Review
Ophthalmology
Austin R. Fox, John H. Fingert
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, characterized by optic nerve damage and visual field defects. While elevated intraocular pressure (IOP) is a significant risk factor, normal tension glaucoma (NTG) can occur within the normal range of IOP. Genetic mutations in optineurin (OPTN), TANK binding kinase 1 (TBK1), and myocilin (MYOC) have been identified as the primary causes of NTG. In this review, we examine pedigree studies and clinical features of NTG associated with these mutations.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Ya-Hui Wei, Yu Cai, Bonnie N. K. Choy, Bai-Bing Li, Ruo-Shi Li, Chen Xing, Xia Wang, Tian Tian, Yuan Fang, Mei Li, Ying-Zi Pan
Summary: NTG patients showed higher DCR values compared to controls, with some DCRs being negatively correlated with CCT and IOP, while others were positively correlated with these factors. The cornea was more deformable in NTG compared to HTG or controls, indicating a potential biomechanical mechanism underlying glaucomatous optic neuropathy in NTG patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Health Care Sciences & Services
Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
Summary: The study found that comorbidities such as hypotension, sleep disturbances, peptic ulcers, and allergic rhinitis are more highly associated with NTG than POAG.
Article
Ophthalmology
David Kuerten, Matthias Fuest, Peter Walter, Babac Mazinani, Niklas Plange
Summary: The study found a relationship between retinal blood flow alterations and contrast sensitivity loss in patients with normal tension glaucoma, indicating a disease-related link between retinal blood flow and visual function. However, this association was not observed in healthy volunteers.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yahui Wei, Yu Cai, Chenying Bao, Yanfei Zhu, Yingzi Pan
Summary: This study aims to analyze the effects of dynamic corneal response parameters (DCRs) on visual field (VF) progression in normal-tension glaucoma (NTG) and hypertension glaucoma (HTG). The results show that the first applanation deflection area (A1Area) is an independent risk factor for VF progression in NTG, while DCRs in HTG are not related to VF progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Urszula Lukasik, Dominika Wrobel-Dudzinska, Jaromir Jarecki, Karolina Gasinska, Tomasz Zarnowski, Anna Swiech, Ewa Kosior-Jarecka
Summary: The aim of this study was to compare the results of OCTA and OCT examinations in patients with NTG and HTG at the early stage of glaucoma. The study found that the only statistical difference between early NTG and HTG in terms of RNFL thickness was observed in the temporal sector, with thinner values in the NTG group. There were no statistical differences between early NTG and HTG in terms of OCTA results.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Jan Lestak, Martin Fus, Marain Rybar, Antonin Benda
Summary: The aim of this study was to compare the values of vessel density (VD) and perfusion parameters in the ophthalmic artery (OA) and central retinal artery (CRA) between hypertensive glaucoma (HTG) and normotensive glaucoma (NTG) patients. The results showed no differences in visual field (VF), VD, PSV-OA, and EDV-CRA between the two groups. However, statistically significant differences were observed in PSV of CRA, EDV of OA, and resistance index (RI) of both CRA and OA.
Article
Ophthalmology
Alasdair N. Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Summary: This study describes the grading methods and baseline characteristics for UK Biobank participants who underwent retinal imaging, and characterizes individuals with retinal features suggestive of age-related macular degeneration, glaucoma, and retinopathy. The results provide important insights into both ocular and systemic health.
Article
Medicine, General & Internal
Young Joo Shin, Eunbi Kim, Bobby Kwanghoon Han, Kayoung Yi
Summary: This study evaluated biomarkers for glaucoma diagnosis in Korea and found that serum MBP level was higher and serum anti-alpha-fodrin antibody level was lower in the glaucoma group compared to the control group. NTG group showed higher anti-SSA and anti-SSB levels and lower anti-alpha-fodrin IgG/IgA levels than HTG group. These biomarkers were useful for diagnosing and discriminating between different types of patients with glaucoma.
Article
Ophthalmology
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Mariam Adeleke, Victoria Vickerstaff, Gareth Ambler, Rachael Hunter, Catey Bunce, Neil Nathwani, Keith Barton, The LiGHT Trial Study Grp
Summary: After 6 years of treatment, selective laser trabeculoplasty (SLT) has been shown to be a more effective and cost-effective primary treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT) compared to intraocular pressure (IOP)-lowering eye drops. The SLT group had better glaucoma symptom scores and 69.8% of eyes in this group achieved or maintained the target IOP without the need for medical or surgical treatment.
Article
Multidisciplinary Sciences
Anne-Sophie Leveque, Magali Bouisse, Jose Labarere, Emanuele Trucco, Stephen Hogg, Tom MacGillivray, Florent Aptel, Christophe Chiquet
Summary: This study investigated the associations between retinal vessel parameters and normal-tension glaucoma (NTG) through a case-control study and a prospective cohort. Measurements of various retinal vessel parameters were taken, and the results showed no significant differences in these parameters between NTG patients and controls.
SCIENTIFIC REPORTS
(2023)
Review
Ophthalmology
Amelien Lauwers, Joao Barbosa Breda, Ingeborg Stalmans
Summary: Glaucoma is a chronic and progressive disease that can cause irreversible blindness if not treated. The natural history of untreated glaucoma is not well understood, although reducing intraocular pressure has been proven effective in slowing disease progression. Understanding the rate of progression and conversion to advanced stages of glaucoma can guide management decisions.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Ho-Kyung Choung, Martha Kim, Sohee Oh, Kyoung Min Lee, Seok Hwan Kim
Summary: The study investigated the association between the position of central retinal vascular trunk (CRVT) and glaucoma in normal-tension glaucoma (NTG) patients. It was found that NTG eyes had a larger offset index relative to control eyes, suggesting that LC/BMO offset may be a local susceptibility factor for NTG.
Article
Ophthalmology
Jing Na He, Tsz Kin Ng, Shi Yao Lu, Pancy Oi Sin Tam, Poemen P. Chan, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Wai Kit Chu
Summary: This study investigated the association between the ANGPT2 gene and primary open-angle glaucoma (POAG) in the Chinese population. The results showed that the SNP rs11775442 was associated with normal tension glaucoma (NTG) in the Hong Kong cohort, while rs13269021 was associated with NTG in males in the Shantou cohort. Further studies are needed to confirm the association between the ANGPT2 locus and NTG in Chinese males.
Article
Neurosciences
Priyamvada M. Pitale, Guofu Shen, Rohini R. Sigireddi, Maria Polo-Prieto, Yong H. Park, Solomon E. Gibson, Peter D. Westenskow, Roomasa Channa, Benjamin J. Frankfort
Summary: The study revealed vascular damage in mice exposed to mild levels of induced ocular hypertension, potentially caused by abnormalities in the intermediate retinal capillary plexus (IRCP). This IRCP-specific phenotype precedes RGC loss, suggesting a possible mechanistic link for early vascular remodeling in glaucoma.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Ophthalmology
Pauline T. Merrill, Christopher R. Henry, Quan Dong Nguyen, Ashvini Reddy, Barry Kapik, Thomas A. Ciulla
Summary: This study investigates the efficacy and safety of suprachoroidal CLS-TA in patients with uveitic macular edema (UME) with or without concurrent systemic corticosteroid or steroid-sparing therapy (ST). The results demonstrate that CLS-TA provides clinically meaningful benefits in improving best-corrected visual acuity and central subfield thickness in UME patients, regardless of concurrent ST usage.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Janet Coleman-Belin, Alon Harris, Bo Chen, Jing Zhou, Thomas Ciulla, Alice Verticchio, Gal Antman, Michael Chang, Brent Siesky
Summary: Common risk factors for ocular pathologies involve age-related damage to the optic nerve. Understanding the mechanisms of age-related changes can help develop targeted treatments for eye diseases. This review focuses on age-related neurodegenerative changes in the optic nerve and their relationship with ocular pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Steven Yeh, Christopher R. Henry, Barry Kapik, Thomas A. Ciulla
Summary: The results of this study demonstrate the effectiveness and tolerability of SCS-TA in the treatment of macular edema secondary to noninfectious uveitis.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Mechanics
Riccardo Sacco, Greta Chiaravalli, Gal Antman, Giovanna Guidoboni, Alice Verticchio, Brent Siesky, Alon Harris
Summary: This article proposes a theoretical model to investigate the relationship between aqueous humor circulation and drainage and intraocular pressure. The model analyzes the balance among aqueous humor secretion, circulation, and drainage, and explores the role of different components in maintaining intraocular pressure.
Review
Ophthalmology
Lucas W. Rowe, Aditya Belamkar, Gal Antman, Amir R. Hajrasouliha, Alon Harris
Summary: Retinopathy of prematurity (ROP) is a vascular disease that affects preterm infants and can lead to preventable blindness. Various imaging modalities have shown changes in ocular blood flow in ROP patients. This review discusses the current literature on vascular imaging and ROP, highlighting differences in vascular imaging parameters between ROP patients and healthy controls. The available data suggest increased peak systolic velocity, vascular tortuosity, smaller foveal avascular zone, and altered foveal vessel density in ROP patients compared to controls. However, more robust longitudinal data is needed to establish these findings.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Alice Chandra Verticchio Vercellin, Alon Harris, Francesco Oddone, Brent Siesky, George Eckert, Aditya Belamkar, Gal Antman, Fani Segev
Summary: In patients with OAG, lower baseline retinal capillary perfusion in the superior retina is significantly associated with long-term structural progression.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Aumer Shughoury, Ashay Bhatwadekar, Denis Jusufbegovic, Amir Hajrasouliha, Thomas A. Ciulla
Summary: The therapeutic landscape of diabetic retinopathy (DR) is rapidly expanding, with new approaches such as anti-VEGF therapies, receptor tyrosine kinase inhibitors, and gene therapy showing promise for the early and long-lasting treatment of this blinding eye disease. However, further research is needed to validate the efficacy of these novel therapeutics and evaluate real-world outcomes.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Review
Pharmacology & Pharmacy
Aumer Shughoury, Duriye D. Sevgi, Thomas A. Ciulla
Summary: Targeting the complement system is a promising therapeutic approach for slowing the progression of GA in AMD, potentially improving visual outcomes. However, increased risk of exudative conversion must be considered, and further research is required to identify clinical criteria and best practices for initiating complement inhibitor therapy for GA.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Ophthalmology
Aumer Shughoury, Evan W. Carr, Ramana S. Moorthy
Summary: This article reports a consecutive series of six new cases of syphilitic uveitis complicated by rhegmatogenous retinal detachment (RRD). The typical characteristics, clinical course, and surgical management of such cases are described. The study found that most retinal detachments occurred within two months of uveitis presentation, and early proliferative vitreoretinopathy was a common complication. The visual outcomes were generally poor.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Meeting Abstract
Ophthalmology
Christopher R. Henry, Barry Kapik, Thomas A. Ciulla
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Viral Kansara, Leroy Muya, Cherry Wan, Shelley Hancock, Thomas A. Ciulla
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Megan E. Cavet, Shelley Hancock, Thomas A. Ciulla
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Thomas Ciulla, Steven Yeh, Seenu M. Hariprasad
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2022)
