期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 24, 页码 26914-26925出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c05021
关键词
aza-BODIPY nanomedicine; fluorescence imaging; photoacoustic imaging; photodynamic therapy; photothermal therapy; synergistic therapy
资金
- National Natural Science Foundation of China [61525402, 61775095]
- Jiangsu Provincial key research and development plan [BE2017741]
- Jiangsu Province Policy Guidance Plan [BZ2019014]
- six talent peak innovation team in Jiangsu Province [TD-SWYY-009]
Cancer phototheranostics, composed of optical diagnosis and phototherapy (including photodynamic therapy and photothermal therapy), is a promising strategy for precise tumor treatment. Due to the unique properties of near-infrared absorption/emission, high reactive oxygen species generation, and photothermal conversion efficiency, aza-borondipyrromethene (aza-BODIPY), as an emerging organic photosensitizer, has shown great potential for tumor phototheranostics. By encapsulating aza-BODIPY photosensitizers within functional amphiphilic polymers, we can afford hydrophilic nanomedicines that selectively target tumor sites via an enhanced permeability and retention effect, thereby efficiently improving diagnosis and therapeutic efficacy. Herein, in this spotlight article, we attempt to highlight our recent contributions in the development of aza-BODIPY-based nanomedicines, which comprises three main sections: (1) to elucidate the design strategy of aza-BODIPY photosensitizers and corresponding nanomedicines; (2) to overview their photophysical properties and biomedical applications in phototheranostics, including fluorescence imaging, photoacoustic imaging, photodynamic therapy, photothermal therapy, and synergistic therapy; and (3) to depict the challenges and future perspectives of aza-BODIPY nanomedicines. It is believed that this Spotlight on Applications article would illuminate the way of developing new aza-BODIPY nanomedicines as well as other organic photosensitizer-based nanomedicines for future clinical translation.
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