Article
Chemistry, Analytical
Sheng-Hong Liu, Xiu-Mei Lin, Zhi-Lan Yang, Bao-Ying Wen, Fan-Li Zhang, Yue-Jiao Zhang, Jian-Feng Li
Summary: The study developed a label-free surface-enhanced Raman spectroscopy strategy using silver nanoparticles solution as a substrate to enhance the Raman signal of capsaicin marker molecule in waste oils. The method showed high sensitivity, accessibility, and reliability for the rapid identification of waste oils and has potential applications in the field of food safety.
Article
Chemistry, Multidisciplinary
Chi Zhang, Soumik Siddhanta, Debadrita Paria, Yaozheng Li, Chao Zheng, Ishan Barman
Summary: A novel nano-PROD platform has been developed for molecular recording by probing vibrational modes of membrane constituents, sustaining live cells in near-physiological conditions and enabling surface-enhanced Raman spectroscopy analysis of specific cell surface markers. This platform shows promise for a range of applications due to its tunability and unique combination of nanoscale topographic features and molecular sensing capabilities.
Article
Biochemical Research Methods
Shirun Peng, Dechan Lu, Bohan Zhang, Ruiyun You, Jingbo Chen, Huiyao Xu, Yudong Lu
Summary: Liquid biopsies have significant potential for early detection of colon cancer. Researchers have developed a label-free and non-invasive detection method using surface-enhanced Raman spectroscopy (SERS) with silver nanoparticles as the substrates. By combining this method with machine learning algorithms, accurate diagnosis models for colon cancer can be established.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jiaqi Liu, Zhichao Liu, Weikang Wang, Yang Tian
Summary: A novel SERS probe CuSP was created for real-time tracking and accurate quantification of extracellular Cu+ and Cu2+ concentrations in the live brain. The CuSP probe demonstrated specific ability for recognition of Cu+ and Cu2+ in a dual-recognition mode.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Cen Ding, Changhong Li, Qing Meng, Chengyuan Qian, Changli Zhang, Liu Yang, Xiaohui Wang, Yanqing Wang
Summary: A label-free fluorescent probe (BTS) was reported for dynamic in situ visualization of A beta 40 aggregation. The probe binds to all forms of A beta 40 with high affinity and can monitor the entire A beta aggregation process with high selectivity and sensitivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Rongyang Liu, Li Jiang, Zizhen Yu, Xufeng Jing, Xiu Liang, Dan Wang, Bo Yang, Chengxing Lu, Wei Zhou, Shangzhong Jin
Summary: The study prepared an MXene-Ti3C2Tx-Ag NPs hybrid biosensor through in-situ electrostatic self-assembly method, showing excellent SERS performance, long-term stability, and good uniformity for biomolecule detection. The biosensor could potentially be applied in clinical diagnosis and monitoring of biological environments, demonstrating its sensitivity and uniformity for label-free quantitative detection of bio-molecular based on SERS method in the field of biotechnology.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Polymer Science
Jia-Hui Xin, Bian-Bian Guo, Chang Liu, Cheng-Ye Zhu, Haoke Zhang, Ben Zhong Tang, Zhi-Kang Xu
Summary: Interfacial polymerization is a widely used method for synthesizing high-performance materials, but monitoring the growth of polymers during this process has been challenging. To overcome this, we have utilized the aggregation-induced emission effect to observe the entire interfacial polymerization process in real time. Using a confocal laser scanning microscope, we obtained clear images of the polymer and characterized its structural heterogeneity. Interestingly, our study revealed that the polymer density is higher away from the interface, contrary to expectations of homogeneity. The changing ratio of monomers in the reaction region explains this density gradient. Additionally, we demonstrated the precise growth kinetics of the polymer under different conditions. Our results provide a novel platform for understanding the mechanisms and properties of interfacial polymerization.
Article
Biochemical Research Methods
Jocelyn Y. Kishi, Ninning Liu, Emma R. West, Kuanwei Sheng, Jack J. Jordanides, Matthew Serrata, Constance L. Cepko, Sinem K. Saka, Peng Yin
Summary: Light-Seq is an approach that utilizes light-directed DNA barcoding for multiplexed spatial indexing in fixed cells and tissues. It enables in situ selection of multiple cell populations for sequencing, allowing analysis of rare cell types without dissociation. This method combines spatial and omics information, providing a workflow for in situ imaging, protein staining, and next generation sequencing of the same cells.
Article
Engineering, Chemical
Ruiyun You, Jie Li, Haonan Wang, Yaling Wu, Jingzheng Weng, Yudong Lu
Summary: In this study, a high-performance label-free surface-enhanced Raman scattering (SERS) biosensor was developed for effective screening of colon cancer by combining concentration, separation, and detection. The biosensor, equipped with a centrifuge tube and a filter containing ultrafiltration membranes (UFMs), allowed for the concentration and separation of colon cancer serum. By reducing signal fluctuations and minimizing interference from small molecule proteins, the biosensor improved the accuracy of detection and retained high diagnostic value proteins. Portable Raman spectroscopy combined with PCA-LDA models further enhanced the screening diagnosis of colon cancer.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Chemistry, Analytical
Niccolo Paccotti, Alessandro Chiado, Chiara Novara, Paola Rivolo, Daniel Montesi, Francesco Geobaldo, Fabrizio Giorgis
Summary: This study aimed to synthesize silver nanoparticles on porous silicon surfaces using microfluidic technology to achieve fine control over the morphology and spatial distribution of the nanostructures. By adjusting synthesis parameters such as precursor concentration, temperature, and flow rate, the effects on the morphology of silver nanoparticles were investigated. The results showed that variations in flow rate affected the uniformity of SERS enhancement, while an increase in temperature or silver precursor concentration led to higher SERS efficiency through the production of larger nanoparticles.
Article
Chemistry, Multidisciplinary
Iris Baffour Ansah, Timothy An, Jun-Yeong Yang, Ho Sang Jung, ChaeWon Mun, Sunghoon Jung, Seunghun Lee, Yejin Jang, Dong-Ho Kim, Meehyein Kim, Sung-Gyu Park
Summary: The authors of this study have proposed a method for rapid, ultrasensitive direct detection of chemicals and biomacromolecules through the in situ electrochemical synthesis of a 3D plasmonic-probe molecule composite skin layer on a 3D Au nanopillar array. By growing plasmonic nanomaterials in the presence of target probe molecules, they were able to enhance light-matter interactions, resulting in highly sensitive and rapid direct detection of both small molecules and large viruses. This approach provides a general platform for highly sensitive and rapid label-free direct detection for chemical and biomedical applications.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Engineering, Electrical & Electronic
Taiji Dong, Bingkun Gao, Bing Yan, Yekun Zhou, Yunkai Wang, Weicheng Wang, Kaichuan Xu, Chunlei Jiang, Zengbo Wang
Summary: In the field of biomedicine, the development of a tapered fiber optic biosensor (TFOB) allows for nondestructive and label-free detection of individual living cells. Through theoretical and simulation analysis, the fiber tip of the TFOB is found to be a highly sensitive sensing element that translates the intensity change of the evanescent field into changes in output power. Experimental results demonstrate the TFOB's ability to detect low-amplitude vibration signals and measure respiratory vibrations of pasta yeast cells.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Iris Baffour Ansah, Won-Chul Lee, ChaeWon Mun, Jong-Joo Rha, Ho Sang Jung, Mijeong Kang, Sung-Gyu Park, Dong-Ho Kim
Summary: A simple solution-based surface-enhanced Raman spectroscopy (SERS) method was developed for rapid and direct ternary detections of ascorbic acid (AA), dopamine (DA), and uric acid (UA) in urine with high sensitivity and selectivity, achieving detection limits of 1, 0.1, and 1 nM respectively. This is the first demonstration of simultaneous detection and quantification of biomolecules using SERS.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Yisheng Wei, Chenxi Wang, Fengcai Lei, Chundong Liu, Jia Li, Zhen Li, Chao Zhang, Yuanmei Gao, Jing Yu
Summary: In this study, a heterostructural nano round brush system consisting of Cu2O/ZnO/Ag was designed to integrate in-situ SERS sensor and high-efficiency photocatalyst for real-time monitoring and precise quantification of photocatalytic reactions. The platform exhibited high precision quantification with a coefficient of determination beyond 0.86 and was comprehensively analyzed for its structure effect, SERS performance, photocatalytic property, and electric field characteristic.
Article
Materials Science, Multidisciplinary
Haolin Wang, Hongyan Bai, Guiqing Wen, Aihui Liang, Zhiliang Jiang
Summary: A novel nanomaterial, COF HB, with high catalytic activity and stability was synthesized to develop a highly sensitive nanoanalysis method. The material exhibited strong catalysis in generating gold nanoparticles and can be used for the detection of small molecular drugs like ampicillin sodium. The research provides insights for developing sensitive nanoanalysis platforms for various applications.
APPLIED MATERIALS TODAY
(2022)
