Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kun Fang, Yuqi Zhang, Jiangyu Yin, Tonghan Yang, Kai Li, Li Wei, Jianbin Li, Wei He
Summary: In this study, pH-responsive and magnetic carboxymethyl starch/alginate hydrogel beads were developed as potential drug carriers for controlled release of anticancer drug. The beads demonstrated excellent stability in simulated stomach fluids and sustained release in simulated intestinal fluids. Applying an external magnetic field enhanced drug release. The beads showed significant cytotoxicity to colon cancer cell lines while having no harmful effects on normal cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Qiqi Sun, Jun Chen, Quan Zhao, Ziyun He, Lei Tang, Yuji Pu, Bin He
Summary: Ulcerative colitis (UC) is an important type of inflammatory bowel disease characterized by chronic intestinal dys-homeostasis. This study developed intrarectal hydrogel microspheres loaded with olsalazine (Olsa) to enhance drug retention and therapeutic effect for UC treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Medicinal
Kai Dong, Shu-Jing Deng, Bin-Yang He, Zi-Yang Guo, Ze-Lin Guan, Xue Leng, Rui-Rui Ma, Dan -Yang Wang, Jian-Feng Xing, Cui-Yu You
Summary: This study developed mucoadhesive nanoparticles (NPs) that could attach to positively charged inflammatory colonic mucosa, enhancing the local concentration and achieving effective targeted therapy for ulcerative colitis (UC).
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Chemistry, Medicinal
Aruzhan Saparbayeva, Juho Lee, Shwe Phyu Hlaing, Jihyun Kim, Dongmin Kwak, Hyunwoo Kim, Eun Hee Lee, Seonghwan Hwang, Min-Soo Kim, Hyung Ryong Moon, Yunjin Jung, Jin-Wook Yoo
Summary: Colon-targeted oral drug delivery systems using nanoparticles and microparticles show promise in treating ulcerative colitis (UC) by reducing side effects and increasing local drug concentration.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Medicine, General & Internal
Geert D'Haens, Remo Panaccione, Filip Baert, Peter Bossuyt, Jean-Frederic Colombel, Silvio Danese, Marla Dubinsky, Brian G. Feagan, Tadakazu Hisamatsu, Allen Lim, James O. Lindsay, Edward V. Loftus, Julian Panes, Laurent Peyrin-Biroulet, Zhihua Ran, David T. Rubin, William J. Sandborn, Stefan Schreiber, Ezequiel Neimark, Alexandra Song, Kristina Kligys, Yinuo Pang, Valerie Pivorunas, Sofie Berg, W. Rachel Duan, Bidan Huang, Jasmina Kalabic, Xiaomei Liao, Anne Robinson, Kori Wallace, Marc Ferrante
Summary: This study evaluated the safety and efficacy of Risankizumab as induction therapy for patients with moderately to severely active Crohn's disease. The results showed that Risankizumab had a significant clinical impact and was well tolerated in treating Crohn's disease.
Article
Agricultural Engineering
Rejish Ramakrishnan, Senthil Vadivu Kulandhaivelu, Swarup Roy
Summary: The study investigated the development of a functional packaging film using alginate, carboxymethyl cellulose, and potato starch, along with grapefruit seed extract. Results showed that the film had a continuous structure without any cracks or pores, and the inclusion of grapefruit seed extract improved the UV barrier properties and maintained transparency. The films also exhibited high antioxidant and antimicrobial properties, as well as reduced water vapor permeability. Additionally, the inclusion of grapefruit seed extract enhanced the flexibility and thermal stability of the film, and effectively extended the shelf life of green chilli by 25 days.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biophysics
Yanan Wang, Yanan Li, Lingyun He, Baiping Mao, Sian Chen, Vanessa Martinez, Xiaoling Guo, Xian Shen, Baohua Liu, Chao Li
Summary: The study found that the esterified alginate-curcumin conjugate exhibited effective anti-inflammatory effects in Raw 264.7 cells, and after oral administration in animals, the majority reached the colon rapidly and released curcumin, effectively reducing colonic inflammation and tissue damage. The curcumin release triggered by commensal flora shows great potential for ulcerative colitis treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Food Science & Technology
Qing-yun Bu, Yue Chen, Yue Ding, Kang-xi Zhang, Ya-Chun Li, Xiao-yan You, Guo-ping Zhao
Summary: As a potential regulator of human health, tea polyphenols (TP) can alleviate intestinal dysbiosis and restore the balance of host-intestinal flora. However, their limited bioavailability due to potential destruction during digestion hinders their effectiveness. In this study, TP-loaded composite microspheres were prepared using sodium alginate (SA) and crosslinked corn starch (CP) to facilitate controlled release of TP in the gastrointestinal tract. The prepared microspheres showed improved TP loading capacity and pH-responsive properties, effectively regulating the homeostatic balance of the intestinal microbiota.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Roberta Ceci, Guglielmo Duranti, Alessia Leonetti, Stefano Pietropaoli, Federico Spinozzi, Lucia Marcocci, Roberto Amendola, Francesco Cecconi, Stefania Sabatini, Paolo Mariottini, Manuela Cervelli
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Review
Biochemistry & Molecular Biology
Chi-Ming Wong, Geetanjali Bansal, Ludmila Pavlickova, Lucia Marcocci, Yuichiro J. Suzuki
ANTIOXIDANTS & REDOX SIGNALING
(2013)
Article
Biochemistry & Molecular Biology
Chi-Ming Wong, Lucia Marcocci, Dividutta Das, Xinhong Wang, Haibei Luo, Makhosazane Zungu-Edmondson, Yuichiro J. Suzuki
FREE RADICAL BIOLOGY AND MEDICINE
(2013)
Article
Multidisciplinary Sciences
Rosaria Campilongo, Maria Letizia Di Martino, Lucia Marcocci, Paola Pietrangeli, Adriano Leuzzi, Milena Grossi, Mariassunta Casalino, Mauro Nicoletti, Gioacchino Micheli, Bianca Colonna, Gianni Prosseda
Article
Multidisciplinary Sciences
Adriano Leuzzi, Maria Letizia Di Martino, Rosaria Campilongo, Maurizio Falconi, Marialuisa Barbagallo, Lucia Marcocci, Paola Pietrangeli, Mariassunta Casalino, Milena Grossi, Gioacchino Micheli, Bianca Colonna, Gianni Prosseda
Article
Agriculture, Multidisciplinary
Armelle Tchoumi Neree, Paola Pietrangeli, Pompilia Ispas Szabo, Mircea Alexandru Mateescu, Lucia Marcocci
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Sergiy G. Gychka, Nataliia V. Shults, Sofia I. Nikolaienko, Lucia Marcocci, Nurefsan E. Sariipek, Vladyslava Rybka, Tatiana A. Malysheva, Vyacheslav A. Dibrova, Yuichiro J. Suzuki, Alexander S. Gavrish
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Caterina Nardella, Angelo Toto, Daniele Santorelli, Livia Pagano, Awa Diop, Valeria Pennacchietti, Paola Pietrangeli, Lucia Marcocci, Francesca Malagrino, Stefano Gianni
Summary: This study analyzed the folding pathway of Crkl-SH2 and its binding reaction with a peptide mimicking Paxillin under different ionic strength and pH conditions. Experimental results demonstrated the presence of an intermediate in the folding process and highlighted the importance of electrostatic interactions in the early event of recognition. Furthermore, a highly conserved histidine residue was found to play a pivotal role in stabilizing the binding complex.
Review
Biochemistry & Molecular Biology
Awa Diop, Daniele Santorelli, Francesca Malagrino, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Lucia Marcocci, Paola Pietrangeli, Stefano Gianni, Angelo Toto
Summary: This review summarizes the latest research on the structure, function, pathogenic role, and regulation of SH2 domains. The findings suggest that pharmacological interest in SH2 domains and a deeper understanding of their binding properties are crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daniele Santorelli, Lucia Marcocci, Valeria Pennacchietti, Caterina Nardella, Awa Diop, Paola Pietrangeli, Livia Pagano, Angelo Toto, Francesca Malagrino, Stefano Gianni
Summary: Cooperativity is a well-established property of folding, but our understanding of this feature in multidomain folding is limited. This study compares the folding of a tandem repeat protein with two PDZ domains to isolated PDZ domains. The results show that while each PDZ domain can fold independently, the full-length construct folds as a single cooperative unit. The analysis provides insights into the molecular basis of cooperativity in multidomain systems.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yuichiro J. Suzuki, Lucia Marcocci, Takashi Shimomura, Yuki Tatenaka, Yuya Ohuchi, Tinatin Brelidze
Article
Biochemistry & Molecular Biology
Lucia Marcocci, Yuichiro J. Suzuki
Article
Chemistry, Analytical
Samaneh Ahmadifar, Tien Canh Le, Lucia Marcocci, Paola Pietrangeli, Mircea Alexandru Mateescu
ANALYTICA CHIMICA ACTA
(2017)
Article
Biochemistry & Molecular Biology
Catherine Jumarie, Marilyne Seide, Lucia Marcocci, Paola Pietrangeli, Mircea Alexandru Mateescu
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2017)