期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 319, 期 1, 页码 C166-C182出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00021.2020
关键词
remodeling; cardiac; aging
资金
- National Institute on Aging [RO1 AG053585]
- Aging and the Gheens Foundation
This review aims to highlight the normal physiological remodeling that occurs in healthy aging hearts, including changes that occur in contractility, conduction, valve function, large and small coronary vessels, and the extracellular matrix. These normal age-related changes serve as the foundation that supports decreased plasticity and limited ability for tissue remodeling during pathophysiological states such as myocardial ischemia and heart failure. This review will identify populations at greater risk for poor tissue remodeling in advanced age along with present and future therapeutic strategies that may ameliorate dysfunctional tissue remodeling in aging hearts.
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