Article
Multidisciplinary Sciences
Yue Cui, Bozhong Shi, Zijie Zhou, Bo Chen, Xiaoyang Zhang, Cong Li, Kai Luo, Zhongqun Zhu, Jinghao Zheng, Xiaomin He
Summary: A long non-coding RNA (CFRL) associated with cardiac fibrosis has been identified, which can promote the proliferation and migration of cardiac fibroblasts. Silencing CFRL significantly alleviates cardiac fibrosis and improves ventricular function. Interfering with CFRL may be considered as a multitarget strategy for treating cardiac fibrosis and heart failure.
Article
Dentistry, Oral Surgery & Medicine
Yingzhi Gu, Yuxing Bai
Summary: This study aimed to determine whether lncRNA MALAT1 promotes the osteogenic differentiation of human PDLSCs in vitro. The results showed that MALAT1 regulates human PDLSC differentiation by regulating the miR-93-5p/SMAD5 axis.
Article
Immunology
Junkui Xu, Yanjiang Pei, Jun Lu, Xiaojun Liang, Yi Li, Junhu Wang, Yingang Zhang
Summary: The study revealed that SNHG7 was downregulated in OA while miR-214-5p was upregulated. SNHG7 enhanced cell viability and suppressed apoptosis and inflammation, whereas upregulation of miR-214-5p had opposite effects on chondrocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Zizhen Si, Lei Yu, Haoyu Jing, Lun Wu, Xidi Wang
Summary: In this study, it was found that ZNF561-AS1 promotes CRC progression via the miR-26a-3p/miR-128-5p-SRSF6 axis. This study provides new insights into the role of ZNF561-AS1 in CRC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Respiratory System
Xiaolong Zhu, Ling He, Xueqin Li, Weiya Pei, Hui Yang, Min Zhong, Mengying Zhang, Kun Lv, Yingying Zhang
Summary: This study reveals that miR-125b-5p is highly expressed in asthma and plays a role in modulating macrophage polarization. By suppressing the expression of miR-125b-5p, allergic airway inflammation in mice can be attenuated. These findings may present a potential therapeutic and diagnostic target for asthma.
BMC PULMONARY MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Lin Yang, Wan-li Deng, Bao-guo Zhao, Yao Xu, Xiao-wen Wang, Yu Fang, Hai-juan Xiao
Summary: LOC554202 is upregulated in HCC patients and can promote HCC progression by competitively binding to miR-485-5p. This suggests that targeting the FOXO3/LOC554202/miR-485-5p/BSG axis may be beneficial for HCC treatment.
CANCER GENE THERAPY
(2022)
Article
Reproductive Biology
Hongmin Guo, Ting Li, Xinhui Sun
Summary: In patients with PCOS, the expression of HOTAIRM1 and PIK3CD is upregulated, while miR-433-5p is downregulated. HOTAIRM1 promotes the expression of PIK3CD, affecting the proliferation and apoptosis of ovarian granulosa cells. miR-433-5p interacts with PIK3CD, modulating the function of granulosa cells.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Cell Biology
Jie Yang, Guangliang Shi, Yafan Gong, Jingzeng Cai, Yingying Zheng, Ziwei Zhang
Summary: The study found that selenium deficiency upregulates ATG7 expression, while miR-17-5p inhibits cardiomyocyte autophagy by targeting ATG7. Additionally, LncRNA 0003250 regulates miR-17-5p, thereby affecting ATG7 and autophagic cell death.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Qi Xu, Demin Cheng, Yi Liu, Honghong Pan, Guanru Li, Ping Li, Yan Li, Wenqing Sun, Dongyu Ma, Chunhui Ni
Summary: The dysregulation of non-coding RNAs, particularly lncRNA-ATB and its downstream targets miR-29b-2-5p and miR-34c-3p, plays a crucial role in regulating EMT and fibrosis in pulmonary diseases. Overexpression of miR-29b-2-5p or miR-34c-3p can inhibit EMT progression and counteract the pro-fibrotic effects of lncRNA-ATB, providing potential therapeutic targets for pulmonary fibrosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Zekun Wang, Yaming Li, Jingwen Yang, Yiran Liang, Xiaolong Wang, Ning Zhang, Xiaoli Kong, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang
Summary: This study reveals that circ-TRIO plays a crucial role in TNBC and is associated with the recurrence and prognosis of TNBC patients. The findings demonstrate that knockdown of circ-TRIO inhibits the proliferation, migration, and invasion of TNBC cells, while overexpression of circ-TRIO has the opposite effects. Mechanistically, circ-TRIO interacts with miR-432-5p to regulate the expression of CCDC58.
CELL DEATH & DISEASE
(2022)
Article
Reproductive Biology
Yimin Ma, Wei Zheng
Summary: PAXIP1-AS1, activated by H3K27ac, functions as a tumor promoter in ovarian cancer by mediating the miR-6744-5p/PCBP2 axis to regulate cell proliferation, apoptosis, migration, and EMT.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Bin Jiang, Jie Xia, Xudong Zhou
Summary: SLC16A1-AS1 acts as a tumor suppressor in breast cancer, and its low expression is associated with poor prognosis. SLC16A1-AS1 inhibits breast cancer carcinogenesis and progression via the SLC16A1-AS1/miR-552-5p/WIF1 pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Su Jung Hwang, Bum Ju Ahn, Min-Wook Shin, Ye-Seul Song, Youngbin Choi, Goo Taeg Oh, Kyu-Won Kim, Hyo-Jong Lee
Summary: Ninj1 plays a critical role in maintaining vascular integrity, while miR-125a-5p acts as a novel regulator in inflammatory diseases and diabetic retinopathy.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Kai Chen, Yifu Hou, Rui Liao, Youzan Li, Hongji Yang, Jun Gong
Summary: Studies have shown that lncRNA SNHG6 is upregulated in HCC, promoting cell proliferation and inhibiting the targeting of E2F1 by competitively binding miR-204-5p.
Article
Oncology
Yufei Lv, Xiaohong Lv, Huike Yang, Xiuying Qi, Xiangchen Wang, Chao Li, Xiaochen Shang, Hongmin Guo, Jianguo Zhang, Yafang Zhang
Summary: The study found that high expression of lncRNA SNHG6 in TNBC cell lines inhibited cell proliferation and migration, while promoting apoptosis. In addition, inhibiting lncRNA SNHG6 expression led to lower tumor weights and volumes in a xenograft mouse model.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xu Min, Zhou Baomei, Ding Yan, Du Shanshan, Su Mengke, Liu Honglin
Summary: This tutorial review comprehensively summarizes the synthesis strategies, characteristics, applications, challenges, and future perspectives of oligonucleotide-peptide complexes (OPCs). The article aims to boost researchers' interests in developing novel OPC synthesis techniques by providing a clear overview of the current situation and limitations in the field.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2022)
Article
Chemistry, Analytical
Shanshan Du, Mengke Su, Chao Wang, Zhongxiang Ding, Yifan Jiang, Honglin Liu
Summary: This study develops a new liquid/liquid interfacial surface-enhanced Raman spectroscopy (SERS) strategy that allows for high-resolution analysis of lipid compounds and has the potential for trace-level identification.
ANALYTICAL CHEMISTRY
(2022)
Article
Computer Science, Information Systems
Yuan-Yu Tsai, Hong-Lin Liu, Cheng-You Ying
Summary: This study proposes a distortion-free data hiding algorithm for high-dynamic-range (HDR) image authentication. By introducing a revision threshold, the proposed algorithm increases the embedding capacity and effectively detects tampered pixels.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Cell Biology
Honglin Liu, Jiani Xie, Limin Fan, Yue Xia, Xia Peng, Jianhua Zhou, Xiaorong Ni
Summary: This study found that cryptotanshinone (CRY) can improve ovarian tissue damage caused by polycystic ovary syndrome (PCOS) by regulating ferroptosis. The specific mechanisms include modulation of oxidative stress, inflammation, and apoptosis signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Weilong Dai, Ke Liu, Rongyang Li, Yan Cao, Ming Shen, Jingli Tao, Honglin Liu
Summary: This study investigated the effect and underlying mechanism of Trillin on myoblast differentiation using a myoblast differentiation model established with mice C2C12 cell line in vitro. The results showed that Trillin significantly inhibited C2C12 differentiation in a dose-dependent manner and increased autophagy. Mechanistically, the activity of AKT/mTOR declined during the inhibition of differentiation by Trillin.
Article
Chemistry, Analytical
Wenxiang Cao, Honglin Liu, Yinjian Hang, Hongzhi Wang, Guodong Li
Summary: This research focuses on how to safely mine in close multi coal seams, especially for large-dip coal seams with complex geological and mechanical conditions. The study found that the overburden strata deform asymmetrically around the coal pillar, leading to non-uniform stress distribution on the floor of the coal pillar and ribs. The results provide a theoretical foundation for a reasonable layout and support technique for roadways in deep zone mining.
Review
Food Science & Technology
Cheng Qu, Yuzhu Li, Shanshan Du, Yuchuang Geng, Mengke Su, Honglin Liu
Summary: Meat nutrition and safety are closely related to people's health and quality of life. Traditional methods for analyzing meat quality have certain disadvantages, while Raman spectroscopy is gaining more attention for its potential in rapid, non-destructive and portable analysis. This review introduces the principles of common Raman techniques in meat analysis and focuses on their applications in structure analysis, quality evaluation, and security control.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Xinying Zhou, Hui Xu, Qianna Li, Qi Wang, Honglin Liu, Yingqi Huang, Yao Liang, Linmiao Lie, Zhenyu Han, Yaoxin Chen, Yulan Huang, Wenle Zhou, Qian Wen, Chaoying Zhou, Shengfeng Hu, Li Ma
Summary: Viperin plays a role in regulating the activation and function of dendritic cells during Mycobacterium tuberculosis infection, and this effect is mediated through NF-kappa B p65 activation pathway. Viperin deficiency enhances the phagocytic activity and clearance ability of dendritic cells against Mtb, and also enhances the interaction between dendritic cells and T cells.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhang, Yinghui Wei, Xiaoxuan Li, Chengyu Li, Liangliang Zhang, Zhaojun Liu, Yan Cao, Weijian Li, Xiying Zhang, Jiaqing Zhang, Ming Shen, Honglin Liu
Summary: CORT inhibits Lhcgr expression in mouse ovarian granulosa cells (GCs), leading to impaired follicular development. The effect of CORT is mediated by its receptor Nr3c1 in GCs. Nr3c1 may regulate Lhcgr transcription by inhibiting the expression of Lhcgr transcription factors AP1 and Creb.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Construction & Building Technology
Guopeng Fan, Naitian Zhang, Songtao Lv, Milkos Borges Cabrera, Jiang Yuan, Xianpeng Fan, Honglin Liu
Summary: The study investigates the correlation between the chemical composition and theological properties of neat asphalt after aging and rejuvenation. The results show that the rheological properties of the asphalt change with aging, but can be reversed by the addition of a regenerating agent. The study also discovers linear relationships among several rheological parameters through correlation analysis.
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Xinying Zhou, Zelin Zhang, Hui Xu, Bo Zhu, Lijie Zhang, Linmiao Lie, Yingqi Huang, Xialin Du, Honglin Liu, Yanfen Li, Yulan Huang, Shengfeng Hu, Chaoying Zhou, Qian Wen, Mailkel P. Pepplenbosch, Li Ma
Summary: Viperin protein is increased in abundance in patients with lymphatic and pulmonary tuberculosis (TB), and its deficiency reduces mycobacterium tuberculosis bacterial loads and enhances macrophage responses. Viperin promotes Mtb infection by inhibiting host innate immune responses in macrophages.
Article
Environmental Sciences
Hengfang Wang, Honglin Liu, Tianhong Yang, Guanghui Lv, Wenjing Li, Yuncai Chen, Deyan Wu
Summary: This study elucidated the responses and potential functions of soil microbial communities during succession in alpine mining areas. The results showed that mining disturbance significantly reduced the relative abundance of archaea, while restoration increased bacterial network node connections and decreased archaeal network connections. The networks of microbial genes related to nitrogen and phosphorus cycle potential varied depending on the succession type.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Green & Sustainable Science & Technology
Guodong Li, Hongzhi Wang, Zhaoxuan Liu, Honglin Liu, Haitian Yan, Zenwei Liu
Summary: The gob-side entry retaining (GER) technique, a member of the pillarless coal mining system, is gaining popularity due to its high resource recovery rate and environmental benefits. The development of the modified high-water backfill material (MBM), which is mixed with aeolian sand, provides a cost-effective solution for coal operators in arid areas. The MBM exhibits high strength, adjustable setting time, and increased peak and residual strength with the addition of aeolian sand.
Article
Biochemistry & Molecular Biology
Aiwen Jiang, Hongyun Guo, Liangliang Zhang, Xiaoyu Jiang, Xiying Zhang, Wangjun Wu, Honglin Liu
Summary: This study found that FFA reduces myogenic differentiation and myotube formation through the AMPK alpha-HDAC4-miR-206 pathway.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Fang Zhao, Quan-Wei Wei, Bo-Jiang Li, Qian-Nan Weng, Yi Jiang, Cai-Bo Ning, Kai-Qing Liu, Wang-Jun Wu, Hong-Lin Liu
Summary: The study found that long-term repeated ACTH administration significantly delayed the initiation of estrus and the pre-ovulatory LH peak in weaned sows, reduced the ovulation rate, affected the concentrations of estrogen and progesterone, and also decreased the mRNA expression of LHR in the corpus luteum.
