Article
Medicine, General & Internal
Naohisa Mihara, Shozo Sonoda, Hiroto Terasaki, Hideki Shiihara, Takato Sakono, Ryoh Funatsu, Taiji Sakamoto
Summary: This study aimed to map and characterize the choroidal thickness in normal eyes and found differences between men and women in terms of thickness and age-related changes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Olivia Xerri, Federico Bernabei, Elise Philippakis, Cyril Burin-Des-Roziers, Pierre-Olivier Barale, Olivier Laplace, Claire Monin, Dominique Bremond-Gignac, Gilles Guerrier, Sophie Valleix, Antoine Brezin, Pierre-Raphael Rothschild
Summary: Highly myopic patients with Stickler syndrome exhibit distinct clinical and SD-OCT features compared to matched controls, including greater choroidal thickness, lower peripapillary atrophy area, and lower prevalence of posterior staphyloma. These findings could be significant for the development and progression of myopic maculopathy in patients with Stickler syndrome.
Article
Ophthalmology
Can Can Xue, Xiaofei Wang, Ying Xiang Han, Qi Zhang, Chun Zhang, Ya Xing Wang, Jost B. Jonas
Summary: This study found that the backward configuration of the peripapillary sclera is associated with the presence, size, and extent of the parapapillary gamma zone. The results suggest that the sclera and the Bruch's membrane play an important role in the biomechanical behavior of the optic nerve head.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Kendra L. Hong, Bruce Burkemper, Anna L. Urrea, Brenda R. Chang, Jae C. Lee, Vivian H. LeTran, Zhongdi Chu, Xiao Zhou, Benjamin Y. Xu, Brandon J. Wong, Brian J. Song, Xuejuan Jiang, Ruikang K. Wang, Rohit Varma, Grace M. Richter
Summary: The study found that hdVAD is higher in early glaucoma patients and may be helpful in detecting early focal damage, but its diagnostic ability is less robust in advanced glaucoma. Combining hdVAD with gRNFL can improve the diagnostic accuracy of glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Ahmet Colakoglu, Iffet Emel Colakoglu, Cemile Banu Cosar
Summary: The study investigated the potential biomechanical measure of the cornea using differential pressure difference (DPD) in air-puff differential tonometry and its relationship with intraocular pressure (IOP), central corneal thickness, corneal curvature, and age. DPD was found to be weakly correlated with central corneal thickness, age, and corneal curvature, but not significantly correlated with IOP 1-30.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Un Chul Park, Eun Kyoung Lee, Bo Hee Kim, Baek-Lok Oh
Summary: The study found that in highly myopic eyes, choroidal and scleral thickness are associated with ocular factors such as axial length and macular curvature. Particularly, the choroid and sclera were thinner in eyes with posterior staphyloma and more severe myopic maculopathy.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Young Ho Kim, Boram Lee, Edward Kang, Jaeryung Oh
Summary: According to choroidal thickness profiles, eyes with AMD and PSD can be classified into different clusters, suggesting that pachydrusen may share a common pathogenesis with PSD.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Sumeyra Koprubasi, Erkan Bulut
Summary: This study revealed that peripapillary choroidal thickness (PPCT) was thinner in obese women compared to healthy women, indicating potential microvascular abnormalities in the optic disc head that could be an initial event in the pathogenesis of obesity-related ocular diseases, especially glaucoma.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Ophthalmology
Federico Bernabei, Marco Pellegrini, Leonardo Taroni, Matilde Roda, Pier Giorgio Toschi, Costantino Schiavi, Giuseppe Giannaccare, Pierre-Raphael Rothschild
Summary: This study compared choroidal vascularity index (CVI) and subfoveal choroidal thickness (CT) between eyes that had undergone encircling scleral buckling (SB) procedure and unoperated fellow eyes (FE). The results showed that eyes treated with encircling SB had increased choroidal thickness, total choroidal area, luminal area, and stromal area compared to fellow eyes, but there was no significant difference in CVI.
Article
Ophthalmology
Young Ho Kim, Boram Lee, Edward Kang, Jaeryung Oh
Summary: The relationship between choroidal thickness profile and clinical outcomes after anti-VEGF treatment in PCV was investigated. Results suggest that baseline nPCT and SFCT/nPCT ratio could be a good biomarker reflecting clinical outcomes in PCV after anti-VEGF treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Ziyi Qi, Xiaoxiao Liu, Shuyu Xiong, Jingjing Wang, Jun Chen, Zhuoting Zhu, Grace Brochert, Bo Zhang, Junjie Deng, Tianyu Cheng, Xiangui He, Xun Xu
Summary: This study aimed to characterize changes in choroidal vasculature in children with different refractive status. The results showed that choroidal vascular index (CVI) was lowest in myopic eyes, followed by emmetropic eyes and hyperopic eyes. CVI varied between different sectors and decreased from nasal to temporal quadrant horizontally and from superior to inferior quadrants vertically. Multiple regression analysis showed that spherical equivalent, axial length, intraocular pressure, choroidal thickness, age, and gender were significantly related to CVI.
Article
Medicine, Research & Experimental
Hua Zhong, Qingqing Dong, Qing Cun, Guangyu He, Yijin Tao, Keyao Song, Yunqing Lu, Qin Zhu, Xi Chen, Qin Chen
Summary: This study identified a positive correlation between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in healthy myopic eyes. This correlation was particularly strong in highly myopic eyes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Ophthalmology
Mert Simsek, Onur Inam, Emine Sen, Ufuk Elgin
Summary: This study found that patients with XFS had decreased choroidal vascularity in the macular and peripapillary regions, while unaffected fellow eyes may show vascular changes in the peripapillary choroid.
Article
Ophthalmology
Claude f. Burgoyne, Ya xing Wang, Jin wook Jeoung, S. E. U. N. G. W. O. O. Hong, S. T. U. A. R. T. Gardiner, J. U. A. N. Reynaud, B. R. A. D. Fortune, Michael j. a. Girard, G. L. E. N. Sharpe, M. A. R. C. E. L. O. Nicolela, Balwantray c. Chauhan, H. O. N. G. L. Yang
Summary: This study used OCT to compare highly myopic and normal eyes and found that pNC-SB increased and pNC-CT decreased in highly myopic eyes, with the greatest changes in the inferior sectors. The results support the hypothesis that sectors of maximum pNC-SB may predict areas of greatest susceptibility to aging and glaucoma in future longitudinal studies of highly myopic eyes.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Charumathi Sabanayagam, Rehena Sultana, Riswana Banu, Tyler Rim, Yih Chung Tham, Sunita Mohan, Miao Li Chee, Ya Xing Wang, Vinay Nangia, Kohta Fujiwara, E. Shyong Tai, Su Jeong Song, Mukharram M. Bikbov, Rajiv Raman, Ching Yu Cheng, Tien Yin Wong, Jost B. Jonas
Summary: This study found an inverse association between BMI and obesity with diabetic retinopathy in Asian adults with diabetes. Overweight did not show a significant association with diabetic retinopathy. Further longitudinal studies are needed to confirm these findings.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Mirinae Jang, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Summary: Seasonal variation in optic disc hemorrhage (DH) was investigated through a retrospective observational study, revealing a higher incidence in winter and a significant association with temperature and intraocular pressure (IOP).
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ahnul Ha, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: This study aimed to investigate the relationship between optic disc morphological changes during myopia progression and the development of retinal nerve fiber layer defect (RNFLD). The results showed that progressive optic disc tilt during myopia progression was associated with a higher risk of RNFLD development in children with large vertical cup-to-disc ratio (vCDR).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Golnoush Mahmoudinezhad, Diana Salazar, Esteban Morales, Peter Tran, Janet Lee, Jean-Pierre Hubschman, Kouros Nouri-Mahdavi, Joseph Caprioli
Summary: This retrospective cohort study aimed to identify clinical characteristics and factors associated with microcystic macular edema (MME) in patients with primary open-angle glaucoma (POAG). The study found that more severe glaucoma and younger age were associated with MME, but MME was not associated with faster global visual field decay.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Sooyeon Choe, Ahnul Ha, Seulggie Choi, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: The purpose of this study was to determine the incidence of infantile cataract (IC) surgery and the risk of secondary glaucoma in the Korean population. A retrospective cohort study was conducted using the Korean National Health Claims database. The study found that the annual incidence of IC surgery ranged from 5.10 to 9.29 cases per 100,000 individuals, and the incidence rate of post-IC surgery glaucoma was 2.29 per 100 person-years. Factors such as intraocular lens implantation were found to reduce the risk of post-IC surgery glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Massood Mohammadi, Erica Su, Leila Chew, Vahid Mohammadzadeh, Joseph Caprioli, Robert E. Weiss, Kouros Nouri-Mahdavi
Summary: The study compared the rates of change in the ganglion cell layer (GCL) and inner plexiform layer (IPL) in glaucoma suspect (GS) and established glaucoma (EG) patients. The results showed that IPL thickness changes occurred earlier than GCL changes in eyes with early damage. Therefore, GCL thickness is more likely to demonstrate change over time compared with IPL in glaucoma suspects.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Golnoush Mahmoudinezhad, Vahid Mohammadzadeh, Jack Martinyan, Kiumars Edalati, Ben Zhou, Dariush Yalzadeh, Navid Amini, Joseph Caprioli, Kouros Nouri-Mahdavi
Summary: The purpose of this study was to compare the accuracy of macular ganglion cell layer (GCL) measurements with ganglion cell/inner plexiform layer (GCIPL) thickness measurements in detecting early glaucoma. The results showed that GCL and GCIPL thicknesses were equivalent in identifying early glaucoma with current OCT technology. This may be due to limitations in inner macular layer segmentation and concurrent changes within the inner plexiform layer in early glaucoma.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Haroon Adam Rasheed, Tyler Davis, Esteban Morales, Zhe Fei, Lourdes Grassi, Agustina De Gainza, Kouros Nouri-Mahdavi, Joseph Caprioli
Summary: In this study, an image analysis pipeline called DDLSNet was developed for automated estimation of the disc damage likelihood scale (DDLS) through rim segmentation and disc size classification. The pipeline demonstrated moderate agreement with clinicians and highlighted the feasibility of automated optic disc photograph grading for assessing glaucoma severity.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Ophthalmology
Haroon Adam Rasheed, Tyler Davis, Esteban Morales, Zhe Fei, Lourdes Grassi, Agustina De Gainza, Kouros Nouri-Mahdavi, Joseph Caprioli
Summary: This study aims to build a fully automated system (RimNet) for direct rim identification in glaucomatous eyes and measurement of rim parameters. The results showed that RimNet demonstrated acceptably accurate rim segmentation and measurements, which are valuable for clinical applications.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Ophthalmology
Sooyeon Choe, Young Kook Kim, Ki Ho Park, Hyuk Jin Choi, Jin Wook Jeoung
Summary: This study investigated the natural history of optic disc with physiologic large cup (PLC), as well as the risk factors for glaucoma conversion. The study identified higher VCDR, violation of the inferior superior nasal temporal neuroretinal rim thickness rule, presence of retinal arterial sclerosis, and lower total bilirubin level as factors associated with glaucoma development.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Lynn Shi, Massood Mohammadi, Vahid Mohammadzadeh, Erica Su, Robert E. Weiss, Joseph Caprioli, Kouros Nouri-Mahdavi
Summary: This study compared the rates of change in RNFL and BMO-MRW thickness in moderate-to-advanced glaucoma. It found that RNFL had a higher rate of change than BMO-MRW in the inferotemporal and inferonasal sectors, and RNFL also had better longitudinal signal-to-noise ratios.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Daniela Khaliliyeh, Agustina De Gainza, Esteban Morales, Joseph Caprioli
Summary: The purpose of this study was to measure the rates of visual field (VF) changes after Ahmed Glaucoma Valve (AGV) implantation and to investigate the risk factors for progression. The study found that there was a continued, significant rate of VF decline after AGV surgery.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ahnul Ha, Sukkyu Sun, Young Kook Kim, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park
Summary: This study assessed the performance of deep-learning models in predicting conversion to normal-tension glaucoma, and found that the models showed good predictive ability.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rami Darwich, Faisal Jarrar, Mustafa Syed, Glen P. Sharpe, Balwantray C. Chauhan
Summary: Both spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) showed similar visualization of optic nerve head (ONH) structures, with a tendency for higher visualization rates with SS-OCT.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Akshay Govind, Shaban Demirel, Kristin Lee, Melissa Amundson, Richard Bryan Bell, Eric Dierks
Summary: This study aimed to identify predictors of intraoperative difficulty, operating time, and postoperative examination abnormalities in subjects undergoing post-traumatic orbital reconstructions. The results showed that medial wall involvement is associated with intraoperative difficulty, and anteriorly positioned fractures are better treated transorbitally.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)