期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 33, 页码 13900-13907出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004377
关键词
asymmetric catalysis; cyclopropanation; heteroleptic complexes; quarternary chiral centers; rhodium carbenes; Stille coupling
资金
- Fonds der Chemischen Industrie
The heteroleptic dirhodium paddlewheel catalyst7with a chiral carboxylate/acetamidate ligand sphere is uniquely effective in asymmetric [2+1] cycloadditions with alpha-diazo-alpha-trimethylstannyl (silyl, germyl) acetate. Originally discovered as a trace impurity in a sample of the homoleptic parent complex [Rh-2((R)-TPCP)(4)] (5), it is shown that the protic acetamidate ligand is quintessential for rendering7highly enantioselective. The -NH group is thought to lock the ensuing metal carbene in place via interligand hydrogen bonding. The resulting stannylated cyclopropanes undergo stereoretentive cross coupling, which shows for the first time that even chiral quarternary carbon centers can be made by the Stille-Migita reaction.
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