期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 36, 页码 15532-15536出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004832
关键词
antiviral agents; inhibitors; influenza; nanoparticles; topology matching
资金
- Deutsche Forschungsgemeinschaft (DFG) through Collaborative Research Center [(SFB) 765]
- China Scholarship Council (CSC)
- DFG
- Projekt DEAL
In this study, we demonstrate the concept of topology-matching design for virus inhibitors. With the current knowledge of influenzaA virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even when used 24hours after the infection, more than 99.999% inhibition is still achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.
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