Review
Surgery
Maria E. Caceres-Tavara, Carmen G. Espinoza-Solano, Wendy Nieto-Gutierrez, Ronald Delgado-Delgado
Summary: This study found only three systematic reviews with critically low methodological quality that evaluated the topic of hypertension and non-morbid obesity. They reported results in favor of metabolic surgery, but with very low certainty of evidence.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Cell Biology
Yuanyuan Zhang, Xinyu Zhao, Xiaona Dong, Yuying Zhang, Haixia Zou, Yaoguang Jin, Wei Guo, Peng Zhai, Xu Chen, Alexei Kharitonenkov
Summary: Researchers have developed a GLP-1/GDF15 fusion protein and tested its potential for weight loss in animals. The molecule, QL1005, showed higher potency than the GLP-1 analog semaglutide in vitro. In obese mice, QL1005 led to reductions in body weight, food intake, insulin, fasting glucose, and triglycerides. In a cynomolgus monkey model of obesity, QL1005 dose-dependently reduced body weight, food intake, insulin, and glucose with limited side effects.
Review
Endocrinology & Metabolism
Jui Tu, Yangmeng Wang, Lihua Jin, Wendong Huang
Summary: Metabolic surgery, such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB), is the most effective approach for treating obesity. The precise mechanisms of how these surgeries work are still unclear, but gut hormones, bile acids and gut microbiota have been identified as potential factors. The long-term goal of metabolic/bariatric surgery research is to develop new pharmacotherapeutic options for obesity and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Suelem Pereira da Cruz, Sabrina Cruz, Silvia Pereira, Carlos Saboya, Juliana Castelar Lack Veiga, Andrea Ramalho
Summary: This study evaluates the influence of vitamin D concentrations and preoperative metabolic phenotypes on the remission of CNCDs after RYGB. The results suggest that preoperative vitamin D adequacy may have a protective effect on metabolic health, even in the presence of an unhealthy phenotype.
Article
Endocrinology & Metabolism
Peirong Tian, Jing Fu, Mengyi Li, Yang Liu, Shibo Bian, Meng Zhang, Jia Liu, Lan Jin, Zhongtao Zhang, Peng Zhang
Summary: This study summarized the Greater China Metabolic and Bariatric Surgery Database (GC-MBD) and compared it with data from other international bariatric surgery registries. By establishing comprehensive national registries, real-world information on clinical practice and patient outcomes can be gathered, and insights into variations in clinical practice can be identified.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Zi-Han Qin, Xin Yang, Ya-Qi Zheng, Li-Ya An, Ting Yang, Yu-Lu Du, Xiao Wang, Shu-Han Zhao, Hao-Han Li, Cheng-Kai Sun, Da-Li Sun, Yue-Ying Lin
Summary: This study aimed to evaluate the quality of surgical guidelines on bariatric/metabolic surgery. Four independent reviewers used the AGREE II tool to assess the methodological quality of the included guidelines and conducted a comparative analysis of the main recommendations for surgical methods. Results showed that nine surgical guidelines were included, with five articles worthy of clinical recommendation based on AGREE II scores over 60%. The overall rigor of development was relatively low with an average score of 50.82%. Only 4 out of 15 key recommendations had a grade A rating.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Paolo Gentileschi, Emanuela Bianciardi, Domenico Benavoli, Michela Campanelli
Summary: Bariatric surgery has been shown to promote remission or significant improvement of Type II Diabetes Mellitus and related comorbidities in obese patients. Different gastrointestinal procedures may have varying effects and mechanisms of action on glucose metabolism. Metabolic surgery integrates knowledge and multidisciplinary expertise to provide a combination of conservative and surgical treatments for Type II diabetes.
ACTA DIABETOLOGICA
(2021)
Article
Cardiac & Cardiovascular Systems
Erik Naslund, Erik Stenberg, Robin Hofmann, Johan Ottosson, Magnus Sundbom, Richard Marsk, Per Svensson, Karolina Szummer, Tomas Jernberg
Summary: Metabolic surgery (Roux-en-Y gastric bypass and sleeve gastrectomy) is associated with a lower risk of major adverse cardiovascular events, death, and new onset heart failure in severely obese patients with previous myocardial infarction. Further confirmation of these findings is needed through a randomized, controlled trial.
Article
Nutrition & Dietetics
Iwona Boniecka, Aneta Czerwonogrodzka-Senczyna, Anna Jeznach-Steinhagen, Krzysztof Pasnik, Dorota Szostak-Wegierek, Samir Zeair
Summary: Bariatric surgery is the most effective treatment for obesity and its complications, but failure to adhere to dietary recommendations can lead to unsatisfactory weight loss and metabolic disorders. This study aimed to evaluate the effects of bariatric surgery on anthropometric parameters and nutrient intake.
Article
Medicine, General & Internal
Nataly Echevarria-Castro, Kevin Silva-Parra, Marcos Polar-Trinidad, Juan C. Sanchez-Vicente, Gustavo Salinas-Sedo, Carlos J. Toro-Huamanchumo
Summary: This study assessed the diagnostic concordance between different criteria for MetS in Peruvian adults undergoing bariatric surgery. Almost perfect concordance was found between all criteria except AACE. IDF and ALAD criteria may be the best options in Latino population undergoing weight loss surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Chemical
Teresa Auguet, Miguel Lopez-Dupla, Jessica Ramos, Laia Bertran, David Riesco, Carmen Aguilar, Anna Ardevol, Montserrat Pinent, Fatima Sabench, Daniel Del Castillo, Cristobal Richart
Summary: This study aimed to determine whether adipocytokines and microbiota-derived metabolites can be used as predictive biomarkers for metabolic improvement post-surgery in women with clinically severe obesity. The results showed that levels of certain cytokines and microbiota-derived metabolites changed after surgery, correlating with improvements in glucose, insulin, and lipid levels.
Article
Endocrinology & Metabolism
Kyuho Kim, Tae Jung Oh, Young Suk Park, Won Chang, Hyen Chung Cho, Jihye Lee, Yun Kyung Lee, Sung Hee Choi, Hak Chul Jang
Summary: This study found that obesity is independently associated with polyneuropathy in subjects without diabetes. However, in subjects with diabetes, although the association between obesity and polyneuropathy is not significant after adjusting for conventional risk factors, increased fibrotic gene expression in fat is associated with polyneuropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Juliana D. D. Oliveira, Carlos A. A. Schiavon, Julia S. S. Oliveira, Renato N. N. Santos, Lucas P. P. Damiani, Dimas Ikeoka, Eliana V. V. Santucci, Rachel Helena V. Machado, Luiz A. A. Bortolotto, Otavio Berwanger, Alexandre B. B. Cavalcanti, Luciano F. F. Drager
Summary: This study used ambulatory blood pressure monitoring to evaluate the rate of hypertension remission after bariatric surgery and identified predictors of mid-term hypertension remission. The results showed that after 36 months, 39% of patients who underwent Roux-en-Y gastric bypass experienced hypertension remission. The duration of hypertension history was the only independent predictor, with a decrease in the likelihood of remission by approximately 15% with each additional year of hypertension history.
Article
Surgery
Matthew J. Sarna, Marcoandrea Giorgi, Andrew R. Luhrs
Summary: Patients with metabolic syndrome are at higher risk of peri-operative complications after bariatric surgery, including death, surgical site infections, myocardial infarction, stroke, acute renal failure, and transfusion requirement.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Genetics & Heredity
Rima M. Chakaroun, Lucas Massier, Anna Heintz-Buschart, Nedal Said, Joerg Fallmann, Alyce Crane, Tatjana Schuetz, Arne Dietrich, Matthias Blueher, Michael Stumvoll, Niculina Musat, Peter Kovacs
Summary: The study found that the bacterial signature in the blood is related to metabolic diseases and can be improved after bariatric surgery. This work provides contaminant-aware evidence for the presence of living bacteria in the blood and suggests a putative crosstalk between components of the blood and metabolism in metabolic health regulation.