Review
Cell Biology
Snehal Raut, Aditya Bhalerao, Michael Powers, Minelly Gonzalez, Salvatore Mancuso, Luca Cucullo
Summary: The brain relies on glucose as its main source of energy, which is transported across the blood-brain barrier by glucose transporters. Glucose is then metabolized into ATP to support cellular functions. Medical conditions like Alzheimer's disease and Parkinson's disease can impair brain metabolism, leading to neurological symptoms.
Article
Biochemistry & Molecular Biology
Sanjay Arora, Takahisa Kanekiyo, Jagdish Singh
Summary: BDNF delivered through lipid-based nanoparticles shows promising results in Alzheimer's Disease animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Yadan Zhang, Junlin He, Liao Shen, Tao Wang, Jun Yang, Yao Li, Yongan Wang, Dongqin Quan
Summary: The study developed transferrin receptor aptamer-functionalized liposomes (Apt-LP) to deliver AChE reactivator across the blood-brain barrier, showing promising results in treating organophosphorus poisoning by improving drug transport efficiency to the brain.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Clinical Neurology
Rosemary J. Jackson, Jonah C. Meltzer, Huong Nguyen, Caitlin Commins, Rachel E. Bennett, Eloise Hudry, Bradley T. Hyman
Summary: The study demonstrates that APOE4 leads to a leaky blood-brain barrier, and astrocyte-produced APOE4, through its interaction with blood vessels, is a crucial regulator of blood-brain barrier integrity.
Article
Chemistry, Multidisciplinary
Sophie Morse, Aishwarya Mishra, Tiffany G. Chan, Rafael T. M. de Rosales, James J. Choi
Summary: The study investigates a noninvasive method of using ultrasound pulses to deliver liposomes across the blood-brain barrier for efficient drug delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Asim Najmi, Shenggang Wang, Yue Huang, Teresa Seefeldt, Yahya Alqahtani, Xiangming Guan
Summary: The blood-brain barrier poses a challenge for the treatment of brain diseases as it prevents drugs from reaching therapeutic concentrations in the brain. Researchers have developed a brain targeting agent called COXP, which self-assembles into brain targeting micelles. This study explores the potential of using COXP as a component of liposomes to prepare brain-targeting liposomes and shows promising results in delivering a fluorescence tracking agent to the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Zahraa S. Al-Ahmady, Ben R. Dickie, Isabelle Aldred, Dhifaf A. Jasim, Jack Barrington, Michael Haley, Eloise Lemarchand, Graham Coutts, Satinderdeep Kaur, Jessica Bates, Sarah Curran, Ruth Goddard, Megan Walker, Adrian Parry-jones, Kostas Kostarelos, Stuart M. Allan
Summary: This study provides compelling evidence that haemorrhagic stroke induces blood-brain barrier injury and offers a unique opportunity to selectively deliver therapeutic molecules using lipid nanoparticles.
Article
Pharmacology & Pharmacy
Huan Wang, Zui Zhang, Juan Guan, Weiyue Lu, Changyou Zhan
Summary: This study investigates the process of GLUT-mediated transcytosis using Glycopeptide-modified nanodisks (Gly-A7R-NDs), revealing the crucial role of lysosomal exocytosis in this process and providing new insights for the development of brain targeting drug delivery.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Chao Yang, Ye Wu, Lin Wang, Sidi Li, Junhu Zhou, Yanli Tan, Jia Song, Huike Xing, Kaikai Yi, Qi Zhan, Jin Zhao, Qixue Wang, Xubo Yuan, Chunsheng Kang
Summary: Exosomes are small extracellular vehicles that can transport genetic materials and proteins between cells. This study explores the mechanisms of exosome-mediated manipulation of brain microvascular endothelial cells and the potential therapeutic role of choline-containing nanocapsules and AKT pathway inhibitors in treating glioblastoma and brain tumor metastasis. The results provide important insights into strategies for BBB penetrating therapies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Paul Kawak, Nour M. Al Sawaftah, William G. Pitt, Ghaleb A. Husseini, Christian Celia, Chiara Laezza
Summary: Glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options due to the blood-brain barrier (BBB). Liposomes offer potential solutions to the limitations of chemotherapy, but passive targeting strategies have been ineffective. The upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics, which show promise in GBM therapy. This review discusses the role of Tf-conjugated liposomes in GBM therapy, recent studies on their drug delivery efficiency, challenges faced, and potential improvements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Sanjay Arora, Divya Sharma, Buddhadev Layek, Jagdish Singh
Summary: Alzheimer's disease is a progressive and incurable CNS disorder characterized by the accumulation of A beta plaques and NFTs, as well as synaptic loss and neuronal signaling imbalance. Current treatments aim to manage symptoms and maintain cognitive functions while slowing down memory loss. Nonviral gene therapy shows promise in addressing these challenges, with advancements in technology offering potential solutions in clinical trials.
MOLECULAR PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Maoxue Tang, Sarah H. Park, Sabrina Petri, Hang Yu, Carlos B. Rueda, E. Dale Abel, Carla Y. Kim, Elizabeth M. C. Hillman, Fanghua Li, Yeojin Lee, Lei Ding, Smitha Jagadish, Wayne N. Frankel, Darryl C. De Vivo, Umrao R. Monani
Summary: Glut1 plays a crucial role in brain angiogenesis through its cell-autonomous function in brain microvascular endothelial cells. Depletion of Glut1 leads to neuroinflammation, reduced BDNF levels, and disease manifestation, with the most severe effects observed when Glut1 scarcity is induced during neonatal brain angiogenesis. Targeting brain endothelial cells during early development is essential for maintaining proper brain angiogenesis and preventing neuroinflammation in Glut1 deficiency syndrome.
Article
Engineering, Biomedical
Marie J. Pauwels, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Andrew Ward, Trevelyan R. Menheniott, Oskar Gustafsson, Francis Combes, Samir El Andaloussi, Niek N. Sanders, Imre Mager, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: The brain is protected by tightly regulated barriers, which impede drug delivery. Extracellular vesicles derived from choroid plexus epithelial cells have the potential to serve as drug delivery vehicles to bypass these barriers.
Article
Chemistry, Multidisciplinary
Sebastien Goutal, Anthony Novell, Sarah Leterrier, Louise Breuil, Erwan Selingue, Matthieu Gerstenmayer, Solene Marie, Bruno Saubamea, Fabien Caille, Oliver Langer, Charles Truillet, Benoit Larrat, Nicolas Tournier
Summary: In this study, the impact of focused ultrasound on P-gp function was investigated using positron emission tomography imaging. The results showed that the function of P-gp is associated with the integrity of the blood-brain barrier, and the down-regulation of P-gp function induced by focused ultrasound can be detected.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Neurosciences
Shanshan Zhang, Lin Gan, Fengye Cao, Hao Wang, Peng Gong, Congcong Ma, Li Ren, Yubo Lin, Xianming Lin
Summary: This review provides an overview of the three barriers formed between the cerebrovascular and the brain parenchyma, focusing on the composition and function of the blood-brain barrier (BBB). It discusses the limitations of the BBB for drug delivery and explores potential strategies for improving CNS drug delivery.
BRAIN RESEARCH BULLETIN
(2022)
Article
Materials Science, Biomaterials
Divya Sharma, Sanjay Arora, Jagdish Singh
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Lindsey Lipp, Divya Sharma, Amrita Banerjee, Jagdish Singh
PHARMACEUTICAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Amrita Banerjee, Divya Sharma, Riddhi Trivedi, Jagdish Singh
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Chemistry, Multidisciplinary
Divya Sharma, Jagdish Singh
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Nanoscience & Nanotechnology
Divya Sharma, Sanjay Arora, Amrita Banerjee, Jagdish Singh
Summary: Localized knockdown of pro-inflammatory adipocytokines in adipose tissue macrophages and adipocytes using RNA interference can reduce inflammatory cytokine levels and increase insulin-sensitizing adipokine levels in obese-diabetic mice, improving insulin sensitivity and glucose tolerance for up to six weeks following a single dose.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Divya Sharma, Sanjay Arora, Jagdish Singh, Buddhadev Layek
Summary: Gene therapy aims to transfer genetic materials into targeted cells for disease treatment or prevention. Nonviral vectors have gained attention for their safety, payload capacity, and stealth abilities, but face challenges in overcoming intracellular and extracellular barriers. This review highlights current advancements in nonviral gene delivery systems and their future potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Medicine, Research & Experimental
Sanjay Arora, Divya Sharma, Buddhadev Layek, Jagdish Singh
Summary: Alzheimer's disease is a progressive and incurable CNS disorder characterized by the accumulation of A beta plaques and NFTs, as well as synaptic loss and neuronal signaling imbalance. Current treatments aim to manage symptoms and maintain cognitive functions while slowing down memory loss. Nonviral gene therapy shows promise in addressing these challenges, with advancements in technology offering potential solutions in clinical trials.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Divya Sharma, Faraj Atassi, Steve Cook, Stacey Marden, Jianyan Wang, Aixiang Xue, David J. Wagner, Guangnong Zhang, Wenzhan Yang
Summary: The objective of this study was to develop extended release subcutaneous thermo-responsive in situ gel-forming delivery systems using commercially available triblock polymers and assess their performance in rats. The disconnect between in vitro ketoprofen drug release and in vivo performance highlights the challenge of accurately predicting in vivo behavior from in vitro results in thermogel formulation development.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lindsey Lipp, Divya Sharma, Amrita Banerjee, Jagdish Singh
Article
Biochemical Research Methods
Divya Sharma, Jagdish Singh
BIOCONJUGATE CHEMISTRY
(2017)