期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 35, 页码 15152-15156出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004142
关键词
in vivo detection; mesoporous nanoparticles; Nile blue; NIR probes; senescence
资金
- Spanish Government (MCUI/AEI/FEDER, UE) [RTI2018-100910-B-C41, RTI2018-101599-B-C22]
- Generalitat Valenciana [PROMETEO/2019/065, PROMETEO 2018/024]
- MINECO/AEI/FEDER, UE
- Spanish Ministry of Economy
- UPV
- IDM
- [SAF2017-84689-R]
In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672 nm is highly quenched inside S3, yet a remarkable emission enhancement is observed upon cap hydrolysis in the presence of beta-galactosidase and dye release. The efficacy of the probe to detect cellular senescence is tested in vitro in melanoma SK-Mel-103 and breast cancer 4T1 cells and in vivo in palbociclib-treated BALB/cByJ mice bearing breast cancer tumor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据