Review
Cardiac & Cardiovascular Systems
Xiaoxu Wang, Yi Luo, Dan Xu, Kun Zhao
Summary: Digoxin use is associated with increased all-cause mortality, especially in patients without heart failure. It is also linked to higher risks of sudden cardiac death and cardiovascular mortality in atrial fibrillation patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Tulio Caldonazo, Hristo Kirov, Mohamed Rahouma, N. Bryce Robinson, Michelle Demetres, Mario Gaudino, Torsten Doenst, POAF MA Grp
Summary: This study conducted a systematic review and meta-analysis to assess the association between new-onset postoperative atrial fibrillation (POAF) after cardiac surgery and perioperative and long-term outcomes. The results showed that POAF was associated with an increased occurrence of various cardiovascular adverse events in the short and long term. However, the causal relationship of this association remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Rachel Eikelboom, Rohan Sanjanwala, Me-Linh Le, Michael H. Yamashita, Rakesh C. Arora
Summary: POAF after cardiac surgery is associated with increased long-term risk of death, highlighting the need for comprehensive prevention and management strategies, including strict follow-up post-discharge. Inconsistent definitions and exclusion criteria for POAF in current studies may impact the accuracy of adjusted analyses. Further research is necessary to elucidate the underlying mechanisms linking POAF and long-term mortality.
ANNALS OF THORACIC SURGERY
(2021)
Review
Pharmacology & Pharmacy
Daniele Pastori, Francesco Baratta, Arianna Di Rocco, Alessio Farcomeni, Maria Del Ben, Francesco Angelico, Francesco Violi, Pasquale Pignatelli, Gregory Y. H. Lip
Summary: This meta-analysis found that in AF patients, statin therapy was associated with a 41% reduction in all-cause mortality and a 25% reduction in cardiovascular mortality. Randomized clinical trials in AF patients are needed to further confirm these findings and clarify specific LDL cholesterol targets for AF.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Medicine, General & Internal
Daria Sgreccia, Marcella Manicardi, Vincenzo Livio Malavasi, Marco Vitolo, Anna Chiara Valenti, Marco Proietti, Gregory Y. H. Lip, Giuseppe Boriani
Summary: Analysis of 10 studies showed no significant differences in all-cause mortality, cardiovascular death, stroke, and stroke/TE risks between symptomatic and asymptomatic AF patients. Therefore, the symptomatic status of AF patients does not impact mortality and stroke/TE events, suggesting that management strategies should not be solely based on symptomatic clinical presentation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Alan Cameron, Huen Ki Cheng, Ren-Ping Lee, Daniel Doherty, Mark Hall, Pouria Khashayar, Gregory Y. H. Lip, Terence Quinn, Azmil Abdul-Rahim, Jesse Dawson
Summary: This study identified various clinical, ECG, and blood-based biomarkers associated with atrial fibrillation (AF) detection after ischemic stroke or TIA. Factors such as older age, female sex, history of heart failure, hypertension, and certain ECG parameters were found to be associated with increased likelihood of AF detection, while other factors like certain lipid concentrations were associated with reduced likelihood. These multimodal biomarkers could potentially be used to guide patient selection for cardiac monitoring after ischemic stroke/TIA, but further prospective assessments are needed to confirm their prognostic utility.
Review
Cell Biology
Marco Proietti, Giulio Francesco Romiti, Valeria Raparelli, Igor Diemberger, Giuseppe Boriani, Laura Adelaide Dalla Vecchia, Giuseppe Bellelli, Emanuele Marzetti, Gregory Y. H. Lip, Matteo Cesari
Summary: This study systematically reviewed the prevalence of frailty in patients with atrial fibrillation (AF) and its association with major outcomes. The results showed a high prevalence of frailty in AF patients and its impact on prognosis and management.
AGEING RESEARCH REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Minha Murtaza, Mirza Mehmood Ali Baig, Jawad Ahmed, Liviu Ionut Serbanoiu, Stefan Sebastian Busnatu
Summary: This research found that cancer patients who developed new-onset atrial fibrillation had a higher mortality rate. Both the surgical and non-surgical subgroups of cancer patients showed a significantly higher mortality rate associated with new-onset atrial fibrillation. This suggests that extra care and specific measures must be taken in the management of cancer patients with new-onset atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Dayang Wang, Xiaoqing Xu, Xiaowan Han, Jing Xie, Hufang Zhou, Wenhua Peng, Guozhong Pan
Summary: This systematic review and meta-analysis found that oral anticoagulants may reduce all-cause mortality among patients with atrial fibrillation and dementia, but they do not significantly affect the risk of major bleeding and ischemic stroke.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Emergency Medicine
Ming-yue Chen, Fang-ping Xiao, Lin Kuai, Hai-bo Zhou, Zhi-qiang Jia, Meng Liu, Hao He, Mei Hong
Summary: The study found a correlation between preexisting atrial fibrillation and increased in-hospital mortality, post-discharge mortality, and ventilator utilization in COVID-19 patients, while new-onset atrial fibrillation during infection was significantly associated with increased mortality risk.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Fadi Alijla, Chepkoech Buttia, Tobias Reichlin, Salman Razvi, Beatrice Minder, Matthias Wilhelm, Taulant Muka, Oscar H. Franco, Arjola Bano
Summary: This systematic review and meta-analysis found that diabetes is associated with an increased likelihood of non-paroxysmal AF rather than paroxysmal AF. Further high quality studies are needed to replicate these findings, adjust for potential confounders, elucidate mechanisms linking diabetes to non-paroxysmal AF, and assess the impact of antidiabetic medications on AF types. These strategies could eventually help decrease the risk of non-paroxysmal AF among patients with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Pharmacology & Pharmacy
William L. Baker, Diana M. Sobieraj, Robert J. DiDomenico
Summary: The use of digoxin in AF patients is associated with higher all-cause mortality, with varying levels of confidence in the results of systematic reviews. Further research in randomized controlled trials with closer monitoring of serum digoxin concentration is needed to better inform clinical practice.
Review
Sport Sciences
William Newman, Gemma Parry--Williams, Jonathan Wiles, Jamie Edwards, Sabina Hulbert, Konstantina Kipourou, Michael Papadakis, Rajan Sharma, Jamie O'Driscoll
Summary: Athletes have a significantly higher risk of developing AF compared to non-athlete controls, particularly those participating in mixed sports and younger age groups. The mode of exercise and age are crucial factors influencing the risk of AF development.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Medicine, General & Internal
Taomin Su, Zheng Fu, Zhihong Nie, Dongfeng Guo
Summary: In subjects with atrial fibrillation and liver disease, non-vitamin K antagonist oral anticoagulants are associated with lower all-cause mortality, intracranial hemorrhage, and stroke compared to warfarin, but not with major bleeding or gastrointestinal bleeding. Further studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Multidisciplinary Sciences
Jeffrey Curran, Amanda Ross-White, Stephanie Sibley
Summary: The objective of this study is to summarize studies examining magnesium versus placebo in the prevention of NOAF outside the setting of cardiac surgery. The study found that the use of magnesium did not significantly reduce the incidence of NOAF.
Editorial Material
Cardiac & Cardiovascular Systems
Ahmed Ibrahim Ahmed, Yushui Han, Ahmed Soliman, Mouaz H. Al-Mallah
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Alka M. Kanaya, Namratha R. Kandula, Jaideep Patel, Mouaz H. Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H. Criqui, Salim S. Virani
Summary: Individuals of South Asian ancestry have a higher risk of atherosclerotic cardiovascular disease. Coronary artery calcium volume and density can identify unique plaque characteristics in this population, providing important prognostic information. Cardiovascular risk factors are associated with CAC density and volume.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Subha Saeed, Jean Michel Saad, Ahmed Ibrahim Ahmed, Yushui Han, Mouaz H. Al-Mallah
Summary: Cardiac amyloidosis presents diagnostic challenges, but specialized amyloid-binding radiotracers may significantly improve diagnostic accuracy and treatment outcomes.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Yushui Han, Ahmed Ibrahim Ahmed, Chris Schwemmer, Myra Cocker, Talal S. Alnabelsi, Jean Michel Saad, Juan C. Ramirez Giraldo, Mouaz H. Al-Mallah
Summary: This study assessed the interoperator and intraoperator variability of coronary CT angiography-derived FFRCT using a machine learning-based postprocessing prototype. The results showed a high degree of reproducibility for FFRCT and greater variability in distal segments compared to proximal/mid segments.
Article
Cardiac & Cardiovascular Systems
Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Maan Malahfji, Mouaz H. Al-Mallah
Summary: This study aimed to determine the prognostic value of positron emission tomography (PET) derived left ventricular mass (LVM) in addition to clinical variables and myocardial flow reserve (MFR). The results showed that LVM was not independently associated with outcomes and had no incremental prognostic value over MFR and clinical variables.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maan Malahfji, Valentina Crudo, Ahmed Ibrahim Ahmed, Mujtaba Saeed, Jean Michel Saad, William A. Zoghbi, Mouaz H. Al-Mallah
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ahmed Ibrahim Ahmed, Mahmoud Al Rifai, Fares Alahdab, Jean Michel Saad, Yushui Han, Moath Said Alfawara, Faisal Nabi, John J. Mahmarian, Mouaz H. Al-Mallah
Summary: This study aimed to assess the prognostic value of myocardial flow reserve (MFR) using the latest generation of digital PET scanners in patients with suspected or known CAD. The results showed that impaired MFR was significantly associated with adverse events, and it significantly improved the predictive ability over traditional risk factors.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Neurosciences
Naga Venkata K. Pothineni, Elsayed Z. Soliman, Mary Cushman, George Howard, Virginia J. Howard, Scott E. Kasner, Suzanne Judd, J. David Rhodes, Francis E. Marchlinski, Rajat Deo
Summary: This study examined the feasibility of telephone guided, mail-in ambulatory long-term cardiac rhythm monitoring in Black and White stroke survivors, and found a high prevalence of arrhythmias among those who completed monitoring.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Moyses Szklo, Jaideep Patel, Michael J. Blaha, Christie M. Ballantyne, Vera Bittner, Pamela Morris, John W. McEvoy, Michael D. Shapiro, Mouaz H. Al-Mallah, Philip Greenland, Salim S. Virani
Summary: This observational study found no significant association between statin therapy and incident diabetes mellitus. The presence of baseline coronary artery calcium did not significantly affect the risk of incident diabetes.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, John S. Gottdiener, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, Gregory M. Marcus
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Malek Nayfeh, Ahmed Ibrahim Ahmed, Fares Alahdab, Mahmoud Al Rifai, Mouaz Al-Mallah
Article
Cardiac & Cardiovascular Systems
Muhammad Imtiaz Ahmad, Mai Z. Soliman, Elsayed Z. Soliman
Summary: The presence of premature ventricular complexes (PVCs) is associated with an increased risk of stroke mortality, particularly in individuals with coronary heart disease (CHD). Prospective studies are needed to investigate whether improved hospital care or modification of PVCs could improve outcomes.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Editorial Material
Cardiac & Cardiovascular Systems
Abdallah El Bizri, Mouaz H. AL-Mallah
Meeting Abstract
Cardiac & Cardiovascular Systems
Ibrahim Ahmed Ahmed, Jean Michel Saad, Yushui Han, Maan Malahfji, Mouaz H. Al-Mallah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)