Article
Surgery
Aranzazu Caballero-Marcos, Magdalena Salcedo, Roberto Alonso-Fernandez, Manuel Rodriguez-Peralvarez, Maria Olmedo, Javier Graus Morales, Valentin Cuervas-Mons, Alba Cachero, Carmelo Loinaz-Segurola, Mercedes Inarrairaegui, Lluis Castells, Sonia Pascual, Carmen Vinaixa-Aunes, Rocio Gonzalez-Grande, Alejandra Otero, Santiago Tome, Javier Tejedor-Tejada, Jose Maria Alamo-Martinez, Luisa Gonzalez-Dieguez, Flor Nogueras-Lopez, Gerardo Blanco-Fernandez, Gema Munoz-Bartolo, Francisco Javier Bustamante, Emilio Fabrega, Mario Romero-Cristobal, Rosa Martin-Mateos, Julia Del Rio-Izquierdo, Ana Arias-Milla, Laura Calatayud, Alberto A. Marcacuzco-Quinto, Victor Fernandez-Alonso, Concepcion Gomez-Gavara, Jordi Colmenero, Patricia Munoz, Jose A. Pons
Summary: This study found that liver transplant recipients have a lower persistence of anti-nucleocapsid IgG antibodies after 6 months of COVID-19, with more pronounced decline in antibody levels. Factors independently associated with antibody persistence beyond 6 months in transplant patients include female gender, longer interval since transplantation, and therapy with renin-angiotensin-aldosterone system inhibitors. Compared to immunocompetent patients, liver transplant recipients show a lower prevalence of anti-SARS-CoV-2 antibodies.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Haley P. Hostetler, Megan L. Neely, Elizabeth Lydon, Lara A. Danziger-Isakov, Jamie L. Todd, Scott M. Palmer
Summary: The study found that a considerable number of lung transplant candidates had undetectable virus-specific antibody titers, especially for varicella zoster virus and measles. Younger age groups had lower immunity rates. These results highlight the importance of screening for immunity to vaccine-preventable infections in this population and the need for revaccination in selected patients before transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Sunjae Bae, Jennifer L. Alejo, Teresa P. Y. Chiang, William A. Werbel, Aaron A. R. Tobian, Linda W. Moore, Ashrith Guha, Howard J. Huang, Richard J. Knight, A. Osama Gaber, R. Mark Ghobrial, Mara A. McAdams-DeMarco, Dorry L. Segev
Summary: The study analyzed the impact of COVID-19 vaccination on the immune response of transplant patients, finding that mTOR inhibitors may have an effect on vaccine responses. However, the results indicated that the likelihood of antibody response was higher in patients using both MMF and mTORi, but this protective tendency disappeared after adjusting for MMF.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Katrina Bazemore, Nitipong Permpalung, Joby Mathew, Merte Lemma, Betelihim Haile, Robin Avery, Hyesik Kong, Moon Kyoo Jang, Temesgen Andargie, Shilpa Gopinath, Steven D. Nathan, Shambhu Aryal, Jonathan Orens, Hannah Valantine, Sean Agbor-Enoh, Pali Shah
Summary: This study suggests that the donor-derived cell-free DNA percentage at the time of respiratory viral infection could be a predictor of chronic lung allograft dysfunction progression in lung transplant recipients. The recipients with higher levels of %ddcfDNA experienced greater decline in lung function and had a higher risk of progression and failure within one year.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Benjamin Coiffard, Philipp M. Lepper, Eloi Prud'Homme, Florence Daviet, Nadim Cassir, Heinrike Wilkens, Sami Hraiech, Frank Langer, Pascal A. Thomas, Martine Reynaud-Gaubert, Robert Bals, Hans-Joachim Schaefers, Laurent Papazian, Frederik Seiler
Summary: It is unclear whether solid organ transplant recipients are at higher risk for severe COVID-19, but the management and treatment strategies for lung transplantation programs in the COVID-19 era have been a major concern worldwide. A survey conducted in June 2020 with 78 responses from 15 countries revealed that the majority of LTx centers have reduced activity and restricted LTx for urgent cases only, with some centers reporting deaths on waiting listed patients. Most centers diagnosed COVID-19 in LTx recipients, with common immunosuppressive management strategies involving decreased dosages or pausing of cell cycle inhibitors, and proposed antiviral strategies including Remdesivir, hydroxychloroquine, and azithromycin.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Antoine Roux, Vincent Bunel, Natalia Belousova, Jonathan Messika, Sebastien Tanaka, Mathilde Salpin, Arnaud Roussel, Laurence Beaumont-Azuar, Clement Picard, Olivier Brugiere, Jerome Devaquet, Edouard Sage, Morgan Le Guen, Jean-Luc Taupin, Magali Devriese, Mathieu Glorion, Francois Parquin
Summary: Lung transplant candidates who are highly sensitized against human leucocyte antigen present a challenge in finding suitable donors. Current desensitization strategies have limitations. Imlifidase, a novel agent derived from Streptococcus pyogenes, has been used successfully to remove antibodies and allow transplantation in kidney candidates. We present the first case of using imlifidase for antibody depletion in a highly sensitized lung transplant candidate who underwent a successful bilateral lung transplant.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Cedric Hirzel, Arnaud G. L'Huillier, Victor H. Ferreira, Tina Marinelli, Terrance Ku, Matthew Ierullo, Congrong Miao, D. Scott Schmid, Stephen Juvet, Atul Humar, Deepali Kumar
Summary: The study investigated the safety and immunogenicity of a recombinant zoster vaccine (RZV) in lung transplant recipients, demonstrating that RZV was safe and elicited significant humoral and cell-mediated immunity in this population, making it a new option for preventing shingles in this group.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Berta Saez-Gimenez, Cristina Berastegui, Miriam Barrecheguren, Eva Revilla-Lopez, Ibai Los Arcos, Rodrigo Alonso, Myriam Aguilar, Victor M. Mora, Isabel Otero, Juan P. Reig, Carlos A. Quezada, Virginia Perez, Manuel Valle, Rosalia Laporta, Maria Deu, Judith Sacanell, Carles Bravo, Joan Gavalda, Manuel Lopez-Meseguer, Victor Monforte
Summary: This study investigated the clinical presentation, treatment, and outcomes of SARS-CoV-2 infection in lung transplant recipients. The multicenter retrospective study found a high mortality rate among lung transplant recipients with SARS-CoV-2 infection, with key factors like initial disease severity predicting subsequent mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Madeleine R. Heldman, Olivia S. Kates, Kassem Safa, Camille N. Kotton, Sarah J. Georgia, Julie M. Steinbrink, Barbara D. Alexander, Marion Hemmersbach-Miller, Emily A. Blumberg, Maria M. Crespo, Ashrit Multani, Angelica Lewis, Omer Eugene Beaird, Brandy Haydel, Ricardo M. La Hoz, Lisset Moni, Yesabeli Condor, Sandra Flores, Carlos G. Munoz, Juan Guitierrez, Esther Diaz, Daniela Diaz, Rodrigo Vianna, Giselle Guerra, Matthias Loebe, Robert M. Rakita, Maricar Malinis, Marwan M. Azar, Vagish Hemmige, Margaret E. McCort, Zohra S. Chaudhry, Pooja Singh, Kailey Hughes, Arzu Velioglu, Julie M. Yabu, Jose A. Morillis, Sapna A. Mehta, Sajal D. Tanna, Michael G. Ison, Rade Tomic, Ariella Candace Derenge, David van Duin, Adrienne Maximin, Carlene Gilbert, Jason D. Goldman, Sameep Sehgal, Dana Weisshaar, Reda E. Girgis, Joanna Nelson, Erika D. Lease, Ajit P. Limaye, Cynthia E. Fisher
Summary: There is higher mortality among lung transplant recipients with COVID-19 compared to non-lung solid organ transplant recipients. Chronic lung allograft dysfunction is independently associated with mortality in lung transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Howard J. Huang, Kenneth Schechtman, Medhat Askar, Cory Bernadt, Brigitte Mittler, Peter Dore, Chad Witt, Derek Byers, Rodrigo Vazquez-Guillamet, Laura Halverson, Ruben Nava, Varun Puri, Andrew Gelman, Daniel Kreisel, Ramsey R. Hachem
Summary: The use of Belatacept for immunosuppression after lung transplantation is associated with increased mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Bruno F. Buzo, Jutta K. Preiksaitis, Kieran Halloran, Jayan Nagendran, Derek R. Townsend, Nathan Zelyas, Wendy Sligl
Summary: This study found that approximately 26.4% of patients tested post-lung transplant had Mycoplasma and/or Ureaplasma airway colonization. Patients with Ureaplasma colonization had higher levels of ammonia, but only three patients developed hyperammonemia syndrome. Airway Ureaplasma positivity in recipients was independently associated with younger age and female donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Tobias Veit, Dieter Munker, Juergen Barton, Katrin Milger, Teresa Kauke, Bruno Meiser, Sebastian Michel, Michael Zoller, Hans Nitschko, Oliver T. Keppler, Jurgen Behr, Nikolaus Kneidinger
Summary: This study assessed the therapeutic efficacy of letermovir in lung transplant recipients with difficult to treat CMV infections. Most patients responded rapidly to letermovir treatment, showing significant reduction in CMV viral load and clearance of infection. However, a small percentage of patients developed a mutation conferring resistance to letermovir.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Nathalie Chavarot, Gillian Divard, Anne Scemla, Lucile Amrouche, Olivier Aubert, Marianne Leruez-Ville, Marc O. Timsit, Claire Tinel, Julien Zuber, Christophe Legendre, Dany Anglicheau, Rebecca Sberro-Soussan
Summary: This study analyzed the characteristics and risk factors of CMV disease after conversion to Belatacept in kidney transplant recipients, finding that older age, D+/R- CMV serostatus, and low eGFR at conversion were independent risk factors. The incidence and cumulative incidence of CMV disease were significantly higher in patients treated with Belatacept compared to the control group.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Marwan Bouras, Karim Asehnoune, Antoine Roquilly
Summary: Traumatic brain injury (TBI) triggers an immediate immune response in brain tissue, followed by a systemic inflammatory response. This response aims to limit excessive systemic inflammation and promote healing, involving the regulation of the autonomic nervous system, hormonal systems, and immune cells. However, it also leads to immunosuppression and tolerance, which increases the risk of secondary infections.
FRONTIERS IN MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Sotaro Fujisawa, Shiro Murata, Masayoshi Isezaki, Shwe Yee Win, Takumi Sato, Eiji Oishi, Akira Taneno, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi
Summary: The poultry red mite is a serious threat to poultry farms and can cause various health problems in chickens, leading to a reduction in productivity. Infestation with these mites induces inflammatory and hemostatic reactions in the host, while the mites secrete immunosuppressants to suppress the host immune response. This study found that PRM infestation increases the expression of anti-inflammatory cytokines and immune checkpoint molecules, thus suppressing the host's immune response.
Article
Cardiac & Cardiovascular Systems
Marco Schiavon, Giovanni Maria Comacchio, Marco Mammana, Eleonora Faccioli, Francesca Stocca, Dario Gregori, Giulia Lorenzoni, Andrea Zuin, Samuele Nicotra, Giulia Pasello, Fiorella Calabrese, Andrea Dell'Amore, Federico Rea
Summary: This study demonstrates that lobectomy with reconstruction of the pulmonary artery is a valuable and oncologically safe alternative to pneumonectomy, with lower short-term mortality and morbidity rates, while not affecting long-term oncologic outcomes.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Alessio Campisi, Andrea Dell'Amore, Yonghui Zhang, Zhitao Gu, Angelo Paolo Ciarrocchi, Eleonora Faccioli, Luca Bertolaccini, Federico Rea, Franco Stella, Wentao Fang
Summary: This study compared the effects of autologous blood patch pleurodesis using different blood volumes on patients with prolonged air leak after lung resection. The results showed that injecting 120mL of blood can significantly reduce chest tube removal time, length of hospital stay, and complications, indicating its potential as an effective treatment option.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Immunology
Eleonora Faccioli, Andrea Dell'Amore, Marco Schiavon, Federico Rea
Summary: A recent history of malignancy is a strict contraindication for lung transplantation, but a 5-year disease-free interval is required in most cases. There are currently no specific guidelines for selecting recipients with a previous history of lung cancer. A case is reported of a patient who underwent lung transplantation for emphysema after undergoing lobectomy and treatment for small cell lung cancer, with no recurrence of neoplastic disease at present.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Oncology
Federica Pezzuto, Francesca Lunardi, Luca Vedovelli, Francesco Fortarezza, Loredana Urso, Federica Grosso, Giovanni Luca Ceresoli, Izidor Kern, Gregor Vlacic, Eleonora Faccioli, Marco Schiavon, Dario Gregori, Federico Rea, Giulia Pasello, Fiorella Calabrese
Summary: The CDKN2A gene is important in the pathogenesis of malignant pleural mesothelioma (MPM). The study found that p14/ARF-positive epithelioid mesotheliomas may represent a more aggressive pathological phenotype, while p14/ARF-negative tumors seem less sensitive to immune checkpoint inhibitors. The association between p14/ARF-positive MPMs and PD-L1 expression suggests a possible interaction between the two pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Francesco Fortarezza, Mila Della Barbera, Federica Pezzuto, Francesca Lunardi, Eleonora Faccioli, Giulia Pasello, Federico Rea, Stefania Rizzo, Fiorella Calabrese
Summary: The histological diagnosis of pleural epithelioid mesothelioma can be challenging in cases of rare variants or patients with previous or concomitant tumors. Immunohistochemical reactions play a role in obtaining a sensitive and specific diagnosis of malignant pleural mesothelioma but sometimes the final interpretation remains inconclusive. Ultrastructural examination has historically been a useful tool in defining the mesothelial nature of neoplastic cells.
Article
Cardiac & Cardiovascular Systems
Alessio Campisi, Andrea Dell'Amore, Piotr Gabryel, Angelo Paolo Ciarrocchi, Magdalena Sielewicz, Yonghui Zhang, Zhitao Gu, Eleonora Faccioli, Franco Stella, Federico Rea, Wentao Fang, Cezary Piwkowski
Summary: This study evaluated the effectiveness and safety of autologous blood patch pleurodesis (ABPP) for prolonged air leaks (PAL) after lung resections. The results showed that ABPP significantly reduced the number of days before chest tube removal and length of hospital stay, with fewer perioperative complications.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Schiavon, Paolo Mendogni, Eleonora Faccioli, Giulia Lorenzoni, Alessandra Mazzucco, Mario Nosotti, Federico Rea
Summary: This study examined the use of lobar reduction in lung transplantation for small-sized recipients. The results showed that lobar reduction had comparable early and long-term outcomes to standard lung transplantation, with no significant impact on patients' morbidity and survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Eleonora Faccioli, Andrea Dell'Amore, Pia Ferrigno, Marco Schiavon, Marco Mammana, Stefano Terzi, Federico Rea
Summary: Bronchial stenoses are challenging complications after lung transplantation, with 7.0% of patients experiencing it in this study. While endoscopic management was effective in most cases, 1 patient required re-transplantation and 6 patients underwent bronchoplasty or sleeve resection. Of these patients, 2 remained alive with preserved pulmonary function at a median of 12 months post-surgery.
Editorial Material
Cardiac & Cardiovascular Systems
Marco Schiavon, Andrea Lloret Madrid, Federica Pezzuto, Chiara Giraudo, Giovanni Maria Comacchio, Eleonora Faccioli, Andrea Dell'Amore, Fiorella Calabrese, Federico Rea
Summary: This article presents a case of spontaneous regression of thoracic malignancy in a patient with epidermal growth factor receptor-mutant adenocarcinoma. The patient experienced contralateral aspiration pneumonia before surgery, but showed complete pathologic regression without any preoperative oncologic treatment. Immune system activation and the role of tumor microenvironment in disease progression and treatment are highlighted.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Ilhan Inci, Jonas Peter Ehrsam, Dirk Van Raemdonck, Laurens Joseph Ceulemans, Thorsten Krueger, Angela Koutsokera, Marco Schiavon, Eleonora Faccioli, Mario Nosotti, Lorenzo Rosso, Frank D'Ovidio, Miguel Leiva-Juarez, Clemens Aigner, Alexis Slama, Waleed Saleh, Khaled Manaa Alkattan, Pascal Alexandre Thomas, Geoffrey Brioude, Alberto Benazzo, Konrad Hoetzenecker
Summary: This study investigated the outcomes of recipients bridged to a first-time retransplantation (ReTx) by extracorporeal life support (ECLS). The results showed that the overall survival of the ECLS-ReTx group was significantly worse compared to the regular-ReTx and index-Tx groups. Risk factors such as recipient age, intertransplant interval, primary graft dysfunction as transplant indication, and type of ECLS were identified as significant factors affecting mortality in ECLS-ReTx recipients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Eleonora Faccioli, Andrea Dell'Amore
ANNALS OF CARDIOTHORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Fiorella Calabrese, Anja C. Roden, Elizabeth Pavlisko, Francesca Lunardi, Desley Neil, Benjamin Adam, David Hwang, Martin Goddard, Gerald J. Berry, Marina Ivanovic, Jan von der Thusen, Laure Gibault, Chieh-Yu Lin, Katharina Wassilew, Carolyn Glass, Glen Westall, Adriana Zeevi, Deborah Jo Levine, Antoine Roux
Summary: Routine monitoring and histopathologic analysis play crucial roles in identifying complications and determining the etiology of lung-transplanted patients. This study created a template to standardize pathological assessment and grading, facilitating multicenter studies and medical decision-making.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Schiavon, S. Camagni, F. Venuta, L. Rosso, M. Boffini, F. Parisi, A. Bertani, F. Meloni, P. Paladini, E. Faccioli, M. Colledan, D. Diso, M. Cattaneo, F. Scalini, S. Alfieri, M. Morosini, L. Luzzi, G. Lorenzoni, A. Dell'Amore, F. Rea
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Dell'Amore, P. Ferrigno, M. Schiavon, N. Sella, E. Faccioli, A. Pangoni, G. Lorenzoni, F. Pettenuzzo, D. Pittarello, E. Serra, F. Calabrese, M. Loy, P. Navalesi, F. Rea
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Faccioli, F. Pezzuto, M. Schiavon, A. Dell'Amore, G. Lorenzoni, S. Vuljan, P. Ferrigno, F. Fortarezza, D. Gregori, F. Calabrese, F. Rea
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)