Article
Pharmacology & Pharmacy
Dipesh Khanal, Jinhee Kim, Jing Zhang, Wei-Ren Ke, Mark M. Banaszak Holl, Hak Kim Chan
Summary: The aim of this research was to use optical photothermal infrared spectroscopy (OPTIR) to analyse the chemical composition of pharmaceutical dry powder inhalation (DPI) aerosol particles. The study confirmed the presence of specific chemical peaks related to the drugs and excipients in the size-segregated particles of DPI formulations. It also found that the drug to excipient distribution ratio varied in different formulations, indicating heterogeneity. The results showed that OPTIR can serve as a valuable analytical platform for screening the physicochemical properties of DPI aerosols in solid state.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Chemical
Jagadeeswari Vanamu, Abanti Sahoo
Summary: Dry coating using suitable coating powder polymers is crucial in pharmaceutical industry for drug protection, with advantages of reducing overall coating amount and curing time. Electrostatic dry powder coating is a recent advancement attracting pharmaceutical industries, influencing parameters to achieve efficient products through processes like dry powder coating and hot-melt extrusion.
Review
Pharmacology & Pharmacy
Rachel Yoon Kyung Chang, Michael Y. T. Chow, Dipesh Khanal, Donghao Chen, Hak-Kim Chan
Summary: Therapeutic biologics delivered through pulmonary route offer safe and effective treatment options for respiratory diseases, but require careful formulation strategies, manufacturing processes, and stability considerations.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Engineering, Chemical
Kuriakose Kunnath, Liang Chen, Kai Zheng, Rajesh N. Dave
Summary: The ability to predict porosity and its reduction after nano-silica dry coating based on Bond number and cohesion force estimated through a multi-asperity contact model was examined for twenty different pharmaceutical powders. A new model for estimating bulk density improvements after dry coating was found to be reasonably predictive despite variations in size, particle size distribution, aspect ratios, material density, and dispersive surface energy. Microcrystalline Cellulose (MCC) excipients were outliers in the porosity prediction model based on Bond numbers, with unique characteristics leading to poor packing regardless of size.
Article
Pharmacology & Pharmacy
Dipesh Khanal, Wei-Ren Ke, Hak-Kim Chan
Summary: Raman spectroscopy was used to evaluate the effects of temperature and humidity on the physicochemical stability of inhalable spray-dried powders containing budesonide and crystalline or amorphous lactose. The study found that powders prepared from solution exhibited better stability, while powders prepared from suspension were prone to recrystallization and changes in chemical composition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of mouthpiece designs in carrier-based dry powder inhalation on aerosol particle characteristics. It is found that a mouthpiece with a spiral channel and mixing chamber is effective in delivering drug particles uniformly to the peripheral target regions of the respiratory system under low flow velocities.
Review
Pharmacology & Pharmacy
Anne Haaije de Boer, Paul Hagedoorn, Floris Grasmeijer
Summary: In this article, examples of ancient inhalation therapy and the development of early dry powder inhalers are discussed. The use of databases and personal communication with historians and custodians of historic manuscripts and artifacts were used to verify information. The article suggests that inhalation therapy may have a longer and more widespread history than currently known.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Natasha L. Velez-Silva, James K. Drennen III, Carl A. Anderson
Summary: This study focuses on assessing the impact of powder physical variation on near-infrared (NIR) spectroscopy and develops an in-line characterization method for powder stream density in a simulated continuous system. The results demonstrate that powder density is a significant source of spectral variability due to flow rate. This study is important for facilitating continuous process scale-up and ensuring the robustness of analytical models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Andrew Megarry, Hakan Wikstrom, Frida Bilen, Johan Remmelgas, Alexander Liljeblad, Pirjo Tajarobi
Summary: In this study, five well-known excipients and a model drug substance with different particle properties were selected to understand the impact of different blends. Two pilot-scale unvented IBCs were used, and the discharge rates and powder behavior were measured and recorded. The videos showed that air burst was necessary for powder flow, and the air flow inside the IBC was strong. Good indicators of flow/no flow were found, but there was a linear correlation between orifice flow and IBC discharge rate for predicting the rate.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of adding bypass holes in a dry powder inhaler on aerosol particle characteristics. The direction, size, and position of the bypass holes in the inhaler passage were found to significantly influence the spray output. Adding bypass holes decreased the mean penetration length of drug particles by 12%, but simultaneously increased the spray angle by 35%, resulting in a significant decrease in forward particle momentum.
Article
Chemistry, Medicinal
Ewa Nauka, Reto Maurer, Amilcar A. Gonzalez, Wei Zhang, Ajit S. Narang, Chen Mao
Summary: This study assesses the prevalence of funnel flow pattern for common pharmaceutical powder blends discharging from modern IBCs in drug product manufacturing, identifying several key factors contributing to the funnel flow pattern. Experimental results indicate that funnel flow pattern is prevalent in pharmaceutical powder blends.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Engineering, Chemical
Andreas Kottlan, Benjamin J. Glasser, Johannes G. Khinast
Summary: A single-tablet-scale mixing process utilizing vibratory mixing principle was developed to achieve homogeneous powder blend quickly. High-speed video recordings and image analysis were used to study mixing performance under different vibration frequencies and accelerations. The results showed that varying vibration parameters could lead to different mixing intensities, with lower frequencies resulting in faster mixing and successful production of a homogeneous blend within seconds.
Article
Pharmacology & Pharmacy
Adriana M. Ledo, Stefan Thibodeaux, Lisa Duong, Erhan Altinoglu, Thomas Dimke, Duncan Shaw, David Rowlands, Ellena Growcott
Summary: This study introduces a new in vitro system to study epithelial absorption of inhaled dry powders in lung barrier models. The system allows for the coupling of drug dissolution and permeability assessments. The results highlight the value of this in vitro drug aerosolization setup for research and development of inhaled medicines.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Andrea Konecna, Fadil Iyikanat, F. Javier Garcia de Abajo
Summary: The study demonstrates the possibility of identifying single isotope atom impurities in a nanostructure using transmission electron microscopy and spectroscopy. It shows the superior spatial resolution and ability to probe complete sets of vibrational modes by electron beams compared to conventional far-field spectroscopy.
Article
Chemistry, Multidisciplinary
Daniel J. Rizzo, Sara Shabani, Bjarke S. Jessen, Jin Zhang, Alexander S. McLeod, Carmen Rubio-Verdu, Francesco L. Ruta, Matthew Cothrine, Jiaqiang Yan, David G. Mandrus, Stephen E. Nagler, Angel Rubio, James C. Hone, Cory R. Dean, Abhay N. Pasupathy, D. N. Basov
Summary: The researchers successfully created nanometer-scale lateral p-n junctions using graphene/alpha-RuCl3 heterostructure near graphene nanobubbles. Through STM/STS and s-SNOM techniques, they investigated the electronic and optical responses of nanobubble p-n junctions, achieving p-n junctions with a width of around 3 nm and an electric field of approximately 10(8) V/m. The study also utilized ab initio density functional theory calculations to corroborate experimental data and provide insights into charge transfer mechanisms in 2D materials.
Review
Pharmacology & Pharmacy
Jing Zhang, Dipesh Khanal, Mark M. Banaszak Holl
Summary: The development of effective drug delivery systems requires in-depth characterization of the micro- or nanostructure of the material vectors with high spatial resolution, resulting in a deep understanding of the design-function relationship and maximum therapeutic efficacy. AFM-IR, combining the high spatial resolution of AFM and the capabilities of IR spectroscopy, is a powerful tool for the detailed characterization of drug delivery systems at the nanoscale, including identification of chemical composition. This review highlights the applications of AFM-IR in various drug delivery systems and discusses the challenges and future perspectives for its application in drug delivery vector characterization.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Infectious Diseases
Sue C. Nang, Yu-Wei Lin, Aleksandra Petrovic Fabijan, Rachel Y. K. Chang, Gauri G. Rao, Jonathan Iredell, Hak-Kim Chan, Jian Li
Summary: This review examines the current literature on phage pharmacology and highlights major pharmacological challenges for phage therapy. The lack of PK/PD information represents a major challenge for phage therapy, as therapeutic phages are biological entities with complex PK/PD.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
Yuncheng Wang, Dipesh Khanal, Adit B. Alreja, Hang Yang, Rachel Y. K. Chang, Waiting Tai, Mengyu Li, Daniel C. Nelson, Warwick J. Britton, Hak-Kim Chan
Summary: This study investigated the feasibility of producing inhalable powders of endolysins Cpl-1 and ClyJ-3 using spray drying method with excipients. The results showed that ClyJ-3 lost its bioactivity before the drying process, while Cpl-1 maintained its bioactivity in the spray-dried powders. Cpl-1 formulations with leucine and either lactose or trehalose exhibited promising physico-chemical properties and aerosol performances. These findings suggest that endolysin Cpl-1 can be formulated as spray dry powders for potential treatment of pulmonary infections.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Dipesh Khanal, Jinhee Kim, Jing Zhang, Wei-Ren Ke, Mark M. Banaszak Holl, Hak Kim Chan
Summary: The aim of this research was to use optical photothermal infrared spectroscopy (OPTIR) to analyse the chemical composition of pharmaceutical dry powder inhalation (DPI) aerosol particles. The study confirmed the presence of specific chemical peaks related to the drugs and excipients in the size-segregated particles of DPI formulations. It also found that the drug to excipient distribution ratio varied in different formulations, indicating heterogeneity. The results showed that OPTIR can serve as a valuable analytical platform for screening the physicochemical properties of DPI aerosols in solid state.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Gihane Nasr, Sanaa Daakour, Mark M. Banaszak Holl, Carla Attallah, Aline Hamade, Helene Greige-Gerges
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Athiya Azeem, Gajendra Singh, Lunjian Li, Hak-Kim Chan, Runyu Yang, Shaokoon Cheng, Agisilaos Kourmatzis
Summary: This study quantified the probability of agglomerate-to-wall collision using a unique image processing technique. The purpose was to investigate the effects of flow rate and particle size on the percentage of colliding agglomerates within a powder dispersion device.
PHARMACEUTICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Grace Tsz Yan Yau, Waiting Tai, Jonathon Carl Arnold, Hak-Kim Chan, Philip Chi Lip Kwok
Summary: The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. This review examines the preclinical and clinical evidence on the therapeutic use of CBD in treating various brain disorders, as well as different drug delivery approaches for CBD.
PHARMACEUTICAL RESEARCH
(2023)
Article
Oncology
Hiu Ting Chan, Satoshi Nagayama, Masumi Otaki, Yoon Ming Chin, Yosuke Fukunaga, Masashi Ueno, Yusuke Nakamura, Siew-Kee Low
Summary: This study compared the clinical utility and sensitivity of two different approaches to ctDNA analyses in colorectal cancer patients. It found that tumor-informed ctDNA analysis was more accurate in monitoring genetic mutations compared to tumor-agnostic analysis. Serial monitoring of ctDNA allowed for the early detection of disease recurrence, with a median of 5 months earlier than radiological imaging.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Izabela Milogrodzka, Duy Tue Nguyen Pham, Gopal R. Sama, Hajar Samadian, Jiali Zhai, Liliana de Campo, Nigel M. Kirby, Timothy F. Scott, Mark M. Banaszak Holl, Leonie van't Hag
Summary: Biomimetic cubic phases have various applications including protein encapsulation for biosensors and drug delivery. In this study, we obtained cubic phases with high concentrations of cholesterol and phospholipids. The results show that the cubic phase structure can be maintained with higher concentrations of biomimetic membrane additives than previously reported.
Article
Pharmacology & Pharmacy
Qixuan Zhu, Dazhao Gou, Hak-Kim Chan, Agisilaos Kourmatzis, Runyu Yang
Summary: This study conducted a numerical investigation using coupled computational fluid dynamics (CFD) and discrete element method (DEM) to evaluate the impact of design changes in a commercial dry powder inhaler (DPI) device on the aerosolization of an API-only formulation. Six different designs were proposed by modifying the mouthpiece and chamber of the original geometry. The performances of these designs were evaluated in terms of powder deposition and fine powder fraction (FPF) in the device. The study found that the resistance and FPF emitted varied with different designs, highlighting the importance of the mouthpiece and chamber design on powder dispersion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biology
Kevin H. Putera, Jinhee Kim, So Young Baek, Stephen H. Schlecht, Melanie L. Beaulieu, Victoria Haritos, Ellen M. Arruda, James A. Ashton-Miller, Edward M. Wojtys, Mark Banaszak M. Holl
Summary: Approximately 300,000 ACL tears occur annually in the US, with 50% leading to knee osteoarthritis within a decade. Repetitive loading causes collagen unravelling and structural failure, but the relationship between tissue changes is poorly understood. This study shows that submaximal loading of cadaver knees leads to collagen unravelling and tissue compliance increase, particularly in highly mineralized regions at the ACL femoral enthesis.
COMMUNICATIONS BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Rahul Sharma, Kevin Putera, Mark M. Banaszak Holl, Gil Garnier, Victoria S. Haritos
Summary: Fine nanocellulose fibers were obtained through a tandem enzyme reaction using carboxylated cellulose, as an alternative to the conventional toxic chemical process. The combination of fungal laccases and lytic polysaccharide monooxygenases (LPMOs) mimicked nature and resulted in hydrolyzed and oxidized cellulose, leading to the formation of nanofibers.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Cell Biology
Rohan Flint, Daniel R. Laucirica, Hak-Kim Chan, Barbara J. Chang, Stephen M. Stick, Anthony Kicic
Summary: Pulmonary bacterial infections pose a significant health risk to individuals with chronic respiratory diseases, and the emergence of antimicrobial resistance has necessitated the development of alternative therapies. Phage therapy, which targets antimicrobial-resistant pathogens, shows promise as an adjunct or alternative to antibiotics. Delivery of phages to the lungs is crucial for respiratory infections, and nebulization has been identified as a potential method. However, the factors that affect phage stability during nebulized delivery have not been fully characterized.
