemistry

(2009) Albrecht Mannschreck et al.   JOURNAL OF CHEMICAL EDUCATION

Enantiomerically enriched atropisomeric N,N′-diaryl ureas by oxidative kinetic resolution of their 2-sulfanyl derivatives

(2009) Jonathan Clayden et al.   TETRAHEDRON LETTERS